-
1
-
-
33845338724
-
Projections of global mortality and burden of disease from 2002 to 2030
-
Mathers CD, Loncar D: Projections of global mortality and burden of disease from 2002 to 2030. PLoS medicine, 2006; 3: e442
-
(2006)
PLoS medicine
, vol.3
, pp. e442
-
-
Mathers, C.D.1
Loncar, D.2
-
2
-
-
0025597137
-
The LDL receptor locus in familial hypercholesterolemia: Mutational analysis of a membrane protein
-
Hobbs HH, Russell DW, Brown MS, Goldstein JL: The LDL receptor locus in familial hypercholesterolemia: mutational analysis of a membrane protein. Annu Rev Genet, 1990; 24: 133–70
-
(1990)
Annu Rev Genet
, vol.24
, pp. 133-170
-
-
Hobbs, H.H.1
Russell, D.W.2
Brown, M.S.3
Goldstein, J.L.4
-
3
-
-
9644266673
-
Post-transcriptional regulation of low density lipoprotein receptor protein by proprotein convertase subtilisin/kexin type 9a in mouse liver
-
Park SW, Moon YA, Horton JD: Post-transcriptional regulation of low density lipoprotein receptor protein by proprotein convertase subtilisin/kexin type 9a in mouse liver. J Biol Chem, 2004; 279: 50630–38
-
(2004)
J Biol Chem
, vol.279
, pp. 50630-50638
-
-
Park, S.W.1
Moon, Y.A.2
Horton, J.D.3
-
4
-
-
10344253854
-
NARC-1/PCSK9 and its natural mutants: Zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol
-
Benjannet S, Rhainds D, Essalmani R et al: NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol. J Biol chem, 2004; 279: 48865–75
-
(2004)
J Biol chem
, vol.279
, pp. 48865-48875
-
-
Benjannet, S.1
Rhainds, D.2
Essalmani, R.3
-
6
-
-
66349126280
-
PCSK9: A convertase that coordinates LDL catabolism
-
Horton JD, Cohen JC, Hobbs HH: PCSK9: a convertase that coordinates LDL catabolism. J Lipid Re, 2000; 50(Suppl.): S172–77
-
(2000)
J Lipid Re
, vol.50
, pp. S172-SD177
-
-
Horton, J.D.1
Cohen, J.C.2
Hobbs, H.H.3
-
7
-
-
33846679386
-
Molecular biology of PCSK9: Its role in LDL metabolism
-
Horton JD, Cohen JC, Hobbs HH: Molecular biology of PCSK9: its role in LDL metabolism. Trends Biochem Sci, 2007; 32: 71–77
-
(2007)
Trends Biochem Sci
, vol.32
, pp. 71-77
-
-
Horton, J.D.1
Cohen, J.C.2
Hobbs, H.H.3
-
8
-
-
57649193160
-
Atherosclerosis Risk in Communities Study I (2009) Variation in PCSK9, low LDL cholesterol, and risk of peripheral arterial disease
-
Folsom AR, Peacock JM, Boerwinkle E: Atherosclerosis Risk in Communities Study I (2009) Variation in PCSK9, low LDL cholesterol, and risk of peripheral arterial disease. Atherosclerosis, 202: 211–15
-
Atherosclerosis
, vol.202
, pp. 211-215
-
-
Folsom, A.R.1
Peacock, J.M.2
Boerwinkle, E.3
-
9
-
-
0037603589
-
Mutations in PCSK9 cause autosomal dominant hypercholesterolemia
-
Abifadel M, Varret M, Rabes JP et al: Mutations in PCSK9 cause autosomal dominant hypercholesterolemia. Nat Genet, 2003; 34: 154–56
-
(2003)
Nat Genet
, vol.34
, pp. 154-156
-
-
Abifadel, M.1
Varret, M.2
Rabes, J.P.3
-
10
-
-
78651302317
-
The proprotein convertase subtilisin/kexin type 9 gene E670G polymorphism and serum lipid levels in the Guangxi Bai Ku Yao and Han populations
-
Aung LH, Yin RX, Miao L et al: The proprotein convertase subtilisin/kexin type 9 gene E670G polymorphism and serum lipid levels in the Guangxi Bai Ku Yao and Han populations. Lipids Health Dis, 2011; 10: 5
-
(2011)
Lipids Health Dis
, vol.10
, pp. 5
-
-
Aung, L.H.1
Yin, R.X.2
Miao, L.3
-
11
-
-
18944392912
-
A common PCSK9 haplotype, encompassing the E670G coding single nucleotide polymorphism, is a novel genetic marker for plasma low-density lipoprotein cholesterol levels and severity of coronary atherosclerosis
-
Chen SN, Ballantyne CM, Gotto AM Jr et al: A common PCSK9 haplotype, encompassing the E670G coding single nucleotide polymorphism, is a novel genetic marker for plasma low-density lipoprotein cholesterol levels and severity of coronary atherosclerosis. J Am Coll Cardiol, 2005; 45: 1611–19
-
(2005)
J Am Coll Cardiol
, vol.45
, pp. 1611-1619
-
-
Chen, S.N.1
Ballantyne, C.M.2
Gotto, A.M.3
-
12
-
-
40949104944
-
Proprotein convertase subtilisin/ kexin type 9 (PCSK9) gene is a risk factor of large-vessel atherosclerosis stroke
-
Abboud S, Karhunen PJ, Lutjohann D et al: Proprotein convertase subtilisin/ kexin type 9 (PCSK9) gene is a risk factor of large-vessel atherosclerosis stroke. PloS one, 2007; 2: e1043
-
(2007)
PloS one
, vol.2
-
-
Abboud, S.1
Karhunen, P.J.2
Lutjohann, D.3
-
13
-
-
73449143804
-
Effects of PCSK9 variants on common carotid artery intima media thickness and relation to ApoE alleles
-
Norata GD, Garlaschelli K, Grigore L et al: Effects of PCSK9 variants on common carotid artery intima media thickness and relation to ApoE alleles. Atherosclerosis, 2010; 208: 177–82
-
(2010)
Atherosclerosis
, vol.208
, pp. 177-182
-
-
Norata, G.D.1
Garlaschelli, K.2
Grigore, L.3
-
14
-
-
33344464808
-
A spectrum of PCSK9 alleles contributes to plasma levels of low-density lipoprotein cholesterol
-
Kotowski IK, Pertsemlidis A, Luke A et al: A spectrum of PCSK9 alleles contributes to plasma levels of low-density lipoprotein cholesterol. Am J Hum Genet, 2006; 78: 410–22
-
(2006)
Am J Hum Genet
, vol.78
, pp. 410-422
-
-
Kotowski, I.K.1
Pertsemlidis, A.2
Luke, A.3
-
15
-
-
49949100564
-
Genetic variation at the PCSK9 locus moderately lowers low-density lipoprotein cholesterol levels, but does not significantly lower vascular disease risk in an elderly population
-
Polisecki E, Peter I, Robertson M et al: Genetic variation at the PCSK9 locus moderately lowers low-density lipoprotein cholesterol levels, but does not significantly lower vascular disease risk in an elderly population. Atherosclerosis, 2008; 200: 95–101
-
(2008)
Atherosclerosis
, vol.200
, pp. 95-101
-
-
Polisecki, E.1
Peter, I.2
Robertson, M.3
-
16
-
-
36849085368
-
The PCSK9 gene R46L variant is associated with lower plasma lipid levels and cardiovascular risk in healthy U.K. Men
-
Scartezini M, Hubbart C, Whittall RA et al: The PCSK9 gene R46L variant is associated with lower plasma lipid levels and cardiovascular risk in healthy U.K. men. Clin Sci, 2007; 113: 435–41
-
(2007)
Clin Sci
, vol.113
, pp. 435-441
-
-
Scartezini, M.1
Hubbart, C.2
Whittall, R.A.3
-
17
-
-
33748601835
-
The E670G SNP in the PCSK9 gene is associated with polygenic hypercholesterolemia in men but not in women
-
Evans D, Beil FU: The E670G SNP in the PCSK9 gene is associated with polygenic hypercholesterolemia in men but not in women. BMC Med Genet, 2006; 7: 66
-
(2006)
BMC Med Genet
, vol.7
, pp. 66
-
-
Evans, D.1
Beil, F.U.2
-
18
-
-
33646382116
-
The c.43_44insCTG variation in PCSK9 is associated with low plasma LDL-cholesterol in a Caucasian population
-
Yue P, Averna M, Lin X, Schonfeld G: The c.43_44insCTG variation in PCSK9 is associated with low plasma LDL-cholesterol in a Caucasian population. Hum Mutat, 2006; 27: 460–66
-
(2006)
Hum Mutat
, vol.27
, pp. 460-466
-
-
Yue, P.1
Averna, M.2
Lin, X.3
Schonfeld, G.4
-
19
-
-
38049077373
-
Genetic variants in PCSK9 in the Japanese population: Rare genetic variants in PCSK9 might collectively contribute to plasma LDL cholesterol levels in the general population
-
Miyake Y, Kimura R, Kokubo Y et al: Genetic variants in PCSK9 in the Japanese population: rare genetic variants in PCSK9 might collectively contribute to plasma LDL cholesterol levels in the general population. Atherosclerosis, 2008; 196: 29–36
-
(2008)
Atherosclerosis
, vol.196
, pp. 29-36
-
-
Miyake, Y.1
Kimura, R.2
Kokubo, Y.3
-
20
-
-
0030635582
-
-
American Diabetes Association: clinical practice recommendations 1997. Diabetes Care, 1997; 20: S1–S70
-
(1997)
Diabetes Care
, vol.20
, pp. S1-S70
-
-
-
21
-
-
18944381751
-
SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci
-
Shi YY, He L: SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci. Cell Res, 2005; 15: 97–98
-
(2005)
Cell Res
, vol.15
, pp. 97-98
-
-
Shi, Y.Y.1
He, L.2
-
22
-
-
64149129845
-
A partition-ligation-combination-subdivision EM algorithm for haplotype inference with multiallelic markers: Update of the SHEsis
-
Li Z, Zhang Z, He Z et al: A partition-ligation-combination-subdivision EM algorithm for haplotype inference with multiallelic markers: update of the SHEsis (http://analysis.bio-x.cn). Cell Res, 2009; 19: 519–23
-
(2009)
Cell Res
, vol.19
, pp. 519-523
-
-
Li, Z.1
Zhang, Z.2
He, Z.3
-
23
-
-
0037417807
-
The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): Liver regeneration and neuronal differentiation
-
Seidah NG, Benjannet S, Wickham L et al: The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation. Proc Natl Acad Sci USA, 2003; 100: 928–33
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 928-933
-
-
Seidah, N.G.1
Benjannet, S.2
Wickham, L.3
-
24
-
-
60649101883
-
Molecular basis of PCSK9 function
-
Lambert G, Charlton F, Rye KA, Piper DE: Molecular basis of PCSK9 function. Atherosclerosis, 2009; 203: 1–7
-
(2009)
Atherosclerosis
, vol.203
, pp. 1-7
-
-
Lambert, G.1
Charlton, F.2
Rye, K.A.3
Piper, D.E.4
-
25
-
-
46349103159
-
Secreted proprotein convertase subtilisin/kexin type 9 reduces both hepatic and extrahepatic low-density lipoprotein receptors in vivo
-
Schmidt RJ, Beyer TP, Bensch WR et al: Secreted proprotein convertase subtilisin/kexin type 9 reduces both hepatic and extrahepatic low-density lipoprotein receptors in vivo. Biochem Biophys Res Commun, 2008; 370: 634–40
-
(2008)
Biochem Biophys Res Commun
, vol.370
, pp. 634-640
-
-
Schmidt, R.J.1
Beyer, T.P.2
Bensch, W.R.3
-
26
-
-
3943090528
-
Apolipoprotein B100 metabolism in autosomal-dominant hypercholesterolemia related to mutations in PCSK9
-
Ouguerram K, Chetiveaux M, Zair Y et al: Apolipoprotein B100 metabolism in autosomal-dominant hypercholesterolemia related to mutations in PCSK9. Arterioscler Thromb Vasc Biol, 2004; 24: 1448–53
-
(2004)
Arterioscler Thromb Vasc Biol
, vol.24
, pp. 1448-1453
-
-
Ouguerram, K.1
Chetiveaux, M.2
Zair, Y.3
-
27
-
-
18144406186
-
Evidence for effect of mutant PCSK9 on apolipoprotein B secretion as the cause of unusually severe dominant hypercholesterolaemia
-
Sun XM, Eden ER, Tosi I et al: Evidence for effect of mutant PCSK9 on apolipoprotein B secretion as the cause of unusually severe dominant hypercholesterolaemia. Hum Mol Genet, 2005; 14: 1161–69
-
(2005)
Hum Mol Genet
, vol.14
, pp. 1161-1169
-
-
Sun, X.M.1
Eden, E.R.2
Tosi, I.3
-
28
-
-
29944443017
-
Novel mutations of the PCSK9 gene cause variable phenotype of autosomal dominant hypercholesterolemia
-
Allard D, Amsellem S, Abifadel M et al: Novel mutations of the PCSK9 gene cause variable phenotype of autosomal dominant hypercholesterolemia. Hum Mutat, 2005; 26: 497
-
(2005)
Hum Mutat
, vol.26
, pp. 497
-
-
Allard, D.1
Amsellem, S.2
Abifadel, M.3
-
29
-
-
2442670243
-
Mutations in the PCSK9 gene in Norwegian subjects with autosomal dominant hypercholesterolemia
-
Leren TP: Mutations in the PCSK9 gene in Norwegian subjects with autosomal dominant hypercholesterolemia. Clin Genet, 2004; 65: 419–22
-
(2004)
Clin Genet
, vol.65
, pp. 419-422
-
-
Leren, T.P.1
-
30
-
-
34250724846
-
Relation of PCSK9 mutations to serum low-density lipoprotein cholesterol in childhood and adulthood (from The Bogalusa Heart Study)
-
Hallman DM, Srinivasan SR, Chen W et al: Relation of PCSK9 mutations to serum low-density lipoprotein cholesterol in childhood and adulthood (from The Bogalusa Heart Study). Am J Cardiol, 2007; 100: 69–72
-
(2007)
Am J Cardiol
, vol.100
, pp. 69-72
-
-
Hallman, D.M.1
Srinivasan, S.R.2
Chen, W.3
-
31
-
-
34447299120
-
The C679X mutation in PCSK9 is present and lowers blood cholesterol in a Southern African population
-
Hooper AJ, Marais AD, Tanyanyiwa DM, Burnett JR: The C679X mutation in PCSK9 is present and lowers blood cholesterol in a Southern African population. Atherosclerosis, 2007; 193: 445–48
-
(2007)
Atherosclerosis
, vol.193
, pp. 445-448
-
-
Hooper, A.J.1
Marais, A.D.2
Tanyanyiwa, D.M.3
Burnett, J.R.4
-
32
-
-
33750090075
-
The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: Functional consequences of natural mutations and post-translational modifications
-
Benjannet S, Rhainds D, Hamelin J et al: The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications. J Biol Chem, 2006; 281: 30561–72
-
(2006)
J Biol Chem
, vol.281
, pp. 30561-30572
-
-
Benjannet, S.1
Rhainds, D.2
Hamelin, J.3
-
33
-
-
33750597734
-
Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice
-
Lagace TA, Curtis DE, Garuti R et al: Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice. J Clin Invest, 2006; 116: 2995–3005
-
(2006)
J Clin Invest
, vol.116
, pp. 2995-3005
-
-
Lagace, T.A.1
Curtis, D.E.2
Garuti, R.3
-
34
-
-
33748752232
-
Fasting induces hyperlipidemia in mice overexpressing proprotein convertase subtilisin kexin type 9: Lack of modulation of very-low-density lipoprotein hepatic output by the low-density lipoprotein receptor
-
Lambert G, Jarnoux AL, Pineau T et al: Fasting induces hyperlipidemia in mice overexpressing proprotein convertase subtilisin kexin type 9: lack of modulation of very-low-density lipoprotein hepatic output by the low-density lipoprotein receptor. Endocrinology, 2006; 147: 4985–95
-
(2006)
Endocrinology
, vol.147
, pp. 4985-4995
-
-
Lambert, G.1
Jarnoux, A.L.2
Pineau, T.3
-
35
-
-
84901452665
-
Effect of E670G Polymorphism in PCSK9 Gene on the Risk and Severity of Coronary Heart Disease and Ischemic Stroke in a Tunisian Cohort
-
Slimani A, Harira Y, Trabelsi I et al: Effect of E670G Polymorphism in PCSK9 Gene on the Risk and Severity of Coronary Heart Disease and Ischemic Stroke in a Tunisian Cohort. J Mol Neurosci, 2014; 53(2): 150–57
-
(2014)
J Mol Neurosci
, vol.53
, Issue.2
, pp. 150-157
-
-
Slimani, A.1
Harira, Y.2
Trabelsi, I.3
|