The architecture of fibroblast monolayers of different origin differentially influences tumor cell growth

International Journal of Cancer

Volumn 131, Issue 10, 2012, Pages 2274-2283

  Flaberg, Emilie ^a   Guven, Hayrettin ^a   Savchenko, Andrii ^a   Pavlova, Tatiana ^a   Kashuba, Vladimir ^a,b   Szekely, Laszlo ^a   Klein, George ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b INSTITUTE OF MOLECULAR BIOLOGY AND GENETICS   (Ukraine)

Author keywords

cancer associated fibroblasts; fibroblasts; stroma; Tumor microenvironment

Indexed keywords

ADULT; ARTICLE; CANCER INHIBITION; CELL CLONING; CELL CONTACT; CELL COUNT; CELL FUNCTION; CELL IMMORTALIZATION; CELL MATURATION; CELL MEMBRANE; CELL MOTILITY; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CHILD; COCULTURE; CONTROLLED STUDY; CYTOARCHITECTURE; EX VIVO STUDY; EXPLANT; FIBROBLAST; GENE EXPRESSION; GENE SEGREGATION; HERNIA; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MOLECULAR MECHANICS; PHENOTYPE; PRIORITY JOURNAL; SKIN FIBROBLAST; TIME LAPSE IMAGING; TUMOR GROWTH; TUMOR MICROENVIRONMENT; TUMOR SEEDING;

ANIMALS; CELL COMMUNICATION; CELL LINE, TRANSFORMED; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CLUSTER ANALYSIS; COCULTURE TECHNIQUES; CONTACT INHIBITION; FIBROBLASTS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; MICE; NEOPLASMS; PHENOTYPE; PRIMARY CELL CULTURE; TUMOR MICROENVIRONMENT;

EID: 84867095073     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.27521     Document Type: Article

References (23)

1. Allen M, Jones JL,. Jekyll and Hyde: the role of the microenvironment on the progression of cancer. J Pathol 2011; 223: 162-176.
2. Bissell MJ, Hines WC,. Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression. Nat Med 2011; 17: 320-29.
3. Klein G,. Toward a genetics of cancer resistance. Proc Natl Acad Sci USA 2009; 106: 859-63.
4. Klein G, Imreh S, Zabarovsky ER,. Why do we not all die of cancer at an early age? Adv Cancer Res 2007; 98: 1-16.
5. Bredberg A,. Cancer resistance and Peto's paradox. Proc Natl Acad Sci USA 2009; 106: E51; author reply E52.
6. Caulin AF, Maley CC,. Peto's Paradox: evolution's prescription for cancer prevention. Trends Ecol Evol 2011; 26: 175-182.
7. Beliveau A, Mott JD, Lo A, Chen EI, Koller AA, Yaswen P, Muschler J, Bissell MJ,. Raf-induced MMP9 disrupts tissue architecture of human breast cells in three-dimensional culture and is necessary for tumor growth in vivo. Genes Dev 2010; 24: 2800-11.
8. Itoh M, Nelson CM, Myers CA, Bissell MJ,. Rap1 integrates tissue polarity, lumen formation, and tumorigenic potential in human breast epithelial cells. Cancer Res 2007; 67: 4759-66.
9. Partanen JI, Nieminen AI, Makela TP, Klefstrom J,. Suppression of oncogenic properties of c-Myc by LKB1-controlled epithelial organization. Proc Natl Acad Sci USA 2007; 104: 14694-99.
10. Partanen JI, Nieminen AI, Klefstrom J,. 3D view to tumor suppression: Lkb1, polarity and the arrest of oncogenic c-Myc. Cell Cycle 2009; 8: 716-724.
11. Erez N, Truitt M, Olson P, Arron ST, Hanahan D,. Cancer-associated fibroblasts are activated in incipient neoplasia to orchestrate tumor-promoting inflammation in an NF-kappaB-dependent manner. Cancer Cell 2010; 17: 135-147.
12. Stoker M., Regulation of growth and orientation in hamster cells transformed by polyoma virus. Virology 1964; 24: 165-174.
13. Stoker MG, Shearer M, O'Neill C,. Growth inhibition of polyoma-transformed cells by contact with static normal fibroblasts. J Cell Sci 1966; 1: 297-310.
14. Goetz JG, Minguet S, Navarro-Lerida I, Lazcano JJ, Samaniego R, Calvo E, Tello M, Osteso-Ibanez T, Pellinen T, Echarri A, Cerezo A, Klein-Szanto AJ, et al. Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis. Cell 2011; 146: 148-163.
15. Ostman, A,. and, Augsten, M,. Cancer-associated fibroblasts and tumor growth-bystanders turning into key players. Curr Opin Genet Dev 2009; 19: 67-73.
16. Flaberg E, Sabelstrom P, Strandh C, Szekely L,. Extended field laser confocal microscopy (EFLCM): combining automated Gigapixel image capture with in silico virtual microscopy. BMC Med Imaging 2008; 8: 1-13.
17. Flaberg E, Markasz L, Petranyi G, Stuber G, Dicso F, Alchihabi N, Olah E, Csizy I, Jozsa T, Andren O, Johansson JE, Andersson SO, et al. High-throughput live-cell imaging reveals differential inhibition of tumor cell proliferation by human fibroblasts. Int J Cancer 2011; 128: 2793-2802.
18. Bodnar AG, Ouellette M, Frolkis M, Holt SE, Chiu CP, Morin GB, Harley CB, Shay JW, Lichtsteiner S, Wright WE,. Extension of life-span by introduction of telomerase into normal human cells. Science 1998; 279: 349-352.
19. Stranneheim H, Werne B, Sherwood E, Lundeberg J,. Scalable transcriptome preparation for massive parallel sequencing. PLoS One 2011; 6: e21910.
20. Bilder D,. Epithelial polarity and proliferation control: links from the Drosophila neoplastic tumor suppressors. Genes Dev 2004; 18: 1909-1925.
21. Pagliarini RA, Xu T,. A genetic screen in Drosophila for metastatic behavior. Science 2003; 302: 1227-1231.
22. Alberts B,. Molecular biology of the cell. 5th edn. New York: Garland Science, 2008
23. Royer C, Lu X,. Epithelial cell polarity: a major gatekeeper against cancer? Cell Death Differ 2011; 18: 1470-77.