Post-lanosterol biosynthesis of cholesterol and cancer

Current Opinion in Pharmacology

Volumn 12, Issue 6, 2012, Pages 717-723

  Lasunción, Miguel A ^a,b,c   Martín Sánchez, Covadonga ^a,b   Canfrán Duque, Alberto ^a   Busto, Rebeca ^a,b  

^a HOSPITAL RAMÓN Y CAJAL   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c UNIVERSITY OF ALCALÁ   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; CYCLIN DEPENDENT KINASE 1; LANOSTEROL; MICRORNA; MICRORNA 33; PROTEIN P53; SELECTIVE ESTROGEN RECEPTOR MODULATOR; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TAMOXIFEN; UNCLASSIFIED DRUG;

ADJUVANT THERAPY; ARTICLE; CANCER CELL; CANCER GROWTH; CANCER PROGNOSIS; CARCINOGENESIS; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE PROGRESSION; CELL CYCLE REGULATION; CELL DIFFERENTIATION; CELL FUNCTION; CELL PROLIFERATION; CHEMOPROPHYLAXIS; CHOLESTEROL METABOLISM; DRUG MECHANISM; ESTROGEN RECEPTOR POSITIVE BREAST CANCER; HUMAN; LIPID MEMBRANE; LIPID RAFT; MALIGNANT NEOPLASTIC DISEASE; MAMMAL CELL; METABOLIC REGULATION; MULTIGENE FAMILY; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SREBF1 GENE; SREBF2 GENE; STEROL SYNTHESIS;

EID: 84870525053     PISSN: 14714892     EISSN: 14714973     Source Type: Journal    
DOI: 10.1016/j.coph.2012.07.001     Document Type: Review

References (69)

1. S.B. Kritchevsky, and D. Kritchevsky Serum cholesterol and cancer risk: an epidemiologic perspective Annu Rev Nutr 12 1992 391 416
2. S.J. Winawer, B.J. Flehinger, J. Buchalter, E. Herbert, and M. Shike Declining serum cholesterol levels prior to diagnosis of colon cancer. A time-trend, case-control study JAMA 263 1990 2083 2085
3. Y.K. Ho, R.G. Smith, M.S. Brown, and J.L. Goldstein Low-density lipoprotein (LDL) receptor activity in human acute myelogenous leukemia cells Blood 52 1978 1099 1114
4. C. Tomowiak, A. Kennel, H. Gary-Gouy, N. Hadife, P. Feugier, T. Haferlach, M.C. Béné, and A. Dalloul High membrane cholesterol in CLL B-cells and differential expression of cholesterol synthesis genes in IG GENE-unmutated vs mutated cells Br J Med Med Res 2 2012 313 326
5. H. Gary-Gouy, A. Sainz-Perez, J.B. Marteau, A. Marfaing-Koka, J. Delic, H. Merle-Beral, P. Galanaud, and A. Dalloul Natural phosphorylation of CD5 in chronic lymphocytic leukemia B cells and analysis of CD5-regulated genes in a B cell line suggest a role for CD5 in malignant phenotype J Immunol 179 2007 4335 4344
6. S. Vitols, B. Angelin, S. Ericsson, G. Gahrton, G. Juliusson, M. Masquelier, C. Paul, C. Peterson, M. Rudling, and K. Soderberg-Reid Uptake of low density lipoproteins by human leukemic cells in vivo: relation to plasma lipoprotein levels and possible relevance for selective chemotherapy Proc Natl Acad Sci U S A 87 1990 2598 2602
7. P. Henriksson, M. Eriksson, S. Ericsson, M. Rudling, R. Stege, L. Berglund, and B. Angelin Hypocholesterolaemia and increased elimination of low-density lipoproteins in metastatic cancer of the prostate Lancet 2 1989 1178 1180
8. S. Vitols, G. Gahrton, M. Bjorkholm, and C. Peterson Hypocholesterolaemia in malignancy due to elevated low-density-lipoprotein-receptor activity in tumour cells: evidence from studies in patients with leukaemia Lancet 2 1985 1150 1154
9. S. Venkatanarayanan, and B. Nagarajan Association between tumour status and serum lipoprotein cholesterol in hemopoietic malignancy Biochem Int 17 1988 499 507
10. E. De Stefani, M. Mendilaharsu, H. Deneo-Pellegrini, and A. Ronco Influence of dietary levels of fat, cholesterol, and calcium on colorectal cancer Nutr Cancer 29 1997 83 89
11. R. Jarvinen, P. Knekt, T. Hakulinen, H. Rissanen, and M. Heliovaara Dietary fat, cholesterol and colorectal cancer in a prospective study Br J Cancer 85 2001 357 361
12. J. Martínez-Botas, Y. Suárez, A.J. Ferruelo, D. Gómez-Coronado, and M.A. Lasunción Cholesterol starvation decreases p34(cdc2) kinase activity and arrests the cell cycle at G2 FASEB J 13 1999 1359 1370
13. C. Fernández, M. Martín, D. Gómez-Coronado, and M.A. Lasunción Effects of distal cholesterol biosynthesis inhibitors on cell proliferation and cell cycle progression J Lipid Res 46 2005 920 929
14. Y. Suárez, C. Fernández, B. Ledo, M. Martín, D. Gómez-Coronado, and M.A. Lasunción Sterol stringency of proliferation and cell cycle progression in human cells Biochim Biophys Acta 1734 2005 203 213
15. F. Xu, S.D. Rychnovsky, J.D. Belani, H.H. Hobbs, J.C. Cohen, and R.B. Rawson Dual roles for cholesterol in mammalian cells Proc Natl Acad Sci U S A 102 2005 14551 14556
16. A.B. Awad, H. Williams, and C.S. Fink Phytosterols reduce in vitro metastatic ability of MDA-MB-231 human breast cancer cells Nutr Cancer 40 2001 157 164
17. P.G. Bradford, and A.B. Awad Phytosterols as anticancer compounds Mol Nutr Food Res 51 2007 161 170
18. S. Rodríguez-Acebes, P. de la Cueva, A.J. Ferruelo, C. Fernández-Hernando, M.A. Lasunción, J. Martínez-Botas, and D. Gómez-Coronado Dose-dependent dual effects of cholesterol and desmosterol on J774 macrophage proliferation Biochem Biophys Res Commun 377 2008 484 488
19. S. Rodríguez-Acebes, P. de la Cueva, C. Fernández-Hernando, A.J. Ferruelo, M.A. Lasunción, R.B. Rawson, J. Martínez-Botas, and D. Gómez-Coronado Desmosterol can replace cholesterol in sustaining cell proliferation and regulating the SREBP pathway in a sterol-Delta24- reductase-deficient cell line Biochem J 420 2009 305 315
20. Y. Suárez, C. Fernández, B. Ledo, A.J. Ferruelo, M. Martín, M.A. Vega, D. Gómez-Coronado, and M.A. Lasunción Differential effects of ergosterol and cholesterol on Cdk1 activation and SRE-driven transcription Eur J Biochem 269 2002 1761 1771
21. C. Rujanavech, and D.F. Silbert LM cell growth and membrane lipid adaptation to sterol structure J Biol Chem 261 1986 7196 7203
22. K. Keyomarsi, L. Sandoval, V. Band, and A.B. Pardee Synchronization of tumor and normal cells from G1 to multiple cell cycles by lovastatin Cancer Res 51 1991 3602 3609
23. R.Y.C. Poon, H. Toyoshima, and T. Hunter Redistribution of the CDK inhibitor p27 between different cycling. CDK complexes in the mouse fibroblast cell cycle and in cells arrested with lovastatin or ultraviolet irradiation Mol Biol Cell 6 1995 1197 1213
24. S. Rao, M. Lowe, T.W. Herliczek, and K. Keyomarsi Lovastatin mediated G1 arrest in normal and tumor breast cells is through inhibition of CDK2 activity and redistribution of p21 and p27, independent of p53 Oncogene 17 1998 2392 2402
25. C. Fernández, M.V. Lobo, D. Gómez-Coronado, and M.A. Lasunción Cholesterol is essential for mitosis progression and its deficiency induces polyploid cell formation Exp Cell Res 300 2004 109 120
26. M.M. Ng, F. Chang, and D.R. Burgess Movement of membrane domains and requirement of membrane signaling molecules for cytokinesis Dev Cell 9 2005 781 790
27. V. Bronte, P. Serafini, E. Apolloni, and P. Zanovello Tumor-induced immune dysfunctions caused by myeloid suppressor cells J Immunother 24 2001 431 446
28. B. Almand, J.R. Resser, B. Lindman, S. Nadaf, J.I. Clark, E.D. Kwon, D.P. Carbone, and D.I. Gabrilovich Clinical significance of defective dendritic cell differentiation in cancer Clin Cancer Res 6 2000 1755 1766
29. M.C. Cabot, C.J. Welsh, M.F. Callaham, and E. Huberman Alterations in lipid metabolism induced by 12-O-tetradecanoylphorbol-13-acetate in differentiating human myeloid leukemia cells Cancer Res 40 1980 3674 3679
30. R. Manning, A. Fallani, and S. Ruggieri Lipid changes in HL-60 cells on differentiation into macrophages by treatment with a phorbol ester Lipids 30 1995 811 815
31. S. Yachnin, D.B. Toub, and V. Mannickarottu Divergence in cholesterol biosynthetic rates and 3-hydroxy-3-methylglutaryl-CoA reductase activity as a consequence of granulocyte versus monocyte-macrophage differentiation in HL-60 cells Proc Natl Acad Sci U S A 81 1984 894 897
32. R.A. Cooper, S.H. Ip, P.A. Cassileth, and A.L. Kuo Inhibition of sterol and phospholipid synthesis in HL-60 promyelocytic leukemia cells by inducers of myeloid differentiation Cancer Res 41 1981 1847 1852
33. C.C. Sánchez-Martín, A. Dávalos, C. Martín-Sánchez, G. de la Peña, C. Fernández-Hernando, and M.A. Lasunción Cholesterol starvation induces differentiation of human leukemia HL-60 cells Cancer Res 67 2007 3379 3386
34. S. Vainio, M. Jansen, M. Koivusalo, T. Rog, M. Karttunen, I. Vattulainen, and E. Ikonen Significance of sterol structural specificity. Desmosterol cannot replace cholesterol in lipid rafts J Biol Chem 281 2006 348 355
35. J. Sánchez-Wandelmer, A. Dávalos, E. Herrera, M. Giera, S. Cano, G. de la Peña, M.A. Lasunción, and R. Busto Inhibition of cholesterol biosynthesis disrupts lipid raft/caveolae and affects insulin receptor activation in 3T3-L1 preadipocytes Biochim Biophys Acta 1788 2009 1731 1739
36. J. Sánchez-Wandelmer, A. Dávalos, G. de la Peña, S. Cano, M. Giera, A. Canfrán-Duque, F. Bracher, A. Martín-Hidalgo, C. Fernández-Hernando, and M.A. Lasunción Haloperidol disrupts lipid rafts and impairs insulin signaling in SH-SY5Y cells Neuroscience 167 2010 143 153
37. V.C. Jordan Chemoprevention of breast cancer with selective oestrogen-receptor modulators Nat Rev Cancer 7 2007 46 53
38. B. Kedjouar, P. de Medina, M. Oulad-Abdelghani, B. Payre, S. Silvente-Poirot, G. Favre, J.C. Faye, and M. Poirot Molecular characterization of the microsomal tamoxifen binding site J Biol Chem 279 2004 34048 34061
39. B. Payre, P. de Medina, N. Boubekeur, L. Mhamdi, J. Bertrand-Michel, F. Terce, I. Fourquaux, D. Goudouneche, M. Record, and M. Poirot Microsomal antiestrogen-binding site ligands induce growth control and differentiation of human breast cancer cells through the modulation of cholesterol metabolism Mol Cancer Ther 7 2008 3707 3718
40. P. de Medina, M.R. Paillasse, G. Segala, M. Poirot, and S. Silvente-Poirot Identification and pharmacological characterization of cholesterol-5,6-epoxide hydrolase as a target for tamoxifen and AEBS ligands Proc Natl Acad Sci U S A 107 2010 13520 13525
41. P. de Medina, M.R. Paillasse, G. Segala, F. Khallouki, S. Brillouet, F. Dalenc, F. Courbon, M. Record, M. Poirot, and S. Silvente-Poirot Importance of cholesterol and oxysterols metabolism in the pharmacology of tamoxifen and other AEBS ligands Chem Phys Lipids 164 2011 432 437
42. T.M. Holm, A. Braun, B.L. Trigatti, C. Brugnara, M. Sakamoto, M. Krieger, and N.C. Andrews Failure of red blood cell maturation in mice with defects in the high-density lipoprotein receptor SR-BI Blood 99 2002 1817 1824
43. J. Fan, M.B. Rone, and V. Papadopoulos Translocator protein 2 is involved in cholesterol redistribution during erythropoiesis J Biol Chem 284 2009 30484 30497
44. F. Damiola, C. Keime, S. Gonin-Giraud, S. Dazy, and O. Gandrillon Global transcription analysis of immature avian erythrocytic progenitors: from self-renewal to differentiation Oncogene 23 2004 7628 7643
45. C. Mejia-Pous, F. Damiola, and O. Gandrillon Cholesterol synthesis-related enzyme oxidosqualene cyclase is required to maintain self-renewal in primary erythroid progenitors Cell Prolif 44 2011 441 452
46. M.Y. Lee, J.M. Ryu, S.H. Lee, J.H. Park, and H.J. Han Lipid rafts play an important role for maintenance of embryonic stem cell self-renewal J Lipid Res 51 2010 2082 2089
47. M.T. Bengoechea-Alonso, and J. Ericsson SREBP in signal transduction: cholesterol metabolism and beyond Curr Opin Cell Biol 19 2007 215 222
48. M.T. Bengoechea-Alonso, T. Punga, and J. Ericsson Hyperphosphorylation regulates the activity of SREBP1 during mitosis Proc Natl Acad Sci U S A 102 2005 11681 11686
49. M.T. Bengoechea-Alonso, and J. Ericsson Cdk1/cyclin B-mediated phosphorylation stabilizes SREBP1 during mitosis Cell Cycle 5 2006 1708 1718
50. N. Inoue, H. Shimano, M. Nakakuki, T. Matsuzaka, Y. Nakagawa, T. Yamamoto, R. Sato, A. Takahashi, H. Sone, and N. Yahagi Lipid synthetic transcription factor SREBP-1a activates p21WAF1/CIP1, a universal cyclin-dependent kinase inhibitor Mol Cell Biol 25 2005 8938 8947
51. M. Nakakuki, H. Shimano, N. Inoue, M. Tamura, T. Matsuzaka, Y. Nakagawa, N. Yahagi, H. Toyoshima, R. Sato, and N. Yamada A transcription factor of lipid synthesis, sterol regulatory element-binding protein (SREBP)-1a causes G(1) cell-cycle arrest after accumulation of cyclin-dependent kinase (cdk) inhibitors FEBS J 274 2007 4440 4452
52. S.L. Ettinger, R. Sobel, T.G. Whitmore, M. Akbari, D.R. Bradley, M.E. Gleave, and C.C. Nelson Dysregulation of sterol response element-binding proteins and downstream effectors in prostate cancer during progression to androgen independence Cancer Res 64 2004 2212 2221
53. W.A. Freed-Pastor, H. Mizuno, X. Zhao, A. Langerod, S.H. Moon, R. Rodriguez-Barrueco, A. Barsotti, A. Chicas, W. Li, and A. Polotskaia Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway Cell 148 2012 244 258
54. Y. Suárez, and W.C. Sessa MicroRNAs as novel regulators of angiogenesis Circ Res 104 2009 442 454
55. B. Zhang, X. Pan, G.P. Cobb, and T.A. Anderson microRNAs as oncogenes and tumor suppressors Dev Biol 302 2007 1 12
56. S. Huang, and X. He The role of microRNAs in liver cancer progression Br J Cancer 104 2011 235 240
57. K.J. Moore, K.J. Rayner, Y. Suarez, and C. Fernandez-Hernando microRNAs and cholesterol metabolism Trends Endocrinol Metab 21 2010 699 706
58. C. Esau, S. Davis, S.F. Murray, X.X. Yu, S.K. Pandey, M. Pear, L. Watts, S.L. Booten, M. Graham, and R. McKay miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting Cell Metab 3 2006 87 98
59. C. Coulouarn, V.M. Factor, J.B. Andersen, M.E. Durkin, and S.S. Thorgeirsson Loss of miR-122 expression in liver cancer correlates with suppression of the hepatic phenotype and gain of metastatic properties Oncogene 28 2009 3526 3536
60. S. Bai, M.W. Nasser, B. Wang, S.H. Hsu, J. Datta, H. Kutay, A. Yadav, G. Nuovo, P. Kumar, and K. Ghoshal MicroRNA-122 inhibits tumorigenic properties of hepatocellular carcinoma cells and sensitizes these cells to sorafenib J Biol Chem 284 2009 32015 32027
61. W.C. Tsai, P.W. Hsu, T.C. Lai, G.Y. Chau, C.W. Lin, C.M. Chen, C.D. Lin, Y.L. Liao, J.L. Wang, and Y.P. Chau MicroRNA-122, a tumor suppressor microRNA that regulates intrahepatic metastasis of hepatocellular carcinoma Hepatology 49 2009 1571 1582
62. K.J. Rayner, Y. Suárez, A. Dávalos, S. Parathath, M.L. Fitzgerald, N. Tamehiro, E.A. Fisher, K.J. Moore, and C. Fernández- Hernando MiR-33 contributes to the regulation of cholesterol homeostasis Science 328 2010 1570 1573
63. A. Dávalos, L. Goedeke, P. Smibert, C.M. Ramírez, N.P. Warrier, U. Andreo, D. Cirera-Salinas, K. Rayner, U. Suresh, and J.C. Pastor-Pareja miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling Proc Natl Acad Sci U S A 108 2011 9232 9237
64. S.H. Najafi-Shoushtari, F. Kristo, Y. Li, T. Shioda, D.E. Cohen, R.E. Gerszten, and A.M. Naar MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis Science 328 2010 1566 1569
65. A. Herrera-Merchán, C. Cerrato, G. Luengo, O. Domínguez, M.A. Piris, M. Serrano, and S. González miR-33-mediated downregulation of p53 controls hematopoietic stem cell self-renewal Cell Cycle 9 2010 3277 3285
66. M. Thomas, K. Lange-Grunweller, U. Weirauch, D. Gutsch, A. Aigner, A. Grunweller, and R.K. Hartmann The proto-oncogene Pim-1 is a target of miR-33a Oncogene 31 2012 918 928
67. D. Cirera-Salinas, M. Pauta, R.M. Allen, A.G. Salerno, C.M. Ramirez, A. Chamorro-Jorganes, A.C. Wanschel, M.A. Lasunción, M. Morales-Ruiz, and Y. Suárez Mir-33 regulates cell proliferation and cell cycle progression Cell Cycle 11 2012 922 933
68. A.F. Ibrahim, U. Weirauch, M. Thomas, A. Grunweller, R.K. Hartmann, and A. Aigner MicroRNA replacement therapy for miR-145 and miR-33a is efficacious in a model of colon carcinoma Cancer Res 71 2011 5214 5224
69. L. Trapani, M. Segatto, P. Ascenzi, and V. Pallottini Potential role of nonstatin cholesterol lowering agents IUBMB Life 63 2011 964 971