Cathelicidin is involved in the intracellular killing of mycobacteria in macrophages

Cellular Microbiology

Volumn 13, Issue 10, 2011, Pages 1601-1617

  Sonawane, Avinash ^a,b   Santos, José Carlos ^c   Mishra, Bibhuti B ^d   Jena, Prajna ^a   Progida, Cinzia ^e   Sorensen, Ole E ^f   Gallo, Richard ^g   Appelberg, Rui ^c   Griffiths, Gareth ^e  

^a KIIT UNIVERSITY   (India)

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^c UNIVERSITY OF PORTO   (Portugal)

^d UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^e UNIVERSITY OF OSLO   (Norway)

^f LUND UNIVERSITY   (Sweden)

^g UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITRIOL; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; MESSENGER RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; GENE OVEREXPRESSION; IN VITRO STUDY; INTRACELLULAR KILLING; LYSOSOME; MACROPHAGE; MOUSE; MYCOBACTERIUM; MYCOBACTERIUM BOVIS; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PHAGOSOME; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RNA INTERFERENCE; UPREGULATION;

ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; BIOLOGICAL AGENTS; CELLS, CULTURED; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMANS; MACROPHAGES; MICE; MICE, KNOCKOUT; MICROBIAL VIABILITY; MYCOBACTERIUM BOVIS; MYCOBACTERIUM SMEGMATIS; RECOMBINANT PROTEINS;

CORYNEBACTERINEAE; MURINAE; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS;

EID: 80052794411     PISSN: 14625814     EISSN: 14625822     Source Type: Journal    
DOI: 10.1111/j.1462-5822.2011.01644.x     Document Type: Article

References (47)

1. Agerberth, B., Charo, J., Werr, J., Olsson, B., Idali, F., Lindbom, L., etal. (2000) The human antimicrobial and chemotactic peptides LL-37 and alpha-defensins are expressed by specific lymphocyte and monocyte populations. Blood 96: 3086-3093.
2. Anderson, R.M. (1999) The pandemic of antibiotic resistance. Nat Med 5: 147-149.
3. Anes, E., Kühnel, M.P., Bos, E., Moniz-Pereira, J., Habermann, A., and Griffiths, G. (2003) Selected lipids activate phagosome actin assembly and maturation resulting in killing of pathogenic mycobacteria. Nat Cell Biol 5: 793-802.
4. Anes, E., Peyron, P., Staali, L., Jordao, L., Gutierrez, M.G., Kress, H., etal. (2006) Dynamic life and death interactions between Mycobacterium smegmatis and J774 macrophages. Cell Microbiol 8: 939-960.
5. Armstrong, J.A., and Hart, P.D. (1971) Response of cultured macrophages to Mycobacterium tuberculosis with observations of fusion of lysosomes with phagosomes. J Exp Med 134: 713-740.
6. Bals, R., and Wilson, J.M. (2003) Cathelicidins - a family of multifunctional antimicrobial peptides. Cell Mol Life Sci 60: 711-720.
7. Bergman, P., Johansson, L., Asp, V., Plant, L., Gudmundsson, G.H., Jonsson, A.B., and Agerberth, B. (2005) Neisseria gonorrhoeae downregulates expression of the human antimicrobial peptide LL-37. Cell Microbiol 7: 1009-1017.
8. Bülow, E., Bengtsson, N., Calafat, J., Gullberg, U., and Olsson, I. (2002) Sorting of neutrophil-specific granule protein human cathelicidin, hCAP-18, when constitutively expressed in myeloid cells. J Leukoc Biol 72: 147-153.
9. Castro, M.S., and Fontes, W. (2005) Plant defense and antimicrobial peptides. Protein Pept Lett 12: 11-16.
10. Chan, J., Tanaka, K., Carroll, D., Flynn, J., and Bloom, B.R. (1995) Effects of nitric oxide synthase inhibitors on murine infection with Mycobacterium tuberculosis. Infect Immun 63: 736.
11. Douvas, G., Looker, D.L., Vatter, A.E., and Crowle, A.J. (1985) Gamma interferon activates human macrophages to become tumoricidal and leishmanicidal but enhances replication of macrophage-associated mycobacteria. Infect Immun 50: 1-8.
12. Dye, C., Williams, B.G., Espinal, M.A., and Raviglone, M.C. (2002) Erasing the world's slow stain: strategies to beat multidrug-resistant tuberculosis. Science 295: 2042-2046.
13. Fisher, M. (2002) Diagnosis of MDR-TB: a developing world problem on a developed world budget. Expert Rev Mol Diagn 2: 151-159.
14. Flesch, I., and Kaufmann, S.H.E. (1990) Activation of tuberculostatic macrophage functions by gamma interferon, interleukin-4, and tumor necrosis factor. Infect Immun 58: 2675-2677.
15. Flynn, J.L., and Chan, J. (2001) Immunology of tuberculosis. Annu Rev Immunol 19: 93-129.
16. Fratti, R.A., Chua, J., Vergne, I., and Deretic, V. (2003) Mycobacterium tuberculosis glycosylated phosphatidylinositol causes phagosome maturation arrest. Proc Natl Acad Sci USA 100: 5437-5442.
17. Gallo, R., Kim, K., Bernfield, M., Kozak, C., Zanetti, M., Merluzzi, L., and Gennaro, R. (1997) Identification of CRAMP, a cathelin-related antimicrobial peptide expressed in the embryonic and adult mouse. J Biol Chem 272: 13088-13093.
18. Gomes, M.S., Fernandes, S.S., Cordeiro, J.V., Silva Gomes, S., Vieira, A., and Appelberg, R. (2008) Engagement of Toll-like receptor 2 in mouse macrophages infected withMycobacterium avium induces non-oxidative and TNF-independent anti-mycobacterial activity. Eur J Immunol 38: 2180-2189.
19. Gottlieb, S.F., Rose, N.R., Maurizi, J., and Lanphier, E.H. (1964) Oxygen inhibition of growth of Mycobacterium tuberculosis. J Bacteriol 87: 838.
20. Gutierrez, M.G., Master, S.S., Singh, S.B., Taylor, G.A., Colombo, M.I., and Deretic, V. (2004) Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. Cell 119: 753-766.
21. Gutierrez, M.G., Mishra, B.B., Jordao, L., Elliott, E., Anes, E., and Griffiths, G. (2008) NF-B activation controls phagolysosome fusion-mediated killing of mycobacteria by macrophages. J Immunol 181: 2651-2663.
22. Islam, D., Bandholtz, L., Nilsson, J., Wigzell, H., Christensson, B., Agerberth, B., and Gudmundsson, G.H. (2001) Downregulation of bactericidal peptides in enteric infections: a novel immune escape mechanism with bacterial DNA as a potential regulator. Nat Med 7: 180-185.
23. Jackett, P.S., Aber, V.R., and Lowrie, D.B. (1978) Virulence of Mycobacterium tuberculosis and susceptibility to peroxidative killing systems. J Gen Microbiol 107: 273.
24. Jackett, P.S., Andrew, P.W., Aber, V.R., and Lowrie, D.B. (1981) Hydrogenperoxide and superoxide release by alveolar macrophages from normal and BCG vaccinated guinea-pigs after intravenous challenge with Mycobacterium tuberculosis. Br J Exp Pathol 62: 419.
25. Jann, N.J., Schmaler, M., Radek, K., Gallo, R., Nizet, V., Peschel, A., and Landmann, R. (2009) Neutrophil antimicrobial defense against Staphylococcus aureus is mediated by phagolysosomal but not extracellular trap-associated cathelicidin. J Leukoc Biol 86: 1159-1169.
26. Jena, P., Mishra, B., Leippe, M., Hasilik, A., Griffiths, G., and Sonawane, A. (2011) Membrane-active antimicrobial peptides and human placental lysosomal extracts are highly active against mycobacteria. Peptides 32: 881-887.
27. Johansson, J., Gudmundsson, G.H., Rottenberg, M.E., Berndt, K.D., and Agerberth, B. (1998) Conformation-dependent antibacterial activity of the naturally occurring human peptide LL-37. J Biol Chem 273: 3718-3724.
28. Jordao, L., Bleck, C.K., Mayorga, L., Griffiths, G., and Anes, E. (2008) On the killing of mycobacteria by macrophages. Cell Microbiol 10: 529-548.
29. Liu, P.T., Stenger, S., Li, H., Wenzel, L., Tan, B.H., Krutzik, S.R., etal. (2006) Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science 311: 1770-1773.
30. Liu, P.T., Stenger, S., Tang, D.H., and Modlin, R.L. (2007) Vitamin D-mediated human antimicrobial activity against Mycobacterium tuberculosis is dependent on the induction of cathelicidin. J Immunol 179: 2060-2063.
31. Martineau, A., Wilkinson, K., Newton, S., Floto, R., Norman, A., Skolimowska, K., etal. (2007) IFN- and TNF-independent vitamin D-inducible human suppression of mycobacteria: the role of cathelicidin LL-37. J Immunol 178: 7190-7198.
32. Mae, M., Iyori, M., Yasuda, M., Shamsul, H.M., Kataoka, H., Kiura, K., etal. (2007) The diacylated lipopeptide FSL-1 enhances phagocytosis of bacteria by macrophages through a Toll-like receptor 2-mediated signaling pathway. FEMS Immunol Med Microbiol 49: 398-409.
33. Nizet, V., Ohtake, T., Lauth, X., Trowbridge, J., Rudisill, J., Dorschner, R.A., etal. (2001) Innate antimicrobial peptide protects the skin from invasive bacterial infection. Nature 414: 454-457.
34. Ottenhof, T.H., Kumararatne, D., and Casanova, J.L. (1998) Novel human immunodeficiencies reveal the essential role of type-1 cytokines in immunity to intracellular bacteria. Immunol Today 19: 491-494.
35. Rook, G.A.W., Steele, J., Ainsworth, M., and Champion, B.R. (1986) Activation of macrophages to inhibit proliferation of Mycobacterium tuberculosis: comparison of the effects of recombinant gamma interferon on human monocytes and murine peritoneal macrophages. Immunology 59: 333-338.
36. Russell, D.G., Mwandumba, H.C., and Rhoades, E.E. (2002) Mycobacterium and the coat of many lipids. J Cell Biol 158: 421-426.
37. Scott, M.G., and Hancock, R.E. (2000) Cationic antimicrobial peptides and their multifunctional role in the immune system. Crit Rev Immunol 20: 407-431.
38. Sorensen, O.E., Arnljots, K., Cowland, J.B., Bainton, D.F., and Borregaard, N. (1997a) The human antibacterial cathelicidin, hCAP-18, is synthesized in myelocytes and metamyelocytes and localized to specific granules in neutrophils. Blood 90: 2796-2803.
39. Sorensen, O., Cowland, J.B., Askaa, J., and Borregaard, N. (1997b) An ELISA for hCAP-18, the cathelicidin present in human neutrophils and plasma. J Immunol Methods 206: 53-59.
40. Sorensen, O.E., Follin, P., Johnsen, A.H., Calafat, J., Tjabringa, G.S., Hiemstra, P.S., and Borregaard, N. (2001) Human cathelicidin, hCAP-18, is processed to the antimicrobial peptide LL-37 by extracellular cleavage with proteinase 3. Blood 97: 3951-3959.
41. Vergne, I., Chua, J., and Deretic, V. (2003) Mycobacterium tuberculosis phagosome maturation arrest selective targeting of PI3P-dependent membrane trafficking. Traffic 4: 600-606.
42. Voigt, W. (2005) Sulforhodamine B assay and chemosensitivity. Methods Mol Med 110: 39-48.
43. WHO (2008) Global tuberculosis control - surveillance, planning, financing. WHO report 2008.
44. Ying, X., Liu, W., Shena, H., Yana, J., Yanga, E., and Wang, H. (2010) Recombinant Mycobacterium bovis BCG expressing chimeric protein of Ag85B and ESAT-6 enhances immunostimulatory activity of human macrophages. Microbes Infect 12: 683-689.
45. Yount, N.Y., and Yeaman, M.R. (2005) Immunocontinuum: perspectives in antimicrobial peptide mechanisms of action and resistance. Protein Pept Lett 12: 49-67.
46. Yount, N.Y., Bayer, A.S., Xiong, Y.Q., and Yeaman, M.R. (2006) Advances in antimicrobial peptide immunobiology. Biopolymers 84: 435-458.
47. Yuk, J., Shin, D., Lee, H., Yang, C., Jin, H., Kim, K.K., etal. (2009) Vitamin D3 induces autophagy in human monocytes/macrophages via cathelicidin. Cell Host Microbe 6: 231-243.