The anti-HER3 (ErbB3) therapeutic antibody 9F7-F11 induces HER3 ubiquitination and degradation in tumors through JNK1/2-dependent ITCH/AIP4 activation

Oncotarget

Volumn 7, Issue 24, 2016, Pages 37013-37029

  Le Clorennec, Christophe ^a,b,c   Lazrek, Yassamine ^a,b,c,d,g   Dubreuil, Olivier ^d,h   Larbouret, Christel ^a,b,c   Poul, Marie Alix ^a,b,c   Mondon, Philippe ^d,i   Melino, Gerry ^e,f   Pèlegrin, André ^a,b,c   Chardès, Thierry ^a,b,c  

^a INSTITUT DE RECHERCHE EN CANCÉROLOGIE DE MONTPELLIER   (France)

^b UNIV MONTPELLIER   (France)

^c CENTRE VAL D AURELLE   (France)

^d Millegen SA   (France)

^e UNIVERSITY OF ROME TOR VERGATA   (Italy)

^f UNIVERSITY OF LEICESTER   (United Kingdom)

^g INSTITUT PASTEUR DE LA GUYANE   (French Guiana)

^h Centre Pierre Potier   (France)

ⁱ LFB Biotechnologies Research Department   (France)

Author keywords

Antibody; Cancer; HER3; ITCH AIP4; Treatment

Indexed keywords

ANTIBODY 9F7 F11; ANTINEOPLASTIC AGENT; DEUBIQUITINASE; EPIDERMAL GROWTH FACTOR RECEPTOR 3; JANUS KINASE 1; JANUS KINASE 2; PROTEASOME; PROTEIN USP8; PROTEIN USP9X; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; 9F7-F11 ANTIBODY; ERBB3 PROTEIN, HUMAN; ITCH PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE 9; MONOCLONAL ANTIBODY; REPRESSOR PROTEIN; STRESS ACTIVATED PROTEIN KINASE 1; UBIQUITIN PROTEIN LIGASE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL LINE; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; ENZYME DEGRADATION; ENZYME STABILITY; HUMAN; HUMAN CELL; PANCREAS CANCER; PROSTATE CANCER; RNA INTERFERENCE; UBIQUITINATION; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; MAPK SIGNALING; METABOLISM; PHYSIOLOGY; TUMOR CELL LINE;

ANTIBODIES, MONOCLONAL; ANTIBODIES, MONOCLONAL, MURINE-DERIVED; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DOWN-REGULATION; HUMANS; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 8; MITOGEN-ACTIVATED PROTEIN KINASE 9; RECEPTOR, ERBB-3; REPRESSOR PROTEINS; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84978160746     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.9455     Document Type: Article

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