Neurobehavioral and Imaging Correlates of Hippocampal Atrophy in a Mouse Model of Vascular Cognitive Impairment

Translational Stroke Research

Volumn 6, Issue 5, 2015, Pages 390-398

  Zuloaga, Kristen L ^a   Zhang, Wenri ^a   Yeiser, Lauren A ^a   Stewart, Blair ^a   Kukino, Ayaka ^b   Nie, Xiao ^a   Roese, Natalie E ^a   Grafe, Marjorie R ^a   Pike, Martin M ^b   Raber, Jacob ^a,b   Alkayed, Nabil J ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Cerebral blood flow; Chronic cerebral hypoperfusion; Cognitive impairment; Vascular dementia

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ATROPHY; BRAIN BLOOD FLOW; BRAIN CORTEX; BRAIN LATERAL VENTRICLE; BRAIN PERFUSION; CAROTID ARTERY OBSTRUCTION; COGNITIVE DEFECT; CONDITIONING; CONTROLLED STUDY; HIPPOCAMPUS; HISTOPATHOLOGY; MALE; MORRIS WATER MAZE TEST; MOUSE; NEUROIMAGING; NONHUMAN; NOVEL OBJECT RECOGNITION TEST; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; ANIMAL; ANIMAL BEHAVIOR; ATROPHY; C57BL MOUSE; COMPLICATION; CONDITIONED REFLEX; DEMENTIA, VASCULAR; DISEASE MODEL; FEAR; MAZE TEST; PATHOLOGY; PHYSIOLOGY; RECOGNITION; VASCULARIZATION;

ANIMALS; ATROPHY; BEHAVIOR, ANIMAL; CEREBRAL CORTEX; CONDITIONING, CLASSICAL; DEMENTIA, VASCULAR; DISEASE MODELS, ANIMAL; FEAR; HIPPOCAMPUS; MAGNETIC RESONANCE IMAGING; MALE; MAZE LEARNING; MICE; MICE, INBRED C57BL; RECOGNITION (PSYCHOLOGY);

EID: 84941175515     PISSN: 18684483     EISSN: 1868601X     Source Type: Journal    
DOI: 10.1007/s12975-015-0412-z     Document Type: Article

References (18)

1. Iadecola C. The pathobiology of vascular dementia. Neuron. 2013;80(4):844–66. doi:10.1016/j.neuron.2013.10.008.
2. Gorelick PB, Scuteri A, Black SE, Decarli C, Greenberg SM, Iadecola C, et al. Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke J Cereb Circ. 2011;42(9):2672–713. doi:10.1161/STR.0b013e3182299496.
3. Jiwa NS, Garrard P, Hainsworth AH. Experimental models of vascular dementia and vascular cognitive impairment: a systematic review. J Neurochem. 2010;115(4):814–28. doi:10.1111/j.1471-4159.2010.06958.x.
4. Yoshizaki K, Adachi K, Kataoka S, Watanabe A, Tabira T, Takahashi K, et al. Chronic cerebral hypoperfusion induced by right unilateral common carotid artery occlusion causes delayed white matter lesions and cognitive impairment in adult mice. Exp Neurol. 2008;210(2):585–91. doi:10.1016/j.expneurol.2007.12.005.
5. Shibata M, Ohtani R, Ihara M, Tomimoto H. White matter lesions and glial activation in a novel mouse model of chronic cerebral hypoperfusion. Stroke J Cereb Circ. 2004;35(11):2598–603. doi:10.1161/01.STR.0000143725.19053.60.
6. Zhao Y, Gu JH, Dai CL, Liu Q, Iqbal K, Liu F, et al. Chronic cerebral hypoperfusion causes decrease of O-GlcNAcylation, hyperphosphorylation of tau and behavioral deficits in mice. Front Aging Neurosci. 2014;6:10. doi:10.3389/fnagi.2014.00010.
7. Bink DI, Ritz K, Aronica E, van der Weerd L, Daemen MJ. Mouse models to study the effect of cardiovascular risk factors on brain structure and cognition. J Cereb Blood Flow Metab Off J Int Soc Cereb Blood Flow Metab. 2013;33(11):1666–84. doi:10.1038/jcbfm.2013.140.
8. Guo H, Itoh Y, Toriumi H, Yamada S, Tomita Y, Hoshino H, et al. Capillary remodeling and collateral growth without angiogenesis after unilateral common carotid artery occlusion in mice. Microcirculation. 2011;18(3):221–7. doi:10.1111/j.1549-8719.2011.00081.x.
9. Fuchtemeier M, Brinckmann MP, Foddis M, Kunz A, Po C, Curato C, et al. Vascular change and opposing effects of the angiotensin type 2 receptor in a mouse model of vascular cognitive impairment. J Cereb Blood Flow Metab Off J Int Soc Cereb Blood Flow Metab. 2014. doi:10.1038/jcbfm.2014.221.
10. Soria G, Tudela R, Marquez-Martin A, Camon L, Batalle D, Munoz-Moreno E, et al. The ins and outs of the BCCAo model for chronic hypoperfusion: a multimodal and longitudinal MRI approach. PLoS One. 2013;8(9):e74631. doi:10.1371/journal.pone.0074631.
11. Benice TS, Raber J. Object recognition analysis in mice using nose-point digital video tracking. J Neurosci Methods. 2008;168(2):422–30.
12. Anagnostaras SG, Wood SC, Shuman T, Cai DJ, LeDuc AD, Zurn KR et al. Automated assessment of Pavlovian conditioned freezing and shock reactivity in mice using the VideoFreeze system. Front Behav Neurosci. 2010;4. doi:10.3389/fnbeh.2010.00158.
13. Ostergaard L, Weisskoff R, Chesler D, Gyldensted C. High resolution measurement of cerebral blood flow using intravascular tracer bolus passages. Part I: mathematical approach and statistical analysis. MRM. 1996;36:715–25.
14. Pike MM, Stoops CN, Langford CP, Akella NS, Nabors LB, Gillespie GY. High-resolution longitudinal assessment of flow and permeability in mouse glioma vasculature: sequential small molecule and SPIO dynamic contrast agent MRI. Magn Reson Med. 2009;61(3):615–25. doi:10.1002/mrm.21931.
15. Meyer JS, Rauch GM, Rauch RA, Haque A, Crawford K. Cardiovascular and other risk factors for Alzheimer’s disease and vascular dementia. Ann N Y Acad Sci. 2000;903(1):411–23. doi:10.1111/j.1749-6632.2000.tb06393.x.
16. Fotuhi M, Do D, Jack C. Modifiable factors that alter the size of the hippocampus with ageing. Nat Rev Neurol. 2012;8(4):189–202.
17. Toyama K, Koibuchi N, Uekawa K, Hasegawa Y, Kataoka K, Katayama T, et al. Apoptosis signal-regulating kinase 1 is a novel target molecule for cognitive impairment induced by chronic cerebral hypoperfusion. Arterioscler Thromb Vasc Biol. 2014;34(3):616–25. doi:10.1161/ATVBAHA.113.302440.
18. Kitagawa K, Yagita Y, Sasaki T, Sugiura S, Omura-Matsuoka E, Mabuchi T, et al. Chronic mild reduction of cerebral perfusion pressure induces ischemic tolerance in focal cerebral ischemia. Stroke J Cereb Circ. 2005;36(10):2270–4. doi:10.1161/01.STR.0000181075.77897.0e.