메뉴 건너뛰기




Volumn 113, Issue 27, 2016, Pages 7551-7556

Tumor-associated fibroblasts predominantly come from local and not circulating precursors

Author keywords

Bone marrow; Collagen; Mesenchymal; Origin; Stroma

Indexed keywords

COLLAGEN TYPE 1; EXPRESSING GREEN FLUORESCENT REPOTER PROTEIN; GREEN FLUORESCENT PROTEIN; UNCLASSIFIED DRUG; ACTIN; ALPHA-SMOOTH MUSCLE ACTIN, MOUSE; ENHANCED GREEN FLUORESCENT PROTEIN;

EID: 84977490719     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1600363113     Document Type: Article
Times cited : (153)

References (68)
  • 2
    • 0002343809 scopus 로고
    • Culture of blood leukocytes. From lymphocytes and monocytes to connective tissue
    • Maximov A (1928) Culture of blood leukocytes. From lymphocytes and monocytes to connective tissue. Arch Exp Zellforsch 5:169-268.
    • (1928) Arch Exp Zellforsch , vol.5 , pp. 169-268
    • Maximov, A.1
  • 3
    • 0024795843 scopus 로고
    • Stromal-hematopoietic interrelationships: Maximov's ideas and modern models
    • Friedenstein A (1989) Stromal-hematopoietic interrelationships: Maximov's ideas and modern models. Haematol Blood Transfus 32:159-167.
    • (1989) Haematol Blood Transfus , vol.32 , pp. 159-167
    • Friedenstein, A.1
  • 4
    • 0028535872 scopus 로고
    • Circulating fibrocytes define a new leukocyte subpopulation that mediates tissue repair
    • Bucala R, Spiegel LA, Chesney J, Hogan M, Cerami A (1994) Circulating fibrocytes define a new leukocyte subpopulation that mediates tissue repair. Mol Med 1(1): 71-81.
    • (1994) Mol Med , vol.1 , Issue.1 , pp. 71-81
    • Bucala, R.1    Spiegel, L.A.2    Chesney, J.3    Hogan, M.4    Cerami, A.5
  • 5
    • 0026322928 scopus 로고
    • Cystic fibrosis: Production of high levels of uromodulin-like protein by HLA-DR blood monocytes differentiating towards a fibroblastic phenotype
    • Labat ML, et al. (1991) Cystic fibrosis: Production of high levels of uromodulin-like protein by HLA-DR blood monocytes differentiating towards a fibroblastic phenotype. Biomed Pharmacother 45(9):387-401.
    • (1991) Biomed Pharmacother , vol.45 , Issue.9 , pp. 387-401
    • Labat, M.L.1
  • 6
    • 0347361659 scopus 로고    scopus 로고
    • + monocytes as a source of progenitors that exhibit mesenchymal cell differentiation
    • Kuwana M, et al. (2003) Human circulating CD14+ monocytes as a source of progenitors that exhibit mesenchymal cell differentiation. J Leukoc Biol 74(5):833-845.
    • (2003) J Leukoc Biol , vol.74 , Issue.5 , pp. 833-845
    • Kuwana, M.1
  • 7
    • 0035877019 scopus 로고    scopus 로고
    • Peripheral blood fibrocytes: Differentiation pathway and migration to wound sites
    • Abe R, Donnelly SC, Peng T, Bucala R, Metz CN (2001) Peripheral blood fibrocytes: Differentiation pathway and migration to wound sites. J Immunol 166(12):7556-7562.
    • (2001) J Immunol , vol.166 , Issue.12 , pp. 7556-7562
    • Abe, R.1    Donnelly, S.C.2    Peng, T.3    Bucala, R.4    Metz, C.N.5
  • 8
    • 4043055316 scopus 로고    scopus 로고
    • Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis
    • Phillips RJ, et al. (2004) Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis. J Clin Invest 114(3):438-446.
    • (2004) J Clin Invest , vol.114 , Issue.3 , pp. 438-446
    • Phillips, R.J.1
  • 9
    • 31844447029 scopus 로고    scopus 로고
    • Hematopoietic origins of fibroblasts: I. Vivo studies of fibroblasts associated with solid tumors
    • LaRue AC, et al. (2006) Hematopoietic origins of fibroblasts: I. In vivo studies of fibroblasts associated with solid tumors. Exp Hematol 34(2):208-218.
    • (2006) Exp Hematol , vol.34 , Issue.2 , pp. 208-218
    • LaRue, A.C.1
  • 10
    • 50349093567 scopus 로고    scopus 로고
    • Bone marrow subsets differentiate into endothelial cells and pericytes contributing to Ewing's tumor vessels
    • Reddy K, Zhou Z, Schadler K, Jia SF, Kleinerman ES (2008) Bone marrow subsets differentiate into endothelial cells and pericytes contributing to Ewing's tumor vessels. Mol Cancer Res 6(6):929-936.
    • (2008) Mol Cancer Res , vol.6 , Issue.6 , pp. 929-936
    • Reddy, K.1    Zhou, Z.2    Schadler, K.3    Jia, S.F.4    Kleinerman, E.S.5
  • 11
    • 64549145804 scopus 로고    scopus 로고
    • Mesenchymal stem cell transition to tumor-associated fibroblasts contributes to fibrovascular network expansion and tumor progression
    • Spaeth EL, et al. (2009) Mesenchymal stem cell transition to tumor-associated fibroblasts contributes to fibrovascular network expansion and tumor progression. PLoS One 4(4):e4992.
    • (2009) PLoS One , vol.4 , Issue.4 , pp. e4992
    • Spaeth, E.L.1
  • 12
    • 79751501829 scopus 로고    scopus 로고
    • Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth
    • Quante M, et al. (2011) Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth. Cancer Cell 19(2):257-272.
    • (2011) Cancer Cell , vol.19 , Issue.2 , pp. 257-272
    • Quante, M.1
  • 13
    • 0036790977 scopus 로고    scopus 로고
    • Diversity, topographic differentiation, and positional memory in human fibroblasts
    • Chang HY, et al. (2002) Diversity, topographic differentiation, and positional memory in human fibroblasts. Proc Natl Acad Sci USA 99(20):12877-12882.
    • (2002) Proc Natl Acad Sci USA , vol.99 , Issue.20 , pp. 12877-12882
    • Chang, H.Y.1
  • 14
    • 84859447666 scopus 로고    scopus 로고
    • Positional identity of murine mesenchymal stem cells resident in different organs is determined in the postsegmentation mesoderm
    • Sági B, et al. (2012) Positional identity of murine mesenchymal stem cells resident in different organs is determined in the postsegmentation mesoderm. Stem Cells Dev 21(5):814-828.
    • (2012) Stem Cells Dev , vol.21 , Issue.5 , pp. 814-828
    • Sági, B.1
  • 15
    • 84934907692 scopus 로고    scopus 로고
    • Gastrointestinal fibroblasts have specialized, diverse transcriptional phenotypes: A comprehensive gene expression analysis of human fibroblasts
    • Higuchi Y, et al. (2015) Gastrointestinal fibroblasts have specialized, diverse transcriptional phenotypes: A comprehensive gene expression analysis of human fibroblasts. PLoS One 10(6):e0129241.
    • (2015) PLoS One , vol.10 , Issue.6 , pp. e0129241
    • Higuchi, Y.1
  • 16
    • 84923875836 scopus 로고    scopus 로고
    • Differential responses to steroid hormones in fibroblasts from the vocal fold, trachea, and esophagus
    • Mukudai S, et al. (2015) Differential responses to steroid hormones in fibroblasts from the vocal fold, trachea, and esophagus. Endocrinology 156(3):1000-1009.
    • (2015) Endocrinology , vol.156 , Issue.3 , pp. 1000-1009
    • Mukudai, S.1
  • 17
    • 84867095073 scopus 로고    scopus 로고
    • The architecture of fibroblast monolayers of different origin differentially influences tumor cell growth
    • Flaberg E, et al. (2012) The architecture of fibroblast monolayers of different origin differentially influences tumor cell growth. Int J Cancer 131(10):2274-2283.
    • (2012) Int J Cancer , vol.131 , Issue.10 , pp. 2274-2283
    • Flaberg, E.1
  • 18
    • 84897482366 scopus 로고    scopus 로고
    • Evolutionary aspects of cancer resistance
    • Klein G (2014) Evolutionary aspects of cancer resistance. Semin Cancer Biol 25:10-14.
    • (2014) Semin Cancer Biol , vol.25 , pp. 10-14
    • Klein, G.1
  • 19
    • 84906058912 scopus 로고    scopus 로고
    • The role played by the microenvironment in site-specific metastasis
    • Klein-Goldberg A, Maman S, Witz IP (2014) The role played by the microenvironment in site-specific metastasis. Cancer Lett 352(1):54-58.
    • (2014) Cancer Lett , vol.352 , Issue.1 , pp. 54-58
    • Klein-Goldberg, A.1    Maman, S.2    Witz, I.P.3
  • 20
    • 50549121134 scopus 로고
    • Distribution of secondary growths in cancer of the breast
    • Paget S (1889) Distribution of secondary growths in cancer of the breast. Lancet 133(3421):571-573.
    • (1889) Lancet , vol.133 , Issue.3421 , pp. 571-573
    • Paget, S.1
  • 21
    • 0004090239 scopus 로고    scopus 로고
    • (Lippincott Williams & Wilkins, Philadelphia), 2nd Ed
    • Cormack DH (2001) Essential Histology (Lippincott Williams & Wilkins, Philadelphia), 2nd Ed.
    • (2001) Essential Histology
    • Cormack, D.H.1
  • 22
    • 33645460730 scopus 로고    scopus 로고
    • Bone marrow-derived cells do not contribute significantly to collagen I synthesis in a murine model of renal fibrosis
    • Roufosse C, et al. (2006) Bone marrow-derived cells do not contribute significantly to collagen I synthesis in a murine model of renal fibrosis. J Am Soc Nephrol 17(3): 775-782.
    • (2006) J Am Soc Nephrol , vol.17 , Issue.3 , pp. 775-782
    • Roufosse, C.1
  • 23
    • 7044284840 scopus 로고    scopus 로고
    • A dual reporter gene transgenic mouse demonstrates heterogeneity in hepatic fibrogenic cell populations
    • Magness ST, Bataller R, Yang L, Brenner DA (2004) A dual reporter gene transgenic mouse demonstrates heterogeneity in hepatic fibrogenic cell populations. Hepatology 40(5):1151-1159.
    • (2004) Hepatology , vol.40 , Issue.5 , pp. 1151-1159
    • Magness, S.T.1    Bataller, R.2    Yang, L.3    Brenner, D.A.4
  • 24
    • 33646384428 scopus 로고    scopus 로고
    • Fibroblasts in cancer
    • Kalluri R, Zeisberg M (2006) Fibroblasts in cancer. Nat Rev Cancer 6(5):392-401.
    • (2006) Nat Rev Cancer , vol.6 , Issue.5 , pp. 392-401
    • Kalluri, R.1    Zeisberg, M.2
  • 25
    • 53449094862 scopus 로고    scopus 로고
    • Stromal myofibroblasts are drivers of invasive cancer growth
    • De Wever O, Demetter P, Mareel M, Bracke M (2008) Stromal myofibroblasts are drivers of invasive cancer growth. Int J Cancer 123(10):2229-2238.
    • (2008) Int J Cancer , vol.123 , Issue.10 , pp. 2229-2238
    • De Wever, O.1    Demetter, P.2    Mareel, M.3    Bracke, M.4
  • 26
    • 84876721085 scopus 로고    scopus 로고
    • Carcinoma-associated fibroblasts: Non-neoplastic tumour-promoting mesenchymal cells
    • Polanska UM, Orimo A (2013) Carcinoma-associated fibroblasts: Non-neoplastic tumour-promoting mesenchymal cells. J Cell Physiol 228(8):1651-1657.
    • (2013) J Cell Physiol , vol.228 , Issue.8 , pp. 1651-1657
    • Polanska, U.M.1    Orimo, A.2
  • 27
    • 84893402747 scopus 로고    scopus 로고
    • Longitudinal confocal microscopy imaging of solid tumor destruction following adoptive T cell transfer
    • Schietinger A, et al. (2013) Longitudinal confocal microscopy imaging of solid tumor destruction following adoptive T cell transfer. OncoImmunology 2(11):e26677.
    • (2013) OncoImmunology , vol.2 , Issue.11 , pp. e26677
    • Schietinger, A.1
  • 28
    • 70449701931 scopus 로고    scopus 로고
    • Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow
    • Morikawa S, et al. (2009) Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow. J Exp Med 206(11):2483-2496.
    • (2009) J Exp Med , vol.206 , Issue.11 , pp. 2483-2496
    • Morikawa, S.1
  • 29
    • 0025015168 scopus 로고
    • A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse
    • Moser AR, Pitot HC, Dove WF (1990) A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse. Science 247(4940):322-324.
    • (1990) Science , vol.247 , Issue.4940 , pp. 322-324
    • Moser, A.R.1    Pitot, H.C.2    Dove, W.F.3
  • 30
    • 24944587964 scopus 로고    scopus 로고
    • Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors
    • De Palma M, et al. (2005) Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors. Cancer Cell 8(3):211-226.
    • (2005) Cancer Cell , vol.8 , Issue.3 , pp. 211-226
    • De Palma, M.1
  • 31
    • 84863151366 scopus 로고    scopus 로고
    • Origins of tumor-associated macrophages and neutrophils
    • Cortez-Retamozo V, et al. (2012) Origins of tumor-associated macrophages and neutrophils. Proc Natl Acad Sci USA 109(7):2491-2496.
    • (2012) Proc Natl Acad Sci USA , vol.109 , Issue.7 , pp. 2491-2496
    • Cortez-Retamozo, V.1
  • 32
    • 44349143198 scopus 로고    scopus 로고
    • Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth
    • Purhonen S, et al. (2008) Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth. Proc Natl Acad Sci USA 105(18):6620-6625.
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.18 , pp. 6620-6625
    • Purhonen, S.1
  • 33
    • 84876681730 scopus 로고    scopus 로고
    • IL-22 promotes fibroblast-mediated wound repair in the skin
    • McGee HM, et al. (2013) IL-22 promotes fibroblast-mediated wound repair in the skin. J Invest Dermatol 133(5):1321-1329.
    • (2013) J Invest Dermatol , vol.133 , Issue.5 , pp. 1321-1329
    • McGee, H.M.1
  • 34
    • 0014747850 scopus 로고
    • Wound healing and collagen formation. 6. The origin of the wound fibroblast studied in parabiosis
    • Ross R, Everett NB, Tyler R (1970) Wound healing and collagen formation. VI. The origin of the wound fibroblast studied in parabiosis. J Cell Biol 44(3):645-654.
    • (1970) J Cell Biol , vol.44 , Issue.3 , pp. 645-654
    • Ross, R.1    Everett, N.B.2    Tyler, R.3
  • 35
    • 57149113728 scopus 로고    scopus 로고
    • Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney
    • Lin SL, Kisseleva T, Brenner DA, Duffield JS (2008) Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney. Am J Pathol 173(6):1617-1627.
    • (2008) Am J Pathol , vol.173 , Issue.6 , pp. 1617-1627
    • Lin, S.L.1    Kisseleva, T.2    Brenner, D.A.3    Duffield, J.S.4
  • 36
    • 73649083676 scopus 로고    scopus 로고
    • Fibroblasts/myofibroblasts that participate in cutaneous wound healing are not derived from circulating progenitor cells
    • Barisic-Dujmovic T, Boban I, Clark SH (2010) Fibroblasts/myofibroblasts that participate in cutaneous wound healing are not derived from circulating progenitor cells. J Cell Physiol 222(3):703-712.
    • (2010) J Cell Physiol , vol.222 , Issue.3 , pp. 703-712
    • Barisic-Dujmovic, T.1    Boban, I.2    Clark, S.H.3
  • 37
    • 84927739773 scopus 로고    scopus 로고
    • Skin fibrosis. Identification and isolation of a dermal lineage with intrinsic fibrogenic potential
    • et al.
    • Rinkevich Y, et al. (2015) Skin fibrosis. Identification and isolation of a dermal lineage with intrinsic fibrogenic potential. Science 348(6232):aaa2151.
    • (2015) Science , vol.348 , Issue.6232 , pp. aaa2151
    • Rinkevich, Y.1
  • 38
    • 78650563018 scopus 로고    scopus 로고
    • Autocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts
    • Kojima Y, et al. (2010) Autocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts. Proc Natl Acad Sci USA 107(46):20009-20014.
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.46 , pp. 20009-20014
    • Kojima, Y.1
  • 39
    • 41949136223 scopus 로고    scopus 로고
    • Endothelial-stromal interactions in angiogenesis
    • Hughes CC (2008) Endothelial-stromal interactions in angiogenesis. Curr Opin Hematol 15(3):204-209.
    • (2008) Curr Opin Hematol , vol.15 , Issue.3 , pp. 204-209
    • Hughes, C.C.1
  • 40
    • 42049113189 scopus 로고    scopus 로고
    • Extracellular matrix metalloproteinase inducer/CD147 promotes myofibroblast differentiation by inducing alpha-smooth muscle actin expression and collagen gel contraction: Implications in tissue remodeling
    • Huet E, et al. (2008) Extracellular matrix metalloproteinase inducer/CD147 promotes myofibroblast differentiation by inducing alpha-smooth muscle actin expression and collagen gel contraction: Implications in tissue remodeling. FASEB J 22(4):1144-1154.
    • (2008) FASEB J , vol.22 , Issue.4 , pp. 1144-1154
    • Huet, E.1
  • 41
    • 33645658336 scopus 로고    scopus 로고
    • Extracellular matrix deposition by fibroblasts is necessary to promote capillary-like tube formation in vitro
    • Berthod F, Germain L, Tremblay N, Auger FA (2006) Extracellular matrix deposition by fibroblasts is necessary to promote capillary-like tube formation in vitro. J Cell Physiol 207(2):491-498.
    • (2006) J Cell Physiol , vol.207 , Issue.2 , pp. 491-498
    • Berthod, F.1    Germain, L.2    Tremblay, N.3    Auger, F.A.4
  • 42
    • 0036124520 scopus 로고    scopus 로고
    • Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors
    • Morikawa S, et al. (2002) Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors. Am J Pathol 160(3):985-1000.
    • (2002) Am J Pathol , vol.160 , Issue.3 , pp. 985-1000
    • Morikawa, S.1
  • 43
    • 26844439647 scopus 로고    scopus 로고
    • Mesenchymal stem cells obtained after bone marrow transplantation or peripheral blood stem cell transplantation originate from host tissue
    • Dickhut A, et al. (2005) Mesenchymal stem cells obtained after bone marrow transplantation or peripheral blood stem cell transplantation originate from host tissue. Ann Hematol 84(11):722-727.
    • (2005) Ann Hematol , vol.84 , Issue.11 , pp. 722-727
    • Dickhut, A.1
  • 44
    • 59649091248 scopus 로고    scopus 로고
    • Mesenchymal stem cells remain host-derived independent of the source of the stem-cell graft and conditioning regimen used
    • Bartsch K, et al. (2009) Mesenchymal stem cells remain host-derived independent of the source of the stem-cell graft and conditioning regimen used. Transplantation 87(2):217-221.
    • (2009) Transplantation , vol.87 , Issue.2 , pp. 217-221
    • Bartsch, K.1
  • 45
    • 50849139576 scopus 로고    scopus 로고
    • A perivascular origin for mesenchymal stem cells in multiple human organs
    • Crisan M, et al. (2008) A perivascular origin for mesenchymal stem cells in multiple human organs. Cell Stem Cell 3(3):301-313.
    • (2008) Cell Stem Cell , vol.3 , Issue.3 , pp. 301-313
    • Crisan, M.1
  • 46
    • 50849122983 scopus 로고    scopus 로고
    • All MSCs are pericytes?
    • Caplan AI (2008) All MSCs are pericytes? Cell Stem Cell 3(3):229-230.
    • (2008) Cell Stem Cell , vol.3 , Issue.3 , pp. 229-230
    • Caplan, A.I.1
  • 47
    • 33845983611 scopus 로고    scopus 로고
    • Concise review: Multipotent mesenchymal stromal cells in blood
    • He Q, Wan C, Li G (2007) Concise review: Multipotent mesenchymal stromal cells in blood. Stem Cells 25(1):69-77.
    • (2007) Stem Cells , vol.25 , Issue.1 , pp. 69-77
    • He, Q.1    Wan, C.2    Li, G.3
  • 48
    • 0037541500 scopus 로고    scopus 로고
    • Adult bone marrow is a rich source of human mesenchymal stem cells but umbilical cord and mobilized adult blood are not
    • Wexler SA, et al. (2003) Adult bone marrow is a rich source of human mesenchymal 'stem' cells but umbilical cord and mobilized adult blood are not. Br J Haematol 121(2):368-374.
    • (2003) Br J Haematol , vol.121 , Issue.2 , pp. 368-374
    • Wexler, S.A.1
  • 49
    • 33745503987 scopus 로고    scopus 로고
    • Mesenchymal stem cells reside in virtually all post-natal organs and tissues
    • da Silva Meirelles L, Chagastelles PC, Nardi NB (2006) Mesenchymal stem cells reside in virtually all post-natal organs and tissues. J Cell Sci 119(Pt 11):2204-2213.
    • (2006) J Cell Sci , vol.119 , pp. 2204-2213
    • Da Silva, M.L.1    Chagastelles, P.C.2    Nardi, N.B.3
  • 50
    • 9244236047 scopus 로고    scopus 로고
    • Bone marrow contribution to tumor-associated myofibroblasts and fibroblasts
    • Direkze NC, et al. (2004) Bone marrow contribution to tumor-associated myofibroblasts and fibroblasts. Cancer Res 64(23):8492-8495.
    • (2004) Cancer Res , vol.64 , Issue.23 , pp. 8492-8495
    • Direkze, N.C.1
  • 51
    • 2342485077 scopus 로고    scopus 로고
    • Bystander elimination of antigen loss variants in established tumors
    • Spiotto MT, Rowley DA, Schreiber H (2004) Bystander elimination of antigen loss variants in established tumors. Nat Med 10(3):294-298.
    • (2004) Nat Med , vol.10 , Issue.3 , pp. 294-298
    • Spiotto, M.T.1    Rowley, D.A.2    Schreiber, H.3
  • 52
    • 41849103115 scopus 로고    scopus 로고
    • IFN-gamma- and TNF-dependent bystander eradication of antigen-loss variants in established mouse cancers
    • Zhang B, Karrison T, Rowley DA, Schreiber H (2008) IFN-gamma- and TNF-dependent bystander eradication of antigen-loss variants in established mouse cancers. J Clin Invest 118(4):1398-1404.
    • (2008) J Clin Invest , vol.118 , Issue.4 , pp. 1398-1404
    • Zhang, B.1    Karrison, T.2    Rowley, D.A.3    Schreiber, H.4
  • 53
    • 0344585901 scopus 로고    scopus 로고
    • Tumor rejection by modulation of tumor stromal fibroblasts
    • Schüler T, Körnig S, Blankenstein T (2003) Tumor rejection by modulation of tumor stromal fibroblasts. J Exp Med 198(10):1487-1493.
    • (2003) J Exp Med , vol.198 , Issue.10 , pp. 1487-1493
    • Schüler, T.1    Körnig, S.2    Blankenstein, T.3
  • 54
    • 51649087512 scopus 로고    scopus 로고
    • Effective immunoconjugate therapy in cancer models targeting a serine protease of tumor fibroblasts
    • Ostermann E, et al. (2008) Effective immunoconjugate therapy in cancer models targeting a serine protease of tumor fibroblasts. Clin Cancer Res 14(14):4584-4592.
    • (2008) Clin Cancer Res , vol.14 , Issue.14 , pp. 4584-4592
    • Ostermann, E.1
  • 55
    • 79960478878 scopus 로고    scopus 로고
    • Evaluation of the tumor targeting of a FAPα-based doxorubicin prodrug
    • Huang S, et al. (2011) Evaluation of the tumor targeting of a FAPα-based doxorubicin prodrug. J Drug Target 19(7):487-496.
    • (2011) J Drug Target , vol.19 , Issue.7 , pp. 487-496
    • Huang, S.1
  • 56
    • 67149143399 scopus 로고    scopus 로고
    • Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
    • Olive KP, et al. (2009) Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science 324(5933):1457-1461.
    • (2009) Science , vol.324 , Issue.5933 , pp. 1457-1461
    • Olive, K.P.1
  • 57
    • 84858602107 scopus 로고    scopus 로고
    • Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma
    • Provenzano PP, et al. (2012) Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma. Cancer Cell 21(3): 418-429.
    • (2012) Cancer Cell , vol.21 , Issue.3 , pp. 418-429
    • Provenzano, P.P.1
  • 58
    • 0037219532 scopus 로고    scopus 로고
    • Stromal antigen targeting by a humanised monoclonal antibody: An early phase II trial of sibrotuzumab in patients with metastatic colorectal cancer
    • Hofheinz RD, et al. (2003) Stromal antigen targeting by a humanised monoclonal antibody: An early phase II trial of sibrotuzumab in patients with metastatic colorectal cancer. Onkologie 26(1):44-48.
    • (2003) Onkologie , vol.26 , Issue.1 , pp. 44-48
    • Hofheinz, R.D.1
  • 59
    • 41849147200 scopus 로고    scopus 로고
    • Phase II trial of single agent Val-boroPro (talabostat) inhibiting fibroblast activation protein in patients with metastatic colorectal cancer
    • Narra K, et al. (2007) Phase II trial of single agent Val-boroPro (talabostat) inhibiting fibroblast activation protein in patients with metastatic colorectal cancer. Cancer Biol Ther 6(11):1691-1699.
    • (2007) Cancer Biol Ther , vol.6 , Issue.11 , pp. 1691-1699
    • Narra, K.1
  • 60
    • 67649666985 scopus 로고    scopus 로고
    • Phase II trial of talabostat and docetaxel in advanced non-small cell lung cancer
    • Eager RM, et al. (2009) Phase II trial of talabostat and docetaxel in advanced non-small cell lung cancer. Clin Oncol (R Coll Radiol) 21(6):464-472.
    • (2009) Clin Oncol (R Coll Radiol) , vol.21 , Issue.6 , pp. 464-472
    • Eager, R.M.1
  • 61
    • 78149298209 scopus 로고    scopus 로고
    • Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alpha
    • Kraman M, et al. (2010) Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alpha. Science 330(6005):827-830.
    • (2010) Science , vol.330 , Issue.6005 , pp. 827-830
    • Kraman, M.1
  • 62
    • 7944220831 scopus 로고    scopus 로고
    • Mesenchymal stem cells: Potential precursors for tumor stroma and targeted-delivery vehicles for anticancer agents
    • Studeny M, et al. (2004) Mesenchymal stem cells: Potential precursors for tumor stroma and targeted-delivery vehicles for anticancer agents. J Natl Cancer Inst 96(21): 1593-1603.
    • (2004) J Natl Cancer Inst , vol.96 , Issue.21 , pp. 1593-1603
    • Studeny, M.1
  • 63
    • 0037309642 scopus 로고    scopus 로고
    • DNase I-hypersensitive sites enhance alpha1(I) collagen gene expression in hepatic stellate cells
    • Yata Y, et al. (2003) DNase I-hypersensitive sites enhance alpha1(I) collagen gene expression in hepatic stellate cells. Hepatology 37(2):267-276.
    • (2003) Hepatology , vol.37 , Issue.2 , pp. 267-276
    • Yata, Y.1
  • 64
    • 0026547421 scopus 로고
    • Stroma is critical for preventing or permitting immunological destruction of antigenic cancer cells
    • Singh S, Ross SR, Acena M, Rowley DA, Schreiber H (1992) Stroma is critical for preventing or permitting immunological destruction of antigenic cancer cells. JExp Med 175(1):139-146.
    • (1992) JExp Med , vol.175 , Issue.1 , pp. 139-146
    • Singh, S.1    Ross, S.R.2    Acena, M.3    Rowley, D.A.4    Schreiber, H.5
  • 65
    • 0031030349 scopus 로고    scopus 로고
    • The immunodominant antigen of an ultraviolet-induced regressor tumor is generated by a somatic point mutation in the DEAD box helicase p68
    • Dubey P, et al. (1997) The immunodominant antigen of an ultraviolet-induced regressor tumor is generated by a somatic point mutation in the DEAD box helicase p68. J Exp Med 185(4):695-705.
    • (1997) J Exp Med , vol.185 , Issue.4 , pp. 695-705
    • Dubey, P.1
  • 66
    • 0022536155 scopus 로고
    • A new approach to the therapy of cancer based on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2
    • Rosenberg SA, et al. (1986) A new approach to the therapy of cancer based on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2. Surgery 100(2):262-272.
    • (1986) Surgery , vol.100 , Issue.2 , pp. 262-272
    • Rosenberg, S.A.1
  • 67
    • 84862520770 scopus 로고    scopus 로고
    • Fiji: An open-source platform for biological-image analysis
    • Schindelin J, et al. (2012) Fiji: An open-source platform for biological-image analysis. Nat Methods 9(7):676-682.
    • (2012) Nat Methods , vol.9 , Issue.7 , pp. 676-682
    • Schindelin, J.1
  • 68
    • 0035976526 scopus 로고    scopus 로고
    • Physiological migration of hematopoietic stem and progenitor cells
    • Wright DE, Wagers AJ, Gulati AP, Johnson FL, Weissman IL (2001) Physiological migration of hematopoietic stem and progenitor cells. Science 294(5548):1933-1936.
    • (2001) Science , vol.294 , Issue.5548 , pp. 1933-1936
    • Wright, D.E.1    Wagers, A.J.2    Gulati, A.P.3    Johnson, F.L.4    Weissman, I.L.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.