Sulfonylurea receptors regulate the channel pore in ATP-sensitive potassium channels via an intersubunit salt bridge

Biochemical Journal

Volumn 464, Issue 3, 2014, Pages 343-354

  Lodwick, David ^a   Rainbow, Richard D ^a   Rubaiy, Hussein N ^a   Al Johi, Mohammed ^a   Vuister, Geerten W ^b   Norman, Robert I ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

Allosteric regulation; Glibenclamide; Inward rectifier; KATP channel; Pinacidil; Sulfonylurea receptor

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; GLIBENCLAMIDE; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.1; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 1; NUCLEOTIDE BINDING DOMAIN 2; NUCLEOTIDE BINDING PROTEIN; PINACIDIL; POTASSIUM CHANNEL; SODIUM CHLORIDE; SULFONYLUREA RECEPTOR; SULFONYLUREA RECEPTOR 2; SULFONYLUREA RECEPTOR 2A; UNCLASSIFIED DRUG; ABCC9 PROTEIN, HUMAN; INWARDLY RECTIFYING POTASSIUM CHANNEL; PROTEIN BINDING; PROTEIN SUBUNIT; UK-ATP-1 POTASSIUM CHANNEL;

ALLOSTERISM; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CHANNEL GATING; CHIMERA; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; EC50; ENDOPLASMIC RETICULUM; HEK293 CELL LINE; HUMAN; HUMAN CELL; IC50; IMMUNOPRECIPITATION; INSIDE OUT PATCH CLAMP; METABOLIC INHIBITION; MUTAGENESIS; NUCLEOTIDE BINDING SITE; POINT MUTATION; PROTEIN EXPRESSION; PROTEIN INTERACTION; REGULATORY MECHANISM; STATIC ELECTRICITY; CHEMISTRY; HYDROGEN BOND; METABOLISM; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN SUBUNIT;

ALLOSTERIC REGULATION; HEK293 CELLS; HUMANS; HYDROGEN BONDING; ION CHANNEL GATING; KATP CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN INTERACTION MAPPING; PROTEIN SUBUNITS; STATIC ELECTRICITY; SULFONYLUREA RECEPTORS;

EID: 84915748092     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20140273     Document Type: Article

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