Inability to activate Rac1-dependent forgetting contributes to behavioral inflexibility in mutants of multiple autism-risk genes

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 27, 2016, Pages 7644-7649

  Dong, Tao ^a   He, Jing ^b   Wang, Shiqing ^a   Wang, Lianzhang ^a   Cheng, Yuqi ^c   Zhong, Yi ^a,d  

^a Tsinghua University   (China)

^b PEKING UNIVERSITY   (China)

^c KUNMING MEDICAL UNIVERSITY   (China)

^d BEIJING INSTITUTE FOR BRAIN DISORDERS   (China)

Author keywords

Autism; Behavioral flexibility; Drosophila; Forgetting; Rac1

Indexed keywords

BOTULINUM TOXIN; FRAGILE X MENTAL RETARDATION PROTEIN; RAC1 PROTEIN; DROSOPHILA PROTEIN; FMR1 PROTEIN, DROSOPHILA; NERVE CELL ADHESION MOLECULE; NEUROLIGIN 4 PROTEIN, DROSOPHILA; NRX PROTEIN, DROSOPHILA; TSC1 PROTEIN, DROSOPHILA; UBE3A PROTEIN, DROSOPHILA; UBIQUITIN PROTEIN LIGASE;

ANIMAL BEHAVIOR; ARTICLE; AUTISM; CONTROLLED STUDY; DOWN REGULATION; DROSOPHILA; HEAT SHOCK; LEARNING; LOSS OF FUNCTION MUTATION; MEMORY; MUSHROOM BODY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; UBIQUITINATION; ANIMAL; GENETICS; MUTATION; PHYSIOLOGY;

ANIMALS; AUTISTIC DISORDER; CELL ADHESION MOLECULES, NEURONAL; DROSOPHILA; DROSOPHILA PROTEINS; FRAGILE X MENTAL RETARDATION PROTEIN; MUTATION; RAC1 GTP-BINDING PROTEIN; REVERSAL LEARNING; UBIQUITIN-PROTEIN LIGASES;

EID: 84977267633     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1602152113     Document Type: Article

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