Design, synthesis and biological evaluation of berberine-benzimidazole hybrids as new type of potentially DNA-targeting antimicrobial agents

European Journal of Medicinal Chemistry

Volumn 122, Issue , 2016, Pages 205-215

  Jeyakkumar, Ponmani ^a   Zhang, Ling ^a   Avula, Srinivasa Rao ^a,b   Zhou, Cheng He ^a  

^a SOUTHWEST UNIVERSITY   (China)

^b CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

Antimicrobial; Benzimidazole; Berberine; DNA; HSA

Indexed keywords

2 BERBERINOXYMETHOXY 1 DECYL 1H BENZO[D]IMIDAZOLE; 2 BERBERINOXYMETHOXY 1 DODECYL 1H BENZO[D]IMIDAZOLE; 2 BERBERINOXYMETHOXY 1 ETHYL 1H BENZO[D]IMIDAZOLE; 2 BERBERINOXYMETHOXY 1 HEPTYL 1H BENZO[D]IMIDAZOLE; 2 BERBERINOXYMETHOXY 1 HEXADECYL 1H BENZO[D]IMIDAZOLE; 2 BERBERINOXYMETHOXY 1 OCTADECYL 1H BENZO[D]IMIDAZOLE; 2 BERBERINOXYMETHOXY 1 OCTYL 1H BENZO[D]IMIDAZOLE; 2 BERBERINOXYMETHOXY 1 PENTYL 1H BENZO[D]IMIDAZOLE; 2 BERBERINOXYMETHOXY 1 PROPYL 1H BENZO[D]IMIDAZOLE; 2 BERBERINOXYMETHOXY 1H BENZO[D]IMIDAZOLE; 2 BERBERINOXYMETHOXY 5 CHLORO 1H BENZO[D]IMIDAZOLE; 2 BERBERINOXYMETHOXY 5 FLURO 1H BENZO[D]IMIDAZOLE; ANTIINFECTIVE AGENT; BENZIMIDAZOLE DERIVATIVE; BERBERINE DERIVATIVE; CHLOROMYCIN; FLUCONAZOLE; HUMAN SERUM ALBUMIN; N 2 FLUROBENZYL 2 BERBERINOXYMETHOXY 1H BENZO[D]IMIDAZOLE; N 2,4 DICHLOROBENZYL 2 BERBERINOXYMETHOXY 1H ENZO[D]IMIDAZOLE; N 3 CHLOROBENZYL 2 BERBERINOXYMETHOXY 1H BENZO[D]IMIDAZOLE; N 3 FLUROBENZYL 2 BERBERINOXYMETHOXY 1H BENZO[D]IMIDAZOLE; N 4 CHLOROBENZYL 2 BERBERINOXYMETHOXY 1H BENZO[D]IMIDAZOLE; N 4 FLUROBENZYL 2 BERBERINOXYMETHOXY 1H BENZO[D]IMIDAZOLE; N 4 NITROBENZYL 2 BERBERINOXYMETHOXY 1H BENZO[D]IMIDAZOLE; NORFLOXACIN; UNCLASSIFIED DRUG; BERBERINE; CALF THYMUS DNA; DNA; SERUM ALBUMIN; WATER;

AGAR GEL ELECTROPHORESIS; ANTIMICROBIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DNA CLEAVAGE; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; ESCHERICHIA COLI; GENE TARGETING; HYDROGEN BOND; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DOCKING; NONHUMAN; SALMONELLA ENTERICA SEROVAR TYPHI; ANIMAL; BACTERIUM; BOVINE; CELL MEMBRANE PERMEABILITY; CHEMISTRY; DRUG EFFECTS; FUNGUS; HUMAN; METABOLISM; MICROBIAL SENSITIVITY TEST; PROTEIN CONFORMATION; SYNTHESIS;

ANIMALS; ANTI-INFECTIVE AGENTS; BACTERIA; BENZIMIDAZOLES; BERBERINE; CATTLE; CELL MEMBRANE PERMEABILITY; CHEMISTRY TECHNIQUES, SYNTHETIC; DNA; DRUG DESIGN; FUNGI; HUMANS; MICROBIAL SENSITIVITY TESTS; MOLECULAR DOCKING SIMULATION; PROTEIN CONFORMATION; SERUM ALBUMIN; WATER;

EID: 84976496761     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2016.06.031     Document Type: Article

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