Impaired cell proliferation in regenerating liver of 3 β-hydroxysterol Δ14-reductase (TM7SF2) knock-out mice

Cell Cycle

Volumn 15, Issue 16, 2016, Pages 2164-2173

  Bartoli, Daniela ^a   Piobbico, Danilo ^a   Bellet, Marina Maria ^a   Bennati, Anna Maria ^a   Roberti, Rita ^a   Della Fazia, Maria Agnese ^a   Servillo, Giuseppe ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

Author keywords

3 Hydroxysterol 14 Reductase; cell cycle; cell proliferation; ER stress; liver regeneration; p53; partial hepatectomy

Indexed keywords

3 BETA HYDROXYSTEROL DELTA 14 REDUCTASE; CHOLESTEROL; CYCLIN A; CYCLIN D1; CYCLIN DEPENDENT KINASE 4; CYCLIN E; CYCLIN E1; LAMIN B; PROTEIN P21; PROTEIN P53; STEROID REDUCTASE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; CELL RECEPTOR; DELTA(14)-STEROL REDUCTASE; LAMIN B RECEPTOR; LIPID; OXIDOREDUCTASE;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATABOLISM; CELL CYCLE PROGRESSION; CELL DIVISION; CELL PROLIFERATION; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; FATTY LIVER; G1 PHASE CELL CYCLE CHECKPOINT; IN VIVO STUDY; LIPID LIVER LEVEL; LIVER CELL; LIVER REGENERATION; LIVER RESECTION; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; ANIMAL; C57BL MOUSE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; COMPLICATION; DEFICIENCY; GENETICS; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY;

ANIMALS; CELL PROLIFERATION; ENDOPLASMIC RETICULUM STRESS; FATTY LIVER; G1 PHASE; HEPATECTOMY; HEPATOCYTES; LIPIDS; LIVER REGENERATION; MALE; MICE, INBRED C57BL; MICE, KNOCKOUT; OXIDOREDUCTASES; RECEPTORS, CYTOPLASMIC AND NUCLEAR; S PHASE;

EID: 84978471892     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.1080/15384101.2016.1195939     Document Type: Article

References (38)

1. N.Fausto. Liver regeneration. J Hepatol 2000; 32:19-31; PMID:10728791; http://dx.doi.org/10.1016/S0168-8278(00)80412-2
2. G.M.Higgins, R.M.Anderson. Experimental pathology of liver:restoration of liver in white rat following partial surgical removal. Arch Pathol (Chic) 1931; 12:186-202.
3. G.K.Michalopoulos, M.C.DeFrances. Liver regeneration. Science 1997; 276:60-6; PMID:9082986; http://dx.doi.org/10.1126/science.276.5309.60
4. R.Taub. Liver regeneration:from myth to mechanism. Nat Rev Mol Cell Biol 2004; 5:836-47; PMID:15459664; http://dx.doi.org/10.1038/nrm1489
5. G.Servillo, M.A.Della Fazia, P.Sassone-Corsi. Transcription factor CREM coordinates the timing of hepatocyte proliferation in the regenerating liver. Genes Dev 1998; 12:3639-43; PMID:9851970; http://dx.doi.org/10.1101/gad.12.23.3639
6. G.Servillo, M.A.Della Fazia, P.Sassone-Corsi. Coupling cAMP signaling to transcription in the liver:pivotal role of CREB and CREM. Exp Cell Res 2002; 275:143-54; PMID:11969286; http://dx.doi.org/10.1006/excr.2002.5491
7. G.Servillo, L.Penna, N.S.Foulkes, M.V.Magni, M.A.Della Fazia, P.Sassone-Corsi. Cyclic AMP signalling pathway and cellular proliferation:induction of CREM during liver regeneration. Oncogene 1997; 14:1601-6; PMID:9129151; http://dx.doi.org/10.1038/sj.onc.1200996
8. M.Castelli, S.Pieroni, C.Brunacci, D.Piobbico, D.Bartoli, M.M.Bellet, E.Colombo, P.G.Pelicci, M.A.Della Fazia, G.Servillo. Hepatocyte odd protein shuttling (HOPS) is a bridging protein in the nucleophosmin-p19(Arf) network. Oncogene 2013; 32:3350-8; PMID:22890319; http://dx.doi.org/10.1038/onc.2012.353
9. M.Castelli, D.Piobbico, D.Bartoli, S.Pieroni, C.Brunacci, M.M.Bellet, M.Chiacchiaretta, M.A.Della Fazia, G.Servillo. Different functions of HOPS isoforms in the cell:HOPS shuttling isoform is determined by RIP cleavage system. Cell Cycle 2014; 13:293-302; PMID:24240191; http://dx.doi.org/10.4161/cc.27054
10. M.A.Della Fazia, M.Castelli, D.Bartoli, S.Pieroni, V.Pettirossi, D.Piobbico, M.Viola-Magni, G.Servillo. HOPS:a novel cAMP-dependent shuttling protein involved in protein synthesis regulation. J Cell Sci 2005; 118:3185-94; PMID:16014383; http://dx.doi.org/10.1242/jcs.02452
11. S.Pieroni, M.A.Della Fazia, M.Castelli, D.Piobbico, D.Bartoli, C.Brunacci, M.M.Bellet, M.Viola-Magni, G.Servillo. HOPS is an essential constituent of centrosome assembly. Cell Cycle 2008; 7:1462-6; PMID:18418082; http://dx.doi.org/10.4161/cc.7.10.5882
12. M.A.Della Fazia, D.Piobbico, D.Bartoli, M.Castelli, S.Brancorsini, M.Viola Magni, G.Servillo. lal-1:a differentially expressed novel gene during proliferation in liver regeneration and in hepatoma cells. Genes Cells 2002; 7:1183-90; PMID:12390252; http://dx.doi.org/10.1046/j.1365-2443.2002.00593.x
13. M.M.Bellet, D.Piobbico, D.Bartoli, M.Castelli, S.Pieroni, C.Brunacci, M.Chiacchiaretta, R.Del Sordo, F.Fallarino, A.Sidoni, et al. NEDD4 controls the expression of GUCD1, a protein upregulated in proliferating liver cells. Cell Cycle 2014; 13:1902-11; PMID:24743017; http://dx.doi.org/10.4161/cc.28760
14. M.A.Della Fazia, V.Pettirossi, E.Ayroldi, C.Riccardi, M.V.Magni, G.Servillo. Differential expression of CD44 isoforms during liver regeneration in rats. J Hepatol 2001; 34:555-61; PMID:11394655; http://dx.doi.org/10.1016/S0168-8278(00)00065-9
15. M.A.Della Fazia, G.Servillo, M.Viola-Magni. Different expression of tyrosine aminotransferase and serine deydratase in rat livers after partial hepatectomy. Biochem Biophys Res Comm 1992; 182:753-9; PMID:1370891; http://dx.doi.org/10.1016/0006-291X(92)91796-S
16. B.Delgado-Coello, M.A.Briones-Orta, M.Macias-Silva, J.Mas-Oliva. Cholesterol:recapitulation of its active role during liver regeneration. Liver Int 2011; 31:1271-84; PMID:21745289; http://dx.doi.org/10.1111/j.1478-3231.2011.02542.x
17. M.A.Fernandez, C.Albor, M.Ingelmo-Torres, S.J.Nixon, C.Ferguson, T.Kurzchalia, F.Tebar, C.Enrich, R.G.Parton, A.Pol. Caveolin-1 is essential for liver regeneration. Science 2006; 313:1628-32; PMID:16973879; http://dx.doi.org/10.1126/science.1130773
18. M.A.Lasuncion, C.Martin-Sanchez, A.Canfran-Duque, R.Busto. Post-lanosterol biosynthesis of cholesterol and cancer. Curr Opin Pharmacol 2012; 12:717-23; PMID:22824432; http://dx.doi.org/10.1016/j.coph.2012.07.001
19. E.Shteyer, Y.Liao, L.J.Muglia, P.W.Hruz, D.A.Rudnick. Disruption of hepatic adipogenesis is associated with impaired liver regeneration in mice. Hepatology 2004; 40:1322-32; PMID:15565660; http://dx.doi.org/10.1002/hep.20462
20. C.Fernandez, V.Lobo Md Mdel, D.Gomez-Coronado, M.A.Lasuncion. Cholesterol is essential for mitosis progression and its deficiency induces polyploid cell formation. Exp Cell Res 2004; 300:109-20; PMID:15383319; http://dx.doi.org/10.1016/j.yexcr.2004.06.029
21. P.Singh, R.Saxena, G.Srinivas, G.Pande, A.Chattopadhyay. Cholesterol biosynthesis and homeostasis in regulation of the cell cycle. PloS One 2013; 8:e58833; PMID:23554937; http://dx.doi.org/10.1371/journal.pone.0058833
22. A.M.Bennati, M.Castelli, M.A.Della Fazia, T.Beccari, D.Caruso, G.Servillo, R.Roberti. Sterol dependent regulation of human TM7SF2 gene expression:role of the encoded 3beta-hydroxysterol Delta14-reductase in human cholesterol biosynthesis. Biochim Biophys Acta 2006; 1761:677-85; PMID:16784888; http://dx.doi.org/10.1016/j.bbalip.2006.05.004
23. A.M.Bennati, G.Schiavoni, S.Franken, D.Piobbico, M.A.Della Fazia, D.Caruso, E.De Fabiani, L.Benedetti, M.G.Cusella De Angelis, V.Gieselmann, et al. Disruption of the gene encoding 3beta-hydroxysterol Delta-reductase (Tm7sf2) in mice does not impair cholesterol biosynthesis. FEBS J 2008; 275:5034-47; PMID:18785926; http://dx.doi.org/10.1111/j.1742-4658.2008.06637.x
24. R.Roberti, A.M.Bennati, G.Galli, D.Caruso, B.Maras, C.Aisa, T.Beccari, M.A.Della Fazia, G.Servillo. Cloning and expression of sterol Delta 14-reductase from bovine liver. Eur J Biochem 2002; 269:283-90; PMID:11784322; http://dx.doi.org/10.1046/j.0014-2956.2001.02646.x
25. G.Schiavoni, A.M.Bennati, M.Castelli, M.A.Fazia, T.Beccari, G.Servillo, R.Roberti. Activation of TM7SF2 promoter by SREBP-2 depends on a new sterol regulatory element, a GC-box, and an inverted CCAAT-box. Biochim Biophys Acta 2010; 1801:587-92; PMID:20138239; http://dx.doi.org/10.1016/j.bbalip.2010.01.013
26. A.L.Olins, G.Rhodes, D.B.Welch, M.Zwerger, D.E.Olins. Lamin B receptor:multi-tasking at the nuclear envelope. Nucleus 2010; 1:53-70; PMID:21327105; http://dx.doi.org/10.4161/nucl.1.1.10515
27. I.Bellezza, R.Roberti, L.Gatticchi, R.Del Sordo, M.G.Rambotti, M.C.Marchetti, A.Sidoni, A.Minelli. A novel role for Tm7sf2 gene in regulating TNFalpha expression. PloS One 2013; 8:e68017; PMID:23935851; http://dx.doi.org/10.1371/journal.pone.0068017
28. I.Garcia-Arcos, P.Gonzalez-Kother, P.Aspichueta, Y.Rueda, B.Ochoa, O.Fresnedo. Lipid analysis reveals quiescent and regenerating liver-specific populations of lipid droplets. Lipids 2010; 45:1101-8; PMID:21063798; http://dx.doi.org/10.1007/s11745-010-3492-2
29. E.P.Newberry, S.M.Kennedy, Y.Xie, J.Luo, S.E.Stanley, C.F.Semenkovich, R.M.Crooke, M.J.Graham, N.O.Davidson. Altered hepatic triglyceride content after partial hepatectomy without impaired liver regeneration in multiple murine genetic models. Hepatology 2008; 48:1097-105; PMID:18697204; http://dx.doi.org/10.1002/hep.22473
30. N.Dioufa, I.Chatzistamou, E.Farmaki, A.G.Papavassiliou, H.Kiaris. p53 antagonizes the unfolded protein response and inhibits ground glass hepatocyte development during endoplasmic reticulum stress. Exp Biol Med (Maywood) 2012; 237:1173-80; PMID:23038705; http://dx.doi.org/10.1258/ebm.2012.012140
31. G.C.Farrell. Probing Prometheus:fat fueling the fire? Hepatology 2004; 40:1252-5; PMID:15558710; http://dx.doi.org/10.1002/hep.20522
32. D.A.Rudnick. Trimming the fat from liver regeneration. Hepatology 2005; 42:1001-3; PMID:16250044; http://dx.doi.org/10.1002/hep.20931
33. M.Hamano, H.Ezaki, S.Kiso, K.Furuta, M.Egawa, T.Kizu, N.Chatani, Y.Kamada, Y.Yoshida, T.Takehara. Lipid overloading during liver regeneration causes delayed hepatocyte DNA replication by increasing ER stress in mice with simple hepatic steatosis. J Gastroenterol 2014; 49:305-16; PMID:23512345; http://dx.doi.org/10.1007/s00535-013-0780-7
34. S.Fu, S.M.Watkins, G.S.Hotamisligil. The role of endoplasmic reticulum in hepatic lipid homeostasis and stress signaling. Cell Metab 2012; 15:623-34; PMID:22560215; http://dx.doi.org/10.1016/j.cmet.2012.03.007
35. B.Luo, A.S.Lee. The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies. Oncogene 2013; 32:805-18; PMID:22508478; http://dx.doi.org/10.1038/onc.2012.130
36. F.Zhang, R.B.Hamanaka, E.Bobrovnikova-Marjon, J.D.Gordan, M.S.Dai, H.Lu, M.C.Simon, J.A.Diehl. Ribosomal stress couples the unfolded protein response to p53-dependent cell cycle arrest. J Biol Chem 2006; 281:30036-45; PMID:16893887; http://dx.doi.org/10.1074/jbc.M604674200
37. J.Folch, M.Lees, G.H.Sloane Stanley. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 1957; 226:497-509; PMID:13428781
38. L.J.Macala, R.K.Yu, S.Ando. Analysis of brain lipids by high performance thin-layer chromatography and densitometry. J Lipid Res 1983; 24:1243-50; PMID:6631248