Diabetes augments cognitive dysfunction in chronic cerebral hypoperfusion by increasing neuronal cell death: Implication of cilostazol for diabetes mellitus-induced dementia

Neurobiology of Disease

Volumn 73, Issue , 2015, Pages 12-23

  Kwon, Kyoung Ja ^a   Lee, Eun Joo ^a   Kim, Min Kyeong ^a   Kim, Soo Young ^a   Kim, Jung Nam ^a   Kim, Jin Ok ^a,b   Kim, Hee Jin ^c   Kim, Hahn Young ^a,b   Han, Jung Soo ^a   Shin, Chan Young ^a   Han, Seol Heui ^a,b  

^a Konkuk University School of Medicine   (South Korea)

^b Konkuk University Hospital   (South Korea)

^c Hanyang University   (South Korea)

Author keywords

Diabetes mellitus; Learning and memory; Neuroprotection; Phosphodiesterase III inhibitor; Vascular dementia

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CASPASE 3; CILOSTAZOL; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; NEUROPROTECTIVE AGENT; TETRAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BRAIN CORTEX; BRAIN PERFUSION; BRAIN REGION; CAROTID ARTERY OBSTRUCTION; CAUSAL ATTRIBUTION; COGNITIVE DEFECT; CONTROLLED STUDY; DEMENTIA; DISEASE EXACERBATION; DRUG EFFICACY; HIPPOCAMPAL CA1 REGION; HIPPOCAMPUS; IMMUNOREACTIVITY; MALE; MEMORY DISORDER; MULTIINFARCT DEMENTIA; NERVE CELL NECROSIS; NEUROPROTECTION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SPATIAL MEMORY; TREATMENT DURATION; ANIMAL; BRAIN; CAROTID ARTERY DISEASE; CELL DEATH; COGNITION DISORDERS; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; FOLLOW UP; INBRED RAT STRAIN; LONG EVANS RAT; MAZE TEST; METABOLISM; PATHOLOGY; REACTION TIME; TUNEL ASSAY;

ANIMALS; BRAIN; BRAIN-DERIVED NEUROTROPHIC FACTOR; CAROTID ARTERY DISEASES; CASPASE 3; CELL DEATH; COGNITION DISORDERS; CREB-BINDING PROTEIN; DIABETES MELLITUS, TYPE 2; DISEASE MODELS, ANIMAL; FOLLOW-UP STUDIES; IN SITU NICK-END LABELING; MALE; MAZE LEARNING; NEUROPROTECTIVE AGENTS; RATS; RATS, INBRED STRAINS; RATS, LONG-EVANS; REACTION TIME; TETRAZOLES;

EID: 84908317310     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2014.08.034     Document Type: Article

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