Relative stability of G-quadruplex structures: Interactions between the human Bcl2 promoter region and derivatives of carbazole and diphenylamine

Biopolymers

Volumn 101, Issue 10, 2014, Pages 1038-1050

  Sheu, Sheh Yi ^a   Huang, Chao Hsien ^a   Zhou, Jia Kai ^a   Yang, Dah Yen ^b  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b INSTITUTE OF ATOMIC AND MOLECULAR SCIENCES   (Taiwan)

Author keywords

bcl2 promoter region; binding affinity; drug design; G quadruplex; molecular dynamics

Indexed keywords

ANILINE; BINDING ENERGY; DRUG DELIVERY; LIGANDS; MOLECULAR DYNAMICS; POLYCYCLIC AROMATIC HYDROCARBONS; SOLVENTS;

BINDING AFFINITIES; DIPHENYLAMINE DERIVATIVES; DRUG DESIGN; G-QUADRUPLEX STRUCTURE; G-QUADRUPLEXES; MOLECULAR DYNAMICS SIMULATIONS; PROMOTER REGION; RELATIVE STABILITIES;

STABILITY;

ANTINEOPLASTIC AGENT; BMVC; BMVC 2; BMVC 4; CARBAZOLE DERIVATIVE; DIPHENYLAMINE DERIVATIVE; DP 1; DP 4; GUANINE QUADRUPLEX; POTASSIUM ION; PROTEIN BCL 2; UNCLASSIFIED DRUG; CARBAZOLE; DIPHENYLAMINE; ION; LIGAND; MOLECULAR PROBE; POTASSIUM;

ARTICLE; BINDING AFFINITY; CORRELATIONAL STUDY; DRUG BINDING SITE; DRUG POTENCY; DRUG SCREENING; DRUG STABILITY; DRUG STRUCTURE; ENERGY YIELD; HUMAN; IONIC STRENGTH; LIGAND BINDING; MOLECULAR DOCKING; MOLECULAR DYNAMICS; PROMOTER REGION; PROTEIN FOLDING; PROTEIN INTERACTION; SOLVENT EFFECT; THEORETICAL STUDY; BINDING SITE; CHEMISTRY; DRUG EFFECTS; GENETICS; METABOLISM; MOLECULAR GENETICS; MOLECULAR PROBE; NUCLEOTIDE SEQUENCE; OSMOLARITY; PROTEIN STABILITY; STATIC ELECTRICITY; THERMODYNAMICS;

BASE SEQUENCE; BINDING SITES; CARBAZOLES; DIPHENYLAMINE; G-QUADRUPLEXES; HUMANS; IONS; LIGANDS; MOLECULAR DYNAMICS SIMULATION; MOLECULAR PROBES; MOLECULAR SEQUENCE DATA; OSMOLAR CONCENTRATION; POTASSIUM; PROMOTER REGIONS, GENETIC; PROTEIN STABILITY; PROTO-ONCOGENE PROTEINS C-BCL-2; STATIC ELECTRICITY; THERMODYNAMICS;

EID: 84904671622     PISSN: 00063525     EISSN: 10970282     Source Type: Journal    
DOI: 10.1002/bip.22497     Document Type: Article

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