NGF controls APP cleavage by downregulating APP phosphorylation at Thr668: relevance for Alzheimer's disease

Aging Cell

Volumn 15, Issue 4, 2016, Pages 661-672

  Triaca, Viviana ^a,b   Sposato, Valentina ^a,b   Bolasco, Giulia ^c   Ciotti, Maria Teresa ^a   Pelicci, Piergiuseppe ^d   Bruni, Amalia C ^e   Cupidi, Chiara ^e   Maletta, Raffaele ^e   Feligioni, Marco ^b   Nisticò, Robert ^b   Canu, Nadia ^a,f   Calissano, Pietro ^b  

^a CNR   (Italy)

^b EUROPEAN BRAIN RESEARCH INSTITUTE   (Italy)

^c EUROPEAN MOLECULAR BIOLOGY LABORATORY EMBL   (Italy)

^d EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^e ASP Catanzaro   (Italy)

^f UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

AD; APP pT668; BACE; NGF; ShcC; TrkA APP interaction

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; CYCLIC AMP DEPENDENT PROTEIN KINASE; NERVE GROWTH FACTOR; PROTEIN TYROSINE KINASE; STRESS ACTIVATED PROTEIN KINASE; THREONINE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DOWN REGULATION; FOREBRAIN; HIPPOCAMPAL SLICE; MOUSE; NONHUMAN; PC12 CELL LINE; PRIMARY CULTURE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN METABOLISM; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

EID: 84977661009     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12473     Document Type: Article

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