Population pharmacokinetic-pharmacodynamic modeling of epidural anesthesia

Anesthesiology

Volumn 109, Issue 4, 2008, Pages 664-674

  Dahan, Albert ^b   Olofsen, Erik ^a   Burm, Antonius G L ^a   Simon, Mischa J G ^a   Veering, Bernadette Th ^b   Van Kleef, Jack W ^a  

^a Department of Anesthesiology ^*

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

LEVOBUPIVACAINE; ROPIVACAINE; AMIDE; BUPIVACAINE; DRUG DERIVATIVE; LOCAL ANESTHETIC AGENT;

ADULT; AGE DISTRIBUTION; ANALGESIC ACTIVITY; ANESTHESIA LEVEL; ARTICLE; COMPARTMENT MODEL; CONTROLLED STUDY; DRUG ABSORPTION; DRUG DISPOSITION; DRUG EFFECT; DRUG HALF LIFE; EPIDURAL ANESTHESIA; FEMALE; HUMAN; INTRAVENOUS ANESTHESIA; MAJOR CLINICAL STUDY; MALE; NERVE BLOCK; PRIORITY JOURNAL; SENSORY NERVE CELL; AGE; AGED; BIOLOGICAL MODEL; MIDDLE AGED;

ADULT; AGE FACTORS; AGED; AMIDES; ANESTHESIA, EPIDURAL; ANESTHETICS, LOCAL; BUPIVACAINE; FEMALE; HUMANS; MALE; MIDDLE AGED; MODELS, BIOLOGICAL;

EID: 54749153705     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/01.anes.0000334302.50559.c9     Document Type: Article

References (26)

1. Burm AGL, Vermeulen NPE, van Kleef JW, de Boer AG, Spierdijk J, Breimer DD: Pharmacokinetics of lignocaine and bupivacaine in surgical patients following epidural administration: Simultaneous investigation of absorption and disposition kinetics using stable isotopes. Clin Pharmacokinet 1987; 13:191-203
2. Veering BT, Burm AGL, Vletter AA, van den Heuvel RPM, Onkenhout W, Spierdijk J: The effect of age on the systemic absorption, disposition and phar-macodynamics of bupivacaine. Clin Pharmacokinet 1992; 22:75-84
3. Simon MJG, Veering BT, Stienstra R, van Kleef JW, Burm AGL: Effect of age on the clinical profile and systemic absorption and disposition of levobupiva-caine after epidural administration. Br J Anaesth 2004; 93:512-20
4. Simon MJG, Veering BT, Stienstra R, van Kleef JW, Williams SGP, McGuire GM, Burm AGL: The systemic absorption and disposition of levobupivacaine 0.5% after epidural administration in surgical patients: A stable-isotope study. Eur J Anaesth 2004; 21:460-70
5. Simon MJG, Veering BT, Vletter AA, Stienstra R, van Kleef JW, Burm AGL: Effect of age on the systemic absorption and systemic disposition of ropivacaine after epidural administration. Anesth Analg 2006; 102:276-82
6. Olofsen E, Dahan A: Population pharmacokinetics/pharmacodynamics of anesthetics. AAPS J 2005; 7:E383-9
7. Schnider TW, Minto CF, Bruckert H, Mandema JW: Population pharmacodynamic modeling and covariate detection for central neural blockade. ANESTHESIOLOGY 1996; 85:502-12
8. Tucker GT, Mather LE: Pharmacokinetics of local anesthetic agents. Br J Anaesth 1975; 47:213-24
9. Hogan Q, Toth J: Anatomy of soft tissues of the spinal canal. Reg Anesth Pain Med 1999; 24:303-10
10. Beal SL, Sheiner LB, Boeckman AJ, editors: NONMEM User's Guides. Ellicott City, Maryland, Icon Development Solutions, 1989 -2006
11. Akaike H: A new look at the statistical model identification. IEEE Trans Automat Contr 1974; 19:716-23
12. Burnham KP, Anderson DR: Multimodel inference: Understanding AIC and BIC in model selection. Sociol Meth Res 2004; 33:261-304
13. Olofsen E: The performance of model selection criteria in the absence of a fixed-dimensional correct model (abstract 1198). Abstracts of the Annual Meeting of the Population Approach Group in Europe. Copenhagen, Denmark, 2007.
14. Sarton E, Olofsen E, Romberg R, DenHartigh J, Kest B, Nieuwenhuijs D, Burm A, Teppema L, Dahan A: Sex differences in morphine analgesia: An experimental study in healthy volunteers. ANESTHESIOLOGY 2000; 93:1245-54
15. Pérez-Urizar J, Granados-Soto V, Flores-Murrietta FJ, Castañeda-Hernandez G: Pharmacokinetic-pharmacodynamic modeling: Why? Arch Med Res 2000; 31:539-45
16. Wright PMC: Population based pharmacokinetic analysis: Why do we need it; what is it; and what has it told us about anaesthetics. Br J Anaesth 1998; 80:488-501
17. Casati A, Putzu M: Bupivacaine, levobupivacaine and ropivacaine: Are they clinically different? Best Pract Res Clin Anaesthesiol 2005; 19:247-68
18. Bromage PR: Epidural Analgesia. Philadelphia, Saunders, 1978, pp 10-45, 263
19. Ferrer-Brechner T: Spinal and epidural anesthesia in the elderly. Semin Anesth 1986; 5:54-61
20. Jacob JM, Love S: Qualitative and quantitative morphology of human sural nerve at different ages. Brain 1985; 108:897-924
21. Dorfman LJ, Bosley TM: Age related changes in peripheral and central nerve conduction in man. Neurology 1979; 29:38-44
22. Burm AGL: Clinical pharmacokinetics of epidural and spinal anesthesia. Clin Pharmacokinet 1989; 16:283-311
23. Shafer SL, Eisenach JC, Hood DD, Tong C: Cerebrospinal fluid pharmaco-kinetics and pharmacodynamics of intrathecal neostigmine methylsulfate in humans. ANESTHESIOLOGY 1998; 89:1074-88
24. Ummenhofer WC, Arends RH, Shen DD, Bernards CM: Comparative spinal distribution and clearance kinetics of intrathecally administered morphine, fen-tanyl, alfentanil, and sufentanil. ANESTHESIOLOGY 2000; 92:739-53
25. Dernedde M, Stadler M, Bardiau F, Boogaerts JG: Continuous epidural infusion of large concentration/small volume versus small concentration/large volume of levobupivacaine for postoperative analgesia. Anesth Analg 2003; 96:796-801
26. Duggan J, Bowler GMR, McClure JH, Wildsmith JAW: Extradural block with bupivacaine: Influence of dose, volume, concentration and patient characteristics. Br J Anaesth 1988; 61:324-31