Sustained activation of mTORC1 in macrophages increases AMPKα-dependent autophagy to maintain cellular homeostasis

BMC Biochemistry

Volumn 17, Issue 1, 2016, Pages

  Pan, Hongjie ^a   Zhong, Xiao Ping ^b   Lee, Sunhee ^a  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

AMP activated protein kinase (AMPK); Autophagy; Macrophages; Mechanistic target of rapamycin (mTOR); Mycobacterium tuberculosis; Tuberous sclerosis 1 (TSC1)

Indexed keywords

CELL PROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE ALPHA; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PROTEIN KINASE; RAPAMYCIN; RAPTOR PROTEIN; REGULATOR PROTEIN; TUBEROUS SCLEROSIS 1 COMPLEX PROTEIN; UNC 51 LIKE KINASE 1; UNCLASSIFIED DRUG; AMPK ALPHA1 SUBUNIT, MOUSE; INTERLEUKIN 1BETA; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MESSENGER RNA; MULTIPROTEIN COMPLEX; TARGET OF RAPAMYCIN KINASE; TUBERIN; TUBEROUS SCLEROSIS COMPLEX 1 PROTEIN; TUMOR SUPPRESSOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; BACTERIAL LOAD; CELLULAR HOMEOSTASIS; CELLULAR PARAMETERS; CONTROLLED STUDY; EMBRYO; FIBROBLAST; INFLAMMATION; KNOCKOUT MOUSE; MACROPHAGE; MOUSE; MOUSE EMBRYONIC FIBROBLAST; NONHUMAN; PROTEIN ANALYSIS; PROTEIN DEFICIENCY; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; TUBERCULOSIS; WILD TYPE MOUSE; ANIMAL; BONE MARROW CELL; CELL CULTURE; CHEMISTRY; CYTOLOGY; DEFICIENCY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE MICROSCOPY; GENETICS; METABOLISM; MICROBIOLOGY; MYCOBACTERIUM TUBERCULOSIS; PATHOGENICITY;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; AUTOPHAGY; BONE MARROW CELLS; CELLS, CULTURED; ENZYME-LINKED IMMUNOSORBENT ASSAY; INTERLEUKIN-1BETA; MACROPHAGES; MICE; MICE, KNOCKOUT; MICROSCOPY, FLUORESCENCE; MULTIPROTEIN COMPLEXES; MYCOBACTERIUM TUBERCULOSIS; RNA, MESSENGER; TOR SERINE-THREONINE KINASES; TUMOR SUPPRESSOR PROTEINS;

EID: 84978472307     PISSN: None     EISSN: 14712091     Source Type: Journal    
DOI: 10.1186/s12858-016-0069-6     Document Type: Article

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