Controlling the Dissociation of Ligands from the Adenosine A2A Receptor through Modulation of Salt Bridge Strength

Journal of Medicinal Chemistry

Volumn 59, Issue 13, 2016, Pages 6470-6479

  Segala, Elena ^a   Guo, Dong ^b   Cheng, Robert K Y ^a   Bortolato, Andrea ^a   Deflorian, Francesca ^a   Doré, Andrew S ^a   Errey, James C ^a   Heitman, Laura H ^b   Ijzerman, Adriaan P ^b   Marshall, Fiona H ^a   Cooke, Robert M ^a  

^a Heptares Therapeutics Ltd   (United Kingdom)

^b LEIDEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

4 [2 [7 AMINO 2 (2 FURYL) 1,2,4 TRIAZOLO[2,3 A][1,3,5]TRIAZIN 5 YLAMINO]ETHYL]PHENOL; ADENOSINE A2A RECEPTOR; G PROTEIN COUPLED RECEPTOR; LIGAND; SODIUM CHLORIDE; TRIAZINE DERIVATIVE; TRIAZOLE DERIVATIVE;

ARTICLE; COMPUTER MODEL; CONTROLLED STUDY; CRYSTAL STRUCTURE; DISSOCIATION RATE CONSTANT; DRUG DESIGN; DRUG RECEPTOR BINDING; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; KINETICS; LIGAND BINDING; MOLECULAR DYNAMICS; MUTAGENESIS; PROTEIN STRUCTURE; THERMOSTABILITY; X RAY CRYSTALLOGRAPHY; CELL CULTURE; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; GENETICS; HEK293 CELL LINE; METABOLISM; MOLECULAR MODEL; PROTEIN ENGINEERING; STRUCTURE ACTIVITY RELATION;

CELLS, CULTURED; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; HEK293 CELLS; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN ENGINEERING; RECEPTOR, ADENOSINE A2A; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZINES; TRIAZOLES;

EID: 84978734536     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.6b00653     Document Type: Article

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