Natural product-inspired rational design, synthesis and biological evaluation of 2,3-dihydropyrano[2,3-f]chromen-4(8H)-one based hybrids as potential mitochondrial apoptosis inducers

European Journal of Medicinal Chemistry

Volumn 122, Issue , 2016, Pages 302-318

  Sakthivel, Palaniappan ^a   Ilangovan, Andivelu ^a   Kaushik, Mahabir Prasad ^b  

^a BHARATHIDASAN UNIVERSITY   (India)

^b DEFENCE RESEARCH AND DEVELOPMENT ESTABLISHMENT   (India)

Author keywords

(+) Calanolide A; 1,3,4 Thiadiazole; Aminopyridine; Deguelin; G Quadruplex DNA; Hybrid molecule; Mitochondrial apoptosis

Indexed keywords

2,3,8,8 TETRAMETHYL 4 OXO 2,3,4,8 TETRAHYDROPYRANO[2,3 F]CHROMENE 6 CARBOXYLIC ACID; 2,3,8,8 TETRAMETHYL 4 OXO N (5 PHENYL 1,3,4 THIADIAZOL 2 YL) 2,3,4,8 TETRAHYDROPYRANO[2,3 F]CHROMENE 6 CARBOXAMIDE; 2,3,8,8 TETRAMETHYL 4 OXO N (PYRIDIN 3 YL) 2,3,4,8 TETRAHYDROPYRANO[2,3 F]CHROMENE 6 CARBOXAMIDE; 2,3,8,8 TETRAMETHYL 4 OXO N (PYRIDIN 4 YL) 2,3,4,8 TETRAHYDROPYRANO[2,3 F]CHROMENE 6 CARBOXAMIDE; 2,3,8,8 TETRAMETHYL 4 OXO N (THIAZOL 4 YL) 2,3,4,8 TETRAHYDROPYRANO[2,3 F]CHROMENE 6 CARBOXAMIDE; 2,3,8,8 TETRAMETHYL 4 OXO N [5 (3,4,5 TRIMETHOXYPHENYL) 1,3,4 THIADIAZOL 2 YL] 2,3,4,8 TETRAHYDROPYRANO[2,3 F]CHROMENE 6 CARBOXAMIDE; 2,3,8,8 TETRAMETHYL 4 OXO N [5 (4 TOLYL) 1,3,4 THIADIAZOL 2 YL] 2,3,4,8 TETRAHYDROPYRANO[2,3 F]CHROMENE 6 CARBOXAMIDE; 2,3,8,8 TETRAMETHYL 4 OXO N [5 (PYRIDIN 4 YL) 1,3,4 THIADIAZOL 2 YL] 2,3,4,8 TETRAHYDROPYRANO[2,3 F]CHROMENE 6 CARBOXAMIDE; 2,3,8,8 TETRAMETHYL 4 OXO N [5 (THIOPHEN 2 YL) 1,3,4 THIADIAZOL 2 YL] 2,3,4,8 TETRAHYDROPYRANO[2,3 F]CHROMENE 6 CARBOXAMIDE; 2,3,8,8 TETRAMETHYL N (NAPHTHALEN 1 YL) 4 OXO 2,3,4,8 TETRAHYDROPYRANO[2,3 F]CHROMENE 6 CARBOXAMIDE; 2,3,8,8 TETRAMETHYL N [5 (4 NITROPHENYL) 1,3,4 THIADIAZOL 2 YL] 2,3,4,8 TETRAHYDROPYRANO[2,3 F]CHROMENE 6 CARBOXAMIDE; APOPTOSIS INDUCING FACTOR; CHROMAN DERIVATIVE; DEGUELIN; GUANINE QUADRUPLEX; LEVAMISOLE; NATURAL PRODUCT; PROTEIN BAX; PROTEIN BCL 2; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; BENZOPYRAN DERIVATIVE; BIOLOGICAL PRODUCT; BIOMIMETIC MATERIAL; DNA;

A549 CELL LINE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA FRAGMENTATION; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; FLUORESCENCE ACTIVATED CELL SORTING; HELA CELL LINE; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; MCF 7 CELL LINE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MOLECULAR DOCKING; PHARMACOPHORE; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; CHEMISTRY; CONFORMATION; DRUG EFFECTS; GENETICS; METABOLISM; SYNTHESIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BENZOPYRANS; BIOLOGICAL PRODUCTS; BIOMIMETIC MATERIALS; CELL LINE, TUMOR; CHEMISTRY TECHNIQUES, SYNTHETIC; DNA; DNA FRAGMENTATION; DRUG DESIGN; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; MOLECULAR DOCKING SIMULATION; NUCLEIC ACID CONFORMATION;

EID: 84976886520     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2016.06.044     Document Type: Article

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