Viewing human DNA polymerase β faithfully and unfaithfully bypass an oxidative lesion by time-dependent crystallography

Journal of the American Chemical Society

Volumn 137, Issue 15, 2015, Pages 5225-5230

  Vyas, Rajan ^a   Reed, Andrew J ^a   Tokarsky, E John ^a,b   Suo, Zucai ^a,b  

^a Department of Chemistry and Biochemistry ^*  (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL BONDS; CONFORMATIONS; CRYSTALLOGRAPHY; DNA; ESTERS; POLYMERS; REACTION INTERMEDIATES;

ANTI-CONFORMATIONS; DEOXYADENOSINE; HUMAN DNA POLYMERASE; PHOSPHODIESTER BONDS; REAL TIME PICTURES; TIME DEPENDENT; TIME-RESOLVED; WATSON-CRICK BASE PAIRS;

X RAY CRYSTALLOGRAPHY;

DNA DIRECTED DNA POLYMERASE BETA; MAGNESIUM ION; NUCLEOTIDE; PHOSPHATE; PYROPHOSPHATE; 8-OXO-7,8-DIHYDRODEOXYGUANINE; GUANINE; METAL; PYROPHOSPHORIC ACID DERIVATIVE;

ARTICLE; BASE PAIRING; CATALYSIS; CHEMICAL REACTION; CONFORMATIONAL TRANSITION; CRYSTALLIZATION; DNA DAMAGE; DNA SYNTHESIS; ESCHERICHIA COLI; HOOGSTEEN BASE PAIRING; HUMAN; HYDROGEN BOND; ION EXCHANGE; NONHUMAN; NUCLEOPHILICITY; OXIDATIVE STRESS; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN STRUCTURE; WATSON CRICK BASE PAIR; X RAY CRYSTALLOGRAPHY; ANALOGS AND DERIVATIVES; BIOCATALYSIS; CHEMISTRY; ENZYME ACTIVE SITE; METABOLISM; MOLECULAR MODEL; OXIDATION REDUCTION REACTION; TIME FACTOR;

BIOCATALYSIS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DIPHOSPHATES; DNA DAMAGE; DNA POLYMERASE BETA; GUANINE; HUMANS; METALS; MODELS, MOLECULAR; OXIDATION-REDUCTION; PROTEIN CONFORMATION; TIME FACTORS;

EID: 84928473520     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/jacs.5b02109     Document Type: Article

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