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Volumn 9, Issue 6, 2016, Pages 621-631

Altered kynurenine pathway metabolism in autism: Implication for immune-induced glutamatergic activity

Author keywords

autism; excitotoxicity; glutamatergic activity; kynurenine pathway; neuroinflammation; quinolinic acid

Indexed keywords

GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 6; KYNURENINE; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; NEOPTERIN; QUINOLINIC ACID; TUMOR NECROSIS FACTOR ALPHA;

EID: 84974784672     PISSN: 19393792     EISSN: 19393806     Source Type: Journal    
DOI: 10.1002/aur.1565     Document Type: Article
Times cited : (79)

References (65)
  • 1
    • 84863100133 scopus 로고    scopus 로고
    • Elevated serum levels of interleukin-17A in children with autism
    • Al-Ayadhi, L., & Mostafa, G. (2012). Elevated serum levels of interleukin-17A in children with autism. Journal of Neuroinflammation, 9, 158.
    • (2012) Journal of Neuroinflammation , vol.9 , pp. 158
    • Al-Ayadhi, L.1    Mostafa, G.2
  • 2
    • 0028018814 scopus 로고
    • Picolinic acid blocks the neurotoxic but not the neuroexcitant properties of quinolinic acid in the rat brain: Evidence from turning behaviour and tyrosine hydroxylase immunohistochemistry
    • Beninger, R.J., Colton, A.M., Ingles, J.L., Jhamandas, K., & Boegman, R.J. (1994). Picolinic acid blocks the neurotoxic but not the neuroexcitant properties of quinolinic acid in the rat brain: Evidence from turning behaviour and tyrosine hydroxylase immunohistochemistry. Neuroscience, 61, 603–612.
    • (1994) Neuroscience , vol.61 , pp. 603-612
    • Beninger, R.J.1    Colton, A.M.2    Ingles, J.L.3    Jhamandas, K.4    Boegman, R.J.5
  • 4
    • 70349754448 scopus 로고    scopus 로고
    • Mechanism for quinolinic acid cytotoxicity in human astrocytes and neurons
    • Braidy, N., Grant, R., Adams, S., Brew, B.J., & Guillemin, G.J. (2009). Mechanism for quinolinic acid cytotoxicity in human astrocytes and neurons. Neurotox Research, 16, 77–86.
    • (2009) Neurotox Research , vol.16 , pp. 77-86
    • Braidy, N.1    Grant, R.2    Adams, S.3    Brew, B.J.4    Guillemin, G.J.5
  • 5
    • 84874031142 scopus 로고    scopus 로고
    • Increased glutamate concentration in the auditory cortex of persons with autism and first-degree relatives: A (1)H-MRS study. Autism Research: Official Journal of the International Society for Autism
    • Brown, M.S., Singel, D., Hepburn, S., & Rojas, D.C. (2013). Increased glutamate concentration in the auditory cortex of persons with autism and first-degree relatives: A (1)H-MRS study. Autism Research: Official Journal of the International Society for Autism Research, 6, 1–10.
    • (2013) Research , vol.6 , pp. 1-10
    • Brown, M.S.1    Singel, D.2    Hepburn, S.3    Rojas, D.C.4
  • 7
    • 20544449602 scopus 로고    scopus 로고
    • Epilepsy in young adults with autism: A prospective population-based follow-up study of 120 individuals diagnosed in childhood
    • Danielsson, S., Gillberg, I.C., Billstedt, E., Gillberg, C., & Olsson, I. (2005). Epilepsy in young adults with autism: A prospective population-based follow-up study of 120 individuals diagnosed in childhood. Epilepsia, 46, 918–923.
    • (2005) Epilepsia , vol.46 , pp. 918-923
    • Danielsson, S.1    Gillberg, I.C.2    Billstedt, E.3    Gillberg, C.4    Olsson, I.5
  • 9
    • 3543049569 scopus 로고    scopus 로고
    • Interrelationship between autism diagnostic observation schedule-generic (ADOS-G), autism diagnostic interview-revised (ADI-R), and the diagnostic and statistical manual of mental disorders (DSM-IV-TR) classification in children and adolescents with mental retardation
    • De Bildt, A., Sytema, S., Ketelaars, C., Kraijer, D., Mulder, E., Volkmar, F., et al. (2004). Interrelationship between autism diagnostic observation schedule-generic (ADOS-G), autism diagnostic interview-revised (ADI-R), and the diagnostic and statistical manual of mental disorders (DSM-IV-TR) classification in children and adolescents with mental retardation. Journal of Autism Dev Disord, 34, 129–137.
    • (2004) Journal of Autism Dev Disord , vol.34 , pp. 129-137
    • De Bildt, A.1    Sytema, S.2    Ketelaars, C.3    Kraijer, D.4    Mulder, E.5    Volkmar, F.6
  • 10
    • 3242669826 scopus 로고    scopus 로고
    • Quinolinic acid promotes seizures and decreases glutamate uptake in young rats: Reversal by orally administered guanosine
    • De Oliveira, D.L., Horn, J.F., Rodrigues, J.M., Frizzo, M.E., Moriguchi, E., Souza, D.O., et al. (2004). Quinolinic acid promotes seizures and decreases glutamate uptake in young rats: Reversal by orally administered guanosine. Brain Research, 1018, 48–54.
    • (2004) Brain Research , vol.1018 , pp. 48-54
    • De Oliveira, D.L.1    Horn, J.F.2    Rodrigues, J.M.3    Frizzo, M.E.4    Moriguchi, E.5    Souza, D.O.6
  • 11
    • 0033596826 scopus 로고    scopus 로고
    • Autism: New data suggest a new hypothesis
    • DeLong, G.R. (1999). Autism: New data suggest a new hypothesis. Neurology, 52, 911–916.
    • (1999) Neurology , vol.52 , pp. 911-916
    • DeLong, G.R.1
  • 12
    • 0018690450 scopus 로고
    • The incidence of seizures among children with autistic symptoms
    • Deykin, E.Y., & MacMahon, B. (1979). The incidence of seizures among children with autistic symptoms. American Journal of Psychiatry, 136, 1310–1312.
    • (1979) American Journal of Psychiatry , vol.136 , pp. 1310-1312
    • Deykin, E.Y.1    MacMahon, B.2
  • 15
    • 80052461635 scopus 로고    scopus 로고
    • Neurochemistry of autism
    • In, J.P. Blass, (Ed.), New York, Springer
    • Folsom, T., & Fatemi, S.H. (2011). Neurochemistry of autism. In J.P. Blass (Ed.), Neurochemical mechanisms in disease (Vol. 1). New York: Springer. pp. 383–398.
    • (2011) Neurochemical mechanisms in disease , vol.1 , pp. 383-398
    • Folsom, T.1    Fatemi, S.H.2
  • 17
    • 84859582577 scopus 로고    scopus 로고
    • Quinolinic acid, the inescapable neurotoxin
    • Guillemin, G.J. (2012). Quinolinic acid, the inescapable neurotoxin. FEBS J, 279, 1356–1365.
    • (2012) FEBS J , vol.279 , pp. 1356-1365
    • Guillemin, G.J.1
  • 19
    • 0035544420 scopus 로고    scopus 로고
    • IFN-beta1b induces kynurenine pathway metabolism in human macrophages: Potential implications for multiple sclerosis treatment
    • Guillemin, G.J., Kerr, S.J., Pemberton, L.A., Smith, D.G., Smythe, G.A., Armati, P.J., et al. (2001). IFN-beta1b induces kynurenine pathway metabolism in human macrophages: Potential implications for multiple sclerosis treatment. Journal of Interferon & Cytokine Research, 21, 1097–1101.
    • (2001) Journal of Interferon & Cytokine Research , vol.21 , pp. 1097-1101
    • Guillemin, G.J.1    Kerr, S.J.2    Pemberton, L.A.3    Smith, D.G.4    Smythe, G.A.5    Armati, P.J.6
  • 20
    • 11144314849 scopus 로고    scopus 로고
    • Expression of indoleamine 2,3-dioxygenase and production of quinolinic acid by human microglia, astrocytes, and neurons
    • Guillemin, G.J., Smythe, G., Takikawa, O., & Brew, B.J. (2005). Expression of indoleamine 2,3-dioxygenase and production of quinolinic acid by human microglia, astrocytes, and neurons. Glia, 49, 15–23.
    • (2005) Glia , vol.49 , pp. 15-23
    • Guillemin, G.J.1    Smythe, G.2    Takikawa, O.3    Brew, B.J.4
  • 22
    • 0021264311 scopus 로고
    • Immune response-associated production of neopterin. Release from macrophages primarily under control of interferon-gamma
    • Huber, C., Batchelor, J.R., Fuchs, D., Hausen, A., Lang, A., Niederwieser, D., et al. (1984). Immune response-associated production of neopterin. Release from macrophages primarily under control of interferon-gamma. The Journal of Experimental Medicine, 160, 310–316.
    • (1984) The Journal of Experimental Medicine , vol.160 , pp. 310-316
    • Huber, C.1    Batchelor, J.R.2    Fuchs, D.3    Hausen, A.4    Lang, A.5    Niederwieser, D.6
  • 23
    • 0034750434 scopus 로고    scopus 로고
    • Proinflammatory and regulatory cytokine production associated with innate and adaptive immune responses in children with autism spectrum disorders and developmental regression
    • Jyonouchi, H., Sun, S., & Le, H. (2001). Proinflammatory and regulatory cytokine production associated with innate and adaptive immune responses in children with autism spectrum disorders and developmental regression. Journal of Neuroimmunology, 120, 170–179.
    • (2001) Journal of Neuroimmunology , vol.120 , pp. 170-179
    • Jyonouchi, H.1    Sun, S.2    Le, H.3
  • 24
    • 0028575313 scopus 로고
    • Picolinic acid protects against quinolinic acid-induced depletion of NADPH diaphorase containing neurons in the rat striatum
    • Kalisch, B.E., Jhamandas, K., Boegman, R.J., & Beninger, R.J. (1994). Picolinic acid protects against quinolinic acid-induced depletion of NADPH diaphorase containing neurons in the rat striatum. Brain Research, 668, 1–8.
    • (1994) Brain Research , vol.668 , pp. 1-8
    • Kalisch, B.E.1    Jhamandas, K.2    Boegman, R.J.3    Beninger, R.J.4
  • 25
    • 84864082805 scopus 로고    scopus 로고
    • Detection and quantitation of forty eight cytokines, chemokines, growth factors and nine acute phase proteins in healthy human plasma, saliva and urine
    • Khan, A. (2012). Detection and quantitation of forty eight cytokines, chemokines, growth factors and nine acute phase proteins in healthy human plasma, saliva and urine. Journal of Proteomics, 75, 4802–4819.
    • (2012) Journal of Proteomics , vol.75 , pp. 4802-4819
    • Khan, A.1
  • 28
    • 0036254794 scopus 로고    scopus 로고
    • Interleukin-12 and interleukin-18 induce indoleamine 2,3-dioxygenase (IDO) activity in human osteosarcoma cell lines independently from interferon-gamma
    • Liebau, C., Baltzer, A.W., Schmidt, S., Roesel, C., Karreman, C., Prisack, J.B., et al. (2002). Interleukin-12 and interleukin-18 induce indoleamine 2,3-dioxygenase (IDO) activity in human osteosarcoma cell lines independently from interferon-gamma. Anticancer Research, 22, 931–936.
    • (2002) Anticancer Research , vol.22 , pp. 931-936
    • Liebau, C.1    Baltzer, A.W.2    Schmidt, S.3    Roesel, C.4    Karreman, C.5    Prisack, J.B.6
  • 32
    • 79954578712 scopus 로고    scopus 로고
    • Schizophrenia and autism: Both shared and disorder-specific pathogenesis via perinatal inflammation?
    • Meyer, U., Feldon, J., & Dammann, O. (2011). Schizophrenia and autism: Both shared and disorder-specific pathogenesis via perinatal inflammation? Pediatric Research, 69, 26R–33R.
    • (2011) Pediatric Research , vol.69 , pp. 26R-33R
    • Meyer, U.1    Feldon, J.2    Dammann, O.3
  • 33
    • 0032555614 scopus 로고    scopus 로고
    • Prevention of allogeneic fetal rejection by tryptophan catabolism
    • Munn, D.H., Zhou, M., Attwood, J.T., Bondarev, I., Conway, S.J., Marshall, B., et al. (1998). Prevention of allogeneic fetal rejection by tryptophan catabolism. Science, 281, 1191–1193.
    • (1998) Science , vol.281 , pp. 1191-1193
    • Munn, D.H.1    Zhou, M.2    Attwood, J.T.3    Bondarev, I.4    Conway, S.J.5    Marshall, B.6
  • 34
    • 65249156122 scopus 로고    scopus 로고
    • Interferon-γ and tumor necrosis factor-α mediate the upregulation of indoleamine 2,3-dioxygenase and the induction of depressive-like behavior in mice in response to bacillus calmette-guérin
    • O'Connor, J.C., André, C., Wang, Y., Lawson, M.A., Szegedi, S.S., Lestage, J., et al. (2009). Interferon-γ and tumor necrosis factor-α mediate the upregulation of indoleamine 2,3-dioxygenase and the induction of depressive-like behavior in mice in response to bacillus calmette-guérin. The Journal of Neuroscience, 29, 4200–4209.
    • (2009) The Journal of Neuroscience , vol.29 , pp. 4200-4209
    • O'Connor, J.C.1    André, C.2    Wang, Y.3    Lawson, M.A.4    Szegedi, S.S.5    Lestage, J.6
  • 35
    • 77952695803 scopus 로고    scopus 로고
    • Attention-deficit hyperactivity disorder (ADHD) and glial integrity: S100B, cytokines and kynurenine metabolism—Effects of medication
    • Oades, R.D., Dauvermann, M.R., Schimmelmann, B.G., Schwarz, M.J., & Myint, A.M. (2010). Attention-deficit hyperactivity disorder (ADHD) and glial integrity: S100B, cytokines and kynurenine metabolism—Effects of medication. Behavioral and Brain Functions, 6, 29.
    • (2010) Behavioral and Brain Functions , vol.6 , pp. 29
    • Oades, R.D.1    Dauvermann, M.R.2    Schimmelmann, B.G.3    Schwarz, M.J.4    Myint, A.M.5
  • 37
    • 0030875855 scopus 로고    scopus 로고
    • Quinolinic acid production by macrophages stimulated with IFN-gamma, TNF-alpha, and IFN-alpha
    • Pemberton, L.A., Kerr, S.J., Smythe, G., & Brew, B.J. (1997). Quinolinic acid production by macrophages stimulated with IFN-gamma, TNF-alpha, and IFN-alpha. Journal of Interferon & Cytokine Research, 17, 589–595.
    • (1997) Journal of Interferon & Cytokine Research , vol.17 , pp. 589-595
    • Pemberton, L.A.1    Kerr, S.J.2    Smythe, G.3    Brew, B.J.4
  • 39
    • 77950022119 scopus 로고    scopus 로고
    • CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-alpha: Relationship to CNS immune responses and depression
    • Raison, C.L., Dantzer, R., Kelley, K.W., Lawson, M.A., Woolwine, B.J., Vogt, G., et al. (2010). CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-alpha: Relationship to CNS immune responses and depression. Molecular Psychiatry, 15, 393–403.
    • (2010) Molecular Psychiatry , vol.15 , pp. 393-403
    • Raison, C.L.1    Dantzer, R.2    Kelley, K.W.3    Lawson, M.A.4    Woolwine, B.J.5    Vogt, G.6
  • 41
    • 0242291090 scopus 로고    scopus 로고
    • Model of autism: Increased ratio of excitation/inhibition in key neural systems
    • Rubenstein, J.L., & Merzenich, M.M. (2003). Model of autism: Increased ratio of excitation/inhibition in key neural systems. Genes, Brain, and Behavior, 2, 255–267.
    • (2003) Genes, Brain, and Behavior , vol.2 , pp. 255-267
    • Rubenstein, J.L.1    Merzenich, M.M.2
  • 43
    • 0021234045 scopus 로고
    • Seizure activity and lesions after intrahippocampal quinolinic acid injection
    • Schwarcz, R., Brush, G.S., Foster, A.C., & French, E.D. (1984). Seizure activity and lesions after intrahippocampal quinolinic acid injection. Experimental Neurology, 84, 1–17.
    • (1984) Experimental Neurology , vol.84 , pp. 1-17
    • Schwarcz, R.1    Brush, G.S.2    Foster, A.C.3    French, E.D.4
  • 45
    • 0036467928 scopus 로고    scopus 로고
    • Concurrent quantification of quinolinic, picolinic, and nicotinic acids using electron-capture negative-ion gas chromatography-mass spectrometry
    • Smythe, G.A., Braga, O., Brew, B.J., Grant, R.S., Guillemin, G.J., Kerr, S.J., et al. (2002). Concurrent quantification of quinolinic, picolinic, and nicotinic acids using electron-capture negative-ion gas chromatography-mass spectrometry. Analytical Biochemistry, 301, 21–26.
    • (2002) Analytical Biochemistry , vol.301 , pp. 21-26
    • Smythe, G.A.1    Braga, O.2    Brew, B.J.3    Grant, R.S.4    Guillemin, G.J.5    Kerr, S.J.6
  • 46
    • 81155157520 scopus 로고    scopus 로고
    • Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: Evidence for an immune-modulated glutamatergic neurotransmission?
    • Steiner, J., Walter, M., Gos, T., Guillemin, G., Bernstein, H.-G., Sarnyai, Z., et al. (2011). Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: Evidence for an immune-modulated glutamatergic neurotransmission? Journal of Neuroinflammation, 8, 94.
    • (2011) Journal of Neuroinflammation , vol.8 , pp. 94
    • Steiner, J.1    Walter, M.2    Gos, T.3    Guillemin, G.4    Bernstein, H.-G.5    Sarnyai, Z.6
  • 47
    • 0027486072 scopus 로고
    • Neuropharmacology of quinolinic and kynurenic acids
    • Stone, T.W. (1993). Neuropharmacology of quinolinic and kynurenic acids. Pharmacological Reviews, 45, 309–379.
    • (1993) Pharmacological Reviews , vol.45 , pp. 309-379
    • Stone, T.W.1
  • 48
    • 0019440926 scopus 로고
    • Quinolinic acid: A potent endogenous excitant at amino acid receptors in CNS
    • Stone, T.W., & Perkins, M.N. (1981). Quinolinic acid: A potent endogenous excitant at amino acid receptors in CNS. European Journal of Pharmacology, 72, 411–412.
    • (1981) European Journal of Pharmacology , vol.72 , pp. 411-412
    • Stone, T.W.1    Perkins, M.N.2
  • 50
    • 79957584847 scopus 로고    scopus 로고
    • Plasma cytokine profiles in subjects with high-functioning autism spectrum disorders
    • Suzuki, K., Matsuzaki, H., Iwata, K., Kameno, Y., Shimmura, C., Kawai, S., et al. (2011). Plasma cytokine profiles in subjects with high-functioning autism spectrum disorders. PLoS One, 6, e20470.
    • (2011) PLoS One , vol.6
    • Suzuki, K.1    Matsuzaki, H.2    Iwata, K.3    Kameno, Y.4    Shimmura, C.5    Kawai, S.6
  • 51
    • 0642343891 scopus 로고    scopus 로고
    • High blood monocyte counts and neopterin levels in children with autistic disorder
    • Sweeten, T.L., Posey, D.J., & McDougle, C.J. (2003). High blood monocyte counts and neopterin levels in children with autistic disorder. American Journal of Psychiatry, 160, 1691–1693.
    • (2003) American Journal of Psychiatry , vol.160 , pp. 1691-1693
    • Sweeten, T.L.1    Posey, D.J.2    McDougle, C.J.3
  • 52
    • 1042289313 scopus 로고    scopus 로고
    • High nitric oxide production in autistic disorder: A possible role for interferon-gamma
    • Sweeten, T.L., Posey, D.J., Shankar, S., & McDougle, C.J. (2004). High nitric oxide production in autistic disorder: A possible role for interferon-gamma. Biological Psychiatry, 55, 434–437.
    • (2004) Biological Psychiatry , vol.55 , pp. 434-437
    • Sweeten, T.L.1    Posey, D.J.2    Shankar, S.3    McDougle, C.J.4
  • 56
    • 84927178221 scopus 로고    scopus 로고
    • Disturbed cingulate glutamate metabolism in adults with high-functioning autism spectrum disorder: Evidence in support of the excitatory/inhibitory imbalance hypothesis
    • Tebartz van Elst, L., Maier, S., Fangmeier, T., Endres, D., Mueller, G.T., Nickel, K., et al. (2014). Disturbed cingulate glutamate metabolism in adults with high-functioning autism spectrum disorder: Evidence in support of the excitatory/inhibitory imbalance hypothesis. Molecular Psychiatry, 19, 1314–1325.
    • (2014) Molecular Psychiatry , vol.19 , pp. 1314-1325
    • Tebartz van Elst, L.1    Maier, S.2    Fangmeier, T.3    Endres, D.4    Mueller, G.T.5    Nickel, K.6
  • 57
    • 73249145672 scopus 로고    scopus 로고
    • Effect of quinolinic acid on human astrocytes morphology and functions: Implications in Alzheimer's disease
    • Ting, K.K., Brew, B.J., & Guillemin, G.J. (2009). Effect of quinolinic acid on human astrocytes morphology and functions: Implications in Alzheimer's disease. Journal of Neuroinflammation, 6, 36.
    • (2009) Journal of Neuroinflammation , vol.6 , pp. 36
    • Ting, K.K.1    Brew, B.J.2    Guillemin, G.J.3
  • 60
    • 79960312085 scopus 로고    scopus 로고
    • Downregulated kynurenine 3-monooxygenase gene expression and enzyme activity in schizophrenia and genetic association with schizophrenia endophenotypes
    • Wonodi, I., Stine, O.C., Sathyasaikumar, K.V., Roberts, R.C., Mitchell, B.D., Hong, L.E., et al. (2011). Downregulated kynurenine 3-monooxygenase gene expression and enzyme activity in schizophrenia and genetic association with schizophrenia endophenotypes. Archives of General Psychiatry, 68, 665–674.
    • (2011) Archives of General Psychiatry , vol.68 , pp. 665-674
    • Wonodi, I.1    Stine, O.C.2    Sathyasaikumar, K.V.3    Roberts, R.C.4    Mitchell, B.D.5    Hong, L.E.6
  • 61
    • 0028039783 scopus 로고
    • Sensorineural hearing loss from quinolinic acid: A neurotoxin in middle ear effusions
    • Yellon, R.F., Rose, E., Kenna, M.A., Doyle, W.J., Casselbrant, M., Diven, W.F., et al. (1994). Sensorineural hearing loss from quinolinic acid: A neurotoxin in middle ear effusions. The Laryngoscope, 104, 176–181.
    • (1994) The Laryngoscope , vol.104 , pp. 176-181
    • Yellon, R.F.1    Rose, E.2    Kenna, M.A.3    Doyle, W.J.4    Casselbrant, M.5    Diven, W.F.6
  • 62
    • 0016687694 scopus 로고
    • Relationships between tryptophan in serum and CSF, and 5-hydroxyindoleacetic acid in CSF of man: Effect of cirrhosis of liver and probenecid administration
    • Young, S.N., Lal, S., Sourkes, T.L., Feldmuller, F., Aronoff, A., & Martin, J.B. (1975). Relationships between tryptophan in serum and CSF, and 5-hydroxyindoleacetic acid in CSF of man: Effect of cirrhosis of liver and probenecid administration. Journal of Neurology, Neurosurgery, and Psychiatry, 38, 322–330.
    • (1975) Journal of Neurology, Neurosurgery, and Psychiatry , vol.38 , pp. 322-330
    • Young, S.N.1    Lal, S.2    Sourkes, T.L.3    Feldmuller, F.4    Aronoff, A.5    Martin, J.B.6
  • 63
    • 84924073241 scopus 로고    scopus 로고
    • Effect of maternal immune activation on the kynurenine pathway in preadolescent rat offspring and on MK801-induced hyperlocomotion in adulthood: Amelioration by COX-2 inhibition
    • Zavitsanou, K., Lim, C.K., Purves-Tyson, T., Karl, T., Kassiou, M., Banister, S.D., & et al. (2014). Effect of maternal immune activation on the kynurenine pathway in preadolescent rat offspring and on MK801-induced hyperlocomotion in adulthood: Amelioration by COX-2 inhibition. Brain, Behavior, and Immunity, 41, 173–181.
    • (2014) Brain, Behavior, and Immunity , vol.41 , pp. 173-181
    • Zavitsanou, K.1    Lim, C.K.2    Purves-Tyson, T.3    Karl, T.4    Kassiou, M.5    Banister, S.D.6


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