Chronic cerebral hypoperfusion causes decrease of O-GlcNAcylation, hyperphosphorylation of tau and behavioral deficits in mice

Frontiers in Aging Neuroscience

Volumn 6, Issue FEB, 2014, Pages

  Zhao, Yang ^a,b   Gu, Jin Hua ^b,c   Dai, Chun Ling ^b   Liu, Qun ^a   Iqbal, Khalid ^b   Liu, Fei ^b   Gong, Cheng Xin ^b  

^a THE FIRST HOSPITAL OF JILIN UNIVERSITY   (China)

^b NEW YORK STATE INSTITUTE FOR BASIC RESEARCH IN DEVELOPMENTAL DISABILITIES   (United States)

^c NANTONG UNIVERSITY   (China)

Author keywords

Alzheimer's disease; Brain insulin signaling; Chronic cerebral hypoperfusion; Cognitive impairment; Neurodegeneration; O GlcNAcylation; Synaptic plasticity markers; Tau phosphorylation

Indexed keywords

INSULIN; TAU PROTEIN;

ACYLATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR CHANGE; BRAIN PERFUSION; CAROTID ARTERY OBSTRUCTION; CHRONIC BRAIN DISEASE; CHRONIC CEREBRAL HYPOPERFUSION; COMMON CAROTID ARTERY; CONTROLLED STUDY; FOOTPRINT TEST; FORCED SWIM TEST; GAIT; IMMUNOHISTOCHEMISTRY; LONG TERM MEMORY; MALE; MEMORY DISORDER; MORRIS WATER MAZE TEST; MOTOR COORDINATION; MOUSE; MULTIINFARCT DEMENTIA; NERVE CELL DEGENERATION; NERVE DEGENERATION; NONHUMAN; O GLCNACYLATION; PROTEIN PHOSPHORYLATION; ROTAROD TEST; SHORT TERM MEMORY; SPATIAL MEMORY; UNILATERAL COMMON CAROTID ARTERY OCCLUSION;

EID: 84895809035     PISSN: None     EISSN: 16634365     Source Type: Journal    
DOI: 10.3389/fnagi.2014.00010     Document Type: Article

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