Effects of essential fatty acid deficiency on prostaglandin E2 production and cell-mediated immunity in a mouse model of leprosy

Infection and Immunity

Volumn 65, Issue 4, 1997, Pages 1152-1157

  Adams, Linda B ^a   Gillis, Thomas P ^a   Hwang, Daniel H ^b   Krahenbuhl, James L ^a  

^a LOUISIANA STATE UNIVERSITY   (United States)

^b PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; LINOLEIC ACID; PROSTAGLANDIN E2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL MEMBRANE; CELL VIABILITY; CELLULAR IMMUNITY; ESSENTIAL FATTY ACID DEFICIENCY; GRANULOMATOUS INFLAMMATION; HOST RESISTANCE; IMMUNE DEFICIENCY; IMMUNE RESPONSE; LEPROSY; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE FUNCTION; MOUSE; MYCOBACTERIUM LEPRAE; NONHUMAN; PRIORITY JOURNAL;

EID: 0030898741     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.65.4.1152-1157.1997     Document Type: Article

References (53)

1. Adams, L. B., S. G. Franzblau, Z. Vavrin, J. B. Hibbs, Jr., and J. L. Krahenbuhl. 1991. L-Arginine-dependent macrophage effector functions inhibit metabolic activity of Mycobacterium leprae. J. Immunol. 147:1642-1646.
2. Apt, A. S., I. B. Kramnik, and A. M. Moroz. 1991. Regulation of T-cell proliferative responses by cells from solid lung tissue of M. tuberculosis-infected mice. Immunology 73:173-179.
3. 2 inhibits production of Th1 lymphokines but not of Th2 lymphokines. J. Immunol. 146:108-113.
4. Bonta, I. L., M. J. Parnham, and M. J. P. Adolf. 1977. Reduced exudation and increased tissue proliferation during chronic inflammation in rats deprived of endogenous prostaglandin precursors. Prostaglandins 14:295-306.
5. Boudreau, M. D., P. S. Chanmugam, S. B. Hart, S. H. Lee, and D. H. Hwang. 1991. Lack of dose response by dietary n-3 fatty acids at a constant n-3/n-6 fatty acid ratio in suppressing eicosanoid biosynthesis from arachidonic acid. Am. J. Clin. Nutr. 54:111-117.
6. Chehl, S., J. Ruby, C. K. Job, and R. C. Hastings. 1983. The growth of Mycobacterium leprae in nude mice. Lepr. Rev. 54:283-304.
7. Colston, M. J., and G. R. Hilson. 1976. Growth of Mycobacterium leprae and M. marinum in congenially athymic (nude) mice. Nature 262:736-741.
8. Converse, P. J., V. L. Haines, A. Wondimu, L. E. Craig, and W. M. Meyers. 1995. Infection of SCID mice with Mycobacterium leprae and control with antigen-activated "immune" human peripheral blood mononuclear cells. Infect. Immun. 63:1047-1054.
9. 2 and reversal by injection of indomethacin, muramyl dipeptide, or interferon-γ. J. Immunol. 136:1820-1827.
10. Ellner, J. J., and P. J. Spagnuolo. 1979. Suppression of antigen and mitogen induced human T lymphocyte DNA synthesis by bacterial lipopolysaccharide: mediation by monocyte activation and production of prostaglandins. J. Immunol. 123:2689-2695.
11. Ellner, J. J., and R. S. Wallis. 1989. Immunologic aspects of mycobacterial infections. Rev. Infect. Dis. 11(Suppl. 2):S455-S459.
12. Folch, J., M. Lees, and G. H. Sloane-Stanley. 1957. A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226:497-509.
13. Franzblau, S. G. 1989. Drug susceptibility testing of Mycobacterium leprae in the BACTEC 460 system. Antimicrob. Agents Chemother. 33:2115-2117.
14. Godal, T., B. Myklestad, D. R. Samuel, and B. Myrvang. 1971. Characterization of the cellular immune defect in lepromatous leprosy: a specific lack of circulating Mycobacterium leprae-reactive lymphocytes. Clin. Exp. Immunol. 9:821.
15. Holman, R. T. 1960. The ratio of trienoic:tetraenoic acids in tissue lipids as a measure of essential fatty acid requirement. J. Nutr. 70:405-410.
16. Hwang, D. 1989. Essential fatty acids and immune response. FASEB J. 3:2052-2061.
17. Hwang, D. H., and A. E. Carroll. 1980. Decreased formation of prostaglandins derived from arachidonic acid by dietary linolenate in rats. Am. J. Clin. Nutr. 33:590-597.
18. Kohsaka, K., T. Mori, and T. Ito. 1976. Lepromatoid lesions developed in nude mouse inoculated with M. leprae. Lepro 45:177-187.
19. Krahenbuhl, J. L., L. D. Sibley, and G.-T. Chae. 1990. γ-Interferon in experimental leprosy. Diagn. Microbiol. Infect. Dis. 13:405-409.
20. Lefkowith, J. B. 1990. Essential fatty acid deficiency: probing the role of arachidonate in biology. Adv. Prostaglandin Thromboxane Leukotriene Res. 20:224-231.
21. Lefkowith, J. B., V. Flippo, H. Sprecher, and P. Needleman. 1985. Paradoxical conservation of cardiac and renal arachidonate content in essential fatty acid deficiency. J. Biol. Chem. 260:15736-15744.
22. Lowe, C., S. J. Brett, and R. J. W. Rees. 1985. Adoptive cell transfer of resistance to Mycobacterium leprae infections in mice. Clin. Exp. Immunol. 61:336-342.
23. Makonkawkeyoon, S., and W. Kasinrerk. 1989. In vitro suppression of interleukin 2 production by Mycobacterium leprae antigen. Clin. Exp. Immunol. 76:398-103.
24. Mehra, V., L. H. Mason, J. P. Fields, and B. R. Bloom. 1979. Lepromin-induced suppressor cells in patients with leprosy. J. Immunol. 123:1813-1817.
25. Merlin, J., and R. Hunt. 1976. Influence of polyunsaturated fatty acids on survival of skin allografts and tumor incidence in mice. Proc. Natl. Acad. Sci. USA 73:928-931.
26. 2. J. Immunol. 145:2616-2625.
27. Nathan, C. F., H. W. Murray, M. E. Weibe, and B. Y. Rubin. 1983. Identification of interferon gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity. J. Exp. Med. 158:670.
28. Nelson, E. E., L. Wong, K. Uyemura, T. H. Rea, and R. L. Modlin. 1987. Lepromin-induced suppressor cells in lepromatous leprosy. Cell. Immunol. 104:99-104.
29. Ottenhoff, T. H. M., D. G. Elferink, P. R. Klatser, and R. R. P. de Vries. 1986. Cloned suppressor T cells from a lepromatous leprosy patient suppress Mycobacterium leprae reactive helper T cells. Nature 322:462-464.
30. Pace, J. L., S. W. Russell, B. A. Torres, H. M. Johnson, and P. W. Gray. 1983. Recombinant mouse gamma interferon induces the priming step in macrophage activation for tumor cell killing. J. Immunol. 130:2011-2013.
31. Ramasesh, N., L. B. Adams, S. G. Franzblau, and J. L. Krahenbuhl. 1991. Effects of activated macrophages on Mycobacterium leprae. Infect. Immun. 59:2864-2869.
32. Ridel, P.-R., P. Jamet, Y. Robin, and M.-A. Bach. 1986. Interleukin-1 released by blood-monocyte-derived macrophages from patients with leprosy. Infect. Immun. 52:303-308.
33. Ridley, D. S., and W. H. Jopling. 1966. Classification of leprosy according to immunity - a five-group system. Int. J. Lepr. 34:255-273.
34. Sana, B., G. Das, H. Vohra, N. K. Ganguly, and G. C. Mishra. 1994. Macrophage-T cell interaction in experimental mycobacterial infection. Selective regulation of co-stimulatory molecules on Mycobacterium-infected macrophages and its implication in the suppression of cell-mediated immune response. Eur. J. Immunol. 24:2618-2624.
35. Salgame, P. R., P. R. Mahadevan, and N. H. Antia. 1983. Mechanism of immunosuppression in leprosy: presence of suppressor factor(s) from macrophages of lepromatous patients. Infect. Immun. 40:1119-1126.
36. Santos, C. F., M. E. Silva, J. R. Nicoli, L. C. Crocco-Afonso, J. E. Santos, E. A. Bambirra, and E. C. Vieira. 1992. Effect of an essential fatty acid deficient diet on experimental infection with Trypanosoma cruzi in germfree and conventional mice. Braz. J. Med. Biol. Res. 25:795-803.
37. Sathish, M., L. K. Bhutani, A. K. Sharma, and I. Nath. 1983. Monocyte-derived soluble suppressor factor(s) in patients with lepromatous leprosy. Infect. Immun. 42:890-899.
38. Schleifer, K. W., and J. M. Mansfield. 1993. Suppressor macrophages in African trypanosomiasis inhibit T cell proliferative responses by nitric oxide and prostaglandins. J. Immunol. 151:5492-5503.
39. Shannon, E. J., S. Chehl, C. K. Job, and R. C. Hastings. 1987. Adoptively transferred reactivity to M. leprae in nude mice infected with M. leprae. Clin. Exp. Immunol. 70:143-151.
40. Shepard, C. C. 1960. The experimental disease that follows the injection of human leprosy bacilli into footpads of mice. J. Exp. Med. 112:445-454.
41. Shepard, C. C., and D. H. MacRae. 1968. A method for counting acid-fast bacteria. Int. J. Lepr. 36:78-82.
42. Sibley, L. D., L. B. Adams, V. Fukutomi, and J. L. Krahenbuhl. 1991. Tumor necrosis factor-alpha triggers antitoxoplasmal activity of IFN-gamma primed macrophages. J. Immunol. 147:2340-2345.
43. Sibley, L. D., and J. L. Krahenbuhl. 1987. Mycobacterium leprae-burdened macrophages are refractory to activation by gamma interferon. Infect. Immun. 55:446-450.
44. Sibley, L. D., and J. L. Krahenbuhl. 1988. Defective activation of granuloma macrophages from Mycobacterium leprae-infected nude mice. J. Leukocyte Biol. 43:60-66.
45. Sibley, L. D., and J. L. Krahenbuhl. 1988. Induction of unresponsiveness to gamma interferon in macrophages infected with Mycobacterium leprae. Infect. Immun. 56:1912-1919.
46. Sieling, P. A., J. S. Abrams, M. Yamamura, P. Salgame, B. R. Bloom, T. H. Rea, and R. L. Modlin. 1993. Immunosuppressive roles for IL-10 and IL-4 in human infection. In vitro modulation of T cell responses in leprosy. J. Immunol. 150:5501-5510.
47. Sigal, E. 1991. The molecular biology of mammalian arachidonic acid metabolism. Am. J. Physiol. 260:L13-L28.
48. Stockpoole, A., and J. Mertin. 1981. The effect of prostaglandin precursors in in vivo models of cell-mediated immunity. Prog. Lipid Res. 20:649-654.
49. Tomioka, H., and H. Saito. 1992. Characterization of immunosuppressive functions of murine peritoneal macrophages induced with various agents. J. Leukocyte Biol. 51:24-31.
50. Waters, M. F. R., and R. J. W. Rees. 1962. Changes in the morphology of Mycobacterium leprae in patients under treatment. Int. J. Lepr. 30:266-277.
51. Weinberg, J. B., H. A. Chapman, Jr., and J. B. Hibbs, Jr. 1978. Characterization of the effects of endotoxin on macrophage tumor cell killing. J. Immunol. 121:72-80.
52. Williams, A. O., S. J. Chanock, and K. C. Flanders. 1995. Transforming growth factor-beta (TGF-β) isoforms in tuberculoid and lepromatous leprosy: immunohistochemical studies. Cell Vision 2:363-372.
53. 2 and indomethacin on the cytotoxic response to mycobacterial antigens. Int. J. Immunopharmacol. 16:525-531.