Capture of a third Mg2+ is essential for catalyzing DNA synthesis

Science

Volumn 352, Issue 6291, 2016, Pages 1334-1337

  Gao, Yang ^a   Yang, Wei ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYADENOSINE TRIPHOSPHATE; DIVALENT CATION; DNA; DNA POLYMERASE; MAGNESIUM ION; DNA DIRECTED DNA POLYMERASE; DNA DIRECTED DNA POLYMERASE ETA; MAGNESIUM; MANGANESE; NUCLEOTIDE;

CATALYSIS; CHEMICAL COMPOUND; CRYSTALLOGRAPHY; DNA; ENZYME ACTIVITY; GENETIC ANALYSIS; MAGNESIUM; METAL BINDING; POLYMERIZATION;

APPARENT DISSOCIATION CONSTANT; ARTICLE; BINDING SITE; CATALYSIS; CHEMICAL REACTION KINETICS; CONFORMATIONAL TRANSITION; DNA SYNTHESIS; ENZYME SUBSTRATE; HUMAN; PRIORITY JOURNAL; TIME RESOLVED X RAY CRYSTALLOGRAPHY; X RAY CRYSTALLOGRAPHY; BIOCATALYSIS; BIOSYNTHESIS; CHEMISTRY; DNA REPLICATION; ULTRASTRUCTURE;

BIOCATALYSIS; CATIONS, DIVALENT; CRYSTALLOGRAPHY, X-RAY; DNA; DNA REPLICATION; DNA-DIRECTED DNA POLYMERASE; MAGNESIUM; MANGANESE; NUCLEOTIDES;

EID: 84975128736     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aad9633     Document Type: Article

References (32)

1. M. Garcia-Viloca, J. Gao, M. Karplus, D. G. Truhlar, Science 303, 186-195 (2004).
2. S. J. Benkovic, S. Hammes-Schiffer, Science 301, 1196-1202 (2003).
3. A. Warshel et al., Chem. Rev. 106, 3210-3235 (2006).
4. P. J. Rothwell, G. Waksman, Adv. Protein Chem. 71, 401-440 (2005).
5. M. D. Tsai, Biochemistry 53, 2749-2751 (2014).
6. T. A. Steitz, J. A. Steitz, Proc. Natl. Acad. Sci. U.S.A. 90, 6498-6502 (1993).
7. T. A. Steitz, J. Biol. Chem. 274, 17395-17398 (1999).
8. W. Yang, J. Y. Lee, M. Nowotny, Mol. Cell 22, 5-13 (2006).
9. C. M. Joyce, S. J. Benkovic, Biochemistry 43, 14317-14324 (2004).
10. K. A. Johnson, J. Biol. Chem. 283, 26297-26301 (2008).
11. S. S. Patel, I. Wong, K. A. Johnson, Biochemistry 30, 511-525 (1991).
12. M. E. Dahlberg, S. J. Benkovic, Biochemistry 30, 4835-4843 (1991).
13. M. T. Washington, L. Prakash, S. Prakash, Cell 107, 917-927 (2001).
14. K. A. Fiala, Z. Suo, Biochemistry 43, 2116-2125 (2004).
15. P. J. Rothwell, V. Mitaksov, G. Waksman, Mol. Cell 19, 345-355 (2005).
16. M. Bakhtina et al., Biochemistry 44, 5177-5187 (2005).
17. T. Nakamura, Y. Zhao, Y. Yamagata, Y. J. Hua, W. Yang, Nature 487, 196-201 (2012).
18. B. D. Freudenthal, W. A. Beard, D. D. Shock, S. H. Wilson, Cell 154, 157-168 (2013).
19. B. D. Freudenthal et al., Nature 517, 635-639 (2015).
20. R. Vyas, A. J. Reed, E. J. Tokarsky, Z. Suo, J. Am. Chem. Soc. 137, 5225-5230 (2015).
21. J. A. Cowan, Chem. Rev. 98, 1067-1088 (1998).
22. P. M. Burgers, F. Eckstein, Proc. Natl. Acad. Sci. U.S.A. 75, 4798-4800 (1978).
23. D. Herschlag, J. A. Piccirilli, T. R. Cech, Biochemistry 30, 4844-4854 (1991).
24. C. Biertümpfel et al., Nature 465, 1044-1048 (2010).
25. Y. Su, A. Patra, J. M. Harp, M. Egli, F. P. Guengerich, J. Biol. Chem. 290, 15921-15933 (2015).
26. E. Y. Wu, L. S. Beese, J. Biol. Chem. 286, 19758-19767 (2011).
27. T. N. Kakuda, Clin. Ther. 22, 685-708 (2000).
28. L. P. Jordheim, D. Durantel, F. Zoulim, C. Dumontet, Nat. Rev. Drug Discov. 12, 447-464 (2013).
29. J. Wagner, R. A. Lerner, C. F. Barbas 3rd, Science 270, 1797-1800 (1995).
30. D. N. Bolon, S. L. Mayo, Proc. Natl. Acad. Sci. U.S.A. 98, 14274-14279 (2001).
31. L. Jiang et al., Science 319, 1387-1391 (2008).
32. D. Röthlisberger et al., Nature 453, 190-195 (2008).