Identification of fumarate hydratase inhibitors with nutrient-dependent cytotoxicity

Journal of the American Chemical Society

Volumn 137, Issue 2, 2015, Pages 564-567

  Takeuchi, Toshifumi ^a   Schumacker, Paul T ^b   Kozmin, Sergey A ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; CYTOTOXICITY; ENZYMES; METABOLISM; NUTRIENTS; STRUCTURAL OPTIMIZATION; THROUGHPUT;

ANTI-PROLIFERATIVE ACTIVITIES; HIGH-THROUGHPUT SCREENS; MITOCHONDRIAL OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION RATE; PHARMACOLOGICAL INHIBITION; PHARMACOLOGICAL INHIBITORS; PHOTOAFFINITY LABELING; TRICARBOXYLIC ACID CYCLE;

ENZYME INHIBITION;

FUMARATE HYDRATASE; FUMARIC ACID DERIVATIVE; ENZYME INHIBITOR; GLUCOSE;

AFFINITY LABELING; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL LINE; CELL CULTURE; CELL GROWTH; CITRIC ACID CYCLE; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME INHIBITION; GROWTH INHIBITION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IN VITRO STUDY; OXIDATIVE PHOSPHORYLATION; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; DRUG SCREENING; ENERGY METABOLISM; METABOLISM; TUMOR CELL LINE;

CELL LINE, TUMOR; CITRIC ACID CYCLE; DRUG EVALUATION, PRECLINICAL; ENERGY METABOLISM; ENZYME INHIBITORS; FUMARATE HYDRATASE; GLUCOSE; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS;

EID: 84921493887     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja5101257     Document Type: Article

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