Inflammation-related induction of absent in melanoma 2 (AIM2) in vascular cells and atherosclerotic lesions suggests a role in vascular pathogenesis

Journal of Vascular Surgery

Volumn 59, Issue 3, 2014, Pages

  Hakimi, Maani ^a   Peters, Andreas ^a   Becker, Anja ^a   Böckler, Dittmar ^a   Dihlmann, Susanne ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ABSENT IN MELANOMA 2 PROTEIN; CELL PROTEIN; EXTRACHROMOSOMAL DNA; GAMMA INTERFERON; POLY(DEOXYADENYLATE DEOXYTHYMIDYLATE); TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADULT; AGED; AORTA; AORTA ANEURYSM; AORTA ATHEROSCLEROSIS; ARTERY INTIMA; ARTERY WALL; ATHEROGENESIS; CAROTID ARTERY; CAROTID ATHEROSCLEROSIS; CELL STIMULATION; CELLULAR STRESS RESPONSE; CHRONIC INFLAMMATION; CONFERENCE PAPER; CONTROLLED STUDY; CYTOSOL; ENDOTHELIUM CELL; FEMALE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INTIMA; MALE; MIDDLE AGED; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SMOOTH MUSCLE FIBER; STIMULUS RESPONSE; UPREGULATION; VASA VASORUM; VASCULAR ENDOTHELIUM; VASCULAR SMOOTH MUSCLE; VASCULAR SURGERY; VERY ELDERLY;

AORTIC DISEASES; ATHEROSCLEROSIS; CAROTID ARTERY DISEASES; CASE-CONTROL STUDIES; CELL LINE; ENDOTHELIAL CELLS; HUMANS; INFLAMMATION MEDIATORS; INTERFERON-GAMMA; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; NECROSIS; NUCLEAR PROTEINS; PLAQUE, ATHEROSCLEROTIC; POLY DA-DT; RNA, MESSENGER; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSCRIPTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 84894537527     PISSN: 07415214     EISSN: 10976809     Source Type: Journal    
DOI: 10.1016/j.jvs.2013.03.048     Document Type: Conference Paper

References (34)

1. G.K. Hansson Inflammation, atherosclerosis, and coronary artery disease N Engl J Med 352 2005 1685 1695
2. P. Libby, P.M. Ridker, and G.K. Hansson Inflammation in atherosclerosis: from pathophysiology to practice J Am Coll Cardiol 54 2009 2129 2138
3. T. Strowig, J. Henao-Mejia, E. Elinav, and R. Flavell Inflammasomes in health and disease Nature 481 2012 278 286
4. N. Yajima, M. Takahashi, H. Morimoto, Y. Shiba, Y. Takahashi, and J. Masumoto et al. Critical role of bone marrow apoptosis-associated speck-like protein, an inflammasome adaptor molecule, in neointimal formation after vascular injury in mice Circulation 117 2008 3079 3087
5. S. Schlaweck, S. Zimmer, R. Struck, E. Bartok, N. Werner, and F. Bauernfeind et al. Critical role of nucleotide-binding oligomerization domain-like receptor 3 in vascular repair Biochem Biophys Res Commun 411 2011 627 631
6. K. Rajamaki, J. Lappalainen, K. Oorni, E. Valimaki, S. Matikainen, and P.T. Kovanen et al. Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation PLoS One 5 2010 e11765
7. P. Duewell, H. Kono, K.J. Rayner, C.M. Sirois, G. Vladimer, and F.G. Bauernfeind et al. NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals Nature 464 2010 1357 1361
8. Y. Yin, Y. Yan, X. Jiang, J. Mai, N.C. Chen, and H. Wang et al. Inflammasomes are differentially expressed in cardiovascular and other tissues Int J Immunopathol Pharmacol 22 2009 311 322
9. T. Burckstummer, C. Baumann, S. Bluml, E. Dixit, G. Durnberger, and H. Jahn et al. An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome Nat Immunol 10 2009 266 272
10. T. Fernandes-Alnemri, J.W. Yu, P. Datta, J. Wu, and E.S. Alnemri AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA Nature 458 2009 509 513
11. V. Hornung, A. Ablasser, M. Charrel-Dennis, F. Bauernfeind, G. Horvath, and D.R. Caffrey et al. AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC Nature 458 2009 514 518
12. T.L. Roberts, A. Idris, J.A. Dunn, G.M. Kelly, C.M. Burnton, and S. Hodgson et al. HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA Science 323 2009 1057 1060
13. T. Fernandes-Alnemri, J.W. Yu, C. Juliana, L. Solorzano, S. Kang, and J. Wu et al. The AIM2 inflammasome is critical for innate immunity to Francisella tularensis Nat Immunol 11 2010 385 393
14. V.A. Rathinam, and K.A. Fitzgerald Inflammasomes and anti-viral immunity J Clin Immunol 30 2010 632 637
15. J.D. Sauer, C.E. Witte, J. Zemansky, B. Hanson, P. Lauer, and D.A. Portnoy Listeria monocytogenes triggers AIM2-mediated pyroptosis upon infrequent bacteriolysis in the macrophage cytosol Cell Host Microbe 7 2010 412 419
16. H. Saiga, S. Kitada, Y. Shimada, N. Kamiyama, M. Okuyama, and M. Makino et al. Critical role of AIM2 in Mycobacterium tuberculosis infection Int Immunol 24 2012 637 644
17. I.F. Chen, F. Ou-Yang, J.Y. Hung, J.C. Liu, H. Wang, and S.C. Wang et al. AIM2 suppresses human breast cancer cell proliferation in vitro and mammary tumor growth in a mouse model Mol Cancer Ther 5 2006 1 7
18. S.M. Woerner, M. Kloor, Y. Schwitalle, H. Youmans, M.K. Doeberitz, and J. Gebert et al. The putative tumor suppressor AIM2 is frequently affected by different genetic alterations in microsatellite unstable colon cancers Genes Chromosomes Cancer 46 2007 1080 1089
19. G. Patsos, A. Germann, J. Gebert, and S. Dihlmann Restoration of absent in melanoma 2 (AIM2) induces G2/M cell cycle arrest and promotes invasion of colorectal cancer cells Int J Cancer 126 2010 1838 1849
20. J. Lee, L. Li, N. Gretz, J. Gebert, and S. Dihlmann Absent in melanoma 2 (AIM2) is an important mediator of interferon-dependent and -independent HLA-DRA and HLA-DRB gene expression in colorectal cancers Oncogene 31 2012 1242 1253
21. S.M. Woerner, M. Kloor, A. Mueller, J. Rueschoff, N. Friedrichs, and R. Buettner et al. Microsatellite instability of selective target genes in HNPCC-associated colon adenomas Oncogene 24 2005 2525 2535
22. S. Michel, M. Kloor, S. Singh, G. Gdynia, W. Roth, and M. von Knebel Doeberitz et al. Coding microsatellite instability analysis in microsatellite unstable small intestinal adenocarcinomas identifies MARCKS as a common target of inactivation Mol Carcinog 49 2000 175 182
23. N. Parameswaran, and S. Patial Tumor necrosis factor-alpha signaling in macrophages Crit Rev Eukaryot Gene Expr 20 2010 87 103
24. J.E. McLaren, and D.P. Ramji Interferon gamma: a master regulator of atherosclerosis Cytokine Growth Factor Rev 20 2009 125 135
25. Y. Dombrowski, M. Peric, S. Koglin, C. Kammerbauer, C. Goss, and D. Anz et al. Cytosolic DNA triggers inflammasome activation in keratinocytes in psoriatic lesions Sci Transl Med 3 2011 82ra38
26. V. Kopfnagel, M. Wittmann, and T. Werfel Human keratinocytes express AIM2 and respond to dsDNA with IL-1beta secretion Exp Dermatol 20 2011 1027 1029
27. L.C. Chen, L.J. Wang, N.M. Tsang, D.M. Ojcius, C.C. Chen, and C.N. Ouyang et al. Tumour inflammasome-derived IL-1beta recruits neutrophils and improves local recurrence-free survival in EBV-induced nasopharyngeal carcinoma EMBO Mol Med 4 2012 1276 1293
28. E.S. Alnemri Sensing cytoplasmic danger signals by the inflammasome J Clin Immunol 30 2010 512 519
29. M. Lamkanfi, and V.M. Dixit Inflammasomes and their roles in health and disease Annu Rev Cell Dev Biol 28 2012 137 161
30. M.A. Beilke Vascular endothelium in immunology and infectious disease Rev Infect Dis 11 1989 273 283
31. S. Kofler, T. Nickel, and M. Weis Role of cytokines in cardiovascular diseases: a focus on endothelial responses to inflammation Clin Sci (Lond) 108 2005 205 213
32. T.N. Tangi, A.A. Elmabsout, T. Bengtsson, A. Sirsjo, and K. Fransen Role of NLRP3 and CARD8 in the regulation of TNF-alpha induced IL-1beta release in vascular smooth muscle cells Int J Mol Med 30 2012 697 702
33. M. Horiuchi, H. Yamada, M. Akishita, M. Ito, K. Tamura, and V.J. Dzau Interferon regulatory factors regulate interleukin-1beta-converting enzyme expression and apoptosis in vascular smooth muscle cells Hypertension 33 1999 162 166
34. G. Buttice, J. Miller, L. Wang, and B.D. Smith Interferon-gamma induces major histocompatibility class II transactivator (CIITA), which mediates collagen repression and major histocompatibility class II activation by human aortic smooth muscle cells Circ Res 98 2006 472 479