Intravenous lipid emulsion given to volunteers does not affect symptoms of lidocaine brain toxicity

Basic and Clinical Pharmacology and Toxicology

Volumn 116, Issue 4, 2015, Pages 378-383

  Heinonen, Juho A ^a   Litonius, Erik ^a,b   Salmi, Tapani ^b   Haasio, Juhani ^b   Tarkkila, Pekka ^b   Backman, Janne T ^a   Rosenberg, Per H ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

INTRALIPID; LIDOCAINE; OXYGEN; PLACEBO; RINGER ACETATE; LIPID EMULSION; LOCAL ANESTHETIC AGENT;

ABNORMAL SENSATION; ADULT; AREA UNDER THE CURVE; ARTICLE; BETA RHYTHM; BLOOD SAMPLING; BOLUS INJECTION; BRAIN TOXICITY; BREATHING RATE; CLINICAL ARTICLE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DELTA RHYTHM; DIZZINESS; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG INTOXICATION; ELECTROENCEPHALOGRAPHY; HEART RATE; HUMAN; INTRAVENOUS ANESTHESIA; MALE; MAXIMUM PLASMA CONCENTRATION; MEAN ARTERIAL PRESSURE; MOUTH TINGLING; MUSCLE TWITCH; ORAL PARESTHESIA; OXYGEN SATURATION; PERCEPTION DEAFNESS; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; SYMPTOM; TONGUE DISEASE; TONGUE NUMBNESS; TONGUE TINGLING; VENOUS BLOOD; VOLUNTEER; BREATHING MECHANICS; DRUG EFFECTS; ELECTROCARDIOGRAPHY; HEMODYNAMICS; NEUROTOXICITY SYNDROMES; PATHOPHYSIOLOGY; PSYCHOLOGY; YOUNG ADULT;

ADULT; ANESTHETICS, LOCAL; ELECTROCARDIOGRAPHY; ELECTROENCEPHALOGRAPHY; FAT EMULSIONS, INTRAVENOUS; HEMODYNAMICS; HUMANS; LIDOCAINE; MALE; NEUROTOXICITY SYNDROMES; RESPIRATORY MECHANICS; YOUNG ADULT;

EID: 84924809843     PISSN: 17427835     EISSN: 17427843     Source Type: Journal    
DOI: 10.1111/bcpt.12321     Document Type: Article

References (27)

1. Neal JM, Mulroy MF, Weinberg GL, American Society of Regional Anesthesia and Pain Medicine. American Society of Regional Anesthesia and Pain Medicine checklist for managing local anesthetic systemic toxicity: 2012 version. Reg Anesth Pain Med 2012;37:16-8.
2. Cave G, Harrop-Griffiths W, Harvey MG, Meek T, Picard J, Short T et al. AAGBI safety guideline: management of severe local anaesthetic toxicity. AAGBI 2010. http://www.aagbi.org/sites/default/files/la_toxicity_2010_0.pdf (last accessed on 28 May 2014).
3. Diaz J, Bernasinski M, Malinovsky J-M. [Reversal of neurologic symptoms related to lidocaine toxicity with a lipid emulsion administration]. Ann Fr Anesth Reanim 2012;31:647.
4. Lange DB, Schwartz D, DaRoza G, Gair R. Use of intravenous lipid emulsion to reverse central nervous system toxicity of an iatrogenic local anesthetic overdose in a patient on peritoneal dialysis. Ann Pharmacother 2012;46:e37.
5. Shi K, Xia Y, Wang Q, Wu Y, Dong X, Chen C et al. The effect of lipid emulsion on pharmacokinetics and tissue distribution of bupivacaine in rats. Anesth Analg 2013;116:804-9.
6. Weinberg GL. Lipid emulsion infusion: resuscitation for local anesthetic and other drug overdose. Anesthesiology 2012;117:180-7.
7. Fettiplace MR, Ripper R, Lis K, Lin B, Lang J, Zider B et al. Rapid cardiotonic effects of lipid emulsion infusion. Crit Care Med 2013;41:e156-62.
8. Mazoit J-X, Le Guen R, Beloeil H, Benhamou D. Binding of long-lasting local anesthetics to lipid emulsions. Anesthesiology 2009;110:380-6.
9. Laine J, Lokajová J, Parshintsev J, Holopainen JM, Wiedmer SK. Interaction of a commercial lipid dispersion and local anesthetics in human plasma: implications for drug trapping by "lipid-sinks". Anal Bioanal Chem 2010;396:2599-607.
10. Kuo I, Akpa BS. Validity of the lipid sink as a mechanism for the reversal of local anesthetic systemic toxicity: a physiologically based pharmacokinetic model study. Anesthesiology 2013;118:1350-61.
11. Litonius ES, Tarkkila P, Neuvonen PJ, Rosenberg PH. Effect of intravenous lipid emulsion on bupivacaine plasma concentration in humans. Anaesthesia 2012;67:600-5.
12. Haasio J, Hekali R, Rosenberg PH. Influence of premedication on lignocaine-induced acute toxicity and plasma concentrations of lignocaine. Br J Anaesth 1988;61:131-4.
13. Lee LA, Posner KL, Cheney FW, Caplan RA, Domino KB. Complications associated with eye blocks and peripheral nerve blocks: an american society of anesthesiologists closed claims analysis. Reg Anesth Pain Med 2008;33:416-22.
14. Scott DB. Evaluation of the toxicity of local anaesthetic agents in man. Br J Anaesth 1975;47:56-61.
15. Bo LD, Mazzucchelli P, Marzo A. Highly sensitive bioassay of lidocaine in human plasma by high-performance liquid chromatography-tandem mass spectrometry. J Chromatogr A 1999;854:3-11.
16. Holm S. A simple sequentially rejective multiple test procedure. Scand J Statist 1979;6:65-70.
17. Detsch O, Erkens U, Jacofsky U, Thiel A, Kochs E, Hempelmann G. Topographical analysis of the EEG effects of a subconvulsive dose of lidocaine in healthy volunteers. Acta Anaesthesiol Scand 1997;41:1039-46.
18. Eriksson E. Effects of local anaesthetics on the EEG. Acta Anaesthesiol Scand 1966;10(Suppl. 25):37-41.
19. Dillane D, Finucane BT. Local anesthetic systemic toxicity. Can J Anaesth 2010;57:368-80.
20. Steen PA, Michenfelder JD. Neurotoxicity of anesthetics. Anesthesiology 1979;50:437-53.
21. Smith SJM. EEG in neurological conditions other than epilepsy: when does it help, what does it add? J Neurol Neurosurg Psychiatry 2005;76(Suppl. 2):ii8-12.
22. Fettiplace MR, Akpa BS, Ripper R, Zider B, Lang J, Rubinstein I et al. Resuscitation with lipid emulsion: dose-dependent recovery from cardiac pharmacotoxicity requires a cardiotonic effect. Anesthesiology 2014;120:915-25.
23. ChemSpider. Royal Society of chemistry 2014. http://www.chemspider.com (last accessed on 28 May 2014).
24. Tucker GT, Mather LE. Clinical pharmacokinetics of local anaesthetics. Clin Pharmacokinet 1979;4:241-78.
25. Cave G, Harvey MG, Willers JW, Uncles DR, Meek T, Picard J et al. LIPAEMIC report: results of clinical use of intravenous lipid emulsion in drug toxicity reported to an online lipid registry. J Med Toxicol 2014;10:133-42.
26. Jorfeldt L, Lewis DH, Löfström JB, Post C. Lung uptake of lidocaine in healthy volunteers. Acta Anaesthesiol Scand 1979;23:567-74.
27. Miles JM, Cattalini M, Sharbrough FW, Wold LE, Wharen RE, Gerich JE et al. Metabolic and neurologic effects of an intravenous medium-chain triglyceride emulsion. JPEN J Parenter Enteral Nutr 1990;15:37-41.