Effect of intralipid® on the dose of ropivacaine or levobupivacaine tolerated by volunteers

Anesthesiology

Volumn 125, Issue 3, 2016, Pages 474-483

  Dureau, Pauline ^b   Charbit, Beny ^b,c   Nicolas, Nathalie ^b   Benhamou, Dan ^a   Mazoit, Jean Xavier ^a  

^a UNIVERSITÉ PARIS SACLAY   (France)

^b PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^c REIMS UNIVERSITY HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

INTRALIPID; LEVOBUPIVACAINE; LIDOCAINE; PLACEBO; ROPIVACAINE; SODIUM CHLORIDE; AMIDE; BUPIVACAINE; EMULSION; LOCAL ANESTHETIC AGENT; PHOSPHOLIPID; SOYBEAN OIL; SOYBEAN OIL, PHOSPHOLIPID EMULSION;

ADULT; AREA UNDER THE CURVE; ARTICLE; BLURRED VISION; CARDIOVASCULAR EFFECT; CIRCUMORAL PARESTHESIA; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DETERMINATION; DRUG DOSE COMPARISON; DRUG HALF LIFE; DRUG INFUSION; DRUG MEGADOSE; DYSARTHRIA; ELEVATED BLOOD PRESSURE; FEMALE; HEARING DISORDER; HEART RATE; HUMAN; LOCAL ANESTHESIA; MALE; MAXIMUM PLASMA CONCENTRATION; METALLIC TASTE; MYOCLONUS; NEUROTOXICITY; NORMAL HUMAN; PARESTHESIA; PLASMA CONCENTRATION-TIME CURVE; PR INTERVAL; PRIORITY JOURNAL; QRS INTERVAL; QTC INTERVAL; RANDOMIZED CONTROLLED TRIAL; SIMULATION; SYSTOLIC BLOOD PRESSURE; TINNITUS; TONGUE DISEASE; VALIDITY; VOLUME OF DISTRIBUTION; ANALOGS AND DERIVATIVES; BLOOD PRESSURE; DOSE RESPONSE; DRUG EFFECTS; ELECTROCARDIOGRAPHY; EMULSION; INTRAVENOUS DRUG ADMINISTRATION; OXIMETRY; PHARMACOLOGY; REFERENCE VALUE; STATISTICS AND NUMERICAL DATA;

AMIDES; ANESTHETICS, LOCAL; BLOOD PRESSURE; BUPIVACAINE; CROSS-OVER STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; ELECTROCARDIOGRAPHY; EMULSIONS; FEMALE; HUMANS; INFUSIONS, INTRAVENOUS; MALE; OXIMETRY; PHOSPHOLIPIDS; REFERENCE VALUES; SOYBEAN OIL;

EID: 84978033436     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/ALN.0000000000001230     Document Type: Article

References (48)

1. Di Gregorio G, Neal JM, Rosenquist RW, Weinberg GL: Clinical presentation of local anesthetic systemic toxicity: A review of published cases, 1979 to 2009. Reg Anesth Pain Med 2010; 35:181-7
2. Weinberg GL, VadeBoncouer T, Ramaraju GA, Garcia-Amaro MF, Cwik MJ: Pretreatment or resuscitation with a lipid infusion shifts the dose-response to bupivacaine-induced asystole in rats. Anesthesiology 1998; 88:1071-5
3. Rosenblatt MA, Abel M, Fischer GW, Itzkovich CJ, Eisenkraft JB: Successful use of a 20% lipid emulsion to resuscitate a patient after a presumed bupivacaine-related cardiac arrest. Anesthesiology 2006; 105:217-8
4. Litz RJ, Popp M, Stehr SN, Koch T. Successful resuscitation of a patient with ropivacaine-induced asystole after axillary plexus block using lipid infusion. Anaesthesia 2006; 61:800-1
5. Weinberg GL: Lipid emulsion infusion: Resuscitation for local anesthetic and other drug overdose. Anesthesiology 2012; 117:180-7
6. Mazoit JX, Le Guen R, Beloeil H, Benhamou D. Binding of long-lasting local anesthetics to lipid emulsions. Anesthesiology 2009; 110:380-6
7. Stehr SN, Ziegeler JC, Pexa A, Oertel R, Deussen A, Koch T, Hübler M. The effects of lipid infusion on myocardial function and bioenergetics in l-bupivacaine toxicity in the isolated rat heart. Anesth Analg 2007; 104:186-92
8. Weinberg GL, Di Gregorio G, Ripper R, Kelly K, Massad M, Edelman L, Schwartz D, Shah N, Zheng S, Feinstein DL: Resuscitation with lipid versus epinephrine in a rat model of bupivacaine overdose. Anesthesiology 2008; 108:907-13
9. Chen Y, Xia Y, Liu L, Shi T, Shi K, Wang Q, Chen L, Papadimos TJ, Xu X. Lipid emulsion reverses bupivacaine-induced asystole in isolated rat hearts: Concentration-response and timeresponse relationships. Anesthesiology 2010; 113:1320-5
10. Cave G, Harvey M, Prince G, Lahner D, Desmet J. Effect of hypertonic saline on electrocardiography QRS duration in rabbit model of bupivacaine toxicity resuscitated by intravenous lipid. Anaesthesia 2010; 65:792-8
11. Candela D, Louart G, Bousquet PJ, Muller L, Nguyen M, Boyer JC, Peray PA, Goret L, Ripart J, Lefrant JY, de La Coussaye JE: Reversal of bupivacaine-induced cardiac electrophysiologic changes by two lipid emulsions in anesthetized and mechanically ventilated piglets. Anesth Analg 2010; 110:1473-9
12. Zausig YA, Zink W, Keil M, Sinner B, Barwing J, Wiese CH, Graf BM: Lipid emulsion improves recovery from bupivacaine-induced cardiac arrest, but not from ropivacaine- or mepivacaine-induced cardiac arrest. Anesth Analg 2009; 109:1323-6
13. H iller DB, Gregorio GD, Ripper R, Kelly K, Massad M, Edelman L, Edelman G, Feinstein DL, Weinberg GL: Epinephrine impairs lipid resuscitation from bupivacaine overdose: A threshold effect. Anesthesiology 2009; 111:498-505
14. Li B, Yan J, Shen Y, Li B, Hu Z, Ma Z. Association of sustained cardiovascular recovery with epinephrine in the delayed lipid-based resuscitation from cardiac arrest induced by bupivacaine overdose in rats. Br J Anaesth 2012; 108:857-63
15. Ludot H, Tharin JY, Belouadah M, Mazoit JX, Malinovsky JM: Successful resuscitation after ropivacaine and lidocaineinduced ventricular arrhythmia following posterior lumbar plexus block in a child. Anesth Analg 2008; 106:1572-4, table of contents
16. Charbonneau H, Marcou TA, Mazoit JX, Zetlaoui PJ, Benhamou D. Early use of lipid emulsion to treat incipient mepivacaine intoxication. Reg Anesth Pain Med 2009; 34:277-8
17. Calenda E, Dinescu SA: Failure of lipid emulsion to reverse neurotoxicity after an ultrasound-guided axillary block with ropivacaine and mepivacaine. J Anesth 2009; 23:472-3
18. Uncles DR, Willers JW, Samuels TL, Chaklader A. Local anaesthetic systemic toxicity treated with intravenous lipid emulsion: Ineffective treatment or selection of an inadequate lipid rescue dose?. Eur J Anaesthesiol 2011; 28:390-1
19. H einonen JA, Litonius E, Salmi T, Haasio J, Tarkkila P, Backman JT, Rosenberg PH: Intravenous lipid emulsion given to volunteers does not affect symptoms of lidocaine brain toxicity. Basic Clin Pharmacol Toxicol 2015; 116:378-83
20. Litonius E, Tarkkila P, Neuvonen PJ, Rosenberg PH: Effect of intravenous lipid emulsion on bupivacaine plasma concentration in humans. Anaesthesia 2012; 67:600-5
21. Kuo I, Akpa BS: Validity of the lipid sink as a mechanism for the reversal of local anesthetic systemic toxicity: A physiologically based pharmacokinetic model study. Anesthesiology 2013; 118:1350-61
22. Scott DB, Lee A, Fagan D, Bowler GM, Bloomfield P, Lundh R. Acute toxicity of ropivacaine compared with that of bupivacaine. Anesth Analg 1989; 69:563-9
23. Knudsen K, Beckman Suurküla M, Blomberg S, Sjövall J, Edvardsson N. Central nervous and cardiovascular effects of i.v. infusions of ropivacaine, bupivacaine and placebo in volunteers. Br J Anaesth 1997; 78:507-14
24. Bardsley H, Gristwood R, Baker H, Watson N, Nimmo W. A comparison of the cardiovascular effects of levobupivacaine and rac-bupivacaine following intravenous administration to healthy volunteers. Br J Clin Pharmacol 1998; 46:245-9
25. Stewart J, Kellett N, Castro D. The central nervous system and cardiovascular effects of levobupivacaine and ropivacaine in healthy volunteers. Anesth Analg 2003; 97:412-6, table of contents
26. Kligfield P, Gettes LS, Bailey JJ, Childers R, Deal BJ, Hancock EW, van Herpen G, Kors JA, Macfarlane P, Mirvis DM, Pahlm O, Rautaharju P, Wagner GS, Josephson M, Mason JW, Okin P, Surawicz B, Wellens H. American Heart Association Electrocardiography and Arrhythmias Committee, Council on Clinical Cardiology; American College of Cardiology Foundation; Heart Rhythm Society: Recommendations for the standardization and interpretation of the electrocardiogram: Part I. The electrocardiogram and its technology: A scientific statement from the American Heart Association Electrocardiography and Arrhythmias Committee, Council on Clinical Cardiology; the American College of Cardiology Foundation; and the Heart Rhythm Society: Endorsed by the International Society for Computerized Electrocardiology. Circulation 2007; 115:1306-24
27. Meunier JF, Goujard E, Dubousset AM, Samii K, Mazoit JX: Pharmacokinetics of bupivacaine after continuous epidural infusion in infants with and without biliary atresia. Anesthesiology 2001; 95:87-95
28. Park GB, Erdtmansky PE, Brown RR, Kullberg MP, Edelson J. Analysis of mepivacaine, bupivacaine, etidocaine, lidocaine, and tetracaine. J Pharm Sci 1980; 69:603-5
29. Sheiner LB, Beal SL, Boeckmann AJ: NONMEM Project Group. San Francisco, University of California at San Francisco, 1990
30. Comets E, Brendel K, Mentré F. Computing normalised prediction distribution errors to evaluate nonlinear mixed-effect models: The npde add-on package for R. Comput Methods Programs Biomed 2008; 90:154-66
31. Gibaldi M, Perrier D. Pharmacokinetics, 2nd edition. New York, Marcel Dekker, 1982, pp 409-17
32. The R Foundation for Statistical Computing. Vienna, Austria, Vienna University of Technology. Available at: http://www.rproject.org/. Accessed June 2, 2014
33. Pinheiro JC, Bates DM: "Mixed-Effects Models in S and S-PLUS." Springer, 2000, pp 57-80
34. Fettiplace MR, Ripper R, Lis K, Lin B, Lang J, Zider B, Wang J, Rubinstein I, Weinberg G. Rapid cardiotonic effects of lipid emulsion infusion. Crit Care Med 2013; 41:e156-62
35. Fettiplace MR, Lis K, Ripper R, Kowal K, Pichurko A, Vitello D, Rubinstein I, Schwartz D, Akpa BS, Weinberg G. Multi-modal contributions to detoxification of acute pharmacotoxicity by a triglyceride micro-emulsion. J Control Release 2015; 198:62-70
36. Kariya N, Cosson C, Mazoit JX: Comparative effect of lidocaine, bupivacaine and RAC 109 on myocardial conduction and contractility in the rabbit. Eur J Pharmacol 2012; 691:110-7
37. Mazoit JX, Decaux A, Bouaziz H, Edouard A. Comparative ventricular electrophysiologic effect of racemic bupivacaine, levobupivacaine, and ropivacaine on the isolated rabbit heart. Anesthesiology 2000; 93:784-92
38. Simon MJ, Veering BT, Vletter AA, Stienstra R, van Kleef JW, Burm AG: The effect of age on the systemic absorption and systemic disposition of ropivacaine after epidural administration. Anesth Analg 2006; 102:276-82
39. Burm AG, van der Meer AD, van Kleef JW, Zeijlmans PW, Groen K. Pharmacokinetics of the enantiomers of bupivacaine following intravenous administration of the racemate. Br J Clin Pharmacol 1994; 38:125-9
40. Burm AG, Stienstra R, Brouwer RP, Emanuelsson BM, van Kleef JW: Epidural infusion of ropivacaine for postoperative analgesia after major orthopedic surgery: Pharmacokinetic evaluation. Anesthesiology 2000; 93:395-403
41. O lofsen E, Burm AG, Simon MJ, Veering BT, van Kleef JW, Dahan A. Population pharmacokinetic-pharmacodynamic modeling of epidural anesthesia. Anesthesiology 2008; 109:664-74
42. Mather LE, Cousins MJ: Local anaesthetics and their current clinical use. Drugs 1979; 18:185-205
43. Nestel PJ, Denborough MA, O?dea J. Disposal of human chylomicrons administered intravenously in ischemic heart disease and essential hyperlipemia. Circ Res 1962; 10:786-91
44. Cohen JC: Chylomicron triglyceride clearance: Comparison of three assessment methods. Am J Clin Nutr 1989; 49:306-13
45. Robin AP, Nordenström J, Askanazi J, Elwyn DH, Carpentier YA, Kinney JM: Plasma clearance of fat emulsion in trauma and sepsis: Use of a three-stage lipid clearance test. JPEN J Parenter Enteral Nutr 1980; 4:505-10
46. Chauvelot-Moachon L, Tallet F, Durlach-Misteli C, Giroud JP: Delipidation of alpha 1-acid glycoprotein. Propranolol binding to this glycoprotein and its modification by extracted material and exogenous lipids. J Pharmacol Methods 1988; 20:15-28
47. O gata K, Takamura N, Tokunaga J, Kawai K, Arimori K, Higuchi S. Dosage plan of a flurbiprofen injection product using inhibition of protein binding by lipid emulsion in rats. J Pharm Pharmacol 2008; 60:15-20
48. Levine M, Skolnik AB, Ruha AM, Bosak A, Menke N, Pizon AF: Complications following antidotal use of intravenous lipid emulsion therapy. J Med Toxicol 2014; 10:10-4