Neonatal diabetes caused by a homozygous KCNJ11 mutation demonstrates that tiny changes in ATP sensitivity markedly affect diabetes risk

Diabetologia

Volumn 59, Issue 7, 2016, Pages 1430-1436

  Vedovato, Natascia ^a   Cliff, Edward ^a,b   Proks, Peter ^a   Poovazhagi, Varadarajan ^c   Flanagan, Sarah E ^d   Ellard, Sian ^d   Hattersley, Andrew T ^d   Ashcroft, Frances M ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b MONASH UNIVERSITY   (Australia)

^c Chengalpattu Medical College   (India)

^d UNIVERSITY OF EXETER MEDICAL SCHOOL   (United Kingdom)

Author keywords

ATP sensitivity; ATP sensitive potassium channel; KCNJ11; Neonatal diabetes; Type 2 diabetes

Indexed keywords

ADENOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; GLIBENCLAMIDE; INSULIN; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; SULFONYLUREA; TOLBUTAMIDE; INWARDLY RECTIFYING POTASSIUM CHANNEL; SULFONYLUREA DERIVATIVE;

ANIMAL CELL; ARTICLE; CASE REPORT; CONTROLLED STUDY; DIABETES MELLITUS; DRUG SUBSTITUTION; ELECTRIC ACTIVITY; GENE; GENE MUTATION; GENETIC PREDISPOSITION; GENETIC RISK; GENETIC VARIATION; HETEROLOGOUS EXPRESSION; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; INFANT; INSULIN RELEASE; KCNJ11 GENE; MALE; NEONATAL DIABETES; NEWBORN; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PERSISTENT HYPERINSULINEMIC HYPOGLYCEMIA OF INFANCY; PRIORITY JOURNAL; WILD TYPE; XENOPUS LAEVIS; ADULT; ANIMAL; DIABETES MELLITUS, TYPE 2; ELECTROPHYSIOLOGY; FEMALE; GENETICS; HETEROZYGOTE; HOMOZYGOTE; METABOLISM; MUTATION; XENOPUS;

ADENOSINE TRIPHOSPHATE; ADULT; ANIMALS; DIABETES MELLITUS, TYPE 2; ELECTROPHYSIOLOGY; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HETEROZYGOTE; HOMOZYGOTE; HUMANS; INFANT; INSULIN; MALE; MUTATION; POTASSIUM CHANNELS, INWARDLY RECTIFYING; SULFONYLUREA COMPOUNDS; XENOPUS;

EID: 84975290967     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-016-3964-x     Document Type: Article

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