Halothiophene benzimidazoles as P1 surrogates of inhibitors of blood coagulation factor Xa

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 14, 2004, Pages 3763-3769

  Mederski, Werner W K R ^a   Dorsch, Dieter ^a   Anzali, Soheila ^a   Gleitz, Johannes ^a   Cezanne, Bertram ^a   Tsaklakidis, Christos ^a  

^a MERCK KGAA   (Germany)

Author keywords

Anti coagulants; Factor Xa inhibitors; Halothiophene benzimidazoles; X ray crystal structures

Indexed keywords

BENZAMIDE DERIVATIVE; BLOOD CLOTTING FACTOR 10A INHIBITOR; IMIDAZOLE DERIVATIVE; THIOPHENE DERIVATIVE;

ARTICLE; BINDING AFFINITY; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION; X RAY ANALYSIS;

ANTITHROMBINS; BENZIMIDAZOLES; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; FACTOR XA; HUMANS; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPSIN;

STAPHYLOCOCCUS PHAGE 3A;

EID: 2942527396     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.04.097     Document Type: Article

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