Endothelial-stromal interactions in angiogenesis

Current Opinion in Hematology

Volumn 15, Issue 3, 2008, Pages 204-209

  Hughes, Christopher C W ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Angiogenesis; Endothelial; Extracellular matrix; Myofibroblast; Pericyte; Tumor stroma

Indexed keywords

FIBROBLAST GROWTH FACTOR; GROWTH FACTOR; METALLOPROTEINASE; MORPHOGEN; TRANSFORMING GROWTH FACTOR BETA;

ANGIOGENESIS; CANCER THERAPY; CELL INTERACTION; ENDOTHELIUM CELL; ENZYME INDUCTION; EXTRACELLULAR MATRIX; FIBROBLAST; GENE EXPRESSION; HUMAN; NONHUMAN; PERICYTE; PHENOTYPE; PRIORITY JOURNAL; REVIEW; STROMA CELL; TUMOR CELL; TUMOR GROWTH;

CELL COMMUNICATION; ENDOTHELIAL CELLS; EXTRACELLULAR MATRIX; FIBROBLASTS; HUMANS; NEOVASCULARIZATION, PATHOLOGIC; NEOVASCULARIZATION, PHYSIOLOGIC; PERICYTES; WOUND HEALING;

EID: 41949136223     PISSN: 10656251     EISSN: 15317048     Source Type: Journal    
DOI: 10.1097/MOH.0b013e3282f97dbc     Document Type: Review

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55. •], this study shows that an increase in pericyte recruitment to tumor vasculature slows tumor growth. Blocking of the PDGF receptor led to a decrease in pericytes in the tumor and an increase in tumor growth. The implication of these two studies is that the balance of pericyte numbers is critical for optimal tumor growth - too many and the vessels are stabilized, thereby restricting sprouting, too few and the vessels are too unstable to support adequate blood flow. Either way, the tumor growth is reduced.