Mutations in KCNJ11 are associated with the development of autosomal dominant, early-onset type 2 diabetes

Diabetologia

Volumn 56, Issue 12, 2013, Pages 2609-2618

  Liu, Limei ^a   Nagashima, Kazuaki ^b   Yasuda, Takao ^c   Liu, Yanjun ^d   Hu, Hai Rong ^e   He, Guang ^a   Feng, Bo ^f   Zhao, Mingming ^a   Zhuang, Langen ^a   Zheng, Taishan ^a   Friedman, Theodore C ^d   Xiang, Kunsan ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b KYOTO UNIVERSITY   (Japan)

^c KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d CHARLES R DREW UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

^e FUDAN UNIVERSITY   (China)

^f TONGJI UNIVERSITY   (China)

Author keywords

Familial early onset type 2 diabetes mellitus; KCNJ11; Kir6.2; Mutation

Indexed keywords

ADENOSINE TRIPHOSPHATE; GLICLAZIDE; INSULIN; SULFONYLUREA;

ADOLESCENT; ADULT; AGED; AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; ASIAN; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CHILD; CHINESE; COHORT ANALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; DISEASE CONTROL; FEMALE; GENE; GENE IDENTIFICATION; GENE MUTATION; GENETIC ANALYSIS; GENETIC VARIABILITY; GLYCEMIC CONTROL; HETEROZYGOSITY; HUMAN; IMPAIRED GLUCOSE TOLERANCE; INSULIN RELEASE; KCNJ11 GENE; MAJOR CLINICAL STUDY; MALE; MOLECULAR PATHOLOGY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUCLEOTIDE SEQUENCE; ONSET AGE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; RAT; SCHOOL CHILD; SENSITIVITY ANALYSIS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; SINGLE NUCLEOTIDE POLYMORPHISM; SITE DIRECTED MUTAGENESIS;

ADOLESCENT; ADULT; AGED; AMINO ACID SUBSTITUTION; ASIAN CONTINENTAL ANCESTRY GROUP; CHILD; DIABETES MELLITUS, TYPE 2; DNA MUTATIONAL ANALYSIS; FEMALE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; KATP CHANNELS; MALE; MIDDLE AGED; MUTATION, MISSENSE; PEDIGREE; POTASSIUM CHANNELS, INWARDLY RECTIFYING;

EID: 84887998859     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-013-3031-9     Document Type: Article

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