High fat diet-induced diabetes in mice exacerbates cognitive deficit due to chronic hypoperfusion

Journal of Cerebral Blood Flow and Metabolism

Volumn 36, Issue 7, 2016, Pages 1257-1270

  Zuloaga, Kristen L ^a   Johnson, Lance A ^a,b   Roese, Natalie E ^a   Marzulla, Tessa ^b   Zhang, Wenri ^a   Nie, Xiao ^a   Alkayed, Farah N ^a   Hong, Christine ^a   Grafe, Marjorie R ^a,b   Pike, Martin M ^c   Raber, Jacob ^a,b,c   Alkayed, Nabil J ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b Knight Cardiovascular Institute ^*  (United States)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

cerebral blood flow; chronic cerebral hypoperfusion; cognitive impairment; diabetes; high fat diet; Vascular cognitive impairment; vascular dementia

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASSOCIATION; BRAIN BLOOD FLOW; BRAIN PERFUSION; CAROTID ARTERY OBSTRUCTION; COGNITIVE DEFECT; CONTROLLED STUDY; DISEASE EXACERBATION; FEAR CONDITIONING TEST; GLIA; HIPPOCAMPUS; LIPID DIET; LOW FAT DIET; MALE; MORRIS WATER MAZE TEST; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; PRIORITY JOURNAL; RECOGNITION; RIGHT HEMISPHERE; SPIN LABELING; TASK PERFORMANCE; WHITE MATTER; ADVERSE EFFECTS; ANIMAL; ANIMAL BEHAVIOR; BRAIN; BRAIN CIRCULATION; C57BL MOUSE; COGNITION DISORDERS; COMMON CAROTID ARTERY; COMPLICATION; DIAGNOSTIC IMAGING; EXPERIMENTAL DIABETES MELLITUS; IMAGE PROCESSING; MAZE TEST; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PSYCHOLOGY; VASCULAR ENDOTHELIUM; VASCULARIZATION;

ANIMALS; BEHAVIOR, ANIMAL; BRAIN; CAROTID ARTERY, COMMON; CAROTID STENOSIS; CEREBROVASCULAR CIRCULATION; COGNITION DISORDERS; DIABETES MELLITUS, EXPERIMENTAL; DIET, HIGH-FAT; ENDOTHELIUM, VASCULAR; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; MAZE LEARNING; MICE, INBRED C57BL;

EID: 84976878434     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1177/0271678X15616400     Document Type: Article

References (32)

1. McCrimmon RJ, Ryan CM, and Frier BM. Diabetes, and cognitive dysfunction. Lancet 2012; 379: 2291-2299
2. Biessels GJ, Staekenborg S, Brunner E, et al. Risk of dementia in diabetes mellitus: a systematic review. Lancet Neurol 2006; 5: 64-74
3. Van Harten B, Oosterman J, Muslimovic D, et al. Cognitive impairment, and MRI correlates in the elderly patients with type 2 diabetes mellitus. Age Ageing 2007; 36: 164-170
4. Roberts RO, Knopman DS, Przybelski SA, et al. Association of type 2 diabetes with brain atrophy, and cognitive impairment. Neurology 2014; 82: 1132-1141
5. Winzell MS, and Ahren B. The high-fat diet fed mouse: a model for studying mechanisms, and treatment of impaired glucose tolerance, and type 2 diabetes. Diabetes 2004; 53: S215-S219
6. Morrison CD, Pistell PJ, Ingram DK, et al. High fat diet increases hippocampal oxidative stress, and cognitive impairment in aged mice: implications for decreased Nrf2 signaling. J Neurochem 2010; 114: 1581-1589
7. Jeon BT, Jeong EA, Shin HJ, et al. Resveratrol attenuates obesity-Associated peripheral, and central inflammation, and improves memory deficit in mice fed a high-fat diet. Diabetes 2012; 61: 1444-1454
8. Lynch CM, Kinzenbaw DA, Chen X, et al. Nox2-derived superoxide contributes to cerebral vascular dysfunction in diet-induced obesity. Stroke 2013; 44: 3195-3201
9. Yoshizaki K, Adachi K, Kataoka S, et al. Chronic cerebral hypoperfusion induced by right unilateral common carotid artery occlusion causes delayed white matter lesions, and cognitive impairment in adult mice. Exp Neurol 2008; 210: 585-591
10. Zhao Y, Gu JH, Dai CL, et al. Chronic cerebral hypoperfusion causes decrease of O-GlcNAcylation, hyperphosphorylation of tau, and behavioral deficits in mice. Front Aging Neurosci 2014; 6: 10
11. Ma J, Xiong JY, Hou WW, et al. Protective effect of carnosine on subcortical ischemic vascular dementia in mice. CNS Neurosci Ther 2012; 18: 745-753
12. Lee JS, Im DS, An YS, et al. Chronic cerebral hypoperfusion in a mouse model of Alzheimer's disease: an additional contributing factor of cognitive impairment. Neurosci Lett 2011; 489: 84-88
13. Zuloaga KL, Zhang W, Yeiser LA, et al. Neurobehavioral, and imaging correlates of hippocampal atrophy in a mouse model of vascular cognitive impairment. Transl Stroke Res 2015; 6: 390-398
14. Benice TS, and Raber J. Object recognition analysis in mice using nose-point digital video tracking. J Neurosci Methods 2008; 168: 422-430
15. Maren S. Neurobiology of Pavlovian fear conditioning. Annu Rev Neurosci 2001; 24: 897-931
16. Kim SG. Quantification of relative cerebral blood flow change by flow-sensitive alternating inversion recovery (FAIR) technique: application to functional mapping. Magn Reson Med 1995; 34: 293-301
17. Lein ES, Hawrylycz MJ, Ao N, et al. Genome-wide atlas of gene expression in the adult mouse brain. Nature 2007; 445: 168-176
18. Iadecola C. The pathobiology of vascular dementia. Neuron 2013; 80: 844-866
19. Jack CR, Petersen RC, Xu YC, et al. Medial temporal atrophy on MRI in normal aging, and very mild Alzheimer's disease. Neurology 1997; 49: 786-794
20. Guo H, Itoh Y, Toriumi H, Yamada S, et al. Capillary remodeling, and collateral growth without angiogenesis after unilateral common carotid artery occlusion in mice. Microcirculation 2011; 18: 221-227
21. Calligaris SD, Lecanda M, Solis F, et al. Mice longterm high-fat diet feeding recapitulates human cardiovascular alterations: an animal model to study the early phases of diabetic cardiomyopathy. PLoS One 2013; 8: e60931
22. Kitayama J, Faraci FM, Gunnett CA, et al. Impairment of dilator responses of cerebral arterioles during diabetes mellitus: role of inducible NO synthase. Stroke 2006; 37: 2129-2133
23. Tucsek Z, Toth P, Sosnowska D, et al. Obesity in aging exacerbates blood-brain barrier disruption, neuroinflammation, and oxidative stress in the mouse hippocampus: effects on expression of genes involved in beta-Amyloid generation, and Alzheimer's disease. J Gerontol A Biol Sci Med Sci 2014; 69: 1212-1226
24. Buckman LB, Hasty AH, Flaherty DK, et al. Obesity induced by a high-fat diet is associated with increased immune cell entry into the central nervous system. Brain Behav Immun 2014; 35: 33-42
25. Tennant KA, and Brown CE. Diabetes augments in vivo microvascular blood flow dynamics after stroke. J Neurosci 2013; 33: 19194-19204
26. Dong YF, Kataoka K, Toyama K, et al. Attenuation of brain damage, and cognitive impairment by direct renin inhibition in mice with chronic cerebral hypoperfusion. Hypertension 2011; 58: 635-642
27. Toyama K, Koibuchi N, Uekawa K, et al. Apoptosis signal-regulating kinase 1 is a novel target molecule for cognitive impairment induced by chronic cerebral hypoperfusion. Arterioscler Thromb Vasc Biol 2014; 34: 616-625
28. Hattori Y, Enmi J, Kitamura A, et al. A novel mouse model of subcortical infarcts with dementia. J Neurosci 2015; 35: 3915-3928
29. Li XL, Aou S, Oomura Y, Hori N, et al. Impairment of long-Term potentiation, and spatial memory in leptin receptor-deficient rodents. Neuroscience 2002; 113: 607-615
30. Lang BT, Yan Y, Dempsey RJ, et al. Impaired neurogenesis in adult type-2 diabetic rats. Brain Res 2009; 1258: 25-33
31. Beauquis J, Saravia F, Coulaud J, et al. Prominently decreased hippocampal neurogenesis in a spontaneous model of type 1 diabetes, the nonobese diabetic mouse. Exp Neurol 2008; 210: 359-367
32. Kwon KJ, Lee EJ, Kim MK, et al. Diabetes augments cognitive dysfunction in chronic cerebral hypoperfusion by increasing neuronal cell death: implication of cilostazol for diabetes mellitus-induced dementia. Neurobiol Dis 2015; 73: 12-23