Reduced TCR-dependent activation through citrullination of a T-cell epitope enhances Th17 development by disruption of the STAT3/5 balance

European Journal of Immunology

Volumn 46, Issue 7, 2016, Pages 1633-1643

  Tibbitt, Christopher ^a   Falconer, Jane ^b,c   Stoop, Jeroen ^d   van Eden, Willem ^e   Robinson, John H ^a   Hilkens, Catharien M U ^a,c  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^c Arthritis Research UK Rheumatoid Arthritis Pathogenesis Centre of Excellence (RACE)   (United Kingdom)

^d LEIDEN UNIVERSITY   (Netherlands)

^e UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Cellular activation; Citrullination; STAT3; STAT5; T helper cells; TCR; Th17 cells

Indexed keywords

AGGRECAN; EPITOPE; INTERLEUKIN 17; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 4; STAT3 PROTEIN; STAT5 PROTEIN; T LYMPHOCYTE ANTIGEN; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ARTICLE; BONE MARROW DERIVED DENDRITIC CELL; CELL DIFFERENTIATION; CELL DISRUPTION; CELL FUNCTION; CELL MATURATION; IMMUNE RESPONSE; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TH17 CELL;

EID: 84978193809     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201546217     Document Type: Article

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