메뉴 건너뛰기




Volumn 166, Issue 1, 2016, Pages 77-87

HIV-1 Neutralizing Antibodies with Limited Hypermutation from an Infant

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; NEUTRALIZING ANTIBODY; GLYCOPROTEIN GP 120; HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY;

EID: 84976608123     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2016.05.055     Document Type: Article
Times cited : (121)

References (61)
  • 2
    • 84929896699 scopus 로고    scopus 로고
    • Antibody responses to envelope glycoproteins in HIV-1 infection
    • Burton, D.R., Mascola, J.R., Antibody responses to envelope glycoproteins in HIV-1 infection. Nat. Immunol. 16 (2015), 571–576.
    • (2015) Nat. Immunol. , vol.16 , pp. 571-576
    • Burton, D.R.1    Mascola, J.R.2
  • 3
    • 84938808649 scopus 로고    scopus 로고
    • The broad neutralizing antibody responses after HIV-1 superinfection are not dominated by antibodies directed to epitopes common in single infection
    • Cortez, V., Wang, B., Dingens, A., Chen, M.M., Ronen, K., Georgiev, I.S., McClelland, R.S., Overbaugh, J., The broad neutralizing antibody responses after HIV-1 superinfection are not dominated by antibodies directed to epitopes common in single infection. PLoS Pathog., 11, 2015, e1004973.
    • (2015) PLoS Pathog. , vol.11 , pp. e1004973
    • Cortez, V.1    Wang, B.2    Dingens, A.3    Chen, M.M.4    Ronen, K.5    Georgiev, I.S.6    McClelland, R.S.7    Overbaugh, J.8
  • 5
    • 84928948416 scopus 로고    scopus 로고
    • Strategies to guide the antibody affinity maturation process
    • Doria-Rose, N.A., Joyce, M.G., Strategies to guide the antibody affinity maturation process. Curr. Opin. Virol. 11 (2015), 137–147.
    • (2015) Curr. Opin. Virol. , vol.11 , pp. 137-147
    • Doria-Rose, N.A.1    Joyce, M.G.2
  • 9
    • 84900517557 scopus 로고    scopus 로고
    • Broadly neutralizing HIV antibodies define a glycan-dependent epitope on the prefusion conformation of gp41 on cleaved envelope trimers
    • Falkowska, E., Le, K.M., Ramos, A., Doores, K.J., Lee, J.H., Blattner, C., Ramirez, A., Derking, R., van Gils, M.J., Liang, C.H., et al. Broadly neutralizing HIV antibodies define a glycan-dependent epitope on the prefusion conformation of gp41 on cleaved envelope trimers. Immunity 40 (2014), 657–668.
    • (2014) Immunity , vol.40 , pp. 657-668
    • Falkowska, E.1    Le, K.M.2    Ramos, A.3    Doores, K.J.4    Lee, J.H.5    Blattner, C.6    Ramirez, A.7    Derking, R.8    van Gils, M.J.9    Liang, C.H.10
  • 10
    • 0030897825 scopus 로고    scopus 로고
    • Neutralization of the human immunodeficiency virus type 1 primary isolate JR-FL by human monoclonal antibodies correlates with antibody binding to the oligomeric form of the envelope glycoprotein complex
    • Fouts, T.R., Binley, J.M., Trkola, A., Robinson, J.E., Moore, J.P., Neutralization of the human immunodeficiency virus type 1 primary isolate JR-FL by human monoclonal antibodies correlates with antibody binding to the oligomeric form of the envelope glycoprotein complex. J. Virol. 71 (1997), 2779–2785.
    • (1997) J. Virol. , vol.71 , pp. 2779-2785
    • Fouts, T.R.1    Binley, J.M.2    Trkola, A.3    Robinson, J.E.4    Moore, J.P.5
  • 11
    • 84869062790 scopus 로고    scopus 로고
    • A combination of broadly neutralizing HIV-1 monoclonal antibodies targeting distinct epitopes effectively neutralizes variants found in early infection
    • Goo, L., Jalalian-Lechak, Z., Richardson, B.A., Overbaugh, J., A combination of broadly neutralizing HIV-1 monoclonal antibodies targeting distinct epitopes effectively neutralizes variants found in early infection. J. Virol. 86 (2012), 10857–10861.
    • (2012) J. Virol. , vol.86 , pp. 10857-10861
    • Goo, L.1    Jalalian-Lechak, Z.2    Richardson, B.A.3    Overbaugh, J.4
  • 12
    • 84866172362 scopus 로고    scopus 로고
    • Neutralizing antibody escape during HIV-1 mother-to-child transmission involves conformational masking of distal epitopes in envelope
    • Goo, L., Milligan, C., Simonich, C.A., Nduati, R., Overbaugh, J., Neutralizing antibody escape during HIV-1 mother-to-child transmission involves conformational masking of distal epitopes in envelope. J. Virol. 86 (2012), 9566–9582.
    • (2012) J. Virol. , vol.86 , pp. 9566-9582
    • Goo, L.1    Milligan, C.2    Simonich, C.A.3    Nduati, R.4    Overbaugh, J.5
  • 13
    • 84902131373 scopus 로고    scopus 로고
    • Early development of broadly neutralizing antibodies in HIV-1-infected infants
    • Goo, L., Chohan, V., Nduati, R., Overbaugh, J., Early development of broadly neutralizing antibodies in HIV-1-infected infants. Nat. Med. 20 (2014), 655–658.
    • (2014) Nat. Med. , vol.20 , pp. 655-658
    • Goo, L.1    Chohan, V.2    Nduati, R.3    Overbaugh, J.4
  • 14
    • 77950806408 scopus 로고    scopus 로고
    • New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0
    • Guindon, S., Dufayard, J.F., Lefort, V., Anisimova, M., Hordijk, W., Gascuel, O., New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0. Syst. Biol. 59 (2010), 307–321.
    • (2010) Syst. Biol. , vol.59 , pp. 307-321
    • Guindon, S.1    Dufayard, J.F.2    Lefort, V.3    Anisimova, M.4    Hordijk, W.5    Gascuel, O.6
  • 20
    • 84875759341 scopus 로고    scopus 로고
    • Somatic mutations of the immunoglobulin framework are generally required for broad and potent HIV-1 neutralization
    • Klein, F., Diskin, R., Scheid, J.F., Gaebler, C., Mouquet, H., Georgiev, I.S., Pancera, M., Zhou, T., Incesu, R.B., Fu, B.Z., et al. Somatic mutations of the immunoglobulin framework are generally required for broad and potent HIV-1 neutralization. Cell 153 (2013), 126–138.
    • (2013) Cell , vol.153 , pp. 126-138
    • Klein, F.1    Diskin, R.2    Scheid, J.F.3    Gaebler, C.4    Mouquet, H.5    Georgiev, I.S.6    Pancera, M.7    Zhou, T.8    Incesu, R.B.9    Fu, B.Z.10
  • 23
    • 0032167410 scopus 로고    scopus 로고
    • Molecular characterization of five neutralizing anti-HIV type 1 antibodies: identification of nonconventional D segments in the human monoclonal antibodies 2G12 and 2F5
    • Kunert, R., Rüker, F., Katinger, H., Molecular characterization of five neutralizing anti-HIV type 1 antibodies: identification of nonconventional D segments in the human monoclonal antibodies 2G12 and 2F5. AIDS Res. Hum. Retroviruses 14 (1998), 1115–1128.
    • (1998) AIDS Res. Hum. Retroviruses , vol.14 , pp. 1115-1128
    • Kunert, R.1    Rüker, F.2    Katinger, H.3
  • 26
    • 84943588030 scopus 로고    scopus 로고
    • Model building and refinement of a natively glycosylated HIV-1 Env protein by high-resolution cryoelectron microscopy
    • Lee, J.H., de Val, N., Lyumkis, D., Ward, A.B., Model building and refinement of a natively glycosylated HIV-1 Env protein by high-resolution cryoelectron microscopy. Structure 23 (2015), 1943–1951.
    • (2015) Structure , vol.23 , pp. 1943-1951
    • Lee, J.H.1    de Val, N.2    Lyumkis, D.3    Ward, A.B.4
  • 28
  • 30
    • 80355131958 scopus 로고    scopus 로고
    • The role of amino acid changes in the human immunodeficiency virus type 1 transmembrane domain in antibody binding and neutralization
    • Lovelace, E., Xu, H., Blish, C.A., Strong, R., Overbaugh, J., The role of amino acid changes in the human immunodeficiency virus type 1 transmembrane domain in antibody binding and neutralization. Virology 421 (2011), 235–244.
    • (2011) Virology , vol.421 , pp. 235-244
    • Lovelace, E.1    Xu, H.2    Blish, C.A.3    Strong, R.4    Overbaugh, J.5
  • 32
    • 84879302728 scopus 로고    scopus 로고
    • HIV-1 neutralizing antibodies: understanding nature's pathways
    • Mascola, J.R., Haynes, B.F., HIV-1 neutralizing antibodies: understanding nature's pathways. Immunol. Rev. 254 (2013), 225–244.
    • (2013) Immunol. Rev. , vol.254 , pp. 225-244
    • Mascola, J.R.1    Haynes, B.F.2
  • 35
    • 84923814773 scopus 로고    scopus 로고
    • Antibody B cell responses in HIV-1 infection
    • Mouquet, H., Antibody B cell responses in HIV-1 infection. Trends Immunol. 35 (2014), 549–561.
    • (2014) Trends Immunol. , vol.35 , pp. 549-561
    • Mouquet, H.1
  • 39
    • 19944428265 scopus 로고    scopus 로고
    • Multiple, linked human immunodeficiency virus type 1 drug resistance mutations in treatment-experienced patients are missed by standard genotype analysis
    • Palmer, S., Kearney, M., Maldarelli, F., Halvas, E.K., Bixby, C.J., Bazmi, H., Rock, D., Falloon, J., Davey, R.T. Jr., Dewar, R.L., et al. Multiple, linked human immunodeficiency virus type 1 drug resistance mutations in treatment-experienced patients are missed by standard genotype analysis. J. Clin. Microbiol. 43 (2005), 406–413.
    • (2005) J. Clin. Microbiol. , vol.43 , pp. 406-413
    • Palmer, S.1    Kearney, M.2    Maldarelli, F.3    Halvas, E.K.4    Bixby, C.J.5    Bazmi, H.6    Rock, D.7    Falloon, J.8    Davey, R.T.9    Dewar, R.L.10
  • 40
    • 0031969423 scopus 로고    scopus 로고
    • Neutralization of human immunodeficiency virus type 1 by antibody to gp120 is determined primarily by occupancy of sites on the virion irrespective of epitope specificity
    • Parren, P.W., Mondor, I., Naniche, D., Ditzel, H.J., Klasse, P.J., Burton, D.R., Sattentau, Q.J., Neutralization of human immunodeficiency virus type 1 by antibody to gp120 is determined primarily by occupancy of sites on the virion irrespective of epitope specificity. J. Virol. 72 (1998), 3512–3519.
    • (1998) J. Virol. , vol.72 , pp. 3512-3519
    • Parren, P.W.1    Mondor, I.2    Naniche, D.3    Ditzel, H.J.4    Klasse, P.J.5    Burton, D.R.6    Sattentau, Q.J.7
  • 43
    • 84884678235 scopus 로고    scopus 로고
    • A next-generation cleaved, soluble HIV-1 Env trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodies
    • Sanders, R.W., Derking, R., Cupo, A., Julien, J.P., Yasmeen, A., de Val, N., Kim, H.J., Blattner, C., de la Peña, A.T., Korzun, J., et al. A next-generation cleaved, soluble HIV-1 Env trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodies. PLoS Pathog., 9, 2013, e1003618.
    • (2013) PLoS Pathog. , vol.9 , pp. e1003618
    • Sanders, R.W.1    Derking, R.2    Cupo, A.3    Julien, J.P.4    Yasmeen, A.5    de Val, N.6    Kim, H.J.7    Blattner, C.8    de la Peña, A.T.9    Korzun, J.10
  • 45
    • 18244422922 scopus 로고    scopus 로고
    • The broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2G12 recognizes a cluster of alpha1–>2 mannose residues on the outer face of gp120
    • Scanlan, C.N., Pantophlet, R., Wormald, M.R., Ollmann Saphire, E., Stanfield, R., Wilson, I.A., Katinger, H., Dwek, R.A., Rudd, P.M., Burton, D.R., The broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2G12 recognizes a cluster of alpha1–>2 mannose residues on the outer face of gp120. J. Virol. 76 (2002), 7306–7321.
    • (2002) J. Virol. , vol.76 , pp. 7306-7321
    • Scanlan, C.N.1    Pantophlet, R.2    Wormald, M.R.3    Ollmann Saphire, E.4    Stanfield, R.5    Wilson, I.A.6    Katinger, H.7    Dwek, R.A.8    Rudd, P.M.9    Burton, D.R.10
  • 47
    • 84908329318 scopus 로고    scopus 로고
    • Characteristics of memory B cells elicited by a highly efficacious HPV vaccine in subjects with no pre-existing immunity
    • Scherer, E.M., Smith, R.A., Simonich, C.A., Niyonzima, N., Carter, J.J., Galloway, D.A., Characteristics of memory B cells elicited by a highly efficacious HPV vaccine in subjects with no pre-existing immunity. PLoS Pathog., 10, 2014, e1004461.
    • (2014) PLoS Pathog. , vol.10 , pp. e1004461
    • Scherer, E.M.1    Smith, R.A.2    Simonich, C.A.3    Niyonzima, N.4    Carter, J.J.5    Galloway, D.A.6
  • 48
    • 61349097791 scopus 로고    scopus 로고
    • B-cell responses to vaccination at the extremes of age
    • Siegrist, C.A., Aspinall, R., B-cell responses to vaccination at the extremes of age. Nat. Rev. Immunol. 9 (2009), 185–194.
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 185-194
    • Siegrist, C.A.1    Aspinall, R.2
  • 49
    • 84888251984 scopus 로고    scopus 로고
    • The effects of somatic hypermutation on neutralization and binding in the PGT121 family of broadly neutralizing HIV antibodies
    • Sok, D., Laserson, U., Laserson, J., Liu, Y., Vigneault, F., Julien, J.P., Briney, B., Ramos, A., Saye, K.F., Le, K., et al. The effects of somatic hypermutation on neutralization and binding in the PGT121 family of broadly neutralizing HIV antibodies. PLoS Pathog., 9, 2013, e1003754.
    • (2013) PLoS Pathog. , vol.9 , pp. e1003754
    • Sok, D.1    Laserson, U.2    Laserson, J.3    Liu, Y.4    Vigneault, F.5    Julien, J.P.6    Briney, B.7    Ramos, A.8    Saye, K.F.9    Le, K.10
  • 53
    • 84894173514 scopus 로고    scopus 로고
    • Structural insights on the role of antibodies in HIV-1 vaccine and therapy
    • West, A.P. Jr., Scharf, L., Scheid, J.F., Klein, F., Bjorkman, P.J., Nussenzweig, M.C., Structural insights on the role of antibodies in HIV-1 vaccine and therapy. Cell 156 (2014), 633–648.
    • (2014) Cell , vol.156 , pp. 633-648
    • West, A.P.1    Scharf, L.2    Scheid, J.F.3    Klein, F.4    Bjorkman, P.J.5    Nussenzweig, M.C.6
  • 55
    • 84951908911 scopus 로고    scopus 로고
    • HIV-specific CD4-induced antibodies mediate broad and potent antibody-dependent cellular cytotoxicity activity and are commonly detected in plasma from HIV-infected humans
    • Williams, K.L., Cortez, V., Dingens, A.S., Gach, J.S., Rainwater, S., Weis, J.F., Chen, X., Spearman, P., Forthal, D.N., Overbaugh, J., HIV-specific CD4-induced antibodies mediate broad and potent antibody-dependent cellular cytotoxicity activity and are commonly detected in plasma from HIV-infected humans. EBioMedicine 2 (2015), 1464–1477.
    • (2015) EBioMedicine , vol.2 , pp. 1464-1477
    • Williams, K.L.1    Cortez, V.2    Dingens, A.S.3    Gach, J.S.4    Rainwater, S.5    Weis, J.F.6    Chen, X.7    Spearman, P.8    Forthal, D.N.9    Overbaugh, J.10
  • 58
  • 59
    • 84905672117 scopus 로고    scopus 로고
    • Immunologic basis for long HCDR3s in broadly neutralizing antibodies against HIV-1
    • Yu, L., Guan, Y., Immunologic basis for long HCDR3s in broadly neutralizing antibodies against HIV-1. Front. Immunol., 5, 2014, 250.
    • (2014) Front. Immunol. , vol.5 , pp. 250
    • Yu, L.1    Guan, Y.2
  • 61
    • 80055115557 scopus 로고    scopus 로고
    • Cross-reactive HIV-1-neutralizing human monoclonal antibodies identified from a patient with 2F5-like antibodies
    • Zhu, Z., Qin, H.R., Chen, W., Zhao, Q., Shen, X., Schutte, R., Wang, Y., Ofek, G., Streaker, E., Prabakaran, P., et al. Cross-reactive HIV-1-neutralizing human monoclonal antibodies identified from a patient with 2F5-like antibodies. J. Virol. 85 (2011), 11401–11408.
    • (2011) J. Virol. , vol.85 , pp. 11401-11408
    • Zhu, Z.1    Qin, H.R.2    Chen, W.3    Zhao, Q.4    Shen, X.5    Schutte, R.6    Wang, Y.7    Ofek, G.8    Streaker, E.9    Prabakaran, P.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.