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Volumn 229, Issue 3, 2016, Pages R83-R98

Kisspeptin across the human lifespan: Evidence from animal studies and beyond

Author keywords

Fertility; Human; Kisspeptin; Reproduction

Indexed keywords

CHORIONIC GONADOTROPIN; FOLLITROPIN; G PROTEIN COUPLED RECEPTOR 54; GONADORELIN; GONADOTROPIN; KISSPEPTIN; KISSPEPTIN 10; LUTEINIZING HORMONE; METASTIN; TESTOSTERONE; G PROTEIN COUPLED RECEPTOR; LIGAND;

EID: 84977674066     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1530/JOE-15-0538     Document Type: Review
Times cited : (39)

References (119)
  • 3
    • 70349644000 scopus 로고    scopus 로고
    • Decreased serum levels of kisspeptin in early pregnancy are associated with intra-uterine growth restriction and pre-eclampsia
    • Armstrong R, Reynolds R, Leask R, Shearing C, Calder A & Riley S 2009 Decreased serum levels of kisspeptin in early pregnancy are associated with intra-uterine growth restriction and pre-eclampsia. Prenatal Diagnosis 29 982-985. (doi:10.1002/pd.2328)
    • (2009) Prenatal Diagnosis , vol.29 , pp. 982-985
    • Armstrong, R.1    Reynolds, R.2    Leask, R.3    Shearing, C.4    Calder, A.5    Riley, S.6
  • 4
    • 0020034662 scopus 로고
    • The role of sex hormones in the mechanism of inhibited LH release in female patients with anorexia nervosa
    • Baranowska B & Zgliczynski S 1982 The role of sex hormones in the mechanism of inhibited LH release in female patients with anorexia nervosa. Acta Endocrinologica 99 334-338. (doi:10.1530/acta.0.0990334)
    • (1982) Acta Endocrinologica , vol.99 , pp. 334-338
    • Baranowska, B.1    Zgliczynski, S.2
  • 6
    • 84977651544 scopus 로고    scopus 로고
    • Mechanisms for prolactin regulation of reproduction
    • Oral presentation at 3rd Joint British Society of Neuroendocrinology and Societe de Neuroendocrinologie, Lille, France.
    • Binart N 2015 Mechanisms for prolactin regulation of reproduction. Oral presentation at 3rd Joint British Society of Neuroendocrinology and Societe de Neuroendocrinologie, Lille, France.
    • (2015)
    • Binart, N.1
  • 8
    • 84905028672 scopus 로고    scopus 로고
    • Implantation failure in female Kiss1-/- mice is independent of their hypogonadic state and can be partially rescued by leukaemia inhibitory factor
    • Calder M, Chan Y, Raj R, Pampillo M, Elbert A, Noonan M, Gillio-Meina C, Caligioni C, Berube N, Bhattacharya M, et al. 2014 Implantation failure in female Kiss1-/- mice is independent of their hypogonadic state and can be partially rescued by leukaemia inhibitory factor. Endocrinology 155 3065-3078. (doi:10.1210/en.2013-1916)
    • (2014) Endocrinology , vol.155 , pp. 3065-3078
    • Calder, M.1    Chan, Y.2    Raj, R.3    Pampillo, M.4    Elbert, A.5    Noonan, M.6    Gillio-Meina, C.7    Caligioni, C.8    Berube, N.9    Bhattacharya, M.10
  • 11
    • 84935891258 scopus 로고    scopus 로고
    • Pharmaceutical options for triggering of final oocyte maturation in ART
    • Castillo J, Humaidan P & Bernabeu R 2014 Pharmaceutical options for triggering of final oocyte maturation in ART. BioMed Research International Article ID 580171. (doi:10.1155/2014.580171)
    • (2014) BioMed Research International
    • Castillo, J.1    Humaidan, P.2    Bernabeu, R.3
  • 12
    • 84859588779 scopus 로고    scopus 로고
    • Plasma kisspeptin levels in pregnancies with diabetes and hypertensive disease as a potential marker of placental dysfunction and adverse perinatal outcome
    • Cetovic A, Miljic D, Ljubic A, Patterson M, Ghatei M, Stamenkovic J, Nikolic-Djurovic M, Pekic S, Doknic M, Clisic A, et al. 2012 Plasma kisspeptin levels in pregnancies with diabetes and hypertensive disease as a potential marker of placental dysfunction and adverse perinatal outcome. Endocrine Research 37 78-88. (doi:10.3109/074358 00.2011.639319)
    • (2012) Endocrine Research , vol.37 , pp. 78-88
    • Cetovic, A.1    Miljic, D.2    Ljubic, A.3    Patterson, M.4    Ghatei, M.5    Stamenkovic, J.6    Nikolic-Djurovic, M.7    Pekic, S.8    Doknic, M.9    Clisic, A.10
  • 13
    • 70949094457 scopus 로고    scopus 로고
    • Kisspeptin/Gpr54-independent GnRH activity in Kiss1 and Gpr54 mutant mice
    • Chan Y, Broder-Fingert S, Wong K M & Seminara S 2009 Kisspeptin/Gpr54-independent GnRH activity in Kiss1 and Gpr54 mutant mice. Journal of Neuroendocrinology 21 1015-1023. (doi:10.1111/j.1365-2826.2009.01926.x)
    • (2009) Journal of Neuroendocrinology , vol.21 , pp. 1015-1023
    • Chan, Y.1    Broder-Fingert, S.2    Wong, K.M.3    Seminara, S.4
  • 15
    • 84864802249 scopus 로고    scopus 로고
    • Kisspeptin administration to women: a window into endogenous kisspeptin secretion and GnRH responsiveness across the menstrual cycle
    • Chan Y, Butler J, Sidhoum V, Pinnell N & Seminara S 2012 Kisspeptin administration to women: a window into endogenous kisspeptin secretion and GnRH responsiveness across the menstrual cycle. Journal of Clinical Endocrinology and Metabolism 8 E1458-E1467. (doi:10.1210/jc.2012-1282)
    • (2012) Journal of Clinical Endocrinology and Metabolism , vol.8 , pp. E1458-E1467
    • Chan, Y.1    Butler, J.2    Sidhoum, V.3    Pinnell, N.4    Seminara, S.5
  • 16
    • 33747399077 scopus 로고    scopus 로고
    • Sexual dimorphism in the organization of the rat hypothalamic infundibular area
    • Ciofi P, Leroy D & Tramu G 2006 Sexual dimorphism in the organization of the rat hypothalamic infundibular area. Neuroscience 4 1731-1745. (doi:10.1016/j.neuroscience.2006.05.041)
    • (2006) Neuroscience , vol.4 , pp. 1731-1745
    • Ciofi, P.1    Leroy, D.2    Tramu, G.3
  • 17
    • 57849101479 scopus 로고    scopus 로고
    • Kisspeptin and seasonality in sheep
    • Clarke I, Smith J, Caraty A, Goodman R & Lehman M 2009 Kisspeptin and seasonality in sheep. Peptides 30 154-163. (doi:10.1016/j. peptides.2008.08.022)
    • (2009) Peptides , vol.30 , pp. 154-163
    • Clarke, I.1    Smith, J.2    Caraty, A.3    Goodman, R.4    Lehman, M.5
  • 18
    • 52049083005 scopus 로고    scopus 로고
    • Kisspeptin-GPR54 signaling is essential for preovulatory gonadotrophin-releasing neuron activation and the luteinising hormone surge
    • Clarkson J, d'Anglemont de Tassigny X, Moreno A, Colledge W & Herbison A 2008 Kisspeptin-GPR54 signaling is essential for preovulatory gonadotrophin-releasing neuron activation and the luteinising hormone surge. Journal of Neuroscience 29 3920-3929. (doi:10.1523/JNEUROSCI.1775-08.2008)
    • (2008) Journal of Neuroscience , vol.29 , pp. 3920-3929
    • Clarkson, J.1    d'Anglemont de Tassigny, X.2    Moreno, A.3    Colledge, W.4    Herbison, A.5
  • 20
    • 84909957531 scopus 로고    scopus 로고
    • Sexual differentiation of the brain requires perinatal kisspeptin-GnRH neuron signalling
    • Clarkson J, Busby E, Kirilov M, Schutz G, Sherwood N & Herbison A 2014 Sexual differentiation of the brain requires perinatal kisspeptin-GnRH neuron signalling. Journal of Neuroscience 34 15297-15305. (doi:10.1523/JNEUROSCI.3061-14.2014)
    • (2014) Journal of Neuroscience , vol.34 , pp. 15297-15305
    • Clarkson, J.1    Busby, E.2    Kirilov, M.3    Schutz, G.4    Sherwood, N.5    Herbison, A.6
  • 24
    • 67650462851 scopus 로고    scopus 로고
    • Dynorphin immunoreactive fibers contact GnRH neurons in the human hypothalamus
    • Dahl S, Amstalden M, Coolen L, Fitzgerald M & Lehman M 2009 Dynorphin immunoreactive fibers contact GnRH neurons in the human hypothalamus. Reproductive Sciences 16 781-787. (doi:10.1177/1933719109336619)
    • (2009) Reproductive Sciences , vol.16 , pp. 781-787
    • Dahl, S.1    Amstalden, M.2    Coolen, L.3    Fitzgerald, M.4    Lehman, M.5
  • 27
    • 0036865059 scopus 로고    scopus 로고
    • Epidemiology and prevention of ovarian hyperstimulation syndrome (OHSS): a review
    • Delvigne A & Rozenberg S 2002 Epidemiology and prevention of ovarian hyperstimulation syndrome (OHSS): a review. Human Reproductive Update 8 559-577. (doi:10.1093/humupd/8.6.559)
    • (2002) Human Reproductive Update , vol.8 , pp. 559-577
    • Delvigne, A.1    Rozenberg, S.2
  • 28
    • 0030698188 scopus 로고    scopus 로고
    • A family with hypogonadotrophic hypogonadism and mutations in the gonadotropin-releasing hormone receptor
    • de Roux N, Young J, Misrahi M, Genet R, Chanson P, Shcaison G & Milgrom E 1997 A family with hypogonadotrophic hypogonadism and mutations in the gonadotropin-releasing hormone receptor. New England Journal of Medicine 337 1597-1602. (doi:10.1056/NEJM199711273372205)
    • (1997) New England Journal of Medicine , vol.337 , pp. 1597-1602
    • de Roux, N.1    Young, J.2    Misrahi, M.3    Genet, R.4    Chanson, P.5    Shcaison, G.6    Milgrom, E.7
  • 29
    • 0141814637 scopus 로고    scopus 로고
    • Hypogonadotrophic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54
    • de Roux N, Genin E, Care J-C, Matsuda F, Chaussain J-L & Milgrom E 2003 Hypogonadotrophic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54. PNAS 100 10972-10976. (doi:10.1073/pnas.1834399100)
    • (2003) PNAS , vol.100 , pp. 10972-10976
    • de Roux, N.1    Genin, E.2    Care, J.-C.3    Matsuda, F.4    Chaussain, J.-L.5    Milgrom, E.6
  • 32
    • 84923879286 scopus 로고    scopus 로고
    • Positive, but not negative feedback actions of estradiol in adult female mice require estrogen receptor a in kisspeptin neurons
    • Dubois S, Acosta-Martinez M, DeJoseph M, Wolfe A, Radovick S, Boehm U, Urban J & Levine J 2015 Positive, but not negative feedback actions of estradiol in adult female mice require estrogen receptor a in kisspeptin neurons. Endocrinology 156 1111-1120. (doi:10.1210/en.2014-1851)
    • (2015) Endocrinology , vol.156 , pp. 1111-1120
    • Dubois, S.1    Acosta-Martinez, M.2    DeJoseph, M.3    Wolfe, A.4    Radovick, S.5    Boehm, U.6    Urban, J.7    Levine, J.8
  • 33
    • 21044448847 scopus 로고    scopus 로고
    • The neuroendocrine timing of puberty
    • Ebling F 2005 The neuroendocrine timing of puberty. Reproduction 129 675-683. (doi:10.1530/rep.1.00367)
    • (2005) Reproduction , vol.129 , pp. 675-683
    • Ebling, F.1
  • 34
    • 84961180255 scopus 로고    scopus 로고
    • The pregnant mouse uterus exhibits a functional kisspeptin/KISS1R signaling system on the day of embryo implantation
    • Fayazi M, Calder M, Bhattacharya M, Vilos G, Power S & Babwah A 2015 The pregnant mouse uterus exhibits a functional kisspeptin/KISS1R signaling system on the day of embryo implantation. Reproductive Biology and Endocrinology 13 105-111. (doi:10.1186/s12958-015-0105-1)
    • (2015) Reproductive Biology and Endocrinology , vol.13 , pp. 105-111
    • Fayazi, M.1    Calder, M.2    Bhattacharya, M.3    Vilos, G.4    Power, S.5    Babwah, A.6
  • 36
    • 77956785165 scopus 로고    scopus 로고
    • A novel developmental role for kisspeptin in the growth of gonadotrophin-releasing hormone neurites to the median eminence in the mouse
    • Fiorini Z & Jasoni C 2010 A novel developmental role for kisspeptin in the growth of gonadotrophin-releasing hormone neurites to the median eminence in the mouse. Journal of Neuroendocrinology 24 1284-1295. (doi:10.1111/j.1365-2826.2010.02059.x)
    • (2010) Journal of Neuroendocrinology , vol.24 , pp. 1284-1295
    • Fiorini, Z.1    Jasoni, C.2
  • 37
    • 84903398988 scopus 로고    scopus 로고
    • Kisspeptin regulation of genes involved in cell invasion and angiogenesis in first trimester human trophoblast cells
    • Francis V, Abera A, Matjila M, Millar R & Katz A 2014 Kisspeptin regulation of genes involved in cell invasion and angiogenesis in first trimester human trophoblast cells. PLoS ONE 9 e99680. (doi:10.1371/journal.pone.0099680)
    • (2014) PLoS ONE , vol.9
    • Francis, V.1    Abera, A.2    Matjila, M.3    Millar, R.4    Katz, A.5
  • 40
    • 0028787067 scopus 로고
    • Naltrexone administration modulates the neuroendocrine control of luteinizing hormone secretion in hypothalamic amenorrhoea
    • Genazzani A, Gastaldi M, Petraglia F, Battaglia C, Surico N, Volpe A & Genazzani A 1995 Naltrexone administration modulates the neuroendocrine control of luteinizing hormone secretion in hypothalamic amenorrhoea. Human Reproduction 10 2868-2871.
    • (1995) Human Reproduction , vol.10 , pp. 2868-2871
    • Genazzani, A.1    Gastaldi, M.2    Petraglia, F.3    Battaglia, C.4    Surico, N.5    Volpe, A.6    Genazzani, A.7
  • 41
    • 77954647851 scopus 로고    scopus 로고
    • Hypothesis: kisspeptin mediates male hypogonadism in obesity and type 2 diabetes
    • George J, Milar R & Anderson R 2010 Hypothesis: kisspeptin mediates male hypogonadism in obesity and type 2 diabetes. Neuroendocrinology 91 302-307. (doi:10.1159/000299767)
    • (2010) Neuroendocrinology , vol.91 , pp. 302-307
    • George, J.1    Milar, R.2    Anderson, R.3
  • 43
    • 84867833642 scopus 로고    scopus 로고
    • Kisspeptin-10 stimulation of gonadotrophin secretion in women is modulated by sex steroid feedback
    • George J, Anderson R & Millar R 2012a Kisspeptin-10 stimulation of gonadotrophin secretion in women is modulated by sex steroid feedback. Human Reproduction 27 3552-3559. (doi:10.1093/humrep/des326)
    • (2012) Human Reproduction , vol.27 , pp. 3552-3559
    • George, J.1    Anderson, R.2    Millar, R.3
  • 44
    • 84878530524 scopus 로고    scopus 로고
    • Exploring the pathophysiology of hypogonadism in men with type 2 diabetes: kisspeptin-10 stimulates serum testosterone and LH secretion in men with type 2 diabetes and mild biochemical hypogonadism
    • George J, Veldhuis J, Tena-Sempere M, Millar R & Anderson R 2012b Exploring the pathophysiology of hypogonadism in men with type 2 diabetes: kisspeptin-10 stimulates serum testosterone and LH secretion in men with type 2 diabetes and mild biochemical hypogonadism. Clinical Endocrinology 79 100-104. (doi:10.1111/cen.12103)
    • (2012) Clinical Endocrinology , vol.79 , pp. 100-104
    • George, J.1    Veldhuis, J.2    Tena-Sempere, M.3    Millar, R.4    Anderson, R.5
  • 46
    • 84904725144 scopus 로고    scopus 로고
    • A role for neurokinin B in pulsatile GnRH secretion in the ewe
    • Goodman R, Coolen L & Lehman M 2014 A role for neurokinin B in pulsatile GnRH secretion in the ewe. Neuroendocrinology 99 18-32. (doi:10.1159/000355285)
    • (2014) Neuroendocrinology , vol.99 , pp. 18-32
    • Goodman, R.1    Coolen, L.2    Lehman, M.3
  • 48
    • 57849161861 scopus 로고    scopus 로고
    • From KISS1 to kisspeptins: an historical perspective and suggested nomenclature
    • Gottsch M, Clifton D & Steiner R 2009 From KISS1 to kisspeptins: an historical perspective and suggested nomenclature. Peptides 1 4-9. (doi:10.1016/j.peptides.2008.06.016)
    • (2009) Peptides , vol.1 , pp. 4-9
    • Gottsch, M.1    Clifton, D.2    Steiner, R.3
  • 49
    • 34548083738 scopus 로고    scopus 로고
    • Prolactin regulation of gonadotropin-releasing hormone neurons to suppress luteinizing hormone secretion in mice
    • Grattan D, Jasoni C, Liu X, Anderson G & Herbison A 2007 Prolactin regulation of gonadotropin-releasing hormone neurons to suppress luteinizing hormone secretion in mice. Endocrinology 148 4344-4351. (doi:10.1210/en.2007-0403)
    • (2007) Endocrinology , vol.148 , pp. 4344-4351
    • Grattan, D.1    Jasoni, C.2    Liu, X.3    Anderson, G.4    Herbison, A.5
  • 52
    • 77953203035 scopus 로고    scopus 로고
    • The kisspeptin system of the human hypothalamus: sexual dimorphism and relationship with gonadotropin-releasing hormone and neurokinin B neurons
    • Hrabovszky E, Ciofi P, Vida B, Horvath M, Keller E, Caraty A, Bloom S, Ghatei M, Dhillo W, Liposits Z, et al. 2010 The kisspeptin system of the human hypothalamus: sexual dimorphism and relationship with gonadotropin-releasing hormone and neurokinin B neurons. European Journal of Neuroscience 31 1984-1998. (doi:10.1111/j.1460-9568.2010.07239.x)
    • (2010) European Journal of Neuroscience , vol.31 , pp. 1984-1998
    • Hrabovszky, E.1    Ciofi, P.2    Vida, B.3    Horvath, M.4    Keller, E.5    Caraty, A.6    Bloom, S.7    Ghatei, M.8    Dhillo, W.9    Liposits, Z.10
  • 54
    • 84866761591 scopus 로고    scopus 로고
    • Low degree of overlap between kisspeptin, neurokinin B, and dynorphin immunoreactivities in the infundibular nucleus of young male human subjects challenges the KNDy neuron concept
    • Hrabovszky E, Sipos M, Molnar C, Ciofi P, Borsay B, Gergely P, Herczeg L, Bloom S, Ghatei M, Dhillo W, et al. 2012 Low degree of overlap between kisspeptin, neurokinin B, and dynorphin immunoreactivities in the infundibular nucleus of young male human subjects challenges the KNDy neuron concept. Endocrinology 153 4978-4989. (doi:10.1210/en.2012-1545)
    • (2012) Endocrinology , vol.153 , pp. 4978-4989
    • Hrabovszky, E.1    Sipos, M.2    Molnar, C.3    Ciofi, P.4    Borsay, B.5    Gergely, P.6    Herczeg, L.7    Bloom, S.8    Ghatei, M.9    Dhillo, W.10
  • 57
    • 84865687105 scopus 로고    scopus 로고
    • Prediction of in vitro fertilisation outcome at different antral follicle count thresholds in a prospective cohort of 1,012 women
    • Jayaprakasan K, Chan Y, Islam R, Haoula Z, Hopkisson J, Coomarasamy A & Raine-Fenning N 2012 Prediction of in vitro fertilisation outcome at different antral follicle count thresholds in a prospective cohort of 1,012 women. Fertility and Sterility 98 657-663. (doi:10.1016/j. fertnstert.2012.05.042)
    • (2012) Fertility and Sterility , vol.98 , pp. 657-663
    • Jayaprakasan, K.1    Chan, Y.2    Islam, R.3    Haoula, Z.4    Hopkisson, J.5    Coomarasamy, A.6    Raine-Fenning, N.7
  • 58
    • 70449111663 scopus 로고    scopus 로고
    • Subcutaneous injection of kisspeptin-54 acutely stimulates gonadotropin secretion in women with hypothalamic amenorrhoea but chronic administration causes tachyphylaxis
    • Jayasena C, Nijher G, Chaudhri O, Murphy K, Ranger A, Lim A, Patel D, Mehta A, Todd C, Ramachandran R, et al. 2009 Subcutaneous injection of kisspeptin-54 acutely stimulates gonadotropin secretion in women with hypothalamic amenorrhoea but chronic administration causes tachyphylaxis. Journal of Clinical Endocrinology 94 4315-4323. (doi:10.1210/jc.2009-0406)
    • (2009) Journal of Clinical Endocrinology , vol.94 , pp. 4315-4323
    • Jayasena, C.1    Nijher, G.2    Chaudhri, O.3    Murphy, K.4    Ranger, A.5    Lim, A.6    Patel, D.7    Mehta, A.8    Todd, C.9    Ramachandran, R.10
  • 65
    • 84867177723 scopus 로고    scopus 로고
    • Hyperprolactinemia and infertility: new insights
    • Kaiser U 2012 Hyperprolactinemia and infertility: new insights. Journal of Clinical Investigation 122 3467-3468. (doi:10.1172/JCI64455)
    • (2012) Journal of Clinical Investigation , vol.122 , pp. 3467-3468
    • Kaiser, U.1
  • 66
    • 78049457221 scopus 로고    scopus 로고
    • LH (as HCG) and FSH surges for final oocyte maturation: sometimes it takes two to tango?
    • Kol S & Humaidan P 2010 LH (as HCG) and FSH surges for final oocyte maturation: sometimes it takes two to tango? Reproductive BioMedicine Online 21 590-592. (doi:10.1016/j.rbmo.2010.06.031)
    • (2010) Reproductive BioMedicine Online , vol.21 , pp. 590-592
    • Kol, S.1    Humaidan, P.2
  • 69
    • 84942763320 scopus 로고    scopus 로고
    • In utero development of kisspeptin/GnRH neural circuitry in male mice
    • Kumar D, Periasamy V, Freese M, Voigt A & Boehm U 2015 In utero development of kisspeptin/GnRH neural circuitry in male mice. Endocrinology 156 3084-3090. (doi:10.1210/EN.2015-1412)
    • (2015) Endocrinology , vol.156 , pp. 3084-3090
    • Kumar, D.1    Periasamy, V.2    Freese, M.3    Voigt, A.4    Boehm, U.5
  • 72
    • 33645552273 scopus 로고    scopus 로고
    • The science behind 25 years of ovarian stimulation for in vitro fertilization
    • Macklon N, Stouffer R, Giudice L & Fauser B 2006 The science behind 25 years of ovarian stimulation for in vitro fertilization. Endocrine Reviews 27 170-207. (doi:10.1210/er.2005-0015)
    • (2006) Endocrine Reviews , vol.27 , pp. 170-207
    • Macklon, N.1    Stouffer, R.2    Giudice, L.3    Fauser, B.4
  • 73
    • 34250760016 scopus 로고    scopus 로고
    • The management of ovarian hyperstimulation syndrome
    • RCOG Green-top Guideline No. 5. London, UK: Royal College of Obstetricians and Gynaecologists.
    • Mathur RS, Drakeley AJ, Raine-Fenning NJ, Evbuomwan IO & Hamoda H 2006 The management of ovarian hyperstimulation syndrome. RCOG Green-top Guideline No. 5. London, UK: Royal College of Obstetricians and Gynaecologists. (available at: https://www.rcog.org.uk/en/guidelines-research-services/guidelines/gtg5/)
    • (2006)
    • Mathur, R.S.1    Drakeley, A.J.2    Raine-Fenning, N.J.3    Evbuomwan, I.O.4    Hamoda, H.5
  • 75
    • 79960758876 scopus 로고    scopus 로고
    • Female reproductive maturation in the absence of kisspeptin/GPR54 signaling
    • Mayer C & Boehm U 2011 Female reproductive maturation in the absence of kisspeptin/GPR54 signaling. Nature Neuroscience 14 704-710. (doi:10.1038/nn.2818)
    • (2011) Nature Neuroscience , vol.14 , pp. 704-710
    • Mayer, C.1    Boehm, U.2
  • 76
    • 33845885316 scopus 로고    scopus 로고
    • Kisspeptins are novel potent vasoconstrictors in humans, with a discrete localisation of their receptor, G protein-coupled receptor 54, to atherosclerosis-prone vessels
    • Mead E, Maguire J, Kuc R & Davenport A 2007 Kisspeptins are novel potent vasoconstrictors in humans, with a discrete localisation of their receptor, G protein-coupled receptor 54, to atherosclerosis-prone vessels. Endocrinology 148 140-147.
    • (2007) Endocrinology , vol.148 , pp. 140-147
    • Mead, E.1    Maguire, J.2    Kuc, R.3    Davenport, A.4
  • 77
  • 78
    • 78649510825 scopus 로고    scopus 로고
    • Kisspeptin antagonists: unraveling the role of kisspeptin in reproductive physiology
    • Millar R, Roseweir A, Tello J, Anderson R, George J, Morgan K & Pawson A 2010 Kisspeptin antagonists: unraveling the role of kisspeptin in reproductive physiology. Brain Research 1364 81-89. (doi:10.1016/j. brainres.2010.09.044)
    • (2010) Brain Research , vol.1364 , pp. 81-89
    • Millar, R.1    Roseweir, A.2    Tello, J.3    Anderson, R.4    George, J.5    Morgan, K.6    Pawson, A.7
  • 79
    • 84867760925 scopus 로고    scopus 로고
    • Morphological evidence for enhanced kisspeptin and neurokinin B signalling in the infundibular nucleus of the aging man
    • Molnar C, Vida B, Sipos M, Ciofi P, Borsay B, Racz K, Herczeg L, Bloom S, Ghatei M, Dhillo W, et al. 2012 Morphological evidence for enhanced kisspeptin and neurokinin B signalling in the infundibular nucleus of the aging man. Endocrinology 153 5428-5439. (doi:10.1210/en.2012-1739)
    • (2012) Endocrinology , vol.153 , pp. 5428-5439
    • Molnar, C.1    Vida, B.2    Sipos, M.3    Ciofi, P.4    Borsay, B.5    Racz, K.6    Herczeg, L.7    Bloom, S.8    Ghatei, M.9    Dhillo, W.10
  • 80
    • 42949164617 scopus 로고    scopus 로고
    • Sex steroids and leptin regulate the 'first Kiss' (KiSS 1/G-protein-coupled receptor 54 system) in human gonadotropin-releasing-hormone-secreting neuroblasts
    • Morelli A, Marini M, Mancina R, Luconi M, Vignozzi L, Fibbi B, Filippi S, Pezzatini A, Forti G, Vannelli G, et al. 2008 Sex steroids and leptin regulate the 'first Kiss' (KiSS 1/G-protein-coupled receptor 54 system) in human gonadotropin-releasing-hormone-secreting neuroblasts. Journal of Sexual Medicine 5 1097-1113. (doi:10.1111/j.1743-6109.2008.00782.x)
    • (2008) Journal of Sexual Medicine , vol.5 , pp. 1097-1113
    • Morelli, A.1    Marini, M.2    Mancina, R.3    Luconi, M.4    Vignozzi, L.5    Fibbi, B.6    Filippi, S.7    Pezzatini, A.8    Forti, G.9    Vannelli, G.10
  • 82
  • 83
    • 4644289298 scopus 로고    scopus 로고
    • Developmental and hormonally regulated messenger ribonucleic acid expression of KiSS-1 and its putative receptor, GPR54, in rat hypothalamus and potent luteinizing hormone-releasing activity of KiSS-1 peptide
    • Navarro V, Castellano J, Fernandez-Fernandez R, Barreiro M, Roa J, Sanchez-Criado J, Aguilar E, Dieguez C, Pinilla L & Tena-Sempere M 2004 Developmental and hormonally regulated messenger ribonucleic acid expression of KiSS-1 and its putative receptor, GPR54, in rat hypothalamus and potent luteinizing hormone-releasing activity of KiSS-1 peptide. Endocrinology 145 4565-4574. (doi:10.1210/en.2004-0413)
    • (2004) Endocrinology , vol.145 , pp. 4565-4574
    • Navarro, V.1    Castellano, J.2    Fernandez-Fernandez, R.3    Barreiro, M.4    Roa, J.5    Sanchez-Criado, J.6    Aguilar, E.7    Dieguez, C.8    Pinilla, L.9    Tena-Sempere, M.10
  • 85
    • 70349342734 scopus 로고    scopus 로고
    • Regulation of gonadotrophin-releasing hormone secretion by kisspeptin/dynorphin/neurokinin B neurons in the arcuate nucleus of the mouse
    • Navarro V, Gottsch M, Chavkin C, Okamura H, Clifton D & Steiner R 2009 Regulation of gonadotrophin-releasing hormone secretion by kisspeptin/dynorphin/neurokinin B neurons in the arcuate nucleus of the mouse. Journal of Neuroscience 29 11859-11866. (doi:10.1523/JNEUROSCI.1569-09.2009)
    • (2009) Journal of Neuroscience , vol.29 , pp. 11859-11866
    • Navarro, V.1    Gottsch, M.2    Chavkin, C.3    Okamura, H.4    Clifton, D.5    Steiner, R.6
  • 86
    • 84892505324 scopus 로고    scopus 로고
    • Disrupted kisspeptin signalling in GnRH neurons leads to hypogonadotrophic hypogonadism
    • Novaira H, Sonko M, Hoffman G, Koo Y, Ko C, Wolfe A & Radovick S 2014 Disrupted kisspeptin signalling in GnRH neurons leads to hypogonadotrophic hypogonadism. Molecular Endocrinology 28 225-238. (doi:10.1210/me.2013-1319)
    • (2014) Molecular Endocrinology , vol.28 , pp. 225-238
    • Novaira, H.1    Sonko, M.2    Hoffman, G.3    Koo, Y.4    Ko, C.5    Wolfe, A.6    Radovick, S.7
  • 87
    • 70849092893 scopus 로고    scopus 로고
    • Kisspeptin signaling in the brain
    • Oakley A, Clifton D & Steiner R 2009 Kisspeptin signaling in the brain. Endocrine Reviews 30 713-743. (doi:10.1210/er.2009-0005)
    • (2009) Endocrine Reviews , vol.30 , pp. 713-743
    • Oakley, A.1    Clifton, D.2    Steiner, R.3
  • 89
    • 0036828229 scopus 로고    scopus 로고
    • Pituitary Hormones are not required for exual differentiation of male mice: phenotype of the T/ebp/Nkx2.1 null mutant mice
    • Pakarinen P, Kimura S, El-Gehani F, Pelliniemi L & Huhtaniemi I 2002 Pituitary Hormones are not required for exual differentiation of male mice: phenotype of the T/ebp/Nkx2.1 null mutant mice. Endocrinology 143 4477-4482. (doi:10.1210/en.2002-220052)
    • (2002) Endocrinology , vol.143 , pp. 4477-4482
    • Pakarinen, P.1    Kimura, S.2    El-Gehani, F.3    Pelliniemi, L.4    Huhtaniemi, I.5
  • 90
    • 84887050754 scopus 로고    scopus 로고
    • The 2013 British Menopause Society & Women's Health Concern recommendations on hormone replacement therapy
    • Panay N, Hamoda H, Arya R & Sawas M 2013 The 2013 British Menopause Society & Women's Health Concern recommendations on hormone replacement therapy. Menopause International 19 59-68. (doi:10.1177/1754045313489645)
    • (2013) Menopause International , vol.19 , pp. 59-68
    • Panay, N.1    Hamoda, H.2    Arya, R.3    Sawas, M.4
  • 91
    • 84864067222 scopus 로고    scopus 로고
    • Kisspeptins and reproduction: physiological roles and regulatory mechanisms
    • Pinilla L, Aguilar E, Dieguez C, Millar R & Tena-Sempere M 2012 Kisspeptins and reproduction: physiological roles and regulatory mechanisms. Physiological Reviews 92 1235-1316. (doi:10.1152/physrev.00037.2010)
    • (2012) Physiological Reviews , vol.92 , pp. 1235-1316
    • Pinilla, L.1    Aguilar, E.2    Dieguez, C.3    Millar, R.4    Tena-Sempere, M.5
  • 92
    • 84931560558 scopus 로고    scopus 로고
    • Neuroendocrine control of the onset of puberty
    • Plant T 2015 Neuroendocrine control of the onset of puberty. Frontiers in Neuroendocrinology 38 73-88. (doi:10.1016/j.yfrne.2015.04.002)
    • (2015) Frontiers in Neuroendocrinology , vol.38 , pp. 73-88
    • Plant, T.1
  • 93
    • 84856085864 scopus 로고    scopus 로고
    • Sexually dimorphic testosterone secretion in prenatal and neonatal mice is independent of kisspeptin-Kiss1r and GnRH signaling
    • Poling M & Kaufmann A 2012 Sexually dimorphic testosterone secretion in prenatal and neonatal mice is independent of kisspeptin-Kiss1r and GnRH signaling. Endocrinology 153 782-793. (doi:10.1210/en.2011-1838)
    • (2012) Endocrinology , vol.153 , pp. 782-793
    • Poling, M.1    Kaufmann, A.2
  • 94
    • 50449101532 scopus 로고    scopus 로고
    • Structural interactions between kisspeptin and GnRH neurons in the mediobasal hypothalamus of the male rhesus monkey (Macaca mulatta) as revealed by double immunofluorescence and confocal microscopy
    • Ramaswamy S, Guerriero K, Gibbs R & Plant T 2008 Structural interactions between kisspeptin and GnRH neurons in the mediobasal hypothalamus of the male rhesus monkey (Macaca mulatta) as revealed by double immunofluorescence and confocal microscopy. Endocrinology 149 4387-4395. (doi:10.1210/en.2008-0438)
    • (2008) Endocrinology , vol.149 , pp. 4387-4395
    • Ramaswamy, S.1    Guerriero, K.2    Gibbs, R.3    Plant, T.4
  • 95
    • 41549109864 scopus 로고    scopus 로고
    • Opposite roles of estrogen receptor (ER)-alpha and ERbeta in the modulation of luteinizing hormone responses to kisspeptin in the female rat: implications for the generation of the preovulatory surge
    • Roa J, Vigo E, Castellano J, Gaytan F, Navarro V, Aguilar E, Dijcks F, Ederveen A, Pinilla L, van Noort P, et al. 2008 Opposite roles of estrogen receptor (ER)-alpha and ERbeta in the modulation of luteinizing hormone responses to kisspeptin in the female rat: implications for the generation of the preovulatory surge. Endocrinology 149 1627-1637. (doi:10.1210/en.2007-1540)
    • (2008) Endocrinology , vol.149 , pp. 1627-1637
    • Roa, J.1    Vigo, E.2    Castellano, J.3    Gaytan, F.4    Navarro, V.5    Aguilar, E.6    Dijcks, F.7    Ederveen, A.8    Pinilla, L.9    van Noort, P.10
  • 96
    • 56649096022 scopus 로고    scopus 로고
    • Changes in predynorphin gene expression and neuronal morphology in the hypothalamus of postmenopausal women
    • Rometo A & Rance N 2008 Changes in predynorphin gene expression and neuronal morphology in the hypothalamus of postmenopausal women. Journal of Neuroendocrinology 20 1376-1381. (doi:10.1111/j.1365-2826.2008.01796.x)
    • (2008) Journal of Neuroendocrinology , vol.20 , pp. 1376-1381
    • Rometo, A.1    Rance, N.2
  • 97
    • 34447115135 scopus 로고    scopus 로고
    • Hypertrophy and increased kisspeptin gene expression in the hypothalamic infundibular nucleus of postmenopausal women and ovarectomized monkeys
    • Rometo A, Krajewski S, Voytko M & Rance N 2007 Hypertrophy and increased kisspeptin gene expression in the hypothalamic infundibular nucleus of postmenopausal women and ovarectomized monkeys. Journal of Clinical Endocrinology and Metabolism 92 2744-2750. (doi:10.1210/jc.2007-0553)
    • (2007) Journal of Clinical Endocrinology and Metabolism , vol.92 , pp. 2744-2750
    • Rometo, A.1    Krajewski, S.2    Voytko, M.3    Rance, N.4
  • 99
    • 84951727949 scopus 로고    scopus 로고
    • Diagnosis and management of menopause: summary of NICE guidance
    • Sarri G, Davies M & Lumsden M 2015 Diagnosis and management of menopause: summary of NICE guidance. British Medical Journal 351 h5746. (doi:10.1136/bmj.h5746)
    • (2015) British Medical Journal , vol.351
    • Sarri, G.1    Davies, M.2    Lumsden, M.3
  • 102
    • 84904686661 scopus 로고    scopus 로고
    • The kisspeptin-GnRH pathway in human reproductive health and disease
    • Skorupskaite K, George J & Anderson R 2014 The kisspeptin-GnRH pathway in human reproductive health and disease. Human Reproductive Update 20 485-500. (doi:10.1093/humupd/dmu009)
    • (2014) Human Reproductive Update , vol.20 , pp. 485-500
    • Skorupskaite, K.1    George, J.2    Anderson, R.3
  • 103
    • 42049102207 scopus 로고    scopus 로고
    • Decreased plasma levels of metastin in early pregnancy are associated with small for gestational age neonates
    • Smets E, Deurloo K, Go A, van Vugt J, Blankenstein M & Oudejans S 2008 Decreased plasma levels of metastin in early pregnancy are associated with small for gestational age neonates. Prenatal Diagnosis 28 299-303. (doi:10.1002/pd.1969)
    • (2008) Prenatal Diagnosis , vol.28 , pp. 299-303
    • Smets, E.1    Deurloo, K.2    Go, A.3    van Vugt, J.4    Blankenstein, M.5    Oudejans, S.6
  • 104
    • 23844435021 scopus 로고    scopus 로고
    • Regulation of Kiss1 gene expression in the brain of the female mouse
    • Smith J, Cunningham M, Rissman E, Clifton D & Steiner R 2005a Regulation of Kiss1 gene expression in the brain of the female mouse. Endocrinology 146 3686-3692.
    • (2005) Endocrinology , vol.146 , pp. 3686-3692
    • Smith, J.1    Cunningham, M.2    Rissman, E.3    Clifton, D.4    Steiner, R.5
  • 107
    • 0036791113 scopus 로고    scopus 로고
    • Identification and characterization of mouse metastasis-suppressor KiSS1 and its G-protein-coupled receptor
    • Stafford L, Xia C, Ma W, Cai Y & Liu M 2002 Identification and characterization of mouse metastasis-suppressor KiSS1 and its G-protein-coupled receptor. Cancer Research 62 5399-5404.
    • (2002) Cancer Research , vol.62 , pp. 5399-5404
    • Stafford, L.1    Xia, C.2    Ma, W.3    Cai, Y.4    Liu, M.5
  • 109
    • 0025341241 scopus 로고
    • The epidemiology of infertility in Aberdeen
    • Templeton A, Fraser C & Thompson B 1990 The epidemiology of infertility in Aberdeen. British Medical Journal 301 148-152 (doi:10.1136/bmj.301.6744.148)
    • (1990) British Medical Journal , vol.301 , pp. 148-152
    • Templeton, A.1    Fraser, C.2    Thompson, B.3
  • 111
  • 112
    • 61349091041 scopus 로고    scopus 로고
    • TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for neurokinin B in the central control of reproduction
    • Topaloglu A, Reimann F, Guclu M, Yalin A, Kotan L, Porter K, Serin A, Mungan N, Cook J, Ozbek M, et al. 2009 TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for neurokinin B in the central control of reproduction. Nature Genetics 41 354-358. (doi:10.1038/ng.306)
    • (2009) Nature Genetics , vol.41 , pp. 354-358
    • Topaloglu, A.1    Reimann, F.2    Guclu, M.3    Yalin, A.4    Kotan, L.5    Porter, K.6    Serin, A.7    Mungan, N.8    Cook, J.9    Ozbek, M.10
  • 116
    • 0027481133 scopus 로고
    • Assisted conception using buserelin and human menopausal gonadotrophins in women with polycystic ovarian syndrome
    • Wada I, Matson P, Troup S & Lieberman B 1993 Assisted conception using buserelin and human menopausal gonadotrophins in women with polycystic ovarian syndrome. British Journal of Obstetrics and Gynaecology 100 365-369. (doi:10.1111/j.1471-0528.1993.tb12981.x)
    • (1993) British Journal of Obstetrics and Gynaecology , vol.100 , pp. 365-369
    • Wada, I.1    Matson, P.2    Troup, S.3    Lieberman, B.4
  • 117
    • 84863267126 scopus 로고    scopus 로고
    • Immunocytochemical localization of kisspeptin neurons in the rat forebrain with special reference to sexual dimorphism and interaction with GnRH neurons
    • Xu Z, Kaga S, Mochiduki A, Tsubomizu J, Adachi S, Sakai T, Inoue K & Adachi A 2012 Immunocytochemical localization of kisspeptin neurons in the rat forebrain with special reference to sexual dimorphism and interaction with GnRH neurons. Endocrine Journal 59 161-171. (doi:10.1507/endocrj.EJ11-0193)
    • (2012) Endocrine Journal , vol.59 , pp. 161-171
    • Xu, Z.1    Kaga, S.2    Mochiduki, A.3    Tsubomizu, J.4    Adachi, S.5    Sakai, T.6    Inoue, K.7    Adachi, A.8
  • 118
    • 84876289515 scopus 로고    scopus 로고
    • Kisspeptin restores pulsatile LH secretion in patients with neurokinin B signalling deficiencies: physiological, pathophysiological and therapeutic implications
    • Young J, George J, Tello J, Francou B, Bouligand J, Guiochon-Mantel A, Brailly-Tabard S, Anderson R & Millar R 2013 Kisspeptin restores pulsatile LH secretion in patients with neurokinin B signalling deficiencies: physiological, pathophysiological and therapeutic implications. Neuroendocrinology 97 193-202. (doi:10.1159/000336376)
    • (2013) Neuroendocrinology , vol.97 , pp. 193-202
    • Young, J.1    George, J.2    Tello, J.3    Francou, B.4    Bouligand, J.5    Guiochon-Mantel, A.6    Brailly-Tabard, S.7    Anderson, R.8    Millar, R.9


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