Peroxiredoxins as biomarkers of oxidative stress

Biochimica et Biophysica Acta - General Subjects

Volumn 1840, Issue 2, 2014, Pages 906-912

  Poynton, Rebecca A ^b   Hampton, Mark B ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

^b Gravida: National Centre for Growth and Development   (New Zealand)

Author keywords

Biomarker; Hydrogen peroxide; Hyperoxidation; Oxidation; Oxidative stress; Peroxiredoxin

Indexed keywords

BIOLOGICAL MARKER; DIMER; HYDROPEROXIDE; PEROXIREDOXIN; PEROXIREDOXIN 1; PEROXIREDOXIN 2; WATER; ENDOTOXIN; GLUTATHIONE PEROXIDASE; HYDROGEN PEROXIDE; HYPOCHLOROUS ACID; MITOGEN ACTIVATED PROTEIN KINASE P38; N ETHYLMALEIMIDE; PEROXIREDOXIN 3; PEROXIREDOXIN 4; PEROXIREDOXIN 6; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SULFIREDOXIN; SULFONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

CELL COMPARTMENTALIZATION; CELL DISRUPTION; CELL METABOLISM; CELLULAR DISTRIBUTION; CYTOPLASM; DISULFIDE BOND; ENZYME LOCALIZATION; ENZYME METABOLISM; HUMAN; MASS SPECTROMETRY; MITOCHONDRION; NONHUMAN; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PRIORITY JOURNAL; REVIEW; SYSTEMS BIOLOGY; ADRENAL CORTEX; ALKYLATION; APOPTOSIS; ASTHMA; BIOACCUMULATION; CIRCADIAN RHYTHM; COCULTURE; CYTOSOL; ENZYME ACTIVATION; ENZYME INHIBITION; ERYTHROCYTE; HIPPOCAMPUS; HOMEOSTASIS; HYPEROXIDATION; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MOLECULAR WEIGHT; NEUTROPHIL; NUCLEOPHILICITY; PEROXIDATION; PEROXISOME; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN CARBONYLATION; PROTEIN EXPRESSION; REPERFUSION INJURY; SCHIZOSACCHAROMYCES POMBE;

4′-4-ACETAMIDO-4′-((IODOACETYL)AMINO)STILBENE-2,2′-DISULFONIC ACID; AMS; BIOMARKER; CYS; CYSTEINE; HYDROGEN PEROXIDE; HYPEROXIDATION; IAM; IODOACETAMIDE; N-ETHYLMALEIMIDE; NEM; OXIDATION; OXIDATIVE STRESS; PEROXIREDOXIN; PRX; SRX; SULFIREDOXIN;

ANIMALS; BIOLOGICAL MARKERS; HUMANS; OXIDATIVE STRESS; PEROXIREDOXINS;

EID: 84890116227     PISSN: 03044165     EISSN: 18728006     Source Type: Journal    
DOI: 10.1016/j.bbagen.2013.08.001     Document Type: Review

References (66)

1. S.G. Rhee, and H.A. Woo Multiple functions of peroxiredoxins: peroxidases, sensors and regulators of the intracellular messenger H(2)O(2), and protein chaperones Antioxid. Redox Signal. 15 2011 781 794
2. Z.A. Wood, E. Schroder, J.R. Harris, and L.B. Poole Structure, mechanism and regulation of peroxiredoxins Trends Biochem. Sci. 28 2003 32 40 (Pubitemid 36051004)
3. K.S. Yang, S.W. Kang, H.A. Woo, S.C. Hwang, H.Z. Chae, K. Kim, and S.G. Rhee Inactivation of human peroxiredoxin I during catalysis as the result of the oxidation of the catalytic site cysteine to cysteine-sulfinic acid J. Biol. Chem. 277 2002 38029 38036 (Pubitemid 35154654)
4. Z.A. Wood, L.B. Poole, and P.A. Karplus Peroxiredoxin evolution and the regulation of hydrogen peroxide signaling Science 300 2003 650 653 (Pubitemid 36520591)
5. Z.A. Wood, L.B. Poole, R.R. Hantgan, and P.A. Karplus Dimers to doughnuts: redox-sensitive oligomerization of 2-cysteine peroxiredoxins Biochemistry 41 2002 5493 5504 (Pubitemid 34429383)
6. D. Parsonage, D.S. Youngblood, G.N. Sarma, Z.A. Wood, P.A. Karplus, and L.B. Poole Analysis of the link between enzymatic activity and oligomeric state in AhpC, a bacterial peroxiredoxin Biochemistry 44 2005 10583 10592 (Pubitemid 41098235)
7. S. Barranco-Medina, J.J. Lazaro, and K.J. Dietz The oligomeric conformation of peroxiredoxins links redox state to function FEBS Lett. 583 2009 1809 1816
8. 2 scavenging and signaling Antioxid. Redox Signal. 10 2008 1565 1576
9. C.C. Winterbourn, and M.B. Hampton Thiol chemistry and specificity in redox signaling Free Radic. Biol. Med. 45 2008 549 561
10. D. Parsonage, P.A. Karplus, and L.B. Poole Substrate specificity and redox potential of AhpC, a bacterial peroxiredoxin Proc. Natl. Acad. Sci. U. S. A. 105 2008 8209 8214 (Pubitemid 351904736)
11. 2 is not reflected in its reaction with other oxidants and thiol reagents J. Biol. Chem. 282 2007 11885 11892 (Pubitemid 47100684)
12. A.A. Sayed, and D.L. Williams Biochemical characterization of 2-Cys peroxiredoxins from Schistosoma mansoni J. Biol. Chem. 279 2004 26159 26166 (Pubitemid 38798761)
13. M. Trujillo, G. Ferrer-Sueta, L. Thomson, L. Flohe, and R. Radi Kinetics of peroxiredoxins and their role in the decomposition of peroxynitrite Subcell. Biochem. 44 2007 83 113
14. A.V. Peskin, A.G. Cox, P. Nagy, P.E. Morgan, M.B. Hampton, M.J. Davies, and C.C. Winterbourn Removal of amino acid, peptide and protein hydroperoxides by reaction with peroxiredoxins 2 and 3 Biochem. J. 432 2010 313 321
15. L.M. Baker, A. Raudonikiene, P.S. Hoffman, and L.B. Poole Essential thioredoxin-dependent peroxiredoxin system from Helicobacter pylori: genetic and kinetic characterization J. Bacteriol. 183 2001 1961 1973 (Pubitemid 32225991)
16. B. Hofmann, H.J. Hecht, and L. Flohe Peroxiredoxins Biol. Chem. 383 2002 347 364 (Pubitemid 34506276)
17. R. Ogusucu, D. Rettori, D.C. Munhoz, L.E. Netto, and O. Augusto Reactions of yeast thioredoxin peroxidases I and II with hydrogen peroxide and peroxynitrite: rate constants by competitive kinetics Free Radic. Biol. Med. 42 2007 326 334 (Pubitemid 46038040)
18. A.G. Cox, A.V. Peskin, L.N. Paton, C.C. Winterbourn, and M.B. Hampton Redox potential and peroxide reactivity of human peroxiredoxin 3 Biochemistry 48 2009 6495 6501
19. A. Hall, D. Parsonage, L.B. Poole, and P.A. Karplus Structural evidence that peroxiredoxin catalytic power is based on transition-state stabilization J. Mol. Biol. 402 2010 194 209
20. P. Nagy, A. Karton, A. Betz, A.V. Peskin, P. Pace, R.J. O'Reilly, M.B. Hampton, L. Radom, and C.C. Winterbourn Model for the exceptional reactivity of peroxiredoxins 2 and 3 with hydrogen peroxide: a kinetic and computational study J. Biol. Chem. 286 2011 18048 18055
21. E. Schroder, J.A. Littlechild, A.A. Lebedev, N. Errington, A.A. Vagin, and M.N. Isupov Crystal structure of decameric 2-Cys peroxiredoxin from human erythrocytes at 1.7 A resolution Structure 8 2000 605 615 (Pubitemid 30409313)
22. A.V. Peskin, N. Dickerhof, R.A. Poynton, L.N. Paton, P.E. Pace, M.B. Hampton, and C.C. Winterbourn Hyperoxidation of peroxiredoxins 2 and 3: rate constants for the reactions of the sulfenic acid of the peroxidatic cysteine J. Biol. Chem. 288 2013 14170 14177
23. T.S. Chang, W. Jeong, S.Y. Choi, S. Yu, S.W. Kang, and S.G. Rhee Regulation of peroxiredoxin I activity by Cdc2-mediated phosphorylation J. Biol. Chem. 277 2002 25370 25376 (Pubitemid 34951848)
24. H.H. Jang, S.Y. Kim, S.K. Park, H.S. Jeon, Y.M. Lee, J.H. Jung, S.Y. Lee, H.B. Chae, Y.J. Jung, K.O. Lee, C.O. Lim, W.S. Chung, J.D. Bahk, D.J. Yun, and M.J. Cho Phosphorylation and concomitant structural changes in human 2-Cys peroxiredoxin isotype I differentially regulate its peroxidase and molecular chaperone functions FEBS Lett. 580 2006 351 355 (Pubitemid 43005361)
25. J.W. Park, G. Piszczek, S.G. Rhee, and P.B. Chock Glutathionylation of peroxiredoxin I induces decamer to dimers dissociation with concomitant loss of chaperone activity Biochemistry 50 2011 3204 3210
26. R. Engelman, P. Weisman-Shomer, T. Ziv, J. Xu, E.S. Arner, and M. Benhar Multilevel regulation of 2-Cys peroxiredoxin reaction cycle by S-nitrosylation J. Biol. Chem. 288 2013 11312 11324
27. H.A. Woo, S.H. Yim, D.H. Shin, D. Kang, D.Y. Yu, and S.G. Rhee Inactivation of peroxiredoxin I by phosphorylation allows localized H(2)O(2) accumulation for cell signaling Cell 140 2010 517 528
28. H.A. Woo, S.W. Kang, H.K. Kim, K.S. Yang, H.Z. Chae, and S.G. Rhee Reversible oxidation of the active site cysteine of peroxiredoxins to cysteine sulfinic acid - immunoblot detection with antibodies specific for the hyperoxidized cysteine-containing sequence J. Biol. Chem. 278 2003 47361 47364 (Pubitemid 37523174)
29. B. Biteau, J. Labarre, and M.B. Toledano ATP-dependent reduction of cysteine-sulphinic acid by S. cerevisiae sulphiredoxin Nature 425 2003 980 984 (Pubitemid 37376931)
30. T.S. Chang, W. Jeong, H.A. Woo, S.M. Lee, S. Park, and S.G. Rhee Characterization of mammalian sulfiredoxin and its reactivation of hyperoxidized peroxiredoxin through reduction of cysteine sulfinic acid in the active site to cysteine J. Biol. Chem. 279 2004 50994 51001 (Pubitemid 40017840)
31. M.M. Stacey, M.C. Vissers, and C.C. Winterbourn Oxidation of 2-cys peroxiredoxins in human endothelial cells by hydrogen peroxide, hypochlorous acid, and chloramines Antioxid. Redox Signal. 17 2012 411 421
32. W. Jeong, S.H. Bae, M.B. Toledano, and S.G. Rhee Role of sulfiredoxin as a regulator of peroxiredoxin function and regulation of its expression Free Radic. Biol. Med. 53 2012 447 456
33. A.G. Cox, C.C. Winterbourn, and M.B. Hampton Mitochondrial peroxiredoxin involvement in antioxidant defence and redox signalling Biochem. J. 425 2010 313 325
34. J.W. Baty, M.B. Hampton, and C.C. Winterbourn Proteomic detection of hydrogen peroxide-sensitive thiol proteins in Jurkat cells Biochem. J. 389 2005 785 795 (Pubitemid 41117338)
35. J.W. Baty, M.B. Hampton, and C.C. Winterbourn Detection of oxidant sensitive thiol proteins by fluorescence labeling and two-dimensional electrophoresis Proteomics 2 2002 1261 1266
36. M.M. Stacey, A.V. Peskin, M.C. Vissers, and C.C. Winterbourn Chloramines and hypochlorous acid oxidize erythrocyte peroxiredoxin 2 Free Radic. Biol. Med. 47 2009 1468 1476
37. A.G. Cox, C.C. Winterbourn, and M.B. Hampton Measuring the redox state of cellular peroxiredoxins by immunoblotting Methods Enzymol. 474 2010 51 66
38. V. Kumar, N. Kitaeff, M.B. Hampton, M.B. Cannell, and C.C. Winterbourn Reversible oxidation of mitochondrial peroxiredoxin 3 in mouse heart subjected to ischemia and reperfusion FEBS Lett. 583 2009 997 1000
39. 2: a quantitative comparison between continuous low-dose and one-time high-dose treatments Free Radic. Biol. Med. 60 2013 325 335
40. F.M. Low, M.B. Hampton, A.V. Peskin, and C.C. Winterbourn Peroxiredoxin 2 functions as a noncatalytic scavenger of low-level hydrogen peroxide in the erythrocyte Blood 109 2007 2611 2617 (Pubitemid 46425910)
41. S.B. Bayer, G. Maghzal, R. Stocker, M.B. Hampton, and C.C. Winterbourn Neutrophil-mediated oxidation of erythrocyte peroxiredoxin 2 as a potential marker of oxidative stress in inflammation FASEB J. 27 2013 3315 3322
42. K.K. Brown, S.E. Eriksson, E.S.J. Arner, and M.B. Hampton Mitochondrial peroxiredoxin 3 is rapidly oxidised in cells treated with isothiocyanates Free Radic. Biol. Med. 45 2008 494 502
43. A.G. Cox, J.M. Pullar, G. Hughes, E.C. Ledgerwood, and M.B. Hampton Oxidation of mitochondrial peroxiredoxin 3 during the initiation of receptor-mediated apoptosis Free Radic. Biol. Med. 44 2008 1001 1009
44. A.G. Cox, K.K. Brown, E.S. Arner, and M.B. Hampton The thioredoxin reductase inhibitor auranofin triggers apoptosis through a Bax/Bak-dependent process that involves peroxiredoxin 3 oxidation Biochem. Pharmacol. 76 2008 1097 1109
45. K.K. Brown, A.G. Cox, and M.B. Hampton Mitochondrial respiratory chain involvement in peroxiredoxin 3 oxidation by phenethyl isothiocyanate and auranofin FEBS Lett. 584 2010 1257 1262
46. C.R. Myers, and J.M. Myers The effects of acrolein on peroxiredoxins, thioredoxins, and thioredoxin reductase in human bronchial epithelial cells Toxicology 257 2009 95 104
47. J.M. Myers, W.E. Antholine, and C.R. Myers The intracellular redox stress caused by hexavalent chromium is selective for proteins that have key roles in cell survival and thiol redox control Toxicology 281 2011 37 47
48. J.M. Myers, and C.R. Myers The effects of hexavalent chromium on thioredoxin reductase and peroxiredoxins in human bronchial epithelial cells Free Radic. Biol. Med. 47 2009 1477 1485
49. V. Kumar, T. Kleffmann, M.B. Hampton, M.B. Cannell, and C.C. Winterbourn Redox proteomics of thiol proteins in mouse heart during ischemia/reperfusion using ICAT reagents and mass spectrometry Free Radic. Biol. Med. 58 2013 109 117
50. S.L. Cuddihy, C.C. Winterbourn, and M.B. Hampton Assessment of redox changes to hydrogen peroxide-sensitive proteins during EGF signaling Antioxid. Redox Signal. 15 2011 167 174
51. S. Gromer, L.D. Arscott, C.H. Williams Jr., R.H. Schirmer, and K. Becker Human placenta thioredoxin reductase. Isolation of the selenoenzyme, steady state kinetics, and inhibition by therapeutic gold compounds J. Biol. Chem. 273 1998 20096 20101 (Pubitemid 28377564)
52. A. Mitsumoto, Y. Nakagawa, A. Takeuchi, K. Okawa, A. Iwamatsu, and Y. Takanezawa Oxidized forms of peroxiredoxins and DJ-1 on two-dimensional gels increased in response to sublethal levels of paraquat Free Radic. Res. 35 2001 301 310 (Pubitemid 32734231)
53. A.G. Cox, A.G. Pearson, J.M. Pullar, T.J. Jonsson, W.T. Lowther, C.C. Winterbourn, and M.B. Hampton Mitochondrial peroxiredoxin 3 is more resilient to hyperoxidation than cytoplasmic peroxiredoxins Biochem. J. 421 2009 51 58
54. S.H. Bae, H.A. Woo, S.H. Sung, H.E. Lee, S.K. Lee, I.S. Kil, and S.G. Rhee Induction of sulfiredoxin via an Nrf2-dependent pathway and hyperoxidation of peroxiredoxin III in the lungs of mice exposed to hyperoxia Antioxid. Redox Signal. 11 2009 937 948
55. C. Musicco, V. Capelli, V. Pesce, A.M. Timperio, M. Calvani, L. Mosconi, L. Zolla, P. Cantatore, and M.N. Gadaleta Accumulation of overoxidized peroxiredoxin III in aged rat liver mitochondria Biochim. Biophys. Acta 1787 2009 890 896
56. S.H. Bae, S.H. Sung, H.E. Lee, H.T. Kang, S.K. Lee, S.Y. Oh, H.A. Woo, I.S. Kil, and S.G. Rhee Peroxiredoxin III and sulfiredoxin together protect mice from pyrazole-induced oxidative liver injury Antioxid. Redox Signal. 17 2012 1351 1361
57. S.H. Bae, S.H. Sung, E.J. Cho, S.K. Lee, H.E. Lee, H.A. Woo, D.Y. Yu, I.S. Kil, and S.G. Rhee Concerted action of sulfiredoxin and peroxiredoxin I protects against alcohol-induced oxidative injury in mouse liver Hepatology 53 2011 945 953
58. H.S. Kwon, Y.J. Bae, K.A. Moon, Y.S. Lee, T. Lee, K.Y. Lee, T.B. Kim, C.S. Park, H.B. Moon, and Y.S. Cho Hyperoxidized peroxiredoxins in peripheral blood mononuclear cells of asthma patients is associated with asthma severity Life Sci. 90 2012 502 508
59. 2-dependent, reversible inactivation of peroxiredoxin III in mitochondria Mol. Cell 46 2012 584 594
60. J.S. O'Neill, and A.B. Reddy Circadian clocks in human red blood cells Nature 469 2011 498 503
61. I.K. Hwang, K.Y. Yoo, D.W. Kim, J.H. Choi, I.S. Lee, and M.H. Won Hyperoxidized peroxiredoxins and glyceraldehyde-3-phosphate dehydrogenase immunoreactivity and protein levels are changed in the gerbil hippocampal CA1 region after transient forebrain ischemia Neurochem. Res. 32 2007 1530 1538 (Pubitemid 47094414)
62. K.Y. Yoo, O.K. Park, J. Yu, B. Yan, H. Li, C.H. Lee, J.H. Choi, D.W. Kim, I.K. Hwang, and M.H. Won Expression and changes of hyperoxidized peroxiredoxins in non-pyramidal and polymorphic cells in the gerbil hippocampus during normal aging Cell. Mol. Neurobiol. 29 2009 413 421
63. A.B. Bernal, M.H. Vickers, M.B. Hampton, R.A. Poynton, and D.M. Sloboda Maternal undernutrition significantly impacts ovarian follicle number and increases ovarian oxidative stress in adult rat offspring PLoS One 5 2010 e15558
64. J. Konig, K. Lotte, R. Plessow, A. Brockhinke, M. Baier, and K.J. Dietz Reaction mechanism of plant 2-Cys peroxiredoxin. Role of the C terminus and the quaternary structure J. Biol. Chem. 278 2003 24409 24420 (Pubitemid 37548592)
65. A.G. Cox, and M.B. Hampton Bcl-2 over-expression promotes genomic instability by inhibiting apoptosis of cells exposed to hydrogen peroxide Carcinogenesis 28 2007 2166 2171 (Pubitemid 47543378)
66. A.M. Day, J.D. Brown, S.R. Taylor, J.D. Rand, B.A. Morgan, and E.A. Veal Inactivation of a peroxiredoxin by hydrogen peroxide is critical for thioredoxin-mediated repair of oxidized proteins and cell survival Mol. Cell 45 2012 398 408