Validity of the lipid sink as a mechanism for the reversal of local anesthetic systemic toxicity: A physiologically based pharmacokinetic model study

Anesthesiology

Volumn 118, Issue 6, 2013, Pages 1350-1361

  Kuo, Ilin ^a   Akpa, Belinda S ^a  

^a University of Illinois at Chicago   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BUPIVACAINE; LIPID EMULSION; PLASMA PROTEIN;

ARTICLE; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG METABOLISM; DRUG OVERDOSE; ERYTHROCYTE; HUMAN; HUMAN TISSUE; LOCAL ANESTHESIA; MALE; NORMAL HUMAN; PLASMA PROTEIN BINDING; PRIORITY JOURNAL;

ANESTHETICS, LOCAL; AREA UNDER CURVE; BLOOD PRESSURE; BUPIVACAINE; FAT EMULSIONS, INTRAVENOUS; HEART RATE; HUMANS; INFUSIONS, INTRAVENOUS; MODELS, BIOLOGICAL; REFERENCE VALUES; REPRODUCIBILITY OF RESULTS;

EID: 84878643234     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/ALN.0b013e31828ce74d     Document Type: Article

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