Synaptic P-Rex1 signaling regulates hippocampal longterm depression and autism-like social behavior

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 50, 2015, Pages E6964-E6972

  Li, Jun ^a,b   Chai, Anping ^c,d   Wang, Lifang ^a,b   Ma, Yuanlin ^a,b   Wu, Zhiliu ^a,b   Yu, Hao ^a,b   Mei, Liwei ^a,b   Lu, Lin ^a,b   Zhang, Chen ^b   Yue, Weihua ^a,b   Xu, Lin ^c,d   Rao, Yi ^b   Zhang, Dai ^a,b  

^a PEKING UNIVERSITY SIXTH HOSPITAL   (China)

^b PEKING UNIVERSITY   (China)

^c KUNMING INSTITUTE OF ZOOLOGY   (China)

^d CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

AMPA receptor endocytosis; Autism; Long term depression; P Rex1; Social recognition

Indexed keywords

AMPA RECEPTOR; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; GUANINE NUCLEOTIDE EXCHANGE FACTOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE DEPENDENT RAC EXCHANGE FACTOR; SYNAPTOPHYSIN; UNCLASSIFIED DRUG; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PREX1 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; AUTISM; COGNITION; CONFERENCE PAPER; CONTROLLED STUDY; DEPRESSION; ENDOCYTOSIS; EXCITATORY POSTSYNAPTIC POTENTIAL; GENE DELETION; GENE DOSAGE; GENE FREQUENCY; GENE SILENCING; GENETIC ASSOCIATION; GENETIC VARIABILITY; HAN CHINESE; HAPLOTYPE; HIPPOCAMPAL CA1 REGION; HIPPOCAMPUS; LONG TERM DEPRESSION; MALE; MOTOR COORDINATION; MOUSE; NONHUMAN; POSTSYNAPTIC DENSITY; PRIORITY JOURNAL; PROMOTER REGION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SOCIAL BEHAVIOR; SOCIAL INTERACTION; SOCIAL LEARNING; SPATIAL LEARNING; SYNAPTIC TRANSMISSION; ANIMAL; COPY NUMBER VARIATION; GENETICS; HUMAN; KNOCKOUT MOUSE; METABOLISM; PATHOPHYSIOLOGY; PSYCHOLOGY; SYNAPSE;

ANIMALS; AUTISTIC DISORDER; CA1 REGION, HIPPOCAMPAL; DNA COPY NUMBER VARIATIONS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; LONG-TERM SYNAPTIC DEPRESSION; MICE; MICE, KNOCKOUT; RECEPTORS, N-METHYL-D-ASPARTATE; SIGNAL TRANSDUCTION; SOCIAL BEHAVIOR; SYNAPSES;

EID: 84950325742     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1512913112     Document Type: Article

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