메뉴 건너뛰기




Volumn 14, Issue 13, 1998, Pages 1115-1128

Molecular characterization of five neutralizing anti-HIV type 1 antibodies: Identification of nonconventional D segments in the human monoclonal antibodies 2G12 and 2F5

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; ANTIGEN P24; COMPLEMENTARY DNA; GLYCOPROTEIN GP 160; GLYCOPROTEIN GP 41; HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; NEUTRALIZING ANTIBODY; NUCLEOTIDE; RNA;

EID: 0032167410     PISSN: 08892229     EISSN: None     Source Type: Journal    
DOI: 10.1089/aid.1998.14.1115     Document Type: Article
Times cited : (97)

References (54)
  • 1
    • 0025950326 scopus 로고
    • Another discontinuous epitope on glycoprotein gp120 that is important in human immunodeficiency virus type 1 neutralization is identified by a monoclonal antibody
    • Ho DD, Fung MS, Cao YZ, Li XL, Sun C, Chang TW, and Sun NC: Another discontinuous epitope on glycoprotein gp120 that is important in human immunodeficiency virus type 1 neutralization is identified by a monoclonal antibody. Proc Natl Acad Sci USA 1991;88:8949-8952.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 8949-8952
    • Ho, D.D.1    Fung, M.S.2    Cao, Y.Z.3    Li, X.L.4    Sun, C.5    Chang, T.W.6    Sun, N.C.7
  • 6
    • 0028235930 scopus 로고
    • Cross-neutralizing activity against divergent human immunodeficiency virus type 1 isolates induced by the gp41 sequence ELDKWAS
    • Muster T, Guinea R, Trkola A, Purtscher M, Klima A, Steindl F, Palese P, and Katinger H: Cross-neutralizing activity against divergent human immunodeficiency virus type 1 isolates induced by the gp41 sequence ELDKWAS. J Virol 1994;68:4031-4034.
    • (1994) J Virol , vol.68 , pp. 4031-4034
    • Muster, T.1    Guinea, R.2    Trkola, A.3    Purtscher, M.4    Klima, A.5    Steindl, F.6    Palese, P.7    Katinger, H.8
  • 7
    • 0028208268 scopus 로고
    • Neutralization of divergent human immunodeficiency virus type 1 variants and primary isolates by IAM-41-2F5, an anti-gp41 human monoclonal antibody
    • Conley AJ, Kessler JA II, Boots LJ, Tung JS, Arnold BA, Keller PM, Shaw AR, and Emini EA: Neutralization of divergent human immunodeficiency virus type 1 variants and primary isolates by IAM-41-2F5, an anti-gp41 human monoclonal antibody. Proc Natl Acad Sci USA 1994;91:3348-3352.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 3348-3352
    • Conley, A.J.1    Kessler II, J.A.2    Boots, L.J.3    Tung, J.S.4    Arnold, B.A.5    Keller, P.M.6    Shaw, A.R.7    Emini, E.A.8
  • 9
    • 0030043169 scopus 로고    scopus 로고
    • Antibody cross-competition analysis of the human immunodeficiency virus type 1 gp120 exterior envelope glycoprotein
    • Moore JP and Sodroski J: Antibody cross-competition analysis of the human immunodeficiency virus type 1 gp120 exterior envelope glycoprotein. J Virol 1996;70:1863-1872.
    • (1996) J Virol , vol.70 , pp. 1863-1872
    • Moore, J.P.1    Sodroski, J.2
  • 10
    • 0030823325 scopus 로고    scopus 로고
    • Potent and synergistic neutralization of human immunodeficiency virus (HIV) type 1 primary isolates by hyperimmune anti-HIV immunoglobulin combined with monoclonal antibodies 2F5 and 2G12
    • Mascola JR, Louder MK, VanCott TC, Sapan CV, Lambert JS, Muenz LR, Bunow B, Birx DL, and Robb ML: Potent and synergistic neutralization of human immunodeficiency virus (HIV) type 1 primary isolates by hyperimmune anti-HIV immunoglobulin combined with monoclonal antibodies 2F5 and 2G12. J Virol 1997;71:7198-7206.
    • (1997) J Virol , vol.71 , pp. 7198-7206
    • Mascola, J.R.1    Louder, M.K.2    Vancott, T.C.3    Sapan, C.V.4    Lambert, J.S.5    Muenz, L.R.6    Bunow, B.7    Birx, D.L.8    Robb, M.L.9
  • 14
    • 0030064149 scopus 로고    scopus 로고
    • Efficient destruction of human immunodeficiency virus in human serum by inhibiting the protective action of complement factor H and decay accelerating factor (DAF, CD55)
    • Stoiber H, Pinter C, Siccardi AG, Clivio A, and Dierich MP: Efficient destruction of human immunodeficiency virus in human serum by inhibiting the protective action of complement factor H and decay accelerating factor (DAF, CD55). J Exp Med 1996; 183:307-310.
    • (1996) J Exp Med , vol.183 , pp. 307-310
    • Stoiber, H.1    Pinter, C.2    Siccardi, A.G.3    Clivio, A.4    Dierich, M.P.5
  • 15
    • 0029059046 scopus 로고
    • Human complement proteins C3b, C4b, factor H and properdin react with specific sites in gp120 and gp41, the envelope proteins of HIV-1
    • Stoiber H, Schneider R, Janatova J, and Dierich MP: Human complement proteins C3b, C4b, factor H and properdin react with specific sites in gp120 and gp41, the envelope proteins of HIV-1. Immunobiology 1995;193:98-113.
    • (1995) Immunobiology , vol.193 , pp. 98-113
    • Stoiber, H.1    Schneider, R.2    Janatova, J.3    Dierich, M.P.4
  • 18
    • 0025760317 scopus 로고
    • Oligonucleotide primers for polymerase chain reaction amplification of human immunoglobulin variable genes and design of family-specific oligonucleotide probes
    • Marks JD, Tristem M, Karpas A, and Winter G: Oligonucleotide primers for polymerase chain reaction amplification of human immunoglobulin variable genes and design of family-specific oligonucleotide probes. Eur J Immunol 1991;21:985-991.
    • (1991) Eur J Immunol , vol.21 , pp. 985-991
    • Marks, J.D.1    Tristem, M.2    Karpas, A.3    Winter, G.4
  • 19
    • 0025160356 scopus 로고
    • Nucleotide sequences of the cDNAs encoding the V-regions of H- and L-chains of a human monoclonal antibody specific to HIV-1-gp41
    • Felgenhauer M, Kohl J, and Ruker F: Nucleotide sequences of the cDNAs encoding the V-regions of H- and L-chains of a human monoclonal antibody specific to HIV-1-gp41. Nucleic Acids Res 1990;18:4927.
    • (1990) Nucleic Acids Res , vol.18 , pp. 4927
    • Felgenhauer, M.1    Kohl, J.2    Ruker, F.3
  • 20
    • 0023989064 scopus 로고
    • Improved tools for biological sequence comparison
    • Pearson WR and Lipman DJ: Improved tools for biological sequence comparison. Proc Natl Acad Sci USA 1988;85:2444-2448.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 2444-2448
    • Pearson, W.R.1    Lipman, D.J.2
  • 21
    • 0025272240 scopus 로고
    • Rapid and sensitive sequence comparison with FASTP and FASTA
    • Pearson WR: Rapid and sensitive sequence comparison with FASTP and FASTA. Methods Enzymol 1990;183:63.
    • (1990) Methods Enzymol , vol.183 , pp. 63
    • Pearson, W.R.1
  • 24
    • 0026785856 scopus 로고
    • The repertoire of human germline VH sequences reveals about fifty groups of VH segments with different hypervariable loops
    • Tomlinson IM, Walter G, Marks JD, Llewelyn MB, and Winter G: The repertoire of human germline VH sequences reveals about fifty groups of VH segments with different hypervariable loops. J Mol Biol 1992;227:776-798.
    • (1992) J Mol Biol , vol.227 , pp. 776-798
    • Tomlinson, I.M.1    Walter, G.2    Marks, J.D.3    Llewelyn, M.B.4    Winter, G.5
  • 25
    • 0027131399 scopus 로고
    • Molecular characterization of human antibodies to bacterial antigens: Utilization of the less frequently expressed VH2 and VH6 heavy chain variable region gene families
    • Andris JS, Brodeur BR, and Capra JD: Molecular characterization of human antibodies to bacterial antigens: Utilization of the less frequently expressed VH2 and VH6 heavy chain variable region gene families. Mol Immunol 1993;30:1601-1616.
    • (1993) Mol Immunol , vol.30 , pp. 1601-1616
    • Andris, J.S.1    Brodeur, B.R.2    Capra, J.D.3
  • 27
    • 0028326520 scopus 로고
    • A directory of human germline V kappa segments reveals a strong bias in their usage
    • Cox JP, Tomlinson IM, and Winter G: A directory of human germline V kappa segments reveals a strong bias in their usage. Eur J Immunol 1994;24:827-836.
    • (1994) Eur J Immunol , vol.24 , pp. 827-836
    • Cox, J.P.1    Tomlinson, I.M.2    Winter, G.3
  • 28
    • 0021768572 scopus 로고
    • Immunoglobulin genes of different subgroups are interdigitated within the VK locus
    • Pech M and Zachau HG: Immunoglobulin genes of different subgroups are interdigitated within the VK locus. Nucleic Acids Res 1984;12:9229-9236.
    • (1984) Nucleic Acids Res , vol.12 , pp. 9229-9236
    • Pech, M.1    Zachau, H.G.2
  • 29
    • 0027363253 scopus 로고
    • The V kappa genes of the L regions and the repertoire of V kappa gene sequences in the human germ line
    • Huber C, Schable KF, Huber E, Klein R, Meindl A, Thiebe R, Lamm R, and Zachau HG: The V kappa genes of the L regions and the repertoire of V kappa gene sequences in the human germ line. Eur J Immunol 1993;23:2868-2875.
    • (1993) Eur J Immunol , vol.23 , pp. 2868-2875
    • Huber, C.1    Schable, K.F.2    Huber, E.3    Klein, R.4    Meindl, A.5    Thiebe, R.6    Lamm, R.7    Zachau, H.G.8
  • 30
    • 0019123187 scopus 로고
    • Human immunoglobulin variable region genes - DNA sequences of two V kappa genes and a pseudogene
    • Bentley DL and Rabbits TH: Human immunoglobulin variable region genes - DNA sequences of two V kappa genes and a pseudogene. Nature (London) 1980;288:730-733.
    • (1980) Nature (London) , vol.288 , pp. 730-733
    • Bentley, D.L.1    Rabbits, T.H.2
  • 31
    • 0018675871 scopus 로고
    • Evolutionary nucleotide replacements in DNA
    • Jukes TH and King JL: Evolutionary nucleotide replacements in DNA. Nature (London) 1979;281:605-606.
    • (1979) Nature (London) , vol.281 , pp. 605-606
    • Jukes, T.H.1    King, J.L.2
  • 32
    • 0022441434 scopus 로고
    • Variable region sequences of murine IgM anti-IgG monoclonal autoantibodies (rheumatoid factors). A structural explanation for the high frequency of IgM anti-IgG B cells
    • Shlomchik MJ, Nemazee DA, Sato VL, Van Snick J, Carson DA, and Weigert MG: Variable region sequences of murine IgM anti-IgG monoclonal autoantibodies (rheumatoid factors). A structural explanation for the high frequency of IgM anti-IgG B cells. J Exp Med 1986;164:407-427.
    • (1986) J Exp Med , vol.164 , pp. 407-427
    • Shlomchik, M.J.1    Nemazee, D.A.2    Sato, V.L.3    Van Snick, J.4    Carson, D.A.5    Weigert, M.G.6
  • 33
    • 0026099589 scopus 로고
    • Preferential utilization of specific immunoglobulin heavy chain diversity and joining segments in adult human peripheral blood B lymphocytes
    • Yamada M, Wasserman R, Reichard BA, Shane S, Caton AJ, and Rovera G: Preferential utilization of specific immunoglobulin heavy chain diversity and joining segments in adult human peripheral blood B lymphocytes. J Exp Med 1991;173:395-407.
    • (1991) J Exp Med , vol.173 , pp. 395-407
    • Yamada, M.1    Wasserman, R.2    Reichard, B.A.3    Shane, S.4    Caton, A.J.5    Rovera, G.6
  • 34
    • 0028609273 scopus 로고
    • Molecular characterization of variable heavy and light chain regions of five HIV type 1-specific human monoclonal antibodies
    • van der Donk EM, Schutten M, Osterhaus AD, and van der Heijden RW: Molecular characterization of variable heavy and light chain regions of five HIV type 1-specific human monoclonal antibodies. AIDS Res Hum Retroviruses 1994;10:1639-1649.
    • (1994) AIDS Res Hum Retroviruses , vol.10 , pp. 1639-1649
    • Van Der Donk, E.M.1    Schutten, M.2    Osterhaus, A.D.3    Van Der Heijden, R.W.4
  • 35
    • 0027367543 scopus 로고
    • Variable region genes of anti-HIV human monoclonal antibodies: Non-restricted use of the V gene repertoire and extensive somatic mutation
    • Moran MJ, Andris JS, Matsumato Y, Capra JD, and Hersh EM: Variable region genes of anti-HIV human monoclonal antibodies: Non-restricted use of the V gene repertoire and extensive somatic mutation. Mol Immunol 1993;30:1543-1551.
    • (1993) Mol Immunol , vol.30 , pp. 1543-1551
    • Moran, M.J.1    Andris, J.S.2    Matsumato, Y.3    Capra, J.D.4    Hersh, E.M.5
  • 37
    • 0025838698 scopus 로고
    • A large array of human monoclonal antibodies to type 1 human immunodeficiency virus from combinatorial libraries of asymptomatic seropositive individuals
    • Burton DR, Barbas CF III, Persson MA, Koenig S, Chanock RM, and Lerner RA: A large array of human monoclonal antibodies to type 1 human immunodeficiency virus from combinatorial libraries of asymptomatic seropositive individuals. Proc Natl Acad Sci USA 1991;88:10134-10137.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 10134-10137
    • Burton, D.R.1    Barbas III, C.F.2    Persson, M.A.3    Koenig, S.4    Chanock, R.M.5    Lerner, R.A.6
  • 38
    • 0027261552 scopus 로고
    • Conformational changes affecting the V3 and CD4-binding domains of human immunodeficiency virus type 1 gp120 associated with Env processing and with binding of ligands to these sites
    • Pinter A, Honnen WJ, and Tilley SA: Conformational changes affecting the V3 and CD4-binding domains of human immunodeficiency virus type 1 gp120 associated with Env processing and with binding of ligands to these sites. J Virol 1993;67:5692-5697.
    • (1993) J Virol , vol.67 , pp. 5692-5697
    • Pinter, A.1    Honnen, W.J.2    Tilley, S.A.3
  • 39
    • 0028348564 scopus 로고
    • In vitro evolution of a neutralizing human antibody to human immunodeficiency virus type 1 to enhance affinity and broaden strain cross-reactivity
    • Barbas CF III, Hu D, Dunlop N, Sawyer L, Cababa D, Hendry RM, Nara PL, and Burton DR: In vitro evolution of a neutralizing human antibody to human immunodeficiency virus type 1 to enhance affinity and broaden strain cross-reactivity. Proc Natl Acad Sci USA 1994;91:3809-3813.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 3809-3813
    • Barbas III, C.F.1    Hu, D.2    Dunlop, N.3    Sawyer, L.4    Cababa, D.5    Hendry, R.M.6    Nara, P.L.7    Burton, D.R.8
  • 40
    • 0028001662 scopus 로고
    • Structural characterization of broadly neutralizing human monoclonal antibodies against the CD4 binding site of HIV-1 gp120
    • Bagley J, Dillon PJ, Rosen C, Robinson J, Sodroski J, and Marasco WA: Structural characterization of broadly neutralizing human monoclonal antibodies against the CD4 binding site of HIV-1 gp120. Mol Immunol 1994;31:1149-1160.
    • (1994) Mol Immunol , vol.31 , pp. 1149-1160
    • Bagley, J.1    Dillon, P.J.2    Rosen, C.3    Robinson, J.4    Sodroski, J.5    Marasco, W.A.6
  • 44
    • 0030130977 scopus 로고    scopus 로고
    • Non-stochastic utilization of Ig V region genes in unselected human peripheral B cells
    • Huang SC, Jiang R, Glas AM, and Milner EC: Non-stochastic utilization of Ig V region genes in unselected human peripheral B cells. Mol Immunol 1996;33:553-560.
    • (1996) Mol Immunol , vol.33 , pp. 553-560
    • Huang, S.C.1    Jiang, R.2    Glas, A.M.3    Milner, E.C.4
  • 45
    • 0030979332 scopus 로고    scopus 로고
    • B cell superantigens in HIV-1 infection
    • Muller S and Kohler H: B cell superantigens in HIV-1 infection. Int Rev Immunol 1997;14:339-349.
    • (1997) Int Rev Immunol , vol.14 , pp. 339-349
    • Muller, S.1    Kohler, H.2
  • 46
    • 0029093328 scopus 로고
    • Molecular characterization of human monoclonal antibodies specific for several HIV proteins: Analysis of the VH3 family expression
    • David D, Goossens D, Desgranges C, Theze J, and Zouali M: Molecular characterization of human monoclonal antibodies specific for several HIV proteins: Analysis of the VH3 family expression. Immunol Lett 1995;47:107-112.
    • (1995) Immunol Lett , vol.47 , pp. 107-112
    • David, D.1    Goossens, D.2    Desgranges, C.3    Theze, J.4    Zouali, M.5
  • 49
    • 0027216150 scopus 로고
    • Restricted immunoglobulin VH usage and VDJ combinations in the human response to Haemophilus influenzae type b capsular polysaccharide. Nucleotide sequences of monospecific anti-Haemophilus antibodies and polyspecific antibodies cross-reacting with self antigens
    • Adderson EE, Shackelford PG, Quinn A, Wilson PM, Cunningham MW, Insel RA, and Carroll WL: Restricted immunoglobulin VH usage and VDJ combinations in the human response to Haemophilus influenzae type b capsular polysaccharide. Nucleotide sequences of monospecific anti-Haemophilus antibodies and polyspecific antibodies cross-reacting with self antigens. J Clin Invest 1993;91:2734-2743.
    • (1993) J Clin Invest , vol.91 , pp. 2734-2743
    • Adderson, E.E.1    Shackelford, P.G.2    Quinn, A.3    Wilson, P.M.4    Cunningham, M.W.5    Insel, R.A.6    Carroll, W.L.7
  • 50
    • 0025868277 scopus 로고
    • Molecular characterization of five human anti-human immunodeficiency virus type 1 antibody heavy chains reveals extensive somatic mutation typical of an antigen-driven immune response
    • Andris JS, Johnson S, Zolla-Pazner S, and Capra JD: Molecular characterization of five human anti-human immunodeficiency virus type 1 antibody heavy chains reveals extensive somatic mutation typical of an antigen-driven immune response. Proc Natl Acad Sci USA 1991;88:7783-7787.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 7783-7787
    • Andris, J.S.1    Johnson, S.2    Zolla-Pazner, S.3    Capra, J.D.4
  • 51
    • 0024400179 scopus 로고
    • Novel rearrangements at the immunoglobulin D locus. Inversions and fusions add to IgH somatic diversity
    • Meek KD, Hasemann CA, and Capra JD: Novel rearrangements at the immunoglobulin D locus. Inversions and fusions add to IgH somatic diversity. J Exp Med 1989;170:39-57.
    • (1989) J Exp Med , vol.170 , pp. 39-57
    • Meek, K.D.1    Hasemann, C.A.2    Capra, J.D.3
  • 52
    • 0028343694 scopus 로고
    • Molecular characterization of human Ig heavy chain DIR genes
    • Sanz I, Wang SS, Meneses G, and Fischbach M: Molecular characterization of human Ig heavy chain DIR genes. J Immunol 1994;152:3958-3969.
    • (1994) J Immunol , vol.152 , pp. 3958-3969
    • Sanz, I.1    Wang, S.S.2    Meneses, G.3    Fischbach, M.4
  • 54
    • 0031586221 scopus 로고    scopus 로고
    • Sequence of the human immunoglobulin diversity (D) segment locus: A systematic analysis provides no evidence for the use of DIR segments, inverted D segments, "minor" D segments or D-D recombination
    • Corbett SJ, Tomlinson IM, Sonnhammer ELL, Buck D, and Winter G: Sequence of the human immunoglobulin diversity (D) segment locus: A systematic analysis provides no evidence for the use of DIR segments, inverted D segments, "minor" D segments or D-D recombination. J Mol Biol 1997;270:587-597.
    • (1997) J Mol Biol , vol.270 , pp. 587-597
    • Corbett, S.J.1    Tomlinson, I.M.2    Sonnhammer, E.L.L.3    Buck, D.4    Winter, G.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.