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Volumn 31, Issue 1, 2009, Pages 11-25

Reduced neuronal co-localisation of nardilysin and the putative α-secretases ADAM10 and ADAM17 in Alzheimer's disease and Down syndrome brains

Author keywords

Alzheimer's disease; Down syndrome; Human cerebral cortex; Immunohistochemistry; Metalloprotease

Indexed keywords


EID: 60849126393     PISSN: 01619152     EISSN: 15744647     Source Type: Journal    
DOI: 10.1007/s11357-008-9076-x     Document Type: Article
Times cited : (20)

References (54)
  • 1
    • 0032497325 scopus 로고    scopus 로고
    • IP4, a high-affinity inositol(1,3,4,5)tetrakisphosphate/ phosphatidylinositol(3,4,5)trisphosphate binding protein
    • IP4, a high-affinity inositol(1,3,4,5)tetrakisphosphate/ phosphatidylinositol(3,4,5)trisphosphate binding protein Biochim Biophys Acta 1387 117 128
    • (1998) Biochim Biophys Acta , vol.1387 , pp. 117-128
    • Aggensteiner, M.1    Stricker, R.2    Reiser, G.3
  • 2
    • 0031049911 scopus 로고    scopus 로고
    • Vesicular acetylcholine transporter (VAChT) protein: A novel and unique marker for cholinergic neurons in the central and peripheral nervous systems
    • U Arvidsson M Riedl R Elde 1997 Vesicular acetylcholine transporter (VAChT) protein: a novel and unique marker for cholinergic neurons in the central and peripheral nervous systems J Comp Neurol 378 454 467
    • (1997) J Comp Neurol , vol.378 , pp. 454-467
    • Arvidsson, U.1    Riedl, M.2    Elde, R.3
  • 3
    • 36749037180 scopus 로고    scopus 로고
    • Role of the APP non-amyloidogenic signaling pathway and targeting alpha-secretase as an alternative drug target for treatment of Alzheimer's disease
    • S Bandyopadhyay LE Goldstein DK Lahiri 2007 Role of the APP non-amyloidogenic signaling pathway and targeting alpha-secretase as an alternative drug target for treatment of Alzheimer's disease Curr Med Chem 14 2848 2864
    • (2007) Curr Med Chem , vol.14 , pp. 2848-2864
    • Bandyopadhyay, S.1    Goldstein, L.E.2    Lahiri, D.K.3
  • 4
    • 33746441928 scopus 로고    scopus 로고
    • The glucagon-miniglucagon interplay: A new level in the metabolic regulation
    • D Bataille G Fontés S Costes 2006 The glucagon-miniglucagon interplay: a new level in the metabolic regulation Ann N Y Acad Sci 1070 161 166
    • (2006) Ann N y Acad Sci , vol.1070 , pp. 161-166
    • Bataille, D.1    Fontés, G.2    Costes, S.3
  • 6
    • 39749142725 scopus 로고    scopus 로고
    • ADAM-10 over-expression increases cortical synaptogenesis
    • KF Bell L Zheng F Fahrenholz 2008 ADAM-10 over-expression increases cortical synaptogenesis Neurobiol Aging 29 554 565
    • (2008) Neurobiol Aging , vol.29 , pp. 554-565
    • Bell, K.F.1    Zheng, L.2    Fahrenholz, F.3
  • 7
    • 0023498924 scopus 로고
    • Immunolocalization of dipeptidyl aminopeptidase (DAP IV) in the developing human brain
    • HG Bernstein E Schon S Ansorge I Rose A Dorn 1987 Immunolocalization of dipeptidyl aminopeptidase (DAP IV) in the developing human brain Int J Dev Neurosci 5 237 242
    • (1987) Int J Dev Neurosci , vol.5 , pp. 237-242
    • Bernstein, H.G.1    Schon, E.2    Ansorge, S.3    Rose, I.4    Dorn, A.5
  • 8
    • 0029964580 scopus 로고    scopus 로고
    • The possible place of cathepsins and cystatins in the puzzle of Alzheimer disease: A review
    • HG Bernstein H Kirschke B Wiederanders 1996 The possible place of cathepsins and cystatins in the puzzle of Alzheimer disease: a review Mol Chem Neuropathol 27 225 247
    • (1996) Mol Chem Neuropathol , vol.27 , pp. 225-247
    • Bernstein, H.G.1    Kirschke, H.2    Wiederanders, B.3
  • 9
    • 0032484549 scopus 로고    scopus 로고
    • Nitric oxide synthase-containing neurons in the human hypothalamus: Reduced number of immunoreactive cells in the paraventricular nucleus of depressive patients and schizophrenics
    • HG Bernstein A Stanarius B Baumann 1998 Nitric oxide synthase-containing neurons in the human hypothalamus: reduced number of immunoreactive cells in the paraventricular nucleus of depressive patients and schizophrenics Neuroscience 83 867 875
    • (1998) Neuroscience , vol.83 , pp. 867-875
    • Bernstein, H.G.1    Stanarius, A.2    Baumann, B.3
  • 10
    • 0033301211 scopus 로고    scopus 로고
    • Regional and cellular distribution of neural visinin-like protein immunoreactivities (VILIP-1 and VILIP-3) in human brain
    • HG Bernstein B Baumann P Danos 1999 Regional and cellular distribution of neural visinin-like protein immunoreactivities (VILIP-1 and VILIP-3) in human brain J Neurocytol 28 655 662
    • (1999) J Neurocytol , vol.28 , pp. 655-662
    • Bernstein, H.G.1    Baumann, B.2    Danos, P.3
  • 11
    • 0346250096 scopus 로고    scopus 로고
    • Comparative localization of ADAMs 10 and 15 in human cerebral cortex normal aging, Alzheimer disease and Down syndrome
    • HG Bernstein A Bukowska D Krell 2003 Comparative localization of ADAMs 10 and 15 in human cerebral cortex normal aging, Alzheimer disease and Down syndrome J Neurocytol 32 153 160
    • (2003) J Neurocytol , vol.32 , pp. 153-160
    • Bernstein, H.G.1    Bukowska, A.2    Krell, D.3
  • 12
    • 34249079207 scopus 로고    scopus 로고
    • Histochemical evidence for wide expression of the metalloendopeptidase nardilysin in human brain neurons
    • HG Bernstein R Stricker H Dobrowolny 2007 Histochemical evidence for wide expression of the metalloendopeptidase nardilysin in human brain neurons Neuroscience 146 1513 1523
    • (2007) Neuroscience , vol.146 , pp. 1513-1523
    • Bernstein, H.G.1    Stricker, R.2    Dobrowolny, H.3
  • 13
    • 0035128444 scopus 로고    scopus 로고
    • Abnormal localization of two neuronal calcium sensor proteins, visinin-like proteins (vilips)-1 and -3, in neocortical brain areas of Alzheimer disease patients
    • K Braunewell P Riederer C Spilker 2001 Abnormal localization of two neuronal calcium sensor proteins, visinin-like proteins (vilips)-1 and -3, in neocortical brain areas of Alzheimer disease patients Dement Geriatr Cogn Disord 12 110 116
    • (2001) Dement Geriatr Cogn Disord , vol.12 , pp. 110-116
    • Braunewell, K.1    Riederer, P.2    Spilker, C.3
  • 14
    • 18244390483 scopus 로고    scopus 로고
    • Mitochondrial abnormalities in Alzheimer brain: Mechanistic implications
    • P Bubber V Haroutunian G Fisch 2005 Mitochondrial abnormalities in Alzheimer brain: mechanistic implications Ann Neurol 57 695 703
    • (2005) Ann Neurol , vol.57 , pp. 695-703
    • Bubber, P.1    Haroutunian, V.2    Fisch, G.3
  • 15
    • 33644874017 scopus 로고    scopus 로고
    • Evaluation of cytokine polymorphisms (TNFalpha, IFNgamma and IL-10) in Down patients with coeliac disease
    • F Cataldo L Scola M Piccione 2005 Evaluation of cytokine polymorphisms (TNFalpha, IFNgamma and IL-10) in Down patients with coeliac disease Dig Liver Dis 37 923 927
    • (2005) Dig Liver Dis , vol.37 , pp. 923-927
    • Cataldo, F.1    Scola, L.2    Piccione, M.3
  • 16
    • 0027979145 scopus 로고
    • Isolation and characterization of a dibasic selective metalloendopeptidase from rat testes that cleaves at the amino terminus of arginine residues
    • V Chesneau AR Pierotti N Barre 1994 Isolation and characterization of a dibasic selective metalloendopeptidase from rat testes that cleaves at the amino terminus of arginine residues J Biol Chem 269 2056 2061
    • (1994) J Biol Chem , vol.269 , pp. 2056-2061
    • Chesneau, V.1    Pierotti, A.R.2    Barre, N.3
  • 17
    • 0037465338 scopus 로고    scopus 로고
    • Nardilysin cleaves peptides at monobasic sites
    • KM Chow O Oakley J Goodman 2003 Nardilysin cleaves peptides at monobasic sites Biochemistry 42 2239 2244
    • (2003) Biochemistry , vol.42 , pp. 2239-2244
    • Chow, K.M.1    Oakley, O.2    Goodman, J.3
  • 18
    • 19744366732 scopus 로고    scopus 로고
    • Nardilysin facilitates complex formation between mitochondrial malate dehydrogenase and citrate synthase
    • Chow KM, Ma Z, Cai J et al (2005) Nardilysin facilitates complex formation between mitochondrial malate dehydrogenase and citrate synthase. Biochim Biophys Acta 1723:292-301
    • (2005) Biochim Biophys Acta , vol.1723 , pp. 292-301
    • Chow, K.M.1    Ma, Z.2    Cai, J.3
  • 19
    • 0032539996 scopus 로고    scopus 로고
    • Regulation of N-arginine dibasic convertase activity by amines: Putative role of a novel acidic domain as an amine binding site
    • E Csuhai G Chen LB Hersh 1998 Regulation of N-arginine dibasic convertase activity by amines: putative role of a novel acidic domain as an amine binding site Biochemistry 37 3787 3794
    • (1998) Biochemistry , vol.37 , pp. 3787-3794
    • Csuhai, E.1    Chen, G.2    Hersh, L.B.3
  • 20
    • 42149110867 scopus 로고    scopus 로고
    • Part-time alpha-secretases: The functional biology of ADAM 9, 10 and 17
    • M Deuss K Reiss D Hartmann 2008 Part-time alpha-secretases: the functional biology of ADAM 9, 10 and 17 Curr Alzheimer Res 5 187 201
    • (2008) Curr Alzheimer Res , vol.5 , pp. 187-201
    • Deuss, M.1    Reiss, K.2    Hartmann, D.3
  • 21
    • 0028799250 scopus 로고
    • Differential correlation between neurochemical deficits, neuropathology, and cognitive status in Alzheimer's disease
    • P Dournaud P Delaere JJ Hauw 1995 Differential correlation between neurochemical deficits, neuropathology, and cognitive status in Alzheimer's disease Neurobiol Aging 16 817 823
    • (1995) Neurobiol Aging , vol.16 , pp. 817-823
    • Dournaud, P.1    Delaere, P.2    Hauw, J.J.3
  • 22
    • 34548688657 scopus 로고    scopus 로고
    • Alpha-secretase as a therapeutic target
    • F Fahrenholz 2007 Alpha-secretase as a therapeutic target Curr Alzheimer Res 4 412 417
    • (2007) Curr Alzheimer Res , vol.4 , pp. 412-417
    • Fahrenholz, F.1
  • 23
    • 34547893833 scopus 로고    scopus 로고
    • Enhancement of alpha-secretase cleavage of amyloid precursor protein by a metalloendopeptidase nardilysin
    • Y Hiraoka M Ohno K Yoshida 2007 Enhancement of alpha-secretase cleavage of amyloid precursor protein by a metalloendopeptidase nardilysin J Neurochem 102 1595 1605
    • (2007) J Neurochem , vol.102 , pp. 1595-1605
    • Hiraoka, Y.1    Ohno, M.2    Yoshida, K.3
  • 24
    • 41849097002 scopus 로고    scopus 로고
    • Ectodomain shedding of TNF-alpha is enhanced by nardilysin via activation of ADAM proteases
    • Y Hiraoka K Yoshida M Ohno 2008 Ectodomain shedding of TNF-alpha is enhanced by nardilysin via activation of ADAM proteases Biochem Biophys Res Commun 370 154 158
    • (2008) Biochem Biophys Res Commun , vol.370 , pp. 154-158
    • Hiraoka, Y.1    Yoshida, K.2    Ohno, M.3
  • 25
    • 0027941838 scopus 로고
    • Families of zinc metalloproteases
    • NM Hooper 1994 Families of zinc metalloproteases FEBS Lett 354 1 6
    • (1994) FEBS Lett , vol.354 , pp. 1-6
    • Hooper, N.M.1
  • 26
    • 0034661511 scopus 로고    scopus 로고
    • N-arginine dibasic convertase (nardilysin) isoforms are soluble dibasic-specific metalloendopeptidases that localize in the cytoplasm and at the cell surface
    • V Hospital V Chesneau A Balogh 2000 N-arginine dibasic convertase (nardilysin) isoforms are soluble dibasic-specific metalloendopeptidases that localize in the cytoplasm and at the cell surface Biochem J 349 587 597
    • (2000) Biochem J , vol.349 , pp. 587-597
    • Hospital, V.1    Chesneau, V.2    Balogh, A.3
  • 27
    • 0036662775 scopus 로고    scopus 로고
    • Heparin-binding epidermal growth factor-like growth factor: Hypoxia-inducible expression in vitro and stimulation of neurogenesis in vitro and in vivo
    • K Jin XO Mao Y Sun 2002 Heparin-binding epidermal growth factor-like growth factor: hypoxia-inducible expression in vitro and stimulation of neurogenesis in vitro and in vivo J Neurosci 22 5365 5373
    • (2002) J Neurosci , vol.22 , pp. 5365-5373
    • Jin, K.1    Mao, X.O.2    Sun, Y.3
  • 28
    • 0346458659 scopus 로고    scopus 로고
    • Increased hippocampal neurogenesis in Alzheimer's disease
    • K Jin AL Peel XO Mao 2004 Increased hippocampal neurogenesis in Alzheimer's disease Proc Natl Acad Sci USA 101 343 347
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 343-347
    • Jin, K.1    Peel, A.L.2    Mao, X.O.3
  • 29
    • 0038458969 scopus 로고    scopus 로고
    • ADAM-10 and ADAM-17 in the inflamed human CNS
    • BC Kieseier H Pischel E Neuen-Jacob 2003 ADAM-10 and ADAM-17 in the inflamed human CNS Glia 42 398 405
    • (2003) Glia , vol.42 , pp. 398-405
    • Kieseier, B.C.1    Pischel, H.2    Neuen-Jacob, E.3
  • 30
    • 33846081524 scopus 로고    scopus 로고
    • Beta-amyloid, oxidative stress and down syndrome
    • IT Lott E Head E Doran 2006 Beta-amyloid, oxidative stress and down syndrome Curr Alzheimer Res 3 521 528
    • (2006) Curr Alzheimer Res , vol.3 , pp. 521-528
    • Lott, I.T.1    Head, E.2    Doran, E.3
  • 31
    • 35148814074 scopus 로고    scopus 로고
    • Transcriptional profiling of Alzheimer blood mononuclear cells by microarray
    • OC Maes S Xu B Yu 2007 Transcriptional profiling of Alzheimer blood mononuclear cells by microarray Neurobiol Aging 28 1795 1809
    • (2007) Neurobiol Aging , vol.28 , pp. 1795-1809
    • Maes, O.C.1    Xu, S.2    Yu, B.3
  • 32
    • 0033793248 scopus 로고    scopus 로고
    • Coordinated expression of beta-amyloid precursor protein and the putative beta-secretase BACE and alpha-secretase ADAM10 in mouse and human brain
    • M Marcinkiewicz NG Seidah 2000 Coordinated expression of beta-amyloid precursor protein and the putative beta-secretase BACE and alpha-secretase ADAM10 in mouse and human brain J Neurochem 75 2133 2143
    • (2000) J Neurochem , vol.75 , pp. 2133-2143
    • Marcinkiewicz, M.1    Seidah, N.G.2
  • 33
    • 0026049620 scopus 로고
    • Somatostatin replacement therapy for Alzheimer dementia
    • MM Mouradian J Blin M Giuffra 1991 Somatostatin replacement therapy for Alzheimer dementia Ann Neurol 30 610 613
    • (1991) Ann Neurol , vol.30 , pp. 610-613
    • Mouradian, M.M.1    Blin, J.2    Giuffra, M.3
  • 34
    • 0026673105 scopus 로고
    • Tumor necrosis factor-alpha and IFN-gamma expression in human thymus. Localization and overexpression in Down syndrome (trisomy 21)
    • M Murphy DS Friend L Pike-Nobile 1992 Tumor necrosis factor-alpha and IFN-gamma expression in human thymus. Localization and overexpression in Down syndrome (trisomy 21) J Immunol 149 2506 2512
    • (1992) J Immunol , vol.149 , pp. 2506-2512
    • Murphy, M.1    Friend, D.S.2    Pike-Nobile, L.3
  • 35
    • 0026783986 scopus 로고
    • A role for tumor necrosis factor-alpha and interferon-gamma in the regulation of interleukin-4-induced human thymocyte proliferation in vitro. Heightened sensitivity in the Down syndrome (trisomy 21) thymus
    • M Murphy W Hyun B Hunte 1992 A role for tumor necrosis factor-alpha and interferon-gamma in the regulation of interleukin-4-induced human thymocyte proliferation in vitro. Heightened sensitivity in the Down syndrome (trisomy 21) thymus Pediatr Res 32 269 276
    • (1992) Pediatr Res , vol.32 , pp. 269-276
    • Murphy, M.1    Hyun, W.2    Hunte, B.3
  • 36
    • 0029436226 scopus 로고
    • A hypothesis to explain the immune defects in Down syndrome
    • M Murphy RM Insoft L Pike-Nobile 1995 A hypothesis to explain the immune defects in Down syndrome Prog Clin Biol Res 393 147 167
    • (1995) Prog Clin Biol Res , vol.393 , pp. 147-167
    • Murphy, M.1    Insoft, R.M.2    Pike-Nobile, L.3
  • 37
    • 0035796401 scopus 로고    scopus 로고
    • N-arginine dibasic convertase is a specific receptor for heparin-binding EGF-like growth factor that mediates cell migration
    • E Nishi A Prat V Hospital 2001 N-arginine dibasic convertase is a specific receptor for heparin-binding EGF-like growth factor that mediates cell migration EMBO J 20 3342 3350
    • (2001) EMBO J , vol.20 , pp. 3342-3350
    • Nishi, E.1    Prat, A.2    Hospital, V.3
  • 38
    • 33750060301 scopus 로고    scopus 로고
    • Nardilysin enhances ectodomain shedding of heparin-binding epidermal growth factor-like growth factor through activation of tumor necrosis factor-alpha-converting enzyme
    • E Nishi Y Hiraoka K Yoshida 2006 Nardilysin enhances ectodomain shedding of heparin-binding epidermal growth factor-like growth factor through activation of tumor necrosis factor-alpha-converting enzyme J Biol Chem 281 31164 31172
    • (2006) J Biol Chem , vol.281 , pp. 31164-31172
    • Nishi, E.1    Hiraoka, Y.2    Yoshida, K.3
  • 39
    • 34547756449 scopus 로고    scopus 로고
    • Alpha- and beta-secretase activity as a function of age and beta-amyloid in Down syndrome and normal brain
    • M Nistor M Don M Parekh 2007 Alpha- and beta-secretase activity as a function of age and beta-amyloid in Down syndrome and normal brain Neurobiol Aging 28 1493 1506
    • (2007) Neurobiol Aging , vol.28 , pp. 1493-1506
    • Nistor, M.1    Don, M.2    Parekh, M.3
  • 40
    • 0028173765 scopus 로고
    • N-arginine dibasic convertase, a metalloendopeptidase as a prototype of a class of processing enzymes
    • AR Pierotti A Prat V Chesneau 1994 N-arginine dibasic convertase, a metalloendopeptidase as a prototype of a class of processing enzymes Proc Natl Acad Sci USA 91 6078 6082
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 6078-6082
    • Pierotti, A.R.1    Prat, A.2    Chesneau, V.3
  • 41
    • 0027479821 scopus 로고
    • Evolutionary families of peptidases
    • ND Rawlings AJ Barrett 1993 Evolutionary families of peptidases Biochem J 290 205 218
    • (1993) Biochem J , vol.290 , pp. 205-218
    • Rawlings, N.D.1    Barrett, A.J.2
  • 44
    • 0021267015 scopus 로고
    • Neurochemical characteristics of early and late onset types of Alzheimer's disease
    • MN Rossor LL Iversen GP Reynolds 1984 Neurochemical characteristics of early and late onset types of Alzheimer's disease Br Med J (Clin Res Ed) 288 961 964
    • (1984) Br Med J (Clin Res Ed) , vol.288 , pp. 961-964
    • Rossor, M.N.1    Iversen, L.L.2    Reynolds, G.P.3
  • 45
    • 0037227232 scopus 로고    scopus 로고
    • Regional specificity in the neuropathologic substrates of schizophrenia: A morphometric analysis of Broca's area 44 and area 9
    • LD Selemon J Mrzljak JE Kleinman 2003 Regional specificity in the neuropathologic substrates of schizophrenia: a morphometric analysis of Broca's area 44 and area 9 Arch Gen Psychiatry 60 69 77
    • (2003) Arch Gen Psychiatry , vol.60 , pp. 69-77
    • Selemon, L.D.1    Mrzljak, J.2    Kleinman, J.E.3
  • 46
    • 0034741796 scopus 로고    scopus 로고
    • Neuronal localization of the TNFalpha converting enzyme (TACE) in brain tissue and its correlation to amyloid plaques
    • DM Skovronsky S Fath VM Lee 2001 Neuronal localization of the TNFalpha converting enzyme (TACE) in brain tissue and its correlation to amyloid plaques J Neurobiol 49 40 46
    • (2001) J Neurobiol , vol.49 , pp. 40-46
    • Skovronsky, D.M.1    Fath, S.2    Lee, V.M.3
  • 47
    • 33645728523 scopus 로고    scopus 로고
    • Neurodegenerative diseases: New concepts of pathogenesis and their therapeutic implications
    • DM Skovronsky VM Lee JQ Trojanowski 2006 Neurodegenerative diseases: new concepts of pathogenesis and their therapeutic implications Annu Rev Pathol 1 151 170
    • (2006) Annu Rev Pathol , vol.1 , pp. 151-170
    • Skovronsky, D.M.1    Lee, V.M.2    Trojanowski, J.Q.3
  • 48
    • 33746904321 scopus 로고    scopus 로고
    • Density of Sgt1-immunopositive neurons is decreased in the cerebral cortex of Alzheimer's disease brain
    • M Spiechowicz HG Bernstein H Dobrowolny 2006 Density of Sgt1-immunopositive neurons is decreased in the cerebral cortex of Alzheimer's disease brain Neurochem Int 49 487 493
    • (2006) Neurochem Int , vol.49 , pp. 487-493
    • Spiechowicz, M.1    Bernstein, H.G.2    Dobrowolny, H.3
  • 51
    • 10744221721 scopus 로고    scopus 로고
    • The proprotein convertase PC2 is involved in the maturation of prosomatostatin to somatostatin-14 but not in the somatostatin deficit in Alzheimer's disease
    • R Winsky-Sommerer D Grouselle C Rougeot 2003 The proprotein convertase PC2 is involved in the maturation of prosomatostatin to somatostatin-14 but not in the somatostatin deficit in Alzheimer's disease Neuroscience 122 437 447
    • (2003) Neuroscience , vol.122 , pp. 437-447
    • Winsky-Sommerer, R.1    Grouselle, D.2    Rougeot, C.3
  • 52
    • 34548595584 scopus 로고    scopus 로고
    • Dysregulation of dynorphins in Alzheimer disease
    • T Yakovleva Z Marinova A Kuzmin 2007 Dysregulation of dynorphins in Alzheimer disease Neurobiol Aging 28 1700 1708
    • (2007) Neurobiol Aging , vol.28 , pp. 1700-1708
    • Yakovleva, T.1    Marinova, Z.2    Kuzmin, A.3
  • 53
    • 33747341626 scopus 로고    scopus 로고
    • The ADAMs family: Coordinators of nervous system development, plasticity and repair
    • P Yang KA Baker T Hagg 2006 The ADAMs family: coordinators of nervous system development, plasticity and repair Prog Neurobiol 79 73 94
    • (2006) Prog Neurobiol , vol.79 , pp. 73-94
    • Yang, P.1    Baker, K.A.2    Hagg, T.3
  • 54
    • 34447634320 scopus 로고    scopus 로고
    • New protein kinase C activator regulates amyloid precursor protein processing in vitro by increasing alpha-secretase activity
    • HQ Yang J Pan MW Ba 2007 New protein kinase C activator regulates amyloid precursor protein processing in vitro by increasing alpha-secretase activity Eur J Neurosci 26 381 391
    • (2007) Eur J Neurosci , vol.26 , pp. 381-391
    • Yang, H.Q.1    Pan, J.2    Ba, M.W.3


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