Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia

Nature Medicine

Volumn 22, Issue 7, 2016, Pages 792-799

  Li, Sheng ^a   Garrett Bakelman, Francine E ^a   Chung, Stephen S ^b   Sanders, Mathijs A ^c   Hricik, Todd ^b   Rapaport, Franck ^b   Patel, Jay ^b   Dillon, Richard ^d   Vijay, Priyanka ^a   Brown, Anna L ^e,f   Perl, Alexander E ^g   Cannon, Joy ^g   Bullinger, Lars ^h   Luger, Selina ^g   Becker, Michael ⁱ   Lewis, Ian D ^e,f,j   To, Luen Bik ^f,j   Delwel, Ruud ^c   Löwenberg, Bob ^c   Döhner, Hartmut ^h   Döhner, Konstanze ^h   Guzman, Monica L ^a   Hassane, Duane C ^a   Roboz, Gail J ^a   Grimwade, David ^d   Valk, Peter J M ^c   D'Andrea, Richard J ^e,f   Carroll, Martin ^g   Park, Christopher Y ^b   Neuberg, Donna ^k   Levine, Ross ^b   Melnick, Ari M ^a   Mason, Christopher E ^a,l   more..

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c ERASMUS MEDICAL CENTER   (Netherlands)

^d KING'S COLLEGE LONDON   (United Kingdom)

^e UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

^f ROYAL ADELAIDE HOSPITAL   (Australia)

^g UNIVERSITY OF PENNSYLVANIA   (United States)

^h UNIVERSITY HOSPITAL ULM   (Germany)

ⁱ UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^j UNIVERSITY OF ADELAIDE   (Australia)

^k DANA FARBER CANCER INSTITUTE   (United States)

^l FEIL FAMILY BRAIN AND MIND RESEARCH INSTITUTE   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

CYTOSINE; TRANSCRIPTOME;

ACUTE MYELOBLASTIC LEUKEMIA; ARTICLE; CANCER GENETICS; CANCER GROWTH; CANCER PATIENT; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; ENTROPY; EPIGENETICS; FEMALE; GENE CONTROL; GENE EXPRESSION; GENE FREQUENCY; GENETIC HETEROGENEITY; GENETIC VARIABILITY; HUMAN; HUMAN CELL; HUMAN TISSUE; LEUKEMIA RELAPSE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SOMATIC MUTATION; ACUTE MYELOID LEUKEMIA; ADULT; ALLELE; DISEASE COURSE; DNA SEQUENCE; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETICS; HIGH THROUGHPUT SEQUENCING; METABOLISM; MIDDLE AGED; MOLECULAR EVOLUTION; MORTALITY; MULTIVARIATE ANALYSIS; PROGNOSIS; PROMOTER REGION; PROPORTIONAL HAZARDS MODEL; SEQUENCE ANALYSIS; SURVIVAL RATE;

ADULT; ALLELES; CPG ISLANDS; CYTOSINE; DISEASE PROGRESSION; DNA METHYLATION; EPIGENESIS, GENETIC; EVOLUTION, MOLECULAR; FEMALE; GENE EXPRESSION REGULATION, LEUKEMIC; GENETIC HETEROGENEITY; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; LEUKEMIA, MYELOID, ACUTE; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PROGNOSIS; PROMOTER REGIONS, GENETIC; PROPORTIONAL HAZARDS MODELS; SEQUENCE ANALYSIS, DNA; SEQUENCE ANALYSIS, RNA; SURVIVAL RATE;

EID: 84975321367     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.4125     Document Type: Article

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