Epidural infusion of ropivacaine for postoperative analgesia after major orthopedic surgery: Pharmacokinetic evaluation

Anesthesiology

Volumn 93, Issue 2, 2000, Pages 395-403

  Burm, Anton G L ^a   Stienstra, Rudolf ^a   Brouwer, Rolf P ^a   Emanuelsson, Britt Marie ^b   Van Kleef, Jack W ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b ASTRAZENECA   (United Kingdom)

Author keywords

Anesthetics; Biotransformation; Clearance; Metabolism

Indexed keywords

ADRENALIN; LIDOCAINE; MIDAZOLAM; OROSOMUCOID; ROPIVACAINE; TEMAZEPAM;

ADULT; AGED; ANESTHESIA INDUCTION; ARTICLE; CLINICAL ARTICLE; EPIDURAL ANESTHESIA; FEMALE; GENERAL ANESTHESIA; HUMAN; MALE; ORTHOPEDIC SURGERY; POSTOPERATIVE ANALGESIA; PREMEDICATION; PRIORITY JOURNAL;

EID: 0033860167     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-200008000-00017     Document Type: Article

References (25)

1. Epidural ropivacaine infusion for postoperative analgesia after major lower abdominal surgery - A dose finding study
2. Continuous extradural infusion of ropivacaine for prevention of postoperative pain after major orthopaedic surgery
3. Continuous epidural infusion of ropivacaine for the prevention of postoperative pain after major orthopaedic surgery: A dose-finding study
4. Postoperative analgesia by continuous extradural infusion of ropivacaine after upper abdominal surgery
5. Comparative systemic toxicity of convulsant and supraconvulsant doses of intravenous ropivacaine, bupivacaine, and lidocaine in the conscious dog
6. Pharmacokinetics and analgesic effect of ropivacaine during continuous epidural infusion for postoperative pain relief
7. Sequential changes of plasma proteins after surgical trauma
8. Pharmacokinetics and protein binding of bupivacaine in postoperative epidural analgesia
9. Plasma concentrations of alfentanil required to supplement nitrous oxide anesthesia for general surgery
10. Capillary gas chromatographic method for the simultaneous determination of local anaesthetics in plasma samples
11. Determination of free concentration of ropivacaine and bupivacaine in blood plasma by ultrafiltration and coupled-column liquid chromatography
12. Immunochemical quantitation of antigens by single radial immunodiffusion
13. Liquid chromatographic bioanalytical determination of ropivacaine, bupivacaine and major metabolites
14. Plasma drug binding: Implications for anesthesiologists
15. Pharmacokinetics and efficacy of long-term epidural ropivacaine infusion for postoperative analgesia
16. Disposition kinetics of ropivacaine in humans
17. Clinical pharmacokinetics of local anaesthetics
18. Clearance approaches in pharmacology
19. Effect of a protein binding change on unbound and total plasma concentrations for drugs of intermediate hepatic extraction
20. Metabolism of ropivacaine in humans is mediated by CYP1A2 and to a minor extent by CYP3A4: An interaction study with fluvoxamine and ketoconazole as in vivo inhibitors
21. Central nervous and cardiovascular effects of i.v. infusions of ropivacaine, bupivacaine and placebo in volunteers
22. Toxicity of bupivacaine and ropivacaine in relation to free plasma concentrations in pregnant rats: A comparative study
23. Ropivacaine, a new amide-type local anesthetic agent, is metabolized by cytochromes P450 1A and 3A in human liver microsomes
24. Metabolism and excretion of ropivacaine in humans
25. The effect of continuous lumbar epidural infusion of ropivacaine (0.1%, 0.2%, and 0.3%) and 0.25% bupivacaine on sensory and motor block in volunteers: A double-blind study