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Volumn 171, Issue 6, 2003, Pages 3025-3033

Differential recognition of altered peptide ligands distinguishes two functionally discordant (arthritogenic and nonarthritogenic) autoreactive T cell hybridoma clones

Author keywords

[No Author keywords available]

Indexed keywords

AGGRECAN; ANTIGEN; CYTOKINE; EPITOPE; GAMMA INTERFERON; GLYCYLARGINYLVALYLARGINYLVALYLASPARAGINYLSERYLALANYLTYROSINE; INTERLEUKIN 5; PEPTIDE; PROTEOGLYCAN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 0042333432     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.171.6.3025     Document Type: Article
Times cited : (18)

References (64)
  • 3
    • 0031880402 scopus 로고    scopus 로고
    • Analysis of type 1 and type 2 T cells in synovial fluid and peripheral blood of patients with rheumatoid arthritis
    • Kusaba, M., J. Honda, T. Fukuda, and K. Oizumi. 1998. Analysis of type 1 and type 2 T cells in synovial fluid and peripheral blood of patients with rheumatoid arthritis. J. Rheumatol. 25:1466.
    • (1998) J. Rheumatol. , vol.25 , pp. 1466
    • Kusaba, M.1    Honda, J.2    Fukuda, T.3    Oizumi, K.4
  • 4
    • 0043121100 scopus 로고
    • Autoimmunity to cartilage collagen and proteoglycan and the development of chronic inflammatory arthritis
    • A. M. Glaurer, ed. Elsevier Publishers (Biomedical Division), Amsterdam
    • Poole, A. R., T. T. Glant, and K. Mikecz. 1988. Autoimmunity to cartilage collagen and proteoglycan and the development of chronic inflammatory arthritis. In The Control of Tissue Damage. A. M. Glaurer, ed. Elsevier Publishers (Biomedical Division), Amsterdam, pp. 55-65.
    • (1988) The Control of Tissue Damage , pp. 55-65
    • Poole, A.R.1    Glant, T.T.2    Mikecz, K.3
  • 5
    • 0002636311 scopus 로고
    • Immune responses to cartilage proteoglycans in inflammatory animal models and human diseases
    • J. F. Woessner and D. S. Howell, eds. Marcel Dekker. New York
    • Glant, T. T., K. Mikecz, E. J. M. A. Thonar, and K. E. Kuettner. 1992. Immune responses to cartilage proteoglycans in inflammatory animal models and human diseases. In Cartilage Degradation: Basic and Clinical Aspects. J. F. Woessner and D. S. Howell, eds. Marcel Dekker. New York, pp. 435-473.
    • (1992) Cartilage Degradation: Basic and Clinical Aspects , pp. 435-473
    • Glant, T.T.1    Mikecz, K.2    Thonar, E.J.M.A.3    Kuettner, K.E.4
  • 7
    • 0032706141 scopus 로고    scopus 로고
    • Rheumatoid arthritis and its animal models: The role of TNF-α and the possible absence of specific immune reactions
    • Klareskog, L., and H. McDevitt. 1999. Rheumatoid arthritis and its animal models: the role of TNF-α and the possible absence of specific immune reactions. Curr. Opin. Immunol. 11:657.
    • (1999) Curr. Opin. Immunol. , vol.11 , pp. 657
    • Klareskog, L.1    McDevitt, H.2
  • 8
    • 0011346576 scopus 로고
    • Cartilage proteoglycans
    • K. E. Kuettner. R. Schleyerbach, and V. C. Hascall, eds. Raven Press, New York
    • Rosenberg, L. C., and J. A. Buckwalter. 1986. Cartilage proteoglycans. In Articular Cartilage Biochemistry. K. E. Kuettner. R. Schleyerbach, and V. C. Hascall, eds. Raven Press, New York, pp. 39-57.
    • (1986) Articular Cartilage Biochemistry , pp. 39-57
    • Rosenberg, L.C.1    Buckwalter, J.A.2
  • 9
    • 0032522487 scopus 로고    scopus 로고
    • Critical role of glycosaminoglycan side chains of cartilage proteoglycan (aggrecan) in antigen recognition and presentation
    • Glant, T. T., E. I. Buzás, A. Finnegan, G. Negroiu, G. Cs-Szabó, and K. Mikecz. 1998. Critical role of glycosaminoglycan side chains of cartilage proteoglycan (aggrecan) in antigen recognition and presentation. J. Immunol. 160:3812.
    • (1998) J. Immunol. , vol.160 , pp. 3812
    • Glant, T.T.1    Buzás, E.I.2    Finnegan, A.3    Negroiu, G.4    Cs-Szabó, G.5    Mikecz, K.6
  • 10
    • 0023254937 scopus 로고
    • Proteoglycan-induced arthritis in BALB/c mice: Clinical features and histopathology
    • Glant, T. T., K. Mikecz, A. Arzoumanian, and A. R. Poole. 1987. Proteoglycan-induced arthritis in BALB/c mice: clinical features and histopathology. Arthritis Rheum. 30:201.
    • (1987) Arthritis Rheum. , vol.30 , pp. 201
    • Glant, T.T.1    Mikecz, K.2    Arzoumanian, A.3    Poole, A.R.4
  • 11
    • 0023197152 scopus 로고
    • Immunity to cartilage proteoglycans in BALB/c mice with progressive polyarthritis and ankylosing spondylitis induced by injection of human cartilage proteoglycan
    • Mikecz, K., T. T. Glant, and A. R. Poole. 1987. Immunity to cartilage proteoglycans in BALB/c mice with progressive polyarthritis and ankylosing spondylitis induced by injection of human cartilage proteoglycan. Arthritis Rheum. 30:306.
    • (1987) Arthritis Rheum , vol.30 , pp. 306
    • Mikecz, K.1    Glant, T.T.2    Poole, A.R.3
  • 12
    • 0031747789 scopus 로고    scopus 로고
    • Progressive polyarthritis induced in BALB/c mice by aggrecan from human osteoarthritic cartilage
    • Glant, T. T., G. Cs-Szabó, H. Nagase, J. J. Jacobs, and K. Mikecz. 1998. Progressive polyarthritis induced in BALB/c mice by aggrecan from human osteoarthritic cartilage. Arthritis Rheum. 41:1007.
    • (1998) Arthritis Rheum. , vol.41 , pp. 1007
    • Glant, T.T.1    Cs-Szabó, G.2    Nagase, H.3    Jacobs, J.J.4    Mikecz, K.5
  • 14
    • 0025306842 scopus 로고
    • Proteoglycan-induced polyarthritis and spondylitis adoptively transferred to naive (nonimmunized) BALB/c mice
    • Mikecz, K., T. T. Glant, E. Buzás, and A. R. Poole. 1990. Proteoglycan-induced polyarthritis and spondylitis adoptively transferred to naive (nonimmunized) BALB/c mice. Arthritis Rheum. 33:866.
    • (1990) Arthritis Rheum. , vol.33 , pp. 866
    • Mikecz, K.1    Glant, T.T.2    Buzás, E.3    Poole, A.R.4
  • 16
    • 0000044133 scopus 로고
    • Inflammatory reactions in arthritis
    • M. E. Davies and J. T. Dingle, eds. Academic Press, London
    • Fassbender, H.-G. 1994. Inflammatory reactions in arthritis. In Immunopharmacology of Joints and Connective Tissue. M. E. Davies and J. T. Dingle, eds. Academic Press, London, pp. 165-198.
    • (1994) Immunopharmacology of Joints and Connective Tissue , pp. 165-198
    • Fassbender, H.-G.1
  • 17
    • 85039640908 scopus 로고    scopus 로고
    • Discordant recognition of altered peptide ligands by two autoreactive murine T cell hybridoma clones specific to the same cartilage proteoglycan (aggrecan)-epitope
    • Buzás, E. I., A. Finnegan, K. Mikecz, G. Cs-Szabo, F. Hudecz, K. Uray, K. Hollo, and T. T. Glant. 1998. Discordant recognition of altered peptide ligands by two autoreactive murine T cell hybridoma clones specific to the same cartilage proteoglycan (aggrecan)-epitope. Arthritis Rheum. 41:S252.
    • (1998) Arthritis Rheum. , vol.41
    • Buzás, E.I.1    Finnegan, A.2    Mikecz, K.3    Cs-Szabo, G.4    Hudecz, F.5    Uray, K.6    Hollo, K.7    Glant, T.T.8
  • 18
    • 0042620304 scopus 로고    scopus 로고
    • T-cell recognition of differentially tolerated epitopes of cartilage proteoglycan (aggrecan) in arthritis
    • Buzás, E. I., K. Mikecz, A. Finnegan, F. Hudecz, and T. T. Glant. 1999. T-cell recognition of differentially tolerated epitopes of cartilage proteoglycan (aggrecan) in arthritis. Arthritis Rheum. 42:S259.
    • (1999) Arthritis Rheum. , vol.42
    • Buzás, E.I.1    Mikecz, K.2    Finnegan, A.3    Hudecz, F.4    Glant, T.T.5
  • 19
    • 0029051713 scopus 로고
    • Antigen-specific B cells present cartilage proteoglycan (aggrecan) to an autoreactive T cell hybridoma derived from a mouse with proteoglycan-induced arthritis
    • Brennan, F. R., K. Mikecz, E. I. Buzás, D. Ragasa, G. Cs-Szabó, G. Negroiu, and T. T. Glant. 1995. Antigen-specific B cells present cartilage proteoglycan (aggrecan) to an autoreactive T cell hybridoma derived from a mouse with proteoglycan-induced arthritis. Clin. Exp. Immunol. 101:414.
    • (1995) Clin. Exp. Immunol. , vol.101 , pp. 414
    • Brennan, F.R.1    Mikecz, K.2    Buzás, E.I.3    Ragasa, D.4    Cs-Szabó, G.5    Negroiu, G.6    Glant, T.T.7
  • 20
    • 0028913104 scopus 로고
    • Presentation of cartilage proteoglycan to a T cell hybridoma derived from a mouse with proteoglycan-induced arthritis
    • Brennan, F. R., G. Negroiu, E. I. Buzás, C. Fülöp, K. Mikecz, and T. T. Glant. 1995. Presentation of cartilage proteoglycan to a T cell hybridoma derived from a mouse with proteoglycan-induced arthritis. Clin. Exp. Immunol. 100:104.
    • (1995) Clin. Exp. Immunol. , vol.100 , pp. 104
    • Brennan, F.R.1    Negroiu, G.2    Buzás, E.I.3    Fülöp, C.4    Mikecz, K.5    Glant, T.T.6
  • 21
    • 0028987402 scopus 로고
    • Interferon-γ but not granulocyte/macrophage colony-stimulating factor augments proteoglycan presentation by synovial cells and chondrocytes to an autopathogenic T cell hybridoma
    • Brennan, F. R., K. Mikecz, E. Buzás, and T. T. Glant. 1995. Interferon-γ but not granulocyte/macrophage colony-stimulating factor augments proteoglycan presentation by synovial cells and chondrocytes to an autopathogenic T cell hybridoma. Immunol. Lett. 45:87.
    • (1995) Immunol. Lett. , vol.45 , pp. 87
    • Brennan, F.R.1    Mikecz, K.2    Buzás, E.3    Glant, T.T.4
  • 23
    • 0025976188 scopus 로고
    • Complete coding sequence and deduced primary structure of the human cartilage large aggregating proteoglycan, aggrecan: Human-specific repeats, and additional alternatively spliced forms
    • Doege, K. J., M. Sasaki, T. Kimura, and Y. Yamada. 1991. Complete coding sequence and deduced primary structure of the human cartilage large aggregating proteoglycan, aggrecan: human-specific repeats, and additional alternatively spliced forms. J. Biol. Chem. 266:894.
    • (1991) J. Biol. Chem. , vol.266 , pp. 894
    • Doege, K.J.1    Sasaki, M.2    Kimura, T.3    Yamada, Y.4
  • 24
    • 0028169987 scopus 로고
    • Complete coding sequence, deduced primary structure, chromosomal localization and structural analysis of murine aggrecan
    • Walcz, E., F. Deák, P. Erhardt, S. N. Coulter, C. Fülöp, P. Horváth, K. J. Doege, and T. T. Glant. 1994. Complete coding sequence, deduced primary structure, chromosomal localization and structural analysis of murine aggrecan. Genomics 22:364.
    • (1994) Genomics , vol.22 , pp. 364
    • Walcz, E.1    Deák, F.2    Erhardt, P.3    Coulter, S.N.4    Fülöp, C.5    Horváth, P.6    Doege, K.J.7    Glant, T.T.8
  • 25
    • 0031572290 scopus 로고    scopus 로고
    • Complete coding sequence of bovine aggrecan: Comparative structural analysis
    • Hering, T. M., J. Kollar, and T. D. Huynh. 1997. Complete coding sequence of bovine aggrecan: comparative structural analysis. Arch. Biochem. Biophys. 345:259.
    • (1997) Arch. Biochem. Biophys , vol.345 , pp. 259
    • Hering, T.M.1    Kollar, J.2    Huynh, T.D.3
  • 26
    • 0031595750 scopus 로고    scopus 로고
    • Modulation of the immunogenicity of antigenic determinants by their flanking residues
    • Moudgil, K. D., E. E. Sercarz, and I. S. Grewal. 1998. Modulation of the immunogenicity of antigenic determinants by their flanking residues, Immunol. Today 19:217.
    • (1998) Immunol. Today , vol.19 , pp. 217
    • Moudgil, K.D.1    Sercarz, E.E.2    Grewal, I.S.3
  • 27
    • 0024464931 scopus 로고
    • Sequences outside a minimal immunodominant site exert negative effects on recognition by staphylococcal nuclease-specific T cell clones
    • Vacchio, M. S., J. A. Berzofsky, U. Krzych, J. A. Smith, R. J. Hodes, and A. Finnegan. 1989. Sequences outside a minimal immunodominant site exert negative effects on recognition by staphylococcal nuclease-specific T cell clones. J. Immunol. 143:2814.
    • (1989) J. Immunol. , vol.143 , pp. 2814
    • Vacchio, M.S.1    Berzofsky, J.A.2    Krzych, U.3    Smith, J.A.4    Hodes, R.J.5    Finnegan, A.6
  • 30
    • 0028339767 scopus 로고
    • Amino acid residues that flank core peptide epitopes and the extracellular domains of CD4 modulate differential signaling through the T cell receptor
    • Vignali, D. A., and J. L. Strominger. 1994. Amino acid residues that flank core peptide epitopes and the extracellular domains of CD4 modulate differential signaling through the T cell receptor. J. Exp. Med. 179:1945.
    • (1994) J. Exp. Med. , vol.179 , pp. 1945
    • Vignali, D.A.1    Strominger, J.L.2
  • 33
    • 0030752253 scopus 로고    scopus 로고
    • A novel first primary anchor extends the MHC class II I-Ad binding motif to encompass nine amino acids
    • Bartnes, K., F. Leon, J. P. Briand, and P. J. Travers. 1997. A novel first primary anchor extends the MHC class II I-Ad binding motif to encompass nine amino acids. Int. Immunol. 9:1185.
    • (1997) Int. Immunol. , vol.9 , pp. 1185
    • Bartnes, K.1    Leon, F.2    Briand, J.P.3    Travers, P.J.4
  • 34
    • 0031780202 scopus 로고    scopus 로고
    • The peptide-binding strategy of the MHC class II I-A molecules
    • Reizes, B., M. Eisenstein, F. Mor, and I. R. Cohen. 1998. The peptide-binding strategy of the MHC class II I-A molecules. Immunol. Today 19:212.
    • (1998) Immunol. Today , vol.19 , pp. 212
    • Reizes, B.1    Eisenstein, M.2    Mor, F.3    Cohen, I.R.4
  • 37
    • 0033783333 scopus 로고    scopus 로고
    • IL-6 and its soluble receptor augment aggrecanase-mediated proteoglycan catabolism in articular cartilage
    • Flannery, C. R., C. B. Little, C. E. Hughes, C. L. Curtis, B. Caterson, and S. A. Jones. 2000. IL-6 and its soluble receptor augment aggrecanase-mediated proteoglycan catabolism in articular cartilage. Matrix Biol. 19:549.
    • (2000) Matrix Biol. , vol.19 , pp. 549
    • Flannery, C.R.1    Little, C.B.2    Hughes, C.E.3    Curtis, C.L.4    Caterson, B.5    Jones, S.A.6
  • 39
    • 0028955365 scopus 로고
    • Selective binding of self peptides to disease-associated major histocompatibility complex (MHC) molecules: A mechanism for MHC-linked susceptibility to human autoimmune diseases
    • Wucherpfennig, K. W., and J. L. Strominger. 1995. Selective binding of self peptides to disease-associated major histocompatibility complex (MHC) molecules: a mechanism for MHC-linked susceptibility to human autoimmune diseases. J. Exp. Med. 181:1597.
    • (1995) J. Exp. Med. , vol.181 , pp. 1597
    • Wucherpfennig, K.W.1    Strominger, J.L.2
  • 40
    • 0029966057 scopus 로고    scopus 로고
    • Essential flexibility in the T-cell recognition of antigen
    • Kersh, G. J., and P. M. Allen. 1996. Essential flexibility in the T-cell recognition of antigen. Nature 380:495.
    • (1996) Nature , vol.380 , pp. 495
    • Kersh, G.J.1    Allen, P.M.2
  • 41
    • 0032171644 scopus 로고    scopus 로고
    • A very high level of crossreactivity is essential feature of the T-cell receptor
    • Mason, D. 1998. A very high level of crossreactivity is essential feature of the T-cell receptor. Immunol. Today 19:395.
    • (1998) Immunol. Today , vol.19 , pp. 395
    • Mason, D.1
  • 42
    • 0029961893 scopus 로고    scopus 로고
    • Structural basis for T cell recognition of altered peptide ligands: A single T cell receptor can productively recognize a large continuum of related ligands
    • Kersh, G. J., and P. M. Allen. 1996. Structural basis for T cell recognition of altered peptide ligands: a single T cell receptor can productively recognize a large continuum of related ligands. J. Exp. Med. 184:1259.
    • (1996) J. Exp. Med. , vol.184 , pp. 1259
    • Kersh, G.J.1    Allen, P.M.2
  • 43
    • 0030046168 scopus 로고    scopus 로고
    • Human self-reactive T cell clones expressing identical T cell receptor β chains differ in their ability to recognize a cryptic self-epitope
    • Quaratino, S., M. Feldmann, C. M. Dayan, O. Acuto, and M. Londei. 1996. Human self-reactive T cell clones expressing identical T cell receptor β chains differ in their ability to recognize a cryptic self-epitope. J. Exp. Med. 183:349.
    • (1996) J. Exp. Med. , vol.183 , pp. 349
    • Quaratino, S.1    Feldmann, M.2    Dayan, C.M.3    Acuto, O.4    Londei, M.5
  • 44
    • 0032549142 scopus 로고    scopus 로고
    • Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen
    • Garcia, K. C., M. Degano, L. R. Pease, M. Huang, P. A. Peterson, L. Teyton, and I. A. Wilson. 1998. Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen. Science 279:1166.
    • (1998) Science , vol.279 , pp. 1166
    • Garcia, K.C.1    Degano, M.2    Pease, L.R.3    Huang, M.4    Peterson, P.A.5    Teyton, L.6    Wilson, I.A.7
  • 45
  • 46
    • 0034548045 scopus 로고    scopus 로고
    • Differential sensitivity to mutations in a single peptide by two TCRs having identical β-chains and closely related α-chains
    • Dittel, B. N., and C. A. Janeway, Jr. 2000. Differential sensitivity to mutations in a single peptide by two TCRs having identical β-chains and closely related α-chains. J. Immunol. 165:6334.
    • (2000) J. Immunol. , vol.165 , pp. 6334
    • Dittel, B.N.1    Janeway C.A., Jr.2
  • 49
    • 0031460674 scopus 로고    scopus 로고
    • Activation of autoreactive T cells by peptides from human pathogens
    • Hausmann, S., and K. W. Wucherpfennig. 1997. Activation of autoreactive T cells by peptides from human pathogens. Curr. Opin. Immunol. 9:831.
    • (1997) Curr. Opin. Immunol. , vol.9 , pp. 831
    • Hausmann, S.1    Wucherpfennig, K.W.2
  • 50
    • 0030816441 scopus 로고    scopus 로고
    • Reactivity patterns of synovial T-cell lines derived from a patient with rheumatoid arthritis. 1. Reactions with defined antigens and auto-antigens suggest the existence of multireactive T-cell clones
    • Melchers, I., J. Jooss-Rudiger, and H. H. Peter. 1997. Reactivity patterns of synovial T-cell lines derived from a patient with rheumatoid arthritis. 1. Reactions with defined antigens and auto-antigens suggest the existence of multireactive T-cell clones. Scand. J. Immunol. 46:187.
    • (1997) Scand. J. Immunol. , vol.46 , pp. 187
    • Melchers, I.1    Jooss-Rudiger, J.2    Peter, H.H.3
  • 51
    • 0032915806 scopus 로고    scopus 로고
    • Molecular mimicry and multiple sclerosis: Degenerate T-cell recognition and the induction of autoimmunity
    • Gran, B., B. Hemmer, M. Vergelli, H. F. McFarland, and R. Martin. 1999. Molecular mimicry and multiple sclerosis: degenerate T-cell recognition and the induction of autoimmunity. Ann. Neurol. 45:559.
    • (1999) Ann. Neurol. , vol.45 , pp. 559
    • Gran, B.1    Hemmer, B.2    Vergelli, M.3    McFarland, H.F.4    Martin, R.5
  • 52
    • 0032472801 scopus 로고    scopus 로고
    • Promiscuous presentation and recognition of nucleosomal autoepitopes in lupus: Role of autoimmune T cell receptor α chain
    • Shi, Y., A. Kaliyaperumal, L. Lu, S. Southwood, A. Sette, M. A. Michaels, and S. K. Datta. 1998. Promiscuous presentation and recognition of nucleosomal autoepitopes in lupus: role of autoimmune T cell receptor α chain. J. Exp. Med. 187:367.
    • (1998) J. Exp. Med. , vol.187 , pp. 367
    • Shi, Y.1    Kaliyaperumal, A.2    Lu, L.3    Southwood, S.4    Sette, A.5    Michaels, M.A.6    Datta, S.K.7
  • 54
    • 0028824098 scopus 로고
    • Low avidity recognition of self-antigen by T cells permits escape from central tolerance
    • Liu, G. Y., P. J. Fairchild, R. M. Smith, J. R. Prowle, D. Kioussis, and D. C. Wraith. 1995. Low avidity recognition of self-antigen by T cells permits escape from central tolerance. Immunity 3:407.
    • (1995) Immunity , vol.3 , pp. 407
    • Liu, G.Y.1    Fairchild, P.J.2    Smith, R.M.3    Prowle, J.R.4    Kioussis, D.5    Wraith, D.C.6
  • 55
    • 0032845223 scopus 로고    scopus 로고
    • The self-directed T cell repertoire against mouse lysozyme reflects the influence of the hierarchy of its own determinants and can be engaged by a foreign lysozyme
    • Moudgil, K. D., S. Southwood, A. Ametani, K. Kim, A. Sette, and E. E. Sercarz. 1999. The self-directed T cell repertoire against mouse lysozyme reflects the influence of the hierarchy of its own determinants and can be engaged by a foreign lysozyme. J. Immunol. 163:4232.
    • (1999) J. Immunol. , vol.163 , pp. 4232
    • Moudgil, K.D.1    Southwood, S.2    Ametani, A.3    Kim, K.4    Sette, A.5    Sercarz, E.E.6
  • 56
    • 0030738184 scopus 로고    scopus 로고
    • Interactions of TCRs with MHC-peptide complexes: A quantitative basis for mechanistic models
    • Margulies, D. H. 1997. Interactions of TCRs with MHC-peptide complexes: a quantitative basis for mechanistic models. Curr. Opin. Immunol. 9:390.
    • (1997) Curr. Opin. Immunol. , vol.9 , pp. 390
    • Margulies, D.H.1
  • 57
    • 0033118783 scopus 로고    scopus 로고
    • T cell receptor specificity and mimoptopes
    • Sparbier, K., and T. Walden. 1999. T cell receptor specificity and mimoptopes. Curr. Opin. Immunol. 11:214.
    • (1999) Curr. Opin. Immunol. , vol.11 , pp. 214
    • Sparbier, K.1    Walden, T.2
  • 58
    • 0036167623 scopus 로고    scopus 로고
    • Processing creates the self
    • Sercarz, E. E. 2002. Processing creates the self. Nat. Immun. 3:110.
    • (2002) Nat. Immun. , vol.3 , pp. 110
    • Sercarz, E.E.1
  • 60
    • 0034812434 scopus 로고    scopus 로고
    • Human endothelial cell presentation of antigen and the homing of memory/effector T cells to skin
    • Pober, J. S., M. S. Kluger, and J. S. Schechner. 2001. Human endothelial cell presentation of antigen and the homing of memory/effector T cells to skin. Ann. NY Acad. Sci. 941:12.
    • (2001) Ann. NY Acad. Sci. , vol.941 , pp. 12
    • Pober, J.S.1    Kluger, M.S.2    Schechner, J.S.3
  • 61
    • 0037341332 scopus 로고    scopus 로고
    • Processing and presentation of the islet autoantigen GAD by vascular endothelial cells promotes transmigration of autoreactive T-cells
    • Greening, J. E., T. I. Tree, K. T. Kotowicz, A. G. van Halteren, B. O. Roep, N. J. Klein, and M. Peakman. 2003. Processing and presentation of the islet autoantigen GAD by vascular endothelial cells promotes transmigration of autoreactive T-cells. Diabetes 52:717.
    • (2003) Diabetes , vol.52 , pp. 717
    • Greening, J.E.1    Tree, T.I.2    Kotowicz, K.T.3    Van Halteren, A.G.4    Roep, B.O.5    Klein, N.J.6    Peakman, M.7
  • 62
    • 0034665305 scopus 로고    scopus 로고
    • Spontaneous thymocyte apoptosis is regulated by mitochondrion-mediated signaling pathway
    • Zhang, J., K. Mikecz, T. T. Glant, and A. Finnegan. 2000. Spontaneous thymocyte apoptosis is regulated by mitochondrion-mediated signaling pathway. J. Immunol. 165:2970.
    • (2000) J. Immunol. , vol.165 , pp. 2970
    • Zhang, J.1    Mikecz, K.2    Glant, T.T.3    Finnegan, A.4
  • 63
    • 0035339916 scopus 로고    scopus 로고
    • A role for CD44 in the production of IFN-γ and immunopathology during infection with Toxoplasma gondii
    • Blass, S. L., E. Puré, and C. A. Hunter. 2001. A role for CD44 in the production of IFN-γ and immunopathology during infection with Toxoplasma gondii. J. Immunol. 166:5726.
    • (2001) J. Immunol. , vol.166 , pp. 5726
    • Blass, S.L.1    Puré, E.2    Hunter, C.A.3
  • 64
    • 0037033434 scopus 로고    scopus 로고
    • T helper 1 and T helper 2 cells are pathogenic in an antigen-specific model of colitis
    • Iqbal, N., J. R. Oliver, F. H. Wagner, A. S. Lazenby, C. O. Elson, and C. T. Weaver. 2002. T helper 1 and T helper 2 cells are pathogenic in an antigen-specific model of colitis. J. Exp. Med. 195:71.
    • (2002) J. Exp. Med. , vol.195 , pp. 71
    • Iqbal, N.1    Oliver, J.R.2    Wagner, F.H.3    Lazenby, A.S.4    Elson, C.O.5    Weaver, C.T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.