메뉴 건너뛰기




Volumn 28, Issue 2, 2014, Pages 225-238

Disrupted kisspeptin signaling in GnRH neurons leads to hypogonadotrophic hypogonadism

Author keywords

[No Author keywords available]

Indexed keywords

CRE RECOMBINASE; ESTRADIOL; FOLLITROPIN; G PROTEIN COUPLED RECEPTOR 54; GONADORELIN; KISSPEPTIN; LUTEINIZING HORMONE; ESTROGEN; G PROTEIN COUPLED RECEPTOR; KISS1R PROTEIN, MOUSE;

EID: 84892505324     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2013-1319     Document Type: Article
Times cited : (88)

References (64)
  • 1
    • 0033734710 scopus 로고    scopus 로고
    • Neuron-specific expression of the rat gonadotropin-releasing hormone gene is conferred by interactions of a defined promoter element with the enhancer in GT1-7 cells
    • Nelson SB, Lawson MA, Kelley CG, Mellon PL. Neuron-specific expression of the rat gonadotropin-releasing hormone gene is conferred by interactions of a defined promoter element with the enhancer in GT1-7 cells. Mol Endocrinol. 2000;14:1509-1522.
    • (2000) Mol Endocrinol. , vol.14 , pp. 1509-1522
    • Nelson, S.B.1    Lawson, M.A.2    Kelley, C.G.3    Mellon, P.L.4
  • 2
    • 0036842222 scopus 로고    scopus 로고
    • Neuron-restricted expression of the rat gonadotropinreleasing hormone gene is conferred by a cell-specific protein complex that binds repeated CAATT elements
    • Kelley CG, Givens ML, Rave-Harel N, Nelson SB, Anderson S, Mellon PL. Neuron-restricted expression of the rat gonadotropinreleasing hormone gene is conferred by a cell-specific protein complex that binds repeated CAATT elements. Mol Endocrinol. 2002; 16:2413-2425.
    • (2002) Mol Endocrinol. , vol.16 , pp. 2413-2425
    • Kelley, C.G.1    Givens, M.L.2    Rave-Harel, N.3    Nelson, S.B.4    Anderson, S.5    Mellon, P.L.6
  • 3
    • 0344064059 scopus 로고    scopus 로고
    • The KiSS-1 receptor GPR54 is essential for the development of the murine reproductive system
    • Funes S, Hedrick JA, Vassileva G, et al. The KiSS-1 receptor GPR54 is essential for the development of the murine reproductive system. Biochem Biophys Res Commun. 2003;312:1357-1363.
    • (2003) Biochem Biophys Res Commun. , vol.312 , pp. 1357-1363
    • Funes, S.1    Hedrick, J.A.2    Vassileva, G.3
  • 5
    • 4344561363 scopus 로고    scopus 로고
    • A role for kisspeptins in the regulation of gonadotropin secretion in the mouse
    • Gottsch ML, Cunningham MJ, Smith JT, et al. A role for kisspeptins in the regulation of gonadotropin secretion in the mouse. Endocrinology. 2004;145:4073-4077.
    • (2004) Endocrinology. , vol.145 , pp. 4073-4077
    • Gottsch, M.L.1    Cunningham, M.J.2    Smith, J.T.3
  • 6
    • 13444255980 scopus 로고    scopus 로고
    • Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54
    • Messager S, Chatzidaki EE, Ma D, et al. Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54. Proc Natl Acad Sci USA. 2005;102:1761-1766.
    • (2005) Proc Natl Acad Sci USA. , vol.102 , pp. 1761-1766
    • Messager, S.1    Chatzidaki, E.E.2    Ma, D.3
  • 7
    • 28744448385 scopus 로고    scopus 로고
    • Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males
    • Dhillo WS, Chaudhri OB, Patterson M, et al. Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males. J Clin Endocrinol Metab. 2005;90:6609-6615.
    • (2005) J Clin Endocrinol Metab. , vol.90 , pp. 6609-6615
    • Dhillo, W.S.1    Chaudhri, O.B.2    Patterson, M.3
  • 8
    • 35948986402 scopus 로고    scopus 로고
    • The role of kisspeptin-GPR54 signaling in the tonic regulation and surge release of gonadotropin-releasing hormone/luteinizing hormone
    • Dungan HM, Gottsch ML, Zeng H, et al. The role of kisspeptin-GPR54 signaling in the tonic regulation and surge release of gonadotropin-releasing hormone/luteinizing hormone. J Neurosci. 2007; 27:12088-12095.
    • (2007) J Neurosci. , vol.27 , pp. 12088-12095
    • Dungan, H.M.1    Gottsch, M.L.2    Zeng, H.3
  • 9
    • 35349022556 scopus 로고    scopus 로고
    • Kisspeptin-54 stimulates gonadotropin release most potently during the preovulatory phase of the menstrual cycle in women
    • Dhillo WS, Chaudhri OB, Thompson EL, et al. Kisspeptin-54 stimulates gonadotropin release most potently during the preovulatory phase of the menstrual cycle in women. J Clin Endocrinol Metab. 2007;92:3958-3966.
    • (2007) J Clin Endocrinol Metab. , vol.92 , pp. 3958-3966
    • Dhillo, W.S.1    Chaudhri, O.B.2    Thompson, E.L.3
  • 11
    • 47949125934 scopus 로고    scopus 로고
    • Kisspeptin can stimulate gonadotropin-releasing hormone (GnRH) release by a direct action at GnRH nerve terminals
    • d'Anglemont de Tassigny X, Fagg LA, Carlton MB, Colledge WH. Kisspeptin can stimulate gonadotropin-releasing hormone (GnRH) release by a direct action at GnRH nerve terminals. Endocrinology. 2008;149:3926-3932.
    • (2008) Endocrinology. , vol.149 , pp. 3926-3932
    • de Tassigny D'Anglemont, X.1    Fagg, L.A.2    Carlton, M.B.3    Colledge, W.H.4
  • 12
    • 34447115135 scopus 로고    scopus 로고
    • Hypertrophy and increased kisspeptin gene expression in the hypothalamic infundibular nucleus of postmenopausal women and ovariectomized monkeys
    • Rometo AM, Krajewski SJ, Voytko ML, Rance NE. Hypertrophy and increased kisspeptin gene expression in the hypothalamic infundibular nucleus of postmenopausal women and ovariectomized monkeys. J Clin Endocrinol Metab. 2007;92:2744-2750.
    • (2007) J Clin Endocrinol Metab. , vol.92 , pp. 2744-2750
    • Rometo, A.M.1    Krajewski, S.J.2    Voytko, M.L.3    Rance, N.E.4
  • 13
    • 77953203035 scopus 로고    scopus 로고
    • The kisspeptin system of the human hypothalamus: Sexual dimorphism and relationship with gonadotropin-releasing hormone and neurokinin B neurons
    • Hrabovszky E, Ciofi P, Vida B, et al. The kisspeptin system of the human hypothalamus: sexual dimorphism and relationship with gonadotropin-releasing hormone and neurokinin B neurons. Eur J Neurosci. 2010;31:1984-1998.
    • (2010) Eur J Neurosci. , vol.31 , pp. 1984-1998
    • Hrabovszky, E.1    Ciofi, P.2    Vida, B.3
  • 15
    • 30544450474 scopus 로고    scopus 로고
    • Activation of gonadotropinreleasing hormone neurons by kisspeptin as a neuroendocrine switch for the onset of puberty
    • Han SK, Gottsch ML, Lee KJ, et al. Activation of gonadotropinreleasing hormone neurons by kisspeptin as a neuroendocrine switch for the onset of puberty. J Neurosci. 2005;25:11349-11356.
    • (2005) J Neurosci. , vol.25 , pp. 11349-11356
    • Han, S.K.1    Gottsch, M.L.2    Lee, K.J.3
  • 16
    • 34047226334 scopus 로고    scopus 로고
    • Kisspeptin expression in the brain: Catalyst for the initiation of puberty
    • Smith JT, Clarke IJ. Kisspeptin expression in the brain: catalyst for the initiation of puberty. Rev Endocr Metab Disord. 2007;8:1-9.
    • (2007) Rev Endocr Metab Disord. , vol.8 , pp. 1-9
    • Smith, J.T.1    Clarke, I.J.2
  • 19
    • 3843063447 scopus 로고    scopus 로고
    • Laser-captured single digoxigeninlabeled neurons of gonadotropin-releasing hormone types reveal a novel G protein-coupled receptor (Gpr54) during maturation in cichlid fish
    • Parhar IS, Ogawa S, Sakuma Y. Laser-captured single digoxigeninlabeled neurons of gonadotropin-releasing hormone types reveal a novel G protein-coupled receptor (Gpr54) during maturation in cichlid fish. Endocrinology. 2004;145:3613-3618.
    • (2004) Endocrinology. , vol.145 , pp. 3613-3618
    • Parhar, I.S.1    Ogawa, S.2    Sakuma, Y.3
  • 20
    • 13244255747 scopus 로고    scopus 로고
    • Kisspeptin activation of go-nadotropin releasing hormone neurons and regulation of KiSS-1 mRNA in the male rat
    • Irwig MS, Fraley GS, Smith JT, et al. Kisspeptin activation of go-nadotropin releasing hormone neurons and regulation of KiSS-1 mRNA in the male rat. Neuroendocrinology. 2004;80:264-272.
    • (2004) Neuroendocrinology. , vol.80 , pp. 264-272
    • Irwig, M.S.1    Fraley, G.S.2    Smith, J.T.3
  • 21
    • 41549121999 scopus 로고    scopus 로고
    • Kisspeptin acts directly and indirectly to increase gonadotropin-releasing hormone neuron activity and its effects are modulated by estradiol
    • Pielecka-Fortuna J, Chu Z, Moenter SM. Kisspeptin acts directly and indirectly to increase gonadotropin-releasing hormone neuron activity and its effects are modulated by estradiol. Endocrinology. 2008;149:1979-1986.
    • (2008) Endocrinology. , vol.149 , pp. 1979-1986
    • Pielecka-Fortuna, J.1    Chu, Z.2    Moenter, S.M.3
  • 22
    • 50449087725 scopus 로고    scopus 로고
    • Kisspeptin excites gonadotropin-releasing hormone neurons through a phospholipase C/calcium-dependent pathway regulating multiple ion channels
    • Liu X, Lee K, Herbison AE. Kisspeptin excites gonadotropin-releasing hormone neurons through a phospholipase C/calcium-dependent pathway regulating multiple ion channels. Endocrinology. 2008;149:4605-4614.
    • (2008) Endocrinology. , vol.149 , pp. 4605-4614
    • Liu, X.1    Lee, K.2    Herbison, A.E.3
  • 23
    • 46349095554 scopus 로고    scopus 로고
    • Small-conductance calcium-activated potassium channels control excitability and firing dynamics in gonadotropin-releasing hormone (GnRH) neurons
    • Liu X, Herbison AE. Small-conductance calcium-activated potassium channels control excitability and firing dynamics in gonadotropin-releasing hormone (GnRH) neurons. Endocrinology. 2008; 149:3598-3604.
    • (2008) Endocrinology. , vol.149 , pp. 3598-3604
    • Liu, X.1    Herbison, A.E.2
  • 25
    • 29644447614 scopus 로고    scopus 로고
    • Role of sequence variations of the GnRH receptor and G protein-coupled receptor 54 gene in male idiopathic hypogonadotropic hypogonadism
    • Lanfranco F, Gromoll J, von Eckardstein S, Herding EM, Nieschlag E, Simoni M. Role of sequence variations of the GnRH receptor and G protein-coupled receptor 54 gene in male idiopathic hypogonadotropic hypogonadism. Eur J Endocrinol. 2005;153:845-852.
    • (2005) Eur J Endocrinol. , vol.153 , pp. 845-852
    • Lanfranco, F.1    Gromoll, J.2    von Eckardstein, S.3    Herding, E.M.4    Nieschlag, E.5    Simoni, M.6
  • 26
    • 15944368215 scopus 로고    scopus 로고
    • Two novel missense mutations in g protein-coupled receptor 54 in a patient with hypogonadotropic hypogonadism
    • Semple RK, Achermann JC, Ellery J, et al. Two novel missense mutations in g protein-coupled receptor 54 in a patient with hypogonadotropic hypogonadism. J Clin Endocrinol Metab. 2005; 90:1849-1855.
    • (2005) J Clin Endocrinol Metab. , vol.90 , pp. 1849-1855
    • Semple, R.K.1    Achermann, J.C.2    Ellery, J.3
  • 27
    • 33947493910 scopus 로고    scopus 로고
    • Neuroendocrine phenotype analysis in five patients with isolated hypogonadotropic hypogonadism due to a L102P inactivating mutation of GPR54
    • Tenenbaum-Rakover Y, Commenges-Ducos M, Iovane A, Aumas C, Admoni O, de Roux N. Neuroendocrine phenotype analysis in five patients with isolated hypogonadotropic hypogonadism due to a L102P inactivating mutation of GPR54. J Clin Endocrinol Metab. 2007;92:1137-1144.
    • (2007) J Clin Endocrinol Metab. , vol.92 , pp. 1137-1144
    • Tenenbaum-Rakover, Y.1    Commenges-Ducos, M.2    Iovane, A.3    Aumas, C.4    Admoni, O.5    de Roux, N.6
  • 28
    • 77954112496 scopus 로고    scopus 로고
    • A novel homozygous splice acceptor site mutation of KISS1R in two siblings with normosmic isolated hypogonadotropic hypogonadism
    • Teles MG, Trarbach EB, Noel SD, et al. A novel homozygous splice acceptor site mutation of KISS1R in two siblings with normosmic isolated hypogonadotropic hypogonadism. Eur J Endocrinol. 2010;163:29-34.
    • (2010) Eur J Endocrinol. , vol.163 , pp. 29-34
    • Teles, M.G.1    Trarbach, E.B.2    Noel, S.D.3
  • 29
    • 79952307060 scopus 로고    scopus 로고
    • A novel loss-of-function mutation in GPR54/KISS1R leads to hypogonadotropic hypogonadism in a highly consanguineous family
    • Nimri R, Lebenthal Y, Lazar L, et al. A novel loss-of-function mutation in GPR54/KISS1R leads to hypogonadotropic hypogonadism in a highly consanguineous family. J Clin Endocrinol Metab. 2011;96:E536-E545.
    • (2011) J Clin Endocrinol Metab. , vol.96
    • Nimri, R.1    Lebenthal, Y.2    Lazar, L.3
  • 30
    • 0031694570 scopus 로고    scopus 로고
    • Gonadotropin-releasing hormone deficiency in the human (idiopathic hypogonadotropic hypogonadism and Kallmann's syndrome): Pathophysiological and genetic considerations
    • Seminara SB, Hayes FJ, Crowley WF Jr. Gonadotropin-releasing hormone deficiency in the human (idiopathic hypogonadotropic hypogonadism and Kallmann's syndrome): pathophysiological and genetic considerations. Endocr Rev. 1998;19:521-539.
    • (1998) Endocr Rev. , vol.19 , pp. 521-539
    • Seminara, S.B.1    Hayes, F.J.2    Crowley Jr., W.F.3
  • 31
    • 84934437093 scopus 로고    scopus 로고
    • Molecular biology of the kisspeptin receptor: Signaling, function, and mutations
    • Bianco SD, Kaiser UB. Molecular biology of the kisspeptin receptor: signaling, function, and mutations. Adv Exp Med Biol. 2013; 784:133-158.
    • (2013) Adv Exp Med Biol. , vol.784 , pp. 133-158
    • Bianco, S.D.1    Kaiser, U.B.2
  • 32
    • 34548335137 scopus 로고    scopus 로고
    • Kisspeptin in reproduction
    • Seminara SB. Kisspeptin in reproduction. Semin Reprod Med. 2007;25:337-343.
    • (2007) Semin Reprod Med. , vol.25 , pp. 337-343
    • Seminara, S.B.1
  • 33
    • 63849260648 scopus 로고    scopus 로고
    • Kisspeptin offers a novel therapeutic target in reproduction
    • Jayasena CN, Dhillo WS. Kisspeptin offers a novel therapeutic target in reproduction. Curr Opin Investig Drugs. 2009;10:311-318.
    • (2009) Curr Opin Investig Drugs. , vol.10 , pp. 311-318
    • Jayasena, C.N.1    Dhillo, W.S.2
  • 34
    • 70449111663 scopus 로고    scopus 로고
    • Subcutaneous injection of kisspeptin-54 acutely stimulates gonadotropin secretion in women with hypothalamic amenorrhea, but chronic administration causes tachyphylaxis
    • Jayasena CN, Nijher GM, Chaudhri OB, et al. Subcutaneous injection of kisspeptin-54 acutely stimulates gonadotropin secretion in women with hypothalamic amenorrhea, but chronic administration causes tachyphylaxis. J Clin Endocrinol Metab. 2009;94: 4315-4323.
    • (2009) J Clin Endocrinol Metab. , vol.94 , pp. 4315-4323
    • Jayasena, C.N.1    Nijher, G.M.2    Chaudhri, O.B.3
  • 35
    • 84864802249 scopus 로고    scopus 로고
    • Kisspeptin administration to women: A window into endogenous kisspeptin secretion and GnRH responsiveness across the menstrual cycle
    • Chan YM, Butler JP, Sidhoum VF, Pinnell NE, Seminara SB. Kisspeptin administration to women: a window into endogenous kisspeptin secretion and GnRH responsiveness across the menstrual cycle. J Clin Endocrinol Metab. 2012;97:E1458-E1467.
    • (2012) J Clin Endocrinol Metab. , vol.97
    • Chan, Y.M.1    Butler, J.P.2    Sidhoum, V.F.3    Pinnell, N.E.4    Seminara, S.B.5
  • 36
    • 10644284011 scopus 로고    scopus 로고
    • Advanced vaginal opening and precocious activation of the reproductive axis by KiSS-1 peptide, the endogenous ligand of GPR54
    • Navarro VM, Fernández-Fernández R, Castellano JM, et al. Advanced vaginal opening and precocious activation of the reproductive axis by KiSS-1 peptide, the endogenous ligand of GPR54. J Physiol. 2004;561:379-386.
    • (2004) J Physiol. , vol.561 , pp. 379-386
    • Navarro, V.M.1    Fernández-Fernández, R.2    Castellano, J.M.3
  • 38
    • 37649008207 scopus 로고    scopus 로고
    • New frontiers in kisspeptin/GPR54 physiology as fundamental gatekeepers of reproductive function
    • Roa J, Aguilar E, Dieguez C, Pinilla L, Tena-Sempere M. New frontiers in kisspeptin/GPR54 physiology as fundamental gatekeepers of reproductive function. Front Neuroendocrinol. 2008;29:48-69.
    • (2008) Front Neuroendocrinol. , vol.29 , pp. 48-69
    • Roa, J.1    Aguilar, E.2    Dieguez, C.3    Pinilla, L.4    Tena-Sempere, M.5
  • 40
    • 84864067222 scopus 로고    scopus 로고
    • Kisspeptins and reproduction: Physiological roles and regulatory mechanisms
    • Pinilla L, Aguilar E, Dieguez C, Millar RP, Tena-Sempere M. Kisspeptins and reproduction: physiological roles and regulatory mechanisms. Physiol Rev. 2012;92:1235-1316.
    • (2012) Physiol Rev. , vol.92 , pp. 1235-1316
    • Pinilla, L.1    Aguilar, E.2    Dieguez, C.3    Millar, R.P.4    Tena-Sempere, M.5
  • 41
    • 84884608698 scopus 로고    scopus 로고
    • Dependence of fertility on kisspeptin-Gpr54 signaling at the GnRH neuron
    • Kirilov M, Clarkson J, Liu X, et al. Dependence of fertility on kisspeptin-Gpr54 signaling at the GnRH neuron. Nat Commun. 2013;4:2492.
    • (2013) Nat Commun. , vol.4 , pp. 2492
    • Kirilov, M.1    Clarkson, J.2    Liu, X.3
  • 42
    • 45549104844 scopus 로고    scopus 로고
    • Temporal and spatial regulation of CRE recombinase expression in gonadotrophin-releasing hormone neurones in the mouse
    • Wolfe A, Divall S, Singh SP, et al. Temporal and spatial regulation of CRE recombinase expression in gonadotrophin-releasing hormone neurones in the mouse. J Neuroendocrinol. 2008;20:909-916.
    • (2008) J Neuroendocrinol. , vol.20 , pp. 909-916
    • Wolfe, A.1    Divall, S.2    Singh, S.P.3
  • 43
    • 77955291345 scopus 로고    scopus 로고
    • Divergent roles of growth factors in the GnRH regulation of puberty in mice
    • Divall SA, Williams TR, Carver SE, et al. Divergent roles of growth factors in the GnRH regulation of puberty in mice. J Clin Invest. 2010;120:2900-2909.
    • (2010) J Clin Invest. , vol.120 , pp. 2900-2909
    • Divall, S.A.1    Williams, T.R.2    Carver, S.E.3
  • 46
    • 69849100015 scopus 로고    scopus 로고
    • Impaired estrogen feedback and infertility in female mice with pituitary-specific deletion of estrogen receptor α (ESR1)
    • Singh SP, Wolfe A, Ng Y, et al. Impaired estrogen feedback and infertility in female mice with pituitary-specific deletion of estrogen receptor α (ESR1). Biol Reprod. 2009;81:488-496.
    • (2009) Biol Reprod. , vol.81 , pp. 488-496
    • Singh, S.P.1    Wolfe, A.2    Ng, Y.3
  • 47
    • 36248998213 scopus 로고    scopus 로고
    • 17-β-Estradiol directly regulates the expression of adrenergic receptors and kisspeptin/GPR54 system in GT1-7 GnRH neurons
    • Jacobi JS, Martin C, Nava G, Jeziorski MC, Clapp C, Martínez de la Escalera G. 17-β-Estradiol directly regulates the expression of adrenergic receptors and kisspeptin/GPR54 system in GT1-7 GnRH neurons. Neuroendocrinology. 2007;86:260-269.
    • (2007) Neuroendocrinology. , vol.86 , pp. 260-269
    • Jacobi, J.S.1    Martin, C.2    Nava, G.3    Jeziorski, M.C.4    Clapp, C.5    Martínez de la Escalera, G.6
  • 48
    • 69249219124 scopus 로고    scopus 로고
    • Kisspeptin increases GnRH mRNA expression and secretion in GnRH secreting neuronal cell lines
    • Novaira HJ, Ng Y, Wolfe A, Radovick S. Kisspeptin increases GnRH mRNA expression and secretion in GnRH secreting neuronal cell lines. Mol Cell Endocrinol. 2009;311:126-134.
    • (2009) Mol Cell Endocrinol. , vol.311 , pp. 126-134
    • Novaira, H.J.1    Ng, Y.2    Wolfe, A.3    Radovick, S.4
  • 49
    • 24944534978 scopus 로고    scopus 로고
    • Real-time PCR for mRNA quantitation
    • Wong ML, Medrano JF. Real-time PCR for mRNA quantitation. BioTechniques. 2005;39:75-85.
    • (2005) BioTechniques. , vol.39 , pp. 75-85
    • Wong, M.L.1    Medrano, J.F.2
  • 51
    • 0020380035 scopus 로고
    • A longitudinal study of estrous cyclicity in aging C57BL/6J mice: I. Cycle frequency, length and vaginal cytology
    • Nelson JF, Felicio LS, Randall PK, Sims C, Finch CE. A longitudinal study of estrous cyclicity in aging C57BL/6J mice: I. Cycle frequency, length and vaginal cytology. Biol Reprod. 1982;27:327-339.
    • (1982) Biol Reprod. , vol.27 , pp. 327-339
    • Nelson, J.F.1    Felicio, L.S.2    Randall, P.K.3    Sims, C.4    Finch, C.E.5
  • 52
    • 0017622991 scopus 로고
    • Preputial separation as an external sign of pubertal development in the male rat
    • Korenbrot CC, Huhtaniemi IT, Weiner RI. Preputial separation as an external sign of pubertal development in the male rat. Biol Reprod. 1977;17:298-303.
    • (1977) Biol Reprod. , vol.17 , pp. 298-303
    • Korenbrot, C.C.1    Huhtaniemi, I.T.2    Weiner, R.I.3
  • 53
    • 0016710655 scopus 로고
    • Body weight and food intake at early estrus of rats on a high-fat diet
    • Frisch RE, Hegsted DM, Yoshinaga K. Body weight and food intake at early estrus of rats on a high-fat diet. Proc Natl Acad Sci USA. 1975;72:4172-4176.
    • (1975) Proc Natl Acad Sci USA. , vol.72 , pp. 4172-4176
    • Frisch, R.E.1    Hegsted, D.M.2    Yoshinaga, K.3
  • 54
    • 77956336197 scopus 로고    scopus 로고
    • Rescue of obesity-induced infertility in female mice due to a pituitary-specific knockout of the insulin receptor
    • Brothers KJ, Wu S, DiVall SA, et al. Rescue of obesity-induced infertility in female mice due to a pituitary-specific knockout of the insulin receptor. Cell Metab. 2010;12:295-305.
    • (2010) Cell Metab. , vol.12 , pp. 295-305
    • Brothers, K.J.1    Wu, S.2    DiVall, S.A.3
  • 55
    • 34547533091 scopus 로고    scopus 로고
    • Hypogonadotropic hypogonadism in mice lacking a functional Kiss1 gene
    • d'Anglemont de Tassigny X, Fagg LA, et al. Hypogonadotropic hypogonadism in mice lacking a functional Kiss1 gene. Proc Natl Acad Sci USA. 2007;104:10714-10719.
    • (2007) Proc Natl Acad Sci USA. , vol.104 , pp. 10714-10719
    • de Tassigny D'Anglemont, X.1    Fagg, L.A.2
  • 56
    • 84870176736 scopus 로고    scopus 로고
    • Genetic mechanisms mediating kisspeptin regulation of GnRH gene expression
    • Novaira HJ, Fadoju D, Diaczok D, Radovick S. Genetic mechanisms mediating kisspeptin regulation of GnRH gene expression. J Neurosci. 2012;32:17391-17400.
    • (2012) J Neurosci. , vol.32 , pp. 17391-17400
    • Novaira, H.J.1    Fadoju, D.2    Diaczok, D.3    Radovick, S.4
  • 58
    • 84857418715 scopus 로고    scopus 로고
    • Defining POMC neurons using transgenic reagents: Impact of transient Pomc expression in diverse immature neuronal populations
    • Padilla SL, Reef D, Zeltser LM. Defining POMC neurons using transgenic reagents: impact of transient Pomc expression in diverse immature neuronal populations. Endocrinology. 2012;153:1219-1231.
    • (2012) Endocrinology. , vol.153 , pp. 1219-1231
    • Padilla, S.L.1    Reef, D.2    Zeltser, L.M.3
  • 59
    • 84857418759 scopus 로고    scopus 로고
    • Capricious Cre: The devil is in the details
    • Morrison CD, Münzberg H. Capricious Cre: the devil is in the details. Endocrinology. 2012;153:1005-1007.
    • (2012) Endocrinology. , vol.153 , pp. 1005-1007
    • Morrison, C.D.1    Münzberg, H.2
  • 60
    • 0033565777 scopus 로고    scopus 로고
    • Promoter transgenics reveal multiple gonadotropin-releasing hormone-I-expressing cell populations of different embryological origin in mouse brain
    • Skynner MJ, Slater R, Sim JA, Allen ND, Herbison AE. Promoter transgenics reveal multiple gonadotropin-releasing hormone-I-expressing cell populations of different embryological origin in mouse brain. J Neurosci. 1999;19:5955-5966.
    • (1999) J Neurosci. , vol.19 , pp. 5955-5966
    • Skynner, M.J.1    Slater, R.2    Sim, J.A.3    Allen, N.D.4    Herbison, A.E.5
  • 61
    • 84857126496 scopus 로고    scopus 로고
    • Inactivating KISS1 mutation and hypogonadotropic hypogonadism
    • Topaloglu AK, Tello JA, Kotan LD, et al. Inactivating KISS1 mutation and hypogonadotropic hypogonadism. N Engl J Med. 2012; 366:629-635.
    • (2012) N Engl J Med. , vol.366 , pp. 629-635
    • Topaloglu, A.K.1    Tello, J.A.2    Kotan, L.D.3
  • 62
    • 47549101608 scopus 로고    scopus 로고
    • Desensitization of gonadotropin responses to kisspeptin in the female rat: Analyses of LH and FSH secretion at different developmental and metabolic states
    • Roa J, Vigo E, García-Galiano D, et al. Desensitization of gonadotropin responses to kisspeptin in the female rat: analyses of LH and FSH secretion at different developmental and metabolic states. Am J Physiol Endocrinol Metab. 2008;294:E1088-E1096.
    • (2008) Am J Physiol Endocrinol Metab. , vol.294
    • Roa, J.1    Vigo, E.2    García-Galiano, D.3
  • 63
    • 70949094457 scopus 로고    scopus 로고
    • Kisspeptin/ Gpr54-independent gonadotrophin-releasing hormone activity in Kiss1 and Gpr54 mutant mice
    • Chan YM, Broder-Fingert S, Wong KM, Seminara SB. Kisspeptin/ Gpr54-independent gonadotrophin-releasing hormone activity in Kiss1 and Gpr54 mutant mice. J Neuroendocrinol. 2009;21:1015-1023.
    • (2009) J Neuroendocrinol. , vol.21 , pp. 1015-1023
    • Chan, Y.M.1    Broder-Fingert, S.2    Wong, K.M.3    Seminara, S.B.4
  • 64
    • 84880651985 scopus 로고    scopus 로고
    • Redundancy in Kiss1 expression safeguards reproduction in the mouse
    • Popa SM, Moriyama RM, Caligioni CS, et al. Redundancy in Kiss1 expression safeguards reproduction in the mouse. Endocrinology. 2013;154:2784-2794.
    • (2013) Endocrinology. , vol.154 , pp. 2784-2794
    • Popa, S.M.1    Moriyama, R.M.2    Caligioni, C.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.