메뉴 건너뛰기




Volumn 7, Issue 24, 2016, Pages 36185-36197

Loss of AIM2 expression promotes hepatocarcinoma progression through activation of mTOR-S6K1 pathway

Author keywords

Absent in melanoma 2; Hepatocellular carcinoma; Inflammasome; Mammalian target of rapamycin; Tumor progression

Indexed keywords

ABSENT IN MELANOMA 2; INTERFERON; MAMMALIAN TARGET OF RAPAMYCIN; RAPAMYCIN; S6 KINASE; S6 KINASE 1; UNCLASSIFIED DRUG; AIM2 PROTEIN, HUMAN; DNA BINDING PROTEIN; MTOR PROTEIN, HUMAN; RIBOSOMAL PROTEIN S6 KINASE, 70KD, POLYPEPTIDE 1; TARGET OF RAPAMYCIN KINASE;

EID: 84978033463     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.9154     Document Type: Article
Times cited : (100)

References (27)
  • 2
    • 81455139907 scopus 로고    scopus 로고
    • Human keratinocytes express AIM2 and respond to dsDNA with IL-1beta secretion
    • Kopfnagel V, Wittmann M, Werfel T. Human keratinocytes express AIM2 and respond to dsDNA with IL-1beta secretion. Exp Dermatol. 2011; 20:1027-1029
    • (2011) Exp Dermatol , vol.20 , pp. 1027-1029
    • Kopfnagel, V.1    Wittmann, M.2    Werfel, T.3
  • 3
    • 84894537527 scopus 로고    scopus 로고
    • Inflammation-related induction of absent in melanoma 2 (AIM2) in vascular cells and atherosclerotic lesions suggests a role in vascular pathogenesis
    • Hakimi M, Peters A, Becker A, Bockler D, Dihlmann S. Inflammation-related induction of absent in melanoma 2 (AIM2) in vascular cells and atherosclerotic lesions suggests a role in vascular pathogenesis. J Vasc Surg. 2014; 59:794-803
    • (2014) J Vasc Surg , vol.59 , pp. 794-803
    • Hakimi, M.1    Peters, A.2    Becker, A.3    Bockler, D.4    Dihlmann, S.5
  • 4
    • 0030775488 scopus 로고    scopus 로고
    • Cloning a novel member of the human interferon-inducible gene family associated with control of tumorigenicity in a model of human melanoma
    • DeYoung KL, Ray ME, Su YA, Anzick SL, Johnstone RW, Trapani JA, Meltzer PS, Trent JM. Cloning a novel member of the human interferon-inducible gene family associated with control of tumorigenicity in a model of human melanoma. Oncogene. 1997; 15:453-457
    • (1997) Oncogene , vol.15 , pp. 453-457
    • DeYoung, K.L.1    Ray, M.E.2    Su, Y.A.3    Anzick, S.L.4    Johnstone, R.W.5    Trapani, J.A.6    Meltzer, P.S.7    Trent, J.M.8
  • 5
    • 35349011610 scopus 로고    scopus 로고
    • The putative tumor suppressor AIM2 is frequently affected by different genetic alterations in microsatellite unstable colon cancers
    • Woerner SM, Kloor M, Schwitalle Y, Youmans H, Doeberitz M, Gebert J, Dihlmann S. The putative tumor suppressor AIM2 is frequently affected by different genetic alterations in microsatellite unstable colon cancers. Genes Chromosomes Cancer. 2007; 46:1080-1089
    • (2007) Genes Chromosomes Cancer , vol.46 , pp. 1080-1089
    • Woerner, S.M.1    Kloor, M.2    Schwitalle, Y.3    Youmans, H.4    Doeberitz, M.5    Gebert, J.6    Dihlmann, S.7
  • 6
    • 66249106029 scopus 로고    scopus 로고
    • Compensation of loss of protein function in microsatellite-unstable colon cancer cells (HCT116): a gene-dependent effect on the cell surface glycan profile
    • Patsos G, Andre S, Roeckel N, Gromes R, Gebert J, Kopitz J, Gabius HJ. Compensation of loss of protein function in microsatellite-unstable colon cancer cells (HCT116): a gene-dependent effect on the cell surface glycan profile. Glycobiology. 2009; 19:726-734
    • (2009) Glycobiology , vol.19 , pp. 726-734
    • Patsos, G.1    Andre, S.2    Roeckel, N.3    Gromes, R.4    Gebert, J.5    Kopitz, J.6    Gabius, H.J.7
  • 7
    • 77949892176 scopus 로고    scopus 로고
    • Restoration of absent in melanoma 2 (AIM2) induces G2/M cell cycle arrest and promotes invasion of colorectal cancer cells
    • Patsos G, Germann A, Gebert J, Dihlmann S. Restoration of absent in melanoma 2 (AIM2) induces G2/M cell cycle arrest and promotes invasion of colorectal cancer cells. Int J Cancer. 2010; 126:1838-1849
    • (2010) Int J Cancer , vol.126 , pp. 1838-1849
    • Patsos, G.1    Germann, A.2    Gebert, J.3    Dihlmann, S.4
  • 10
    • 84886384437 scopus 로고    scopus 로고
    • AIM2, an IFN-inducible cytosolic DNA sensor, in the development of benign prostate hyperplasia and prostate cancer
    • Ponomareva L, Liu H, Duan X, Dickerson E, Shen H, Panchanathan R, Choubey D. AIM2, an IFN-inducible cytosolic DNA sensor, in the development of benign prostate hyperplasia and prostate cancer. Mol Cancer Res. 2013; 11:1193-1202
    • (2013) Mol Cancer Res , vol.11 , pp. 1193-1202
    • Ponomareva, L.1    Liu, H.2    Duan, X.3    Dickerson, E.4    Shen, H.5    Panchanathan, R.6    Choubey, D.7
  • 12
    • 77950362382 scopus 로고    scopus 로고
    • The inflammasomes
    • Schroder K, Tschopp J. The inflammasomes. Cell. 2010; 140:821-832
    • (2010) Cell , vol.140 , pp. 821-832
    • Schroder, K.1    Tschopp, J.2
  • 14
    • 84880468132 scopus 로고    scopus 로고
    • Detection of pyroptosis by measuring released lactate dehydrogenase activity
    • Rayamajhi M, Zhang Y, Miao EA. Detection of pyroptosis by measuring released lactate dehydrogenase activity. Methods Mol Biol. 2013; 1040:85-90
    • (2013) Methods Mol Biol , vol.1040 , pp. 85-90
    • Rayamajhi, M.1    Zhang, Y.2    Miao, E.A.3
  • 15
    • 34547107592 scopus 로고    scopus 로고
    • Hypoxia-driven selection of the metastatic phenotype
    • Sullivan R, Graham CH. Hypoxia-driven selection of the metastatic phenotype. Cancer Metastasis Rev. 2007; 26:319-331
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 319-331
    • Sullivan, R.1    Graham, C.H.2
  • 16
    • 84860616444 scopus 로고    scopus 로고
    • The interrelating dynamics of hypoxic tumor microenvironments and cancer cell phenotypes in cancer metastasis
    • Bartkowiak K, Riethdorf S, Pantel K. The interrelating dynamics of hypoxic tumor microenvironments and cancer cell phenotypes in cancer metastasis. Cancer Microenviron. 2012; 5:59-72
    • (2012) Cancer Microenviron , vol.5 , pp. 59-72
    • Bartkowiak, K.1    Riethdorf, S.2    Pantel, K.3
  • 19
    • 84901266379 scopus 로고    scopus 로고
    • Human rhomboid family-1 suppresses oxygen-independent degradation of hypoxia-inducible factor-1alpha in breast cancer
    • Zhou Z, Liu F, Zhang ZS, Shu F, Zheng Y, Fu L, Li LY. Human rhomboid family-1 suppresses oxygen-independent degradation of hypoxia-inducible factor-1alpha in breast cancer. Cancer Res. 2014; 74:2719-2730
    • (2014) Cancer Res , vol.74 , pp. 2719-2730
    • Zhou, Z.1    Liu, F.2    Zhang, Z.S.3    Shu, F.4    Zheng, Y.5    Fu, L.6    Li, L.Y.7
  • 20
    • 33748056087 scopus 로고    scopus 로고
    • Hypoxia enhances lysophosphatidic acid responsiveness in ovarian cancer cells and lysophosphatidic acid induces ovarian tumor metastasis in vivo
    • Kim KS, Sengupta S, Berk M, Kwak YG, Escobar PF, Belinson J, Mok SC, Xu Y. Hypoxia enhances lysophosphatidic acid responsiveness in ovarian cancer cells and lysophosphatidic acid induces ovarian tumor metastasis in vivo. Cancer Res. 2006; 66:7983-7990
    • (2006) Cancer Res , vol.66 , pp. 7983-7990
    • Kim, K.S.1    Sengupta, S.2    Berk, M.3    Kwak, Y.G.4    Escobar, P.F.5    Belinson, J.6    Mok, S.C.7    Xu, Y.8
  • 22
    • 84939150351 scopus 로고    scopus 로고
    • The novel mTOR inhibitor Torin-2 induces autophagy and downregulates the expression of UHRF1 to suppress hepatocarcinoma cell growth
    • Wang C, Wang X, Su Z, Fei H, Liu X, Pan Q. The novel mTOR inhibitor Torin-2 induces autophagy and downregulates the expression of UHRF1 to suppress hepatocarcinoma cell growth. Oncol Rep. 2015
    • (2015) Oncol Rep
    • Wang, C.1    Wang, X.2    Su, Z.3    Fei, H.4    Liu, X.5    Pan, Q.6
  • 25
    • 84891500326 scopus 로고    scopus 로고
    • Deregulation of the NLRP3 inflammasome in hepatic parenchymal cells during liver cancer progression
    • Wei Q, Mu K, Li T, Zhang Y, Yang Z, Jia X, Zhao W, Huai W, Guo P, Han L. Deregulation of the NLRP3 inflammasome in hepatic parenchymal cells during liver cancer progression. Lab Invest. 2014; 94:52-62
    • (2014) Lab Invest , vol.94 , pp. 52-62
    • Wei, Q.1    Mu, K.2    Li, T.3    Zhang, Y.4    Yang, Z.5    Jia, X.6    Zhao, W.7    Huai, W.8    Guo, P.9    Han, L.10
  • 26
    • 84933051219 scopus 로고    scopus 로고
    • Estrogen suppresses hepatocellular carcinoma cells through ERbeta-mediated upregulation of the NLRP3 inflammasome
    • Wei Q, Guo P, Mu K, Zhang Y, Zhao W, Huai W, Qiu Y, Li T, Ma X, Liu Y, Chen X, Han L. Estrogen suppresses hepatocellular carcinoma cells through ERbeta-mediated upregulation of the NLRP3 inflammasome. Lab Invest. 2015; 95:804-816
    • (2015) Lab Invest , vol.95 , pp. 804-816
    • Wei, Q.1    Guo, P.2    Mu, K.3    Zhang, Y.4    Zhao, W.5    Huai, W.6    Qiu, Y.7    Li, T.8    Ma, X.9    Liu, Y.10    Chen, X.11    Han, L.12
  • 27
    • 84906860991 scopus 로고    scopus 로고
    • MiR-424-5p reversed epithelial-mesenchymal transition of anchorage-independent HCC cells by directly targeting ICAT and suppressed HCC progression
    • Zhang Y, Li T, Guo P, Kang J, Wei Q, Jia X, Zhao W, Huai W, Qiu Y, Sun L, Han L. MiR-424-5p reversed epithelial-mesenchymal transition of anchorage-independent HCC cells by directly targeting ICAT and suppressed HCC progression. Sci Rep. 2014; 4:6248
    • (2014) Sci Rep , vol.4 , pp. 6248
    • Zhang, Y.1    Li, T.2    Guo, P.3    Kang, J.4    Wei, Q.5    Jia, X.6    Zhao, W.7    Huai, W.8    Qiu, Y.9    Sun, L.10    Han, L.11


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.