Activation of TM7SF2 promoter by SREBP-2 depends on a new sterol regulatory element, a GC-box, and an inverted CCAAT-box

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1801, Issue 5, 2010, Pages 587-592

  Schiavoni, Gianluca ^a   Bennati, Anna Maria ^a   Castelli, Marilena ^a   Fazia, Maria Agnese Della ^a   Beccari, Tommaso ^a   Servillo, Giuseppe ^a   Roberti, Rita ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

Author keywords

3beta hydoxysterol delta14 reductase; Cholesterol; Promoter; SREBP 2; TM7SF2

Indexed keywords

CCAAT BINDING FACTOR; LUCIFERASE; NUCLEAR FACTOR Y; STEROL; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TRANSCRIPTION FACTOR SP1;

ARTICLE; CELL STRAIN HEPG2; CONTROLLED STUDY; GEL MOBILITY SHIFT ASSAY; GENE ACTIVATION; GENE DELETION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MUTAGENESIS; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN MOTIF;

ANIMALS; BASE SEQUENCE; DNA MUTATIONAL ANALYSIS; GENE EXPRESSION REGULATION; HUMANS; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; OXIDOREDUCTASES ACTING ON CH-CH GROUP DONORS; PROMOTER REGIONS, GENETIC; REGULATORY SEQUENCES, NUCLEIC ACID; STEROL REGULATORY ELEMENT BINDING PROTEIN 2;

EID: 77649342989     PISSN: 13881981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbalip.2010.01.013     Document Type: Article

References (23)

1. Roberti R., Bennati A.M., Galli G., Caruso D., Maras B., Aisa C., Beccari T., Della Fazia M.A., and Servillo G. Cloning and expression of sterol delta14-reductase from bovine liver. Eur. J. Biochem. 269 (2002) 283-290
2. 14-reductase deficiency. Hum. Mol. Genet. 16 (2007) 1176-1187
3. 14-reductase in mice does not impair cholesterol biosynthesis. FEBS J. 275 (2008) 5034-5047
4. 14-reductase in human cholesterol biosynthesis. Biochim. Biophys. Acta 1761 (2006) 677-685
5. Horton J.D., Shah N.A., Warrington J.A., Anderson N.N., Park S.W., Brown M.S., and Goldstein J.L. Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes. PNAS 100 (2003) 12027-12032
6. Dawson P.A., Hofmann S.L., van der Westhuyzen D.R., Südhof T.C., Brown M.S., and Goldstein J.L. Sterol-dependent repression of low density lipoprotein receptor promoter mediated by 16-base pair sequence adjacent to binding site for transcription factor Spl. J. Biol. Chem. 263 (1988) 3372-3379
7. Smith J.R., Osborne T.F., Brown M.S., Goldstein J.L., and Gil G. Multiple sterol regulatory elements in promoter for hamster 3-hydroxy-3-methylglutaryl-coenzyme A synthase. J. Biol. Chem. 263 (1988) 18480-18487
8. Osborne T.F., Gil G., Goldstein J.L., and Brown M.S. Operator constitutive mutation of 3-hydroxy-3-methylglutaryl coenzyme A reductase promoter abolishes protein binding to sterol regulatory element. J. Biol. Chem. 263 (1988) 3380-3387
9. Ericsson J., Jackson S.M., Lee B.C., and Edwards P.A. Sterol regulatory element binding protein binds to a cis element in the promoter of the farnesyl diphosphate synthase gene. Proc. Natl. Acad. Sci. U.S.A. 93 (1996) 945-950
10. Sanchez H.B., Yieh L., and Osborne T.F. Cooperation by sterol regulatory elements- binding protein and Sp1 in sterol regulation of low density lipoprotein receptor gene. J. Biol. Chem. 270 (1995) 1161-1169
11. Jackson S.M., Ericsson J., Osborne T.F., and Edwards P.A. NF-Y has a novel role in sterol-dependent transcription of two cholesterogenic genes. J. Biol. Chem. 270 (1995) 21445-21448
12. Lopez J.M., Bennett M.K., Sanchez H.B., Rosenfeld J.M., and Osborne T.F. Sterol regulation of acetyl coenzyme A carboxylase: a mechanism for coordinate control of cellular lipid. Proc. Natl. Acad. Sci. U.S.A. 93 (1996) 1049-1053
13. Ericsson J., Jackson S.M., and Edwards P.A. Synergistic binding of sterol regulatory element-binding protein and NF-Y to the farnesyl diphosphate synthase promoter is critical for sterol-regulated expression of the gene. J. Biol. Chem. 271 (1996) 24359-24364
14. Guan G., Dai P.-H., Osborne T.F., Kim J.B., and Shechter I. Multiple sequence elements are involved in the transcriptional regulation of the human squalene synthase gene. J. Biol. Chem. 272 (1997) 10295-10302
15. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72 (1976) 248-254
16. Jackson S.M., Ericsson J., Mantovani R., and Edwards P.A. Synergistic activation of transcription by nuclear factor Y and sterol regulatory element binding protein. J. Lipid Res. 39 (1998) 767-776
17. Inoue J., Sato R., and Maeda M. Multiple DNA elements for sterol regulatory element-binding protein and NF-Y are responsible for sterol-regulated transcription of the genes for human 3-hydroxy-3-methylglutaryl coenzyme A synthase and squalene synthase. J. Biochem. 123 (1998) 1191-1198
18. Kim J.-H., Lee J.N., and Paik Y.-K. Cholesterol biosynthesis from lanosterol. A concerted role for Sp1 and NF-Y-binding sites for sterol-mediated regulation of rat 7-dehydrocholesterol reductase gene expression. J. Biol. Chem. 276 (2001) 18153-18160
19. Bennett M.K., and Osborne T.F. Nutrient regulation of gene expression by the sterol regulatory element binding proteins: increased recruitment of gene-specific coregulatory factors and selective hyperacetylation of histone H3 in vivo. Proc. Natl. Acad. Sci. U.S.A. 97 (2000) 6340-6344
20. Nagai M., Sakakibara J., Nakamura Y., Gejyo F., and Ono T. SREBP-2 and NF-Y are involved in the transcriptional regulation of squalene epoxidase. Biochem. Biophys. Res. Commun. 295 (2002) 74-80
21. Mantovani R., Li X.-Y., Pessara U., van Huisjduijnen R.H., Benoist C., and Mathis D. Dominant negative analogs of NF-YA. J. Biol. Chem. 269 (1994) 20340-20346
22. Mantovani R. The molecular biology of the CCAAT-binding factor NF-Y. Gene 239 (1999) 15-27
23. Reed B.D., Charos A.E., Szekely A.M., Weissman S.M., and Snyder M. Genome-wide occupancy of SREBP-1 and its partners NF-Y and Sp1 reveals novel functional roles and combinatorial regulation of distinct classes of genes. PLoS Genetics 4 7 (2008) e1000133