Computing normalised prediction distribution errors to evaluate nonlinear mixed-effect models: The npde add-on package for R

Computer Methods and Programs in Biomedicine

Volumn 90, Issue 2, 2008, Pages 154-166

  Comets, Emmanuelle ^a,b,d   Brendel, Karl ^c,d   Mentré, France ^c,d  

^a INSERM   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

^d BICHAT HOSPITAL   (France)

Author keywords

Model evaluation; Nonlinear mixed effects model; npde; Population pharmacodynamics; Population pharmacokinetics

Indexed keywords

COMPUTER SIMULATION; COMPUTER SOFTWARE; MATHEMATICAL MODELS; NORMAL DISTRIBUTION; PHARMACOKINETICS;

MODEL EVALUATION; NONLINEAR MIXED-EFFECTS MODEL; NORMALIZED PREDICTION DISTRIBUTION ERRORS (NPDE); POPULATION PHARMACODYNAMICS; POPULATION PHARMACOKINETICS;

ERROR ANALYSIS;

THEOPHYLLINE;

ARTICLE; COMPARTMENT MODEL; ERROR; INDIVIDUALIZATION; PHARMACODYNAMICS; PHARMACOKINETICS; POPULATION MODEL; PREDICTION; SIMULATION; STATISTICAL MODEL;

COMPUTER SIMULATION; DATA INTERPRETATION, STATISTICAL; DATABASES, FACTUAL; HUMANS; NONLINEAR DYNAMICS; PHARMACOKINETICS; PHARMACOLOGY, CLINICAL; SOFTWARE;

EID: 40949086000     PISSN: 01692607     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cmpb.2007.12.002     Document Type: Article

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