Novel hybrids of metronidazole and quinolones: Synthesis, bioactive evaluation, cytotoxicity, preliminary antimicrobial mechanism and effect of metal ions on their transportation by human serum albumin

European Journal of Medicinal Chemistry

Volumn 86, Issue , 2014, Pages 318-334

  Cui, Sheng Feng ^a   Peng, Li Ping ^a   Zhang, Hui Zhen ^a   Rasheed, Syed ^a   Vijaya Kumar, Kannekanti ^a   Zhou, Cheng He ^a  

^a SOUTHWEST UNIVERSITY   (China)

Author keywords

Antibacterial; DNA; HSA; Imidazole; Metronidazole; Quinolone

Indexed keywords

HUMAN SERUM ALBUMIN; METAL ION; METRONIDAZOLE; QUINOLONE DERIVATIVE; ANTIBIOTIC AGENT; ANTIFUNGAL AGENT; CHLOROMYCIN; ETHYL 1 (OXIRAN 2 YLMETHYL) 4 OXO 7 (TRIFLUOROMETHYL) 1,4 DIHYDROQUINOLINE 3 CARBOXYLATE; ETHYL 1 [2 HYDROXY 3 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)PROPYL] 4 OXO 6 (TRIFLUOROMETHYL) 1,4 DIHYDROQUINOLINE 3 CARBOXYLATE; ETHYL 1 [2 HYDROXY 3 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)PROPYL] 6 METHYL 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLATE; ETHYL 1 [2 HYDROXY 3 (4 NITRO 1H IMIDAZOL 1 YL)PROPYL] 4 OXO 7 (TRIFLUOROMETHYL) 1,4 DIHYDROQUINOLINE 3 CARBOXYLATE; ETHYL 1 [2 HYDROXY 3 (4 NITRO 1H IMIDAZOL 1 YL)PROPYL] 6 METHYL 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLATE; ETHYL 6 FLUORO 1 (OXIRAN 2 YLMETHYL) 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLATE; ETHYL 6 FLUORO 1 [2 HYDROXY 3 (4 NITRO 1H IMIDAZOL 1 YL)PROPYL] 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLATE; ETHYL 6 FLUORO1 [2 HYDROXY 3 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)PROPYL] 4 OXO 1,4 DIHYROQUINOLINE 3 CARBOXYLATE; ETHYL 6 METHOXY 1 (OXIRAN 2 YLMETHYL) 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLATE; ETHYL 6 METHYL 1 (OXIRAN 2 YLMETHYL) 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLATE; ETHYL 6,8 DI FLUORO 1 [2 HYDROXY 3 (4 NITRO 1H IMIDAZOL 1 YL)PROPYL] 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLATE; ETHYL 6,8 DICHLORO 1 (OXIRAN 2 YLMETHYL) 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLATE; ETHYL 6,8 DICHLORO 1 [2 HYDROXY 3 (4 NITRO 1H IMIDAZOL 1 YL)PROPYL] 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLATE; ETHYL 6,8 DIFLUORO 1 (OXIRAN 2 YLMETHYL) 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLATE; ETHYL 6,8 DIFLUORO 1 [2 HYDROXY 3 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)PROPYL] 4 OXO 1,4 DIHYROQUINOLINE 3 CARBOXYLATE; ETHYL 7 CHLORO 1 [2 HYDROXY 3 (4 NITRO 1H IMIDAZOL 1 YL)PROPYL] 6 METHOXY 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLATE; ETHYL 7 CHLORO 6 FLUORO 1 (OXIRAN 2 YLMETHYL) 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLATE; ETHYL 7 CHLORO 6 FLUORO1 [2 HYDROXY 3 (4 NITRO 1H IMIDAZOL 1 YL)PROPYL] 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLATE; ETHYL 8 FLUORO 1 (OXIRAN 2 YLMETHYL) 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLATE; ETHYL 8 FLUORO 1 [2 HYDROXY 3 (4 NITRO 1H IMIDAZOL 1 YL)PROPYL] 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLATE; FLUCONAZOLE; NORFLOXACIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; ANTIINFECTIVE AGENT; CALF THYMUS DNA; DNA; ION; MAGNESIUM; SERUM ALBUMIN;

ANTIMICROBIAL ACTIVITY; ARTICLE; BINDING SITE; BIOLOGICAL ACTIVITY; CYTOTOXICITY; DRUG SCREENING; DRUG SOLUBILITY; HUMAN; HUMAN CELL; HYBRID; LIVER CELL; MOLECULAR MODEL; NONHUMAN; PKA; TRAFFIC AND TRANSPORT; ABSORPTION SPECTROSCOPY; ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; CARBON NUCLEAR MAGNETIC RESONANCE; DNA DRUG COMPLEX; DRUG DESIGN; DRUG SYNTHESIS; IN VITRO STUDY; MELTING POINT; PROTON NUCLEAR MAGNETIC RESONANCE; ANIMAL; BACTERIUM; BOVINE; CELL LINE; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; FUNGUS; MICROBIAL SENSITIVITY TEST; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTIFUNGAL AGENTS; BACTERIA; CATTLE; CELL LINE; CELL SURVIVAL; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; FUNGI; HUMANS; IONS; MAGNESIUM; METRONIDAZOLE; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; QUINOLONES; SERUM ALBUMIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84906836140     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.08.063     Document Type: Article

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