How the thymus designs antigen-specific and self-tolerant T cell receptor sequences

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 43, 2008, Pages 16671-16676

  Košmrlj, Andrej ^a   Jha, Abhishek K ^b   Huseby, Eric S ^c   Kardar, Mehran ^a   Chakraborty, Arup K ^a,b  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b Massachusetts Institute of Technology Cambridge   (United States)

^c UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

Statistical mechanics; T cell antigen specificity; Thymic selection

Indexed keywords

PEPTIDE ANTIBODY; T LYMPHOCYTE RECEPTOR;

AMINO ACID COMPOSITION; ANTIGEN SPECIFICITY; ARTICLE; CELL ADHESION; CELL INTERACTION; CELL MATURATION; CELL SELECTION; CROSS REACTION; IMMUNOLOGICAL TOLERANCE; MAJOR HISTOCOMPATIBILITY COMPLEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; THYMUS;

AMINO ACID SEQUENCE; ANIMALS; COMPUTATIONAL BIOLOGY; CROSS REACTIONS; HISTOCOMPATIBILITY ANTIGENS; HUMANS; MODELS, BIOLOGICAL; RECEPTORS, ANTIGEN, T-CELL; SELF TOLERANCE; T-CELL ANTIGEN RECEPTOR SPECIFICITY; THYMUS GLAND;

EID: 55949095006     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0808081105     Document Type: Article

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