STING-Dependent 2′-5′ Oligoadenylate Synthetase-Like Production Is Required for Intracellular Mycobacterium leprae Survival

Journal of Infectious Diseases

Volumn 214, Issue 2, 2016, Pages 311-320

  De Toledo Pinto, Thiago Gomes ^a   Ferreira, Anna Beatriz Robottom ^a   Ribeiro Alves, Marcelo ^a,c   Rodrigues, Luciana Silva ^b   Batista Silva, Leonardo Ribeiro ^a   Silva, Bruno Jorge De Andrade ^a   Lemes, Robertha Mariana Rodrigues ^b   Martinez, Alejandra Nóbrega ^a   Sandoval, Felipe Galvan ^e,f   Alvarado Arnez, Lucia Elena ^a   Rosa, Patrícia Sammarco ^d   Shannon, Edward Joseph ^e,f   Pessolani, Maria Cristina Vidal ^b   Pinheiro, Roberta Olmo ^a   Antunes, Srgio Luís Gomes ^a   Sarno, Euzenir Nunes ^a   Lara, Flávio Alves ^b   Williams, DIana Lynn ^e,f   Ozório Moraes, Milton ^a  

^a IOC Fiocruz   (Brazil)

^b INSTITUTO OSWALDO CRUZ   (Brazil)

^c Funda??o Oswaldo Cruz   (Brazil)

^d INSTITUTO LAURO DE SOUZA LIMA   (Brazil)

^e Bureau of Primary Health Care   (Brazil)

^f LOUISIANA STATE UNIVERSITY   (United States)

Author keywords

Autophagy; Cytoplasmic DNA sensing; Leprosy; Mycobacterium leprae; OASL; Type I IFN

Indexed keywords

2',5' OLIGOADENYLATE SYNTHETASE; EXTRACHROMOSOMAL DNA; INTERFERON; MONOCYTE CHEMOTACTIC PROTEIN 1; POLYPEPTIDE ANTIBIOTIC AGENT; MEMBRANE PROTEIN; MPYS PROTEIN, HUMAN; OASL PROTEIN, HUMAN;

ARTICLE; BACTERIAL GENE; BACTERIAL SURVIVAL; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DOWN REGULATION; ENZYME SYNTHESIS; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; IFN GENE; IMMUNE RESPONSE; INTRACELLULAR SPACE; LEPROSY; MACROPHAGE; MONOCYTE; MYCOBACTERIUM BOVIS BCG; MYCOBACTERIUM LEPRAE; NONHUMAN; OASL GENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCHWANN CELL; SKIN; UPREGULATION; CELL CULTURE; EPITHELIUM CELL; HOST PATHOGEN INTERACTION; METABOLISM; MICROBIAL VIABILITY; MICROBIOLOGY; MYCOBACTERIUM BOVIS; PATHOLOGY; PHYSIOLOGY;

2',5'-OLIGOADENYLATE SYNTHETASE; CELLS, CULTURED; EPITHELIAL CELLS; GENE EXPRESSION PROFILING; GENE KNOCKDOWN TECHNIQUES; HOST-PATHOGEN INTERACTIONS; HUMANS; LEPROSY; MACROPHAGES; MEMBRANE PROTEINS; MICROBIAL VIABILITY; MYCOBACTERIUM BOVIS; MYCOBACTERIUM LEPRAE; SCHWANN CELLS;

EID: 84977109209     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jiw144     Document Type: Article

References (34)

1. van derWel N, Hava D, Houben D, et al. M. tuberculosis and M. leprae translocate from the phagolysosome to the cytosol in myeloid cells. Cell 2007; 129:1287-98.
2. Stanley SA, Johndrow JE, Manzanillo P, Cox JS. The type I IFN response to infection with Mycobacterium tuberculosis requires ESX-1-mediated secretion and contributes to pathogenesis. J Immunol 2007; 178:3143-52.
3. Abdallah AM, Bestebroer J, Savage NDL, et al. Mycobacterial secretion systems ESX-1 and ESX-5 play distinct roles in host cell death and inflammasome activation. J Immunol 2011; 187:4744-53.
4. Houben D, Demangel C, van Ingen J, et al. ESX-1-mediated translocation to the cytosol controls virulence of mycobacteria. Cell Microbiol 2012; 14:1287-98.
5. Manzanillo PS, Shiloh MU, Portnoy DA, Cox JS. Mycobacterium tuberculosis activates the DNA-dependent cytosolic surveillance pathway within macrophages. Cell Host Microbe 2012; 11:469-80.
6. Berry MPR, Graham CM, McNab FW, et al. An interferon-inducible neutrophildriven blood transcriptional signature in human tuberculosis. Nature 2010; 466:973-7.
7. Maertzdorf J, Repsilber D, Parida SK, et al. Human gene expression profiles of susceptibility and resistance in tuberculosis. Genes Immun 2011; 12:15-22.
8. Teles RMB, Graeber TG, Krutzik SR, et al. Type I interferon suppresses type II interferon-triggered human anti-mycobacterial responses. Science 2013; 339:1448-53.
9. Dey B, Dey RJ, Cheung LS, et al. A bacterial cyclic dinucleotide activates the cytosolic surveillance pathway and mediates innate resistance to tuberculosis. Nat Med 2015; 21:401-6.
10. Wassermann R, Gulen MF, Sala C, et al. Mycobacterium tuberculosis differentially activates cGAS-and inflammasome-Dependent intracellular immune responses through ESX-1. Cell Host Microbe 2015; 17:799-810.
11. Collins AC, Cai H, Li T, et al. Cyclic GMP-AMP synthase is an innate immune DNA sensor for mycobacterium tuberculosis. Cell Host Microbe 2015; 17:820-8.
12. Watson RO, Bell SL, MacDuff DA, et al. The cytosolic sensor cGAS detects mycobacterium tuberculosis DNA to induce type I interferons and activate autophagy. Cell Host Microbe 2015; 17:811-9.
13. Ridley DS, Jopling WH. Classification of leprosy according to immunity. a fivegroup system. Int J Lepr Mycobact Dis 1966; 34:255-73.
14. Hagge DA, Oby Robinson S, Scollard D, McCormick G, Williams DL. A new model for studying the effects of Mycobacterium leprae on Schwann cell and neuron interactions. J Infect Dis 2002; 186:1283-96.
15. Adams LB, Gillis TP, Hwang DH, Krahenbuhl JL. Effects of essential fatty acid deficiency on prostaglandin E2 production and cell-mediated immunity in a mouse model of leprosy. Infect Immun 1997; 65:1152-7.
16. Lahiri R, Randhawa B, Krahenbuhl JL. Infection of mouse macrophages with viable Mycobacterium leprae does not induce apoptosis. J Infect Dis 2010; 201:1736-42.
17. Charlab R, Sarno EN, Chatterjee D, Pessolani MC. Effect of unique Mycobacterium leprae phenolic glycolipid-I (PGL-I) on tumour necrosis factor production by human mononuclear cells. Lepr Rev 2001; 72:63-9.
18. Martinez AN, Lahiri R, Pittman TL, et al. Molecular determination of Mycobacterium leprae viability by use of real-time PCR. J Clin Microbiol 2009; 47:2124-30.
19. Irizarry RA, Hobbs B, Collin F, et al. Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostat 2003; 4:249-64.
20. Smyth GK. Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol 2004; 3:1-25.
21. Tusher VG, Tibshirani R, Chu G. Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci U S A 2001; 98:5116-21.
22. Benjamini Y, Drai D, Elmer G, Kafkafi N, Golani I. Controlling the false discovery rate in behavior genetics research. Behav Brain Res 2001; 125:279-84.
23. Guerreiro LTA, Robottom-Ferreira AB, Ribeiro-Alves M, et al. Gene expression profiling specifies chemokine, mitochondrial and lipid metabolism signatures in leprosy. PLoS One 2013; 8:e64748.
24. Ritz C, Spiess A-N. qpcR: an R package for sigmoidal model selection in quantitative real-time polymerase chain reaction analysis. Bioinformatics 2008; 24:1549-51.
25. Mattos KA, Lara FA, Oliveira VGC, et al. Modulation of lipid droplets by Mycobacterium leprae in Schwann cells: a putative mechanism for host lipid acquisition and bacterial survival in phagosomes. Cell Microbiol 2011; 13:259-73.
26. Tanaka Y, Chen ZJ. STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway. Sci Signal 2012; 5:ra20.
27. Mahairas GG, Sabo PJ, Hickey MJ, Singh DC, Stover CK. Molecular analysis of genetic differences between Mycobacterium bovis BCG and virulent M. bovis. J Bacteriol 1996; 178:1274-82.
28. Sonawane A, Santos JC, Mishra BB, et al. Cathelicidin is involved in the intracellular killing of mycobacteria in macrophages. Cell Microbiol 2011; 13:1601-17.
29. Liu PT, Stenger S, Li H, et al. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science 2006; 311:1770-3.
30. Zhu J, Zhang Y, Ghosh A, et al. Antiviral activity of human OASL protein ismediated by enhancing signaling of the RIG-I RNA sensor. Immunity 2014; 40:936-48.
31. Watson RO, Manzanillo PS, Cox JS. Extracellular M. tuberculosis DNA targets bacteria for autophagy by activating the host DNA-sensing pathway. Cell 2012; 150:803-15.
32. Manzanillo PS, Ayres JS, Watson RO, et al. The ubiquitin ligase parkin mediates resistance to intracellular pathogens. Nature 2013; 501:512-6.
33. de Leseleuc L, Orlova M, Cobat A, et al. PARK2 mediates interleukin 6 and monocyte chemoattractant protein 1 production by human macrophages. PLoS Negl Trop Dis 2013; 7:e2015.
34. Urin V, Levin D, Sharma N, et al. Fine tuning of a type 1 interferon antagonist. PLoS One 2015; 10:e0130797.